scholarly journals Tungsten disulfide-based nanocomposites for photothermal therapy

2019 ◽  
Vol 10 ◽  
pp. 811-822 ◽  
Author(s):  
Tzuriel Levin ◽  
Hagit Sade ◽  
Rina Ben-Shabbat Binyamini ◽  
Maayan Pour ◽  
Iftach Nachman ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Transition Metal Dichalcogenides ◽  
Tungsten Disulfide ◽  
Ceric Ammonium Nitrate ◽  
Infrared Range ◽  
Metal Dichalcogenides ◽  
Current Article ◽  
Functionalized Nanotubes

Nanostructures of transition-metal dichalcogenides (TMDC) have raised scientific interest in the last few decades. Tungsten disulfide (WS2) nanotubes and nanoparticles are among the most extensively studied members in this group, and are used for, e.g., polymer reinforcement, lubrication and electronic devices. Their biocompatibility and low toxicity make them suitable for medical and biological applications. One potential application is photothermal therapy (PTT), a method for the targeted treatment of cancer, in which a light-responsive material is irradiated with a laser in the near-infrared range. In the current article we present WS2 nanotubes functionalized with previously reported ceric ammonium nitrate–maghemite (CAN-mag) nanoparticles, used for PTT. Functionalization of the nanotubes with CAN-mag nanoparticles resulted in a magnetic nanocomposite. When tested in vitro with two types of cancer cells, the functionalized nanotubes showed a better PTT activity compared to non-functionalized nanotubes, as well as reduced aggregation and the ability to add a second-step functionality. This ability is demonstrated here with two polymers grafted onto the nanocomposite surface, and other functionalities could be additional cancer therapy agents for achieving increased therapeutic activity.

scholarly journals Comprehensive insights into intracellular fate of WS2 nanosheets for enhanced photothermal therapeutic outcomes via exocytosis inhibition

Nanophotonics ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 2331-2346 ◽  
Author(s):  
Na Kong ◽  
Li Ding ◽  
Xiaobin Zeng ◽  
Junqing Wang ◽  
Wenliang Li ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Transition Metal Dichalcogenides ◽  
Therapeutic Outcomes ◽  
Combination Cancer Therapy ◽  
Metal Dichalcogenides ◽  
Delivery Platform ◽  
Ws2 Nanosheets ◽  
Immense Potential ◽  
Intracellular Fate

AbstractTwo-dimensional (2D) nanosheet (NS)-based photothermal agents (PTAs), such as transition-metal dichalcogenides, have shown immense potential for their use in cancer photothermal therapy (PTT). However, the nano-bio interaction study regarding these NS-based PTAs is still in its infancy. In this study, we used WS2-PEG NS-based PTA as an example to provide comprehensive insights into the experimental understanding of their fate in cancer cells. The data revealed that three different endocytosis pathways (macropinocytosis, clathrin-dependent, and caveolae-dependent endocytosis), autophagy-mediated lysosome accumulation, and exocytosis-induced excretion contribute to the integrated pathways of WS2-PEG NSs within cells. These pathways are consistent with our previous reports on MoS2-PEG NS-based drug delivery platform, indicating that the composition difference of 2D NSs with PEGylation may have little influence on their intercellular fate. Moreover, by blocking the revealed exocytosis pathway-mediated secretion of WS2 NSs in tumor cells, an effective approach is proposed to attain enhanced photothermal therapeutic outcomes with low doses of WS2 NSs and under a low power of a near-infrared (NIR) laser. We expect that the exocytosis inhibition strategy may be a universal one for 2D NSs to achieve combination cancer therapy. This study may also provide more experimental basis for the future development of 2D NS’s application in biomedicine (e.g. PTT).

Synergistic vacancy defects and mechanical strain for the modulation of the mechanical, electronic and optical properties of monolayer tungsten disulfide

2021 ◽  
Vol 23 (10) ◽  
pp. 6298-6308
Author(s):  
Chan Gao ◽  
Xiaoyong Yang ◽  
Ming Jiang ◽  
Lixin Chen ◽  
Zhiwen Chen ◽  
...  
Keyword(s):  
Optical Properties ◽  
Transition Metal ◽  
Mechanical Strain ◽  
Transition Metal Dichalcogenides ◽  
Strain Engineering ◽  
Tungsten Disulfide ◽  
Defect Engineering ◽  
Vacancy Defects ◽  
Electronic And Optical Properties ◽  
Metal Dichalcogenides

The combination of defect engineering and strain engineering for the modulation of the mechanical, electronic and optical properties of monolayer transition metal dichalcogenides (TMDs).

