Therapeutic role of Punica granatum (pomegranate) seed oil extract on bone turnover and resorption induced in ovariectomized rats

2017 ◽  
Vol 21 (10) ◽  
pp. 1299-1306 ◽  
Author(s):  
Nadia Z. Shaban ◽  
I. M. Talaat ◽  
F. H. Elrashidy ◽  
A. Y. Hegazy ◽  
A. S. Sultan
Keyword(s):  
Bone Turnover ◽  
Seed Oil ◽  
Punica Granatum ◽  
Ovariectomized Rats ◽  
Therapeutic Role ◽  
Pomegranate Seed Oil ◽  
Oil Extract ◽  
Pomegranate Seed

scholarly journals The Role of Pometone (Pomegranate seed oil) in Ameliorating the Deleterious Effect of Methionine Overload on Some Histological Aspects of heart and aorta in Female Rabbits (Part-II)

2014 ◽  
Vol 38 (1) ◽  
pp. 62-70
Author(s):  
Baraa Najim Al-Okaily
Keyword(s):  
Cardiac Muscle ◽  
Muscle Fiber ◽  
Seed Oil ◽  
Mononuclear Cells ◽  
Corn Oil ◽  
Control Group ◽  
Aortic Tissue ◽  
Pomegranate Seed Oil ◽  
Pomegranate Seed

This experiment was aimed to investigate the role of pomegranate seed oil (PSO) in ameliorating the deleterious effects of methionine overload on some histopathological structure of heart and aorta in adult female rabbits. Thirty-Two female rabbits divided into four groups eight animals each, and treated for 42 days daily as follows: the first groups were drenched drinking corn oil, serving as control (group C), second group (group T1) were intubated orally with methionine 100mg/kg. B.W, while the third group (groupT2) were intubated orally with methionine 100mg/kg. B.W and pomegranate seed oil (PSO) 30 mg /Kg. B.W, and the animals in group T3 were intubated orally with pomegranate seed oil 30 mg /Kg. B.W. At the end of the experiment rabbits were sacrificed. Serial sections from the heart and aorta were prepared and examined microscopically. Histological examination of heart and aorta of methionine overload treated group (T1) showed edema ,RBCs and few neutrophils infiltration ,with vacuolar degeneration of cardiac muscle cells , fragment of muscle fiber, congested blood vessels between muscle fibers. An increase in thickness of intima, erosion and mononuclear cells infiltration in sub intima of aorta were also observed. Histological sections of heart and aorta in T2 and T3 groups showed the absence of histopathological lesions in aortic tissue with moderate edema between muscle fiber of T2 group as comparing to group T1. In conclusion, the results confirm the cardioprotective role of pomegranate seed oil by ameliorating the effect of methionine overload on cardiac muscle and aorta.

scholarly journals Characterization of constituents, quality and stability of pomegranate seed oil (Punica granatum L.)

2016 ◽  
Vol 36 (1) ◽  
pp. 132-139 ◽  
Author(s):  
Illana Louise Pereira de MELO ◽  
Eliane Bonifácio Teixeira de CARVALHO ◽  
Ana Mara de Oliveira e SILVA ◽  
Luciana Tedesco YOSHIME ◽  
José Augusto Gasparotto SATTLER ◽  
...  
Keyword(s):  
Seed Oil ◽  
Punica Granatum ◽  
Pomegranate Seed Oil ◽  
Pomegranate Seed ◽  
Punica Granatum L

scholarly journals Fatty Acids Composition of Red and Purple Pomegranate (Punica granatum L) Seed Oil

2010 ◽  
Vol 1 (2) ◽  
pp. 74 ◽  
Author(s):  
Hartati Soetjipto ◽  
Murda Pradipta ◽  
KH Timotius
Keyword(s):  
Fatty Acids ◽  
Neutral Lipid ◽  
Acid Content ◽  
Seed Oil ◽  
Lipid Fraction ◽  
Punica Granatum ◽  
Punicic Acid ◽  
Pomegranate Seed Oil ◽  
Pomegranate Seed ◽  
Punica Granatum L

