Angina and Sudden Fatal (Arrhythmia) Cardiac Disorders that affect People with the Presence of Risk Factors that Show a Change in the Electrical Conductivity of the ECG

2021 ◽  
Keyword(s):  
Risk Factors ◽  
Electrical Conductivity ◽  
Fatal Arrhythmia ◽  
Cardiac Disorders

The Evaluation of Cardiac Disorders and Systemic Hypertension in JAK2 V617F Positive Patients at a Multicenter Institution

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 5560-5560
Author(s):  
Abuzar Moradi Tuchayi ◽  
Sid Hemant Sheth ◽  
Roy E. Smith
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Myeloproliferative Neoplasms ◽  
Case Series ◽  
Jak2 V617f ◽  
Jak2 V617f Mutation ◽  
Systemic Hypertension ◽  
P Value ◽  
Cardiac Disorders ◽  
V617f Mutation

Abstract INTRODUCTION: Myeloproliferative neoplasms (MPN) represent a significant risk for arterial and venous thrombosis. The JAK2 V617F mutation is an acquired mutation common in patients with polycythemia vera and essential thrombocythemia. Studies have shown that both cardiovascular disorders and JAK2 V617F mutation are independent risk factors for thrombosis in MPN. Additionally in JAK2 V617F transgenic mice, there is reported association of cardiac hypertrophy and myeloproliferative neoplasms. However, there is limited clinical data regarding which cardiovascular risk factors are associated with JAK2 V617F mutations. Our study evaluated cardiac disorders in patients with and without JAK2 V617F mutation, and compared arterial and venous thrombosis rates between the two groups. METHODS: We performed a retrospective case series study at our multiinstitutional center. Demographic information was collected of patients who were evaluated for JAK2 V617F mutation from 2005 to 2014. 34 patients were female and 35 patients were male. Mean age was 64 .Cardiac disorders were characterized as coronary artery disease (CAD), atrial fibrillation (Afib), left heart failure (LHF), myocardial infarction (MI), and dysrhythmia (DYS) other than Afib. In total, thirty-four patients were JAK2 V617F positive while thirty-five patients were JAK2 V617F negative. Data was analyzed by SPSS software version 11.5 . We used pearson chi square test to compare the incidence of cardiac disorders and systemic hypertension (HTN) between two groups. Two tailed p-value <0.05 was considered statistically significant. RESULTS: 34 patients were female and 35 patients were male. Mean age was 64 .Baseline characteristics including mean age and gender were not significantly different between two groups. In JAK2 V617F positive patients, there was a statistically significant higher incidence of systemic hypertension and atrial fibrillation. The remaining characteristics were not significant. Additionally, we found no difference in rates of arterial and venous thrombotic events between two groups. We did not find any association between JAK2 V617F mutation and deep vein thrombosis (p= 0.154), stroke (p=0.289), pulmonary embolisms (p=0.538), and peripheral arterial disease (p=0. 572). Table P- VALUE JAK2 V617F MUTATION CAD MI LHF AFIB HTN DYS 0.216 0.538 0.289 *0.018* *0.012* 0.289 CONCLUSION: We identified systemic hypertension (p=0.012) and atrial fibrillation (p=0.018) to be strongly associated with JAK2 V617F mutation. This association has not been reported so far. Due to the retrospective nature of this case series, we are unable to determine whether there is a causal relationship between the presence of JAK2 V617F mutation and systemic hypertension and/or Afib. Further investigation is necessary to determine whether there is a causal relationship between the presence of JAK2 V617F mutation and systemic hypertension and/or Afib. Disclosures No relevant conflicts of interest to declare.

Cardiovascular risk factors and cardiac disorders in long-term survivors of pediatric liver transplantation

2014 ◽  
Vol 19 (1) ◽  
pp. 48-55 ◽  
Author(s):  
Shankar Baskar ◽  
Peggy L. George ◽  
Bijan Eghtesad ◽  
Kadakkal Radhakrishnan ◽  
Vera Hupertz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Pediatric Liver Transplantation ◽  
Pediatric Liver ◽  
Cardiac Disorders ◽  
Long Term Survivors

scholarly journals MP556AUTONOMIC DISORDER AND SERUM POTASSIUM LEVEL CHANGE FOR THE RISK FACTORS OF FATAL ARRHYTHMIA IN HEMODIALYSIS PATIENTS