scholarly journals Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaoxia Song ◽  
Zhi Chen ◽  
Xue Zhang ◽  
Junfeng Xiong ◽  
Teng Jiang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Stimuli Responsive ◽  
Lung Cancer Cell ◽  
Precise Movement ◽  
Photothermal Property

AbstractMagnetic micro/nanorobots attracted much attention in biomedical fields because of their precise movement, manipulation, and targeting abilities. However, there is a lack of research on intelligent micro/nanorobots with stimuli-responsive drug delivery mechanisms for cancer therapy. To address this issue, we developed a type of strong covalently bound tri-bead drug delivery microrobots with NIR photothermal response azobenzene molecules attached to their carboxylic surface groups. The tri-bead microrobots are magnetic and showed good cytocompatibility even when their concentration is up to 200 µg/mL. In vitro photothermal experiments demonstrated fast NIR-responsive photothermal property; the microrobots were heated to 50 °C in 4 min, which triggered a significant increase in drug release. Motion control of the microrobots inside a microchannel demonstrated the feasibility of targeted therapy on tumor cells. Finally, experiments with lung cancer cells demonstrated the effectiveness of targeted chemo-photothermal therapy and were validated by cell viability assays. These results indicated that tri-bead microrobots have excellent potential for targeted chemo-photothermal therapy for lung cancer cell treatment.

scholarly journals Monolayer MoS2 for nanoscale photonics

Nanophotonics ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 1557-1577 ◽  
Author(s):  
Xianguang Yang ◽  
Baojun Li
Keyword(s):  
Near Infrared ◽  
Transition Metal Dichalcogenides ◽  
Single Layer ◽  
Band Gaps ◽  
Laser Source ◽  
Two Dimensional ◽  
Strong Light ◽  
Metal Dichalcogenides ◽  
Optoelectronic Applications ◽  
Flexible Photodetector

AbstractTransition metal dichalcogenides are two-dimensional semiconductors with strong in-plane covalent and weak out-of-plane interactions, resulting in exfoliation into monolayers with atomically thin thickness. This creates a new era for the exploration of two-dimensional physics and device applications. Among them, MoS2 is stable in air and easily available from molybdenite, showing tunable band-gaps in the visible and near-infrared waveband and strong light-matter interactions due to the planar exciton confinement effect. In the single-layer limit, monolayer MoS2 exhibits direct band-gaps and bound excitons, which are fundamentally intriguing for achieving the nanophotonic and optoelectronic applications. In this review, we start from the characterization of monolayer MoS2 in our group and understand the exciton modes, then explore thermal excitons and band renormalization in monolayer MoS2. For nanophotonic applications, the recent progress of nanoscale laser source, exciton-plasmon coupling, photoluminescence manipulation, and the MoS2 integration with nanowires or metasurfaces are overviewed. Because of the benefits brought by the unique electronic and mechanical properties, we also introduce the state of the art of the optoelectronic applications, including photoelectric memory, excitonic transistor, flexible photodetector, and solar cell. The critical applications focused on in this review indicate that MoS2 is a promising material for nanophotonics and optoelectronics.

scholarly journals Potential modulations in flatland: near-infrared sensitization of MoS2 phototransistors by a solvatochromic dye directly tethered to sulfur vacancies

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Simon Dalgleish ◽  
Louisa Reissig ◽  
Yoshiaki Shuku ◽  
Giovanni Ligorio ◽  
Kunio Awaga ◽  
...  
Keyword(s):  
Near Infrared ◽  
Transition Metal Dichalcogenides ◽  
Vacancy Defect ◽  
Covalent Attachment ◽  
Conductivity Enhancement ◽  
Defect Sites ◽  
Metal Dichalcogenides ◽  
Solvatochromic Dye ◽  
Dye Molecule ◽  
Dielectric Environment

Abstract Near-infrared sensitization of monolayer MoS2 is here achieved via the covalent attachment of a novel heteroleptic nickel bis-dithiolene complex into sulfur vacancies in the MoS2 structure. Photocurrent action spectroscopy of the sensitized films reveals a discreet contribution from the sensitizer dye centred around 1300 nm (0.95 eV), well below the bandgap of MoS2 (2.1 eV), corresponding to the excitation of the monoanionic dithiolene complex. A mechanism of conductivity enhancement is proposed based on a photo-induced flattening of the corrugated energy landscape present at sulfur vacancy defect sites within the MoS2 due to a dipole change within the dye molecule upon photoexcitation. This method of sensitization might be readily extended to other functional molecules that can impart a change to the dielectric environment at the MoS2 surface under stimulation, thereby extending the breadth of detector applications for MoS2 and other transition metal dichalcogenides.