The aim of this investigation was to determine the content and composition of fatty acid in seed oil of red and purple pomegranate (Punica granatum L). The extraction process was performed by Soxhlet extractor with petroleum ether as solvent. The separation and identification of pomegranate seed oil was done by using GCMS. The total oil content of red and purple  pomegranate  were 128 g/kg d.w  and 103 g/kg d.w respectively. Both showed the same major fatty acids  as palmitic, stearic, oleic, linoleic and  punisic acid. Oleic acid (19-21%) and linoleic acid (20-21%) were found as the most  dominant fatty acids in red pomegranate, whereas purple pomegranate seed oil was dominated by oleic acid (41-43%) and punicic acid  (0-25%). Neutral lipid  fraction of  red and purple pomegranate seed oils was more dominant than glycolipid and phospholipid. Neutral  lipid fraction  of red and purple pomegranate seed oil were  89 % and 91% respectively.  Glycolipid fraction  of red and purple pomegranate seed oil were 8 % and 5 %, whereas phosholipid fraction of red and purple pomegranate seed oil were 3 % and 4 %. The punicic acid content of  total lipid of  purple pomegranate seed oil (PPSO) (0-25%) was higher than red pomegranate (RPSO) (9-16%). On the contrary neutral lipid of red pomegranate showed higher punicic acid content (54-75%) than the purple pomegranate (14-55%). Glycolipid of red pomegranate contained  punicic acid  (0-42%). The punicic acid content  of the phospholipid fraction of  red pomegranate was higher (0-22 %) than the one of purple pomegranate (0-2%).Key words : fatty acid, pomegranate, Punica granatum, punicic acid, seed oil

Pomegranate Seed Oil Modulates Functions and Survival of BV-2 Microglial Cells in vitro

2014 ◽  
Vol 84 (5-6) ◽  
pp. 295-309 ◽  
Author(s):  
Lucia Račková ◽  
Volkan Ergin ◽  
Elif Burcu Bali ◽  
Marcela Kuniaková ◽  
Çimen Karasu
Keyword(s):  
Seed Oil ◽  
Therapeutic Potential ◽  
Fold Increase ◽  
Punica Granatum ◽  
Current Evidence ◽  
No Production ◽  
Omega 3 ◽  
Pomegranate Seed Oil ◽  
Pomegranate Seed

Abstract. Current evidence has demonstrated the immunomodulatory efficacy of omega-3 polyunsaturated fatty acids (PUFAs) in glial cells, suggesting their therapeutic potential for diseases in the central nervous system (CNS). However, conjugated omega-5 PUFAs have also attracted considerable attention because of their suggested anti-inflammatory effects. In the present study, the effect of pomegranate (Punica granatum L.) seed oil (PSEO) (a rich source of omega-5 PUFAs) on the activation of cultured BV-2 microglia was investigated within a 24-hour incubation period. PSEO (25 μg/ml) showed only a slightly smaller inhibitory effect on LPS-stimulated NO production (243 ± 12.5 % of control, p<0.001 vs. 437 ± 9.2 % in stimulated cells) and TNF-α release (87.1 ± 5.62 pg/ml vs. 229 ± 24.4 pg/ml in stimulated cells), as well as iNOS expression (7.36-fold of control, p < 0.01, vs. 17.5-fold increase in stimulated cells) compared to a standardized omega-3 PUFAs mixture (25 μg/ml) and the flavonoid quercetin (25 μmol/l). Unlike quercetin and stobadine, only the PUFA preparations effectively prevented apoptosis of microglia (as confirmed by the suppression of caspase 3 activation) exposed to the toxic concentration of LPS. The PUFA preparations did not provide a notable suppression of the intracellular oxidant generation and did not influence the intracellular distribution of cholesterol (as confirmed by filipin staining). However, they appeared to affect the morphology of activated cells. In conclusion, our data point to the first evidence of immunomodulation and cytoprotection of BV-2 microglia by the pomegranate seed oil, indicating that it may be (comparably to omega-3 PUFAs) efficient against microglia-mediated neuroinflammation while preventing the premature depletion of these immune effector cells in the brain.