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i525-i525
Author(s):  
Nanami Kida ◽  
Akira Hatanaka ◽  
Yasunori Tsujimoto ◽  
Syunro Ageta ◽  
Nariaki Matsuura
Keyword(s):  
Risk Factors ◽  
Serum Potassium ◽  
Potassium Level ◽  
Serum Potassium Level ◽  
Hemodialysis Patients ◽  
Level Change ◽  
Fatal Arrhythmia

scholarly journals Survey on Prevalence of Vegadharana as a Risk Factor for Cardiac Disorders- An Observational Pilot Study

2021 ◽  
pp. 38-45
Author(s):  
Lolashri S.J ◽  
Kiran M Goud ◽  
Prasanna Kulkarni
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Pilot Study ◽  
Driving Forces ◽  
Heart Association ◽  
Survey Study ◽  
Behavioral Risk ◽  
Established Disease ◽  
Cardiac Disorders ◽  
Questionnaire Method

The present era, which is a reflection of changing major driving forces such as social, economic and cultural due to globalization, urbanization and population ageing. By this change, there is raise in the prevalence of certain non-communicable diseases. Cardiac disorders are among such which stands first in increasing mortality rate about 31% globally. Now a day, the prevalence rate is increasing due to behavioral risk factors like tobacco use, unhealthy diet, obesity, physical inactivity, alcohol and smoking. People are also at higher risk of these disorders with the presence of high risk of one or more already established disease conditions like Hyperlipidemia, Hypertension, Diabetes mellitus etc. Indians are being affected by high rates of these major risk factors which are striking for cardiac disorders at an earlier age almost 33% earlier than other demographical regions. Considering all these many organizations like MRFIT, American Heart association, National Lipid organization etc. are conducting various trials since four decades to establish the appropriate relation with risk factors to plan the better lines of management. Ayurveda explains about the concept of Dharaneeya and Adharaneeya vegas, where in Acharyas emphasize that many of the systemic diseases are caused by the forceful suppression of natural urges. Among 13 Dharaneeya vegas 9 are found to be the risk factors in causing various cardiac disorders. With this regard to explore and to assess the prevalence of Vegadharana as risk factor for cardiac disorders, an attempt has made as a pilot survey study on 40 cardiac patients. Aim: To understand the Prevalence and epidemiology of Vegadharana in Cardiac disorders. To observe the Co-relation between Vegadharana and Cardiac disorders. Methodology: It is a Pilot observational study done by using a survey strategy. The questionnaire method in an electronic format was used to collect the data. Descriptive statistics and Co-relation Co-efficient was used to analyze the data obtained. Result: In this Pilot study, the sum of the prevalence of Vegadharana was observed it was found that the frequency of Vegadharana was more in cardiac individuals, especially the category of few times and sometimes with n value=76 and 64 respectively. Conclusion: With the above data, it can be concluded that; Vegadharana has an impact on the expectancy of Cardiac disorders. The data also revealed the co-relation of Vegadharana in permutation which are signifying as higher risk factors in causing cardiac disorders.

Cardiac Disorders as Risk Factors for Alzheimer's Disease

2010 ◽  
Vol 20 (3) ◽  
pp. 749-763 ◽  
Author(s):  
Tânia Corrêa de Toledo Ferraz Alves ◽  
Luiz Kobuti Ferreira ◽  
Mauricio Wajngarten ◽  
Geraldo F. Busatto
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cardiac Disorders

INDICATORS OFMETHODS OF FUNCTIONAL DIAGNOSTICS AND NEUROLOGICAL DISORDERS IN PATIENTS WITH DISCIRCULATORYENCEPHALOPATHY ON THE BACKGROUND OF ARTERIAL HYPOTENSION

2020 ◽  
Vol 2 (1) ◽  
pp. 17-20
Author(s):  
Mavludakhon Mamurova ◽  
◽  
Aziza Djurabekova ◽  
Malikakhon Mamurova ◽  
Dilnoza Shomurodova
Keyword(s):  
Risk Factors ◽  
Neurological Disorders ◽  
Middle Age ◽  
Vascular Lesions ◽  
Arterial Hypotension ◽  
Coagulation System ◽  
Functional Diagnostics ◽  
Cerebral Pathology ◽  
Cardiac Disorders ◽  
Initial Processing

Among the risk factors for vascular cerebral pathology, along with arterial hypertension, atherosclerosis, cardiac disorders and pathology of the blood coagulation system, arterial hypotension (AH) occupies a special place. In hypertension in patients of young and middle age, small focal vascular lesions can be visualized. Our task was the initial processing of instrumental research methods with the identification of the inter connectedness of the indicators of functional diagnostics and neurological disorders in patients with discirculatory encephalopathy on the background of arterial hypotension.