Liquid exfoliated biocompatible WS2@BSA nanosheets with enhanced theranostic capacity

2021 ◽  
Vol 9 (1) ◽  
pp. 148-156
Author(s):  
Haoyang Yi ◽  
Xinyue Zhou ◽  
Chaohui Zhou ◽  
Qingye Yang ◽  
Nengqin Jia
Keyword(s):  
Transition Metal ◽  
Specific Surface ◽  
Light Absorption ◽  
Near Infrared ◽  
Transition Metal Dichalcogenides ◽  
Absorption Capacity ◽  
Infrared Light ◽  
Large Specific Surface Area ◽  
Metal Dichalcogenides ◽  
Theranostic Agents

Ultrathin transition metal dichalcogenides (TMDs) seem to have a promising future in the field of theranostic agents due to their excellent near-infrared light absorption capacity and large specific surface area.

scholarly journals Bioinspired carrier-free peptide conjugated BF2-oxasmaragdyrin dye-based nano self-assemblies: a photostable NIR cancer theragnostic agent

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Kandala Laxman ◽  
B. Pradeep K. Reddy ◽  
Sumit K. Mishra ◽  
Andrea Robinson ◽  
Abhijit De ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Visible Region ◽  
Whole Body ◽  
Water Mixture ◽  
Free Peptide ◽  
Nirf Imaging ◽  
Nir Fluorescence ◽  
Inorganic Nanomaterials

AbstractPhotothermal therapy (PTT) has attracted great interest in cancer treatment, and the quest for potential organic photothermal agents is underway owing to the nonbiodegradable nature and chronic toxicity of existing inorganic nanomaterials. Organic material-based nanoformulations with good photothermal and fluorescence properties in the near-infrared (NIR-I) window are scarce. However, porphyrins are one category of biocompatible systems that are advantageous for photothermal therapy but are currently based in the visible region, causing limited depth of tissue penetration and leading to compromised photothermal and near-infrared fluorescence (NIRF) imaging applications. To overcome these limitations, we report the synthesis of L,L-diphenylalanine conjugated BF2-oxasmaragdyrin (FF-BSC) and the fabrication of monodispersed spherical self-assemblies (FF-BSC NPs) using a USP class 3 solvent-water mixture. The resulting product exhibited excellent photostability (NIR exposure), multicycle photothermal efficacy, and NIR fluorescence. In vitro studies revealed good biocompatibility, efficient cellular internalization, and photothermal efficacy. Preclinical studies of these nano-self-assemblies demonstrated nontoxicity, efficient whole-body NIRF imaging, fractional passive tumor homing, and excellent photothermal tumor ablation potential. The absorbance and fluorescence of FF-BSC NPs in NIR-I make them suitable for theragnostic applications over existing porphyrins/inorganic nanomaterials for future clinical applications.

Correction: In Vitro and In Vivo Near-Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles

2013 ◽  
Vol 25 (7) ◽  
pp. 945-945 ◽  
Author(s):  
Kai Yang ◽  
Huan Xu ◽  
Liang Cheng ◽  
Chunyang Sun ◽  
Jun Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Organic Nanoparticles

Photothermal Therapy of Glioma in a Mouse Model With Near-Infrared Excited Nanoshells

2010 ◽  
Author(s):  
Emily S. Day ◽  
Linna Zhang ◽  
Nastassja A. Lewinski ◽  
Patrick A. Thompson ◽  
Rebekah A. Drezek ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Primary Brain Tumor ◽  
Treatment Modalities ◽  
Photothermal Ablation ◽  
Spherical Silica ◽  
Cancerous Cells ◽  
The Brain

Glioblastoma multiforme is the most common and aggressive primary brain tumor, with median survival of approximately 10 months and only 5% of patients surviving greater than 5 years after treatment (1). Surgery and radiotherapy are the main treatment modalities for primary brain tumors, but the associated risks are high when infiltrative tumors are positioned near sensitive regions in the brain. Nanoshells, nanoparticles characterized by a spherical silica core and a gold shell, may provide the opportunity to treat brain tumors in a minimally invasive manner, reducing the risk associated with treatment. Upon exposure to a near-infrared laser, nanoshells convert light energy into heat that can thermally ablate cancerous cells (2). Targeted photothermal ablation of human glioma and medulloblastoma cells has already been demonstrated with this technique in vitro (3).

Sign in / Sign up

Export Citation Format

Share Document