The Toxic Effect of Cadmium Chloride on Lung Function and Tissue and the Protective Role of Pomegranate Seed Oil in Female Rabbits

The protective role of Pomegranate seed oil (Pometone) on serum protein in sodium fluoride treated female rats

The Iraqi Journal of Veterinary Medicine ◽

10.30539/iraqijvm.v40i1.139 ◽

2016 ◽

Vol 40 (1) ◽

pp. 61-68

Author(s):

Baraa Najim Al-Okaily

Keyword(s):

Drinking Water ◽

Sodium Fluoride ◽

Total Protein ◽

Seed Oil ◽

Protective Role ◽

Female Rats ◽

Serum Total Protein ◽

Pomegranate Seed Oil ◽

Pomegranate Seed

This study is designed to determin the protective role of pomegranate seed oil against deleterious effect induced by sodium fluoride on serum proteins in rats. Forty (40) adult female rats were randomly divided into four equal group (10/group) and treated daily for 40 days as following: Group C administered distilled water (control), group T1 received sodium fluoride 120 ppm/liter in drinking water, group T2 received both sodium fluoride 120 ppm/liter in drinking water and Pometone 30 mg/kg B.w. orally and group T3 administered Pometone 30 mg/kg B.w. orally. Fasting blood samples were collected at 0, 20 and 40 days of the experimental periods and serum samples were aliquoted for estimation serum total protein, albumin and globulin concentrations. Also, protein electrophoresis was measured. The results revealed that sodium fluoride caused significant reduction in serum total protein, albumin and globulin concentrations, in addition to changes in the patterns of serum protein fractions % (albumin, α1-globulin, α2-globulin, β-globulin and γ-globulin) as compared with control rats. In conclusion Pomegranate seed oil caused elevation of proteins concentration as compared to group T1 and could potentially be beneficial in preventing the hepatic damage caused by sodium fluoride.

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The Role of Pometone (Pomegranate seed oil) in Ameliorating the Deleterious Effect of Methionine Overload on Some Histological Aspects of heart and aorta in Female Rabbits (Part-II)

The Iraqi Journal of Veterinary Medicine ◽

10.30539/iraqijvm.v38i1.257 ◽

2014 ◽

Vol 38 (1) ◽

pp. 62-70

Author(s):

Baraa Najim Al-Okaily

Keyword(s):

Cardiac Muscle ◽

Muscle Fiber ◽

Seed Oil ◽

Mononuclear Cells ◽

Corn Oil ◽

Control Group ◽

Aortic Tissue ◽

Pomegranate Seed Oil ◽

Pomegranate Seed

This experiment was aimed to investigate the role of pomegranate seed oil (PSO) in ameliorating the deleterious effects of methionine overload on some histopathological structure of heart and aorta in adult female rabbits. Thirty-Two female rabbits divided into four groups eight animals each, and treated for 42 days daily as follows: the first groups were drenched drinking corn oil, serving as control (group C), second group (group T1) were intubated orally with methionine 100mg/kg. B.W, while the third group (groupT2) were intubated orally with methionine 100mg/kg. B.W and pomegranate seed oil (PSO) 30 mg /Kg. B.W, and the animals in group T3 were intubated orally with pomegranate seed oil 30 mg /Kg. B.W. At the end of the experiment rabbits were sacrificed. Serial sections from the heart and aorta were prepared and examined microscopically. Histological examination of heart and aorta of methionine overload treated group (T1) showed edema ,RBCs and few neutrophils infiltration ,with vacuolar degeneration of cardiac muscle cells , fragment of muscle fiber, congested blood vessels between muscle fibers. An increase in thickness of intima, erosion and mononuclear cells infiltration in sub intima of aorta were also observed. Histological sections of heart and aorta in T2 and T3 groups showed the absence of histopathological lesions in aortic tissue with moderate edema between muscle fiber of T2 group as comparing to group T1. In conclusion, the results confirm the cardioprotective role of pomegranate seed oil by ameliorating the effect of methionine overload on cardiac muscle and aorta.

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Therapeutic role of Punica granatum (pomegranate) seed oil extract on bone turnover and resorption induced in ovariectomized rats

The journal of nutrition health & aging ◽

10.1007/s12603-017-0884-5 ◽

2017 ◽

Vol 21 (10) ◽

pp. 1299-1306 ◽

Cited By ~ 3

Author(s):

Nadia Z. Shaban ◽

I. M. Talaat ◽

F. H. Elrashidy ◽

A. Y. Hegazy ◽

A. S. Sultan

Keyword(s):

Bone Turnover ◽

Seed Oil ◽

Punica Granatum ◽

Ovariectomized Rats ◽

Therapeutic Role ◽

Pomegranate Seed Oil ◽

Oil Extract ◽

Pomegranate Seed

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The Protective role of Pomegranate seed oil (Pometon) on kidney (functional and structural) damage induced by Methionine overload in adult female Rabbits