Evaluation of the Effect of Pomegranate Seed Oil on Healing in a Rat Wound Model With Antioxidant, Vascular, and Histopathological Parameters

2021 ◽  
pp. 153473462110405
Author(s):  
A. Nilhan Atsü, MD ◽  
Zeynep Tosuner, MD ◽  
Tayfun Bilgiç, MD
Keyword(s):  
Seed Oil ◽  
Blood Perfusion ◽  
Punica Granatum ◽  
Tissue Level ◽  
Punch Biopsy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Albino Rats ◽  
Pomegranate Seed Oil ◽  
Significant Difference ◽  
Pomegranate Seed

The study aimed to evaluate the efficiency of pomegranate ( Punica granatum) seed oil in wound healing in excised rats. Sixteen female young Wistar Albino Rats weighing approximately 300 to 320 g were randomly divided into 2 groups as the treatment (=pomegranate seed oil group) and control groups in this experiment. Six different wounds 1 cm apart from the midline and each other were formed with a 6 mm punch biopsy instrument. Three wounds were left open (open wound group) whereas 3 wounds were sutured with 4/0 vicryl (closed wound group). Punica granatum seed oil treatment was administered topically to the treatment group, both to open and closed wounds, once a day for 14 days. Parameters for healing were evaluated. Histopathologic examination was performed for the investigation of inflammation, neovascularization, granulation, and fibroblast generation in addition to serologic (enzyme-linked immunosorbent assay) evaluation of rat malondialchehyche, rat glutathione peroxidase, and rat superoxide dismutase. PeriScan PIM 3 System Laser Doppler Blood Perfusion Imager was used for the calculation of blood perfusion. There was a statistically significant difference between inflammation and neovascularization levels and group type on the 14th day in open wounds( P < .05). On the 21st day, the granulation tissue level in the closed wound group was found to be higher in the pomegranate group ( P = 0.000).The results showed that PSE oil is partially effective, although it is not effective in every parameter examined, in the treatment of excised wounds in rats and may be suitable for clinical treatment in humans but large controlled studies are needed.

scholarly journals A Review Study on Punica granatum L

2015 ◽  
Vol 21 (3) ◽  
pp. 221-227 ◽  
Author(s):  
Erfaneh Shaygannia ◽  
Mahmoud Bahmani ◽  
Behnam Zamanzad ◽  
Mahmoud Rafieian-Kopaei
Keyword(s):  
Antioxidant Activity ◽  
Seed Oil ◽  
Punica Granatum ◽  
Antibacterial Activities ◽  
Inhibitory Effect ◽  
Breast Cancers ◽  
Pomegranate Seed Oil ◽  
Medicinal Properties ◽  
Pomegranate Seed ◽  
Punica Granatum L

Punica granatum L (pomegranate) is a deciduous shrub, native to Iran. Nowadays, besides its use as a fruit, its medicinal properties have attracted the interest of researchers of many countries. Pomegranate fruit has medicinal properties such as anti-inflammatory and antibacterial activities. The pomegranate seed oil has inhibitory effect on skin and breast cancers. The pomegranate seed oil has phytoestrogenic compounds and the fruit is rich in phenolic compounds with strong antioxidant activity. Ellagic acid is one of the main components of pomegranate with phenolic structure and antioxidant activity. This review article presents the recently published findings on different aspects of this plant focusing on its medicinal properties

scholarly journals The protective role of Pomegranate seed oil (Pometone) on serum protein in sodium fluoride treated female rats

2016 ◽  
Vol 40 (1) ◽  
pp. 61-68
Author(s):  
Baraa Najim Al-Okaily
Keyword(s):  
Drinking Water ◽  
Sodium Fluoride ◽  
Total Protein ◽  
Seed Oil ◽  
Protective Role ◽  
Female Rats ◽  
Serum Total Protein ◽  
Pomegranate Seed Oil ◽  
Pomegranate Seed

This study is designed to determin the protective role of pomegranate seed oil against deleterious effect induced by sodium fluoride on serum proteins in rats. Forty (40) adult female rats were randomly divided into four equal group (10/group) and treated daily for 40 days as following: Group C administered distilled water (control), group T1 received sodium fluoride 120 ppm/liter in drinking water, group T2 received both sodium fluoride 120 ppm/liter in drinking water and Pometone 30 mg/kg B.w. orally and group T3 administered Pometone 30 mg/kg B.w. orally. Fasting blood samples were collected at 0, 20 and 40 days of the experimental periods and serum samples were aliquoted for estimation serum total protein, albumin and globulin concentrations. Also, protein electrophoresis was measured. The results revealed that sodium fluoride caused significant reduction in serum total protein, albumin and globulin concentrations, in addition to changes in the patterns of serum protein fractions % (albumin, α1-globulin, α2-globulin, β-globulin and γ-globulin) as compared with control rats. In conclusion Pomegranate seed oil caused elevation of proteins concentration as compared to group T1 and could potentially be beneficial in preventing the hepatic damage caused by sodium fluoride.  

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