scholarly journals Incidence, Clinical Characteristics and Outcome of Cardiac Toxicity in Elderly Patients with Diffuse Large B-Cell Lymphoma

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 5416-5416
Author(s):  
Wei Ping Liu ◽  
Yan Feng Xu ◽  
Yan Xie ◽  
Xiaopei Wang ◽  
Yuqin Song ◽  
...  
Keyword(s):  
Risk Factors ◽  
Elderly Patients ◽  
B Cell ◽  
Cardiac Toxicity ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Cancer Hospital ◽  
Cardiac Disorders ◽  
Large B Cell

Abstract Backgroud: Cardiac toxicity is a life-threatening complication in elderly patients with lymphoma, which lead to a delay or premature termination of chemotherapy. Methods: A total of 462 consecutive patients with diffuse large B-cell lymphoma over 60 years old between 2007 and 2017 were reviewed. Of these, 87 patients were excluded from the study. Finally, 375 lymphoma patients were included. Data about general information, clinical feature, laboratory examination, pathological results, therapeutic methods and cardiac toxicity were collected by case retrieval system. Cardiac toxicity was graded according to National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE). Results: The incidence of cardiac disorders was 5.3% (20/375). The median number of chemotherapy cycles before cardiac toxicity was 1 (range, 1-4). Ventricular arrhythmia was the most frequent cardiac disorder (n=6), followed by palpitations (n=4), left ventricular systolic dysfunction (n=3), heart failure (n=3), atrial fibrillation (n=2), myocardial infarction (n=1) and paroxysmal atrial tachycardia (n=1). At the end of treatment, grades 3 to 5 cardiac events were observed in 8 patients. In a multivariate Cox regression analysis, ECOG performance status ≥2 and history of cardiovascular disease were identified as risk factors for IP. The cumulative incidence of cardiac disorders were 2.3% (6/266) for patients without risk factors, 11.6% (11/95) for patients with 1 risk factors, and 21.4% (3/14), respectively. Conclusion: Cardiac toxicity is not rare in elderly patients with lymphoma, and a comprehensive management strategy is needed. Disclosures Song: Peking University Cancer Hospital (Beijing Cancer Hospital): Employment. Zhu:Beijing Cancer Hospital: Employment.

scholarly journals Influence of cardiovascular risk factors on pre-mild cognitive decline at middle and old age

2021 ◽  
Vol 13 (1) ◽  
pp. 13-17
Author(s):  
N. N. Koberskaya ◽  
N. N. Yakhno ◽  
V. N. Gridin ◽  
D. S. Smirnov
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Cognitive Impairment ◽  
Cardiovascular Risk ◽  
Cognitive Decline ◽  
Cardiovascular Risk Factors ◽  
Rating Scales ◽  
Control Group ◽  
Neuropsychological Characteristics ◽  
Cardiac Disorders

Much attention is currently paid to non-dementia cognitive impairment, such as mild cognitive impairment and pre-mild cognitive decline (PMCD), since their timely detection and optimal correction increase the possibility of preventing dementia.Objective: to analyze the neuropsychological characteristics of patients with PMCD depending on the presence or absence of cardiovascular risk factors (CVRFs): hypertension, cardiac disorders (ischemic heart disease, intracardiac conduction disturbance), and prior stroke and myocardial infarction, as well as diabetes mellitus.Patients and methods. Examinations were made in 182 patients (132 women, 50 men; mean age, 59.32±5.41 years) with PMCD and CVFRs, 101 patients (77 women, 24 men; mean age, 59.45±7.04 years) with PMCD without CVRFs, and 77 control persons (55 women, 22 men; mean age, 60.55±5.65 years). All underwent general clinical, neurological, and clinical psychological studies using rating scales and tests.Results and discussion. The patients with PMCD and CVRFs had lower scores on all neuropsychological tests than the control group and on most tests than the patients with PMCD without CVRFs. In addition to some deterioration in memory indicators, the patients with CVRFs performed worse executive function tests. Cluster analysis showed that in the patients with PMCD, the severity of cognitive decline was considerably affected by hypertension, cardiac disorders, and diabetes mellitus; among them, hypertension was of the most significance.Conclusion. The association of cognitive decline with the burden of CVRFs indicates their important role in the deterioration of cognitive functions in PMCD.

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