The Iraqi Journal of Veterinary Medicine ◽

10.30539/iraqijvm.v38i2.225 ◽

2014 ◽

Vol 38 (2) ◽

pp. 66-73

Author(s):

Ahmed Dawood Salman

Keyword(s):

Adult Female ◽

Structural Damage ◽

Seed Oil ◽

Mononuclear Cells ◽

Corn Oil ◽

Protective Role ◽

Structural Effect ◽

Renal Tubules ◽

Pomegranate Seed Oil ◽

Pomegranate Seed

This study was designed to investigate the protective effect of Pomegranate seed oil (PSO) on kidney damage induced by methionine overload in adult female rabbits. Twenty four adult female local rabbits were randomly divided into four equal groups, and they were treated daily for 42 days,as fallow: the first group (C): rabbits were received ordinary corn oil orally, serving as control, while aniamls in the second group T1 were intubated with methionine (100 mg/kg BW) orally and animals in third group (T2) were intubated with methionine (100mg/kg BW) plus pometon (30mg/kg BW) diluted in corn oil wihle, rabbits in fourth group (T3) were intubated with pometone (30 mg/kg BW) diluted in corn oil.Fasting blood samples were collected from all experimental groups at 0, 21, and 42 days of experiment to study the parameters: Serum creatinine (SC) concentration and Blood urea nitrogen (BUN) concentration. Sections of kidney were assessed for histopathological studies. The result revealed that exposure of animals to methionine in group (T1) for 42 days caused a significant increase (P<0.05) in SC, BUN, concentrations as comparing to pomegranate treated groups and control. While oral intubation of PSO caused significant decrease (P<0.05) in the previous and correct the values near that of the control. Exposure to methionine overload showed severe acute cellular degeneration with mononuclear cells infiltration between renal tubules while there was no clear pathlogical lesions in kidney section after PSO intubation. In conclusion, it seems that Pomegranate seed oil intubation possessed renoprotactive (functional and structural) effect against deleterious damage induced by Methionine overload in rabbits.

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The possible protective role of pumpkin seed oil in ameliorating tongue mucosal damage induced by orlistat in adult male albino rats: A light and scanning electron microscopic study

Egyptian Journal of Histology ◽

10.21608/ejh.2020.25027.1258 ◽

2020 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

Amira Kassab ◽

Khalid Ahmed Moustafa ◽

Amal Abd-El-Hafez

Keyword(s):

Seed Oil ◽

Mucosal Damage ◽

Protective Role ◽

Albino Rats ◽

Electron Microscopic ◽

Pumpkin Seed ◽

Scanning Electron Microscopic Study ◽

Scanning Electron Microscopic ◽

Pumpkin Seed Oil

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In Vitro Estimation of Photo-Protective Potential of Pomegranate Seed Oil and Development of a Nanoformulation

Current Nutrition & Food Science ◽

10.2174/1573401314666180223134235 ◽

2019 ◽

Vol 15 (1) ◽

pp. 87-102 ◽

Cited By ~ 2

Author(s):

Surbhi Dhawan ◽

Sanju Nanda

Keyword(s):

Particle Size ◽

Zeta Potential ◽

Seed Oil ◽

Topical Delivery ◽

Inflammatory Activity ◽

Pomegranate Seed Oil ◽

Protective Potential ◽

Release Studies ◽

Pomegranate Seed

Background: Since ancient times, people have been using natural resources for photoprotection purposes. One such highly recognised natural agent is pomegranate seed oil, considered as wonder oil owing to the presence of several beneficial phytoconstituents. Objective: The study aimed to establish the photoprotective potential of pomegranate seed oil through various in vitro and biochemical studies along with the formation of nanoemulsion, an efficient topical delivery system for the oil. Method: Photo-protective potential of the oil was estimated by determining in vitro antioxidant and anti-inflammatory activity, total phenolic content, anti elastase, antihyaluronidase and anticollagenase activities of the oil. Ultrasonication method was used to formulate nanoemulsions. The optimisation was done following the central composite design. The characterisation was done by particle size analysis, zeta potential, polydispersity index, pH, viscosity, stability testing and transmission electron microscopy. The optimised nanoemulsion was loaded into a gel base for topical application and further release studies were carried out. Results: The IC50 values of anti-elastase, anti-collagenase and anti-hyaluronidase were found to be 309 mg/ml, 4 mg/ml and 95 mg/ml respectively. The results of anti-oxidant and anti-inflammatory activity were also significant, which thereby established the photo-protective potential of the oil. The optimum batch 2 had particle size 83.90 nm, 0.237 PDI and -5.37 mV zeta potential. The morphology was confirmed by TEM. Batch 2 was incorporated into a gel base and release studies showed 74.12 % release within 7 hours. Conclusion: Pomegranate seed oil possesses a potential photo-protective ability. Nanoemulsions proved to be a promising carrier for the topical delivery of the oil.

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