scholarly journals In Quest of a COVID-19 Vaccine

The Physician ◽  
2020 ◽  
Vol 6 (2) ◽  
Author(s):  
K K Aggarwal ◽  
Nirmal Kumar Ganguly

Covid-19 or Coronavirus disease-2019, caused by the novel Coronavirus (SARS CoV-2), continues to be a major global public health crisis. There is no specific drug for its treatment and no immunity against the virus. Allowing herd immunity to develop naturally would add to the already high morbidity and mortality and it may take many years. But, the speed with which the virus is spreading leaves us with no choice but to have a vaccine, or at least an emergency-use vaccine ready for use, at the earliest. There are frantic efforts across the world to develop a vaccine. Different approaches such as inactivated and attenuated vaccines, viral vector-based vaccines and DNA- and RNA-based vaccines are being studied. Many vaccines have shown promise in preclinical studies; many have completed or are in phase 1 trials. A safe and effective vaccine against Covid-19 is eagerly awaited. But, even when a vaccine is available, public health measures such as personal hygiene, social distancing, will be equally important to reduce disease transmission. In this article, we give a brief overview of the types of vaccines and the various vaccine initiatives around the world.

2020 ◽  

In the past 100 years, the world has faced four distinctly different pandemics: the Spanish flu of 1918-1919, the SARS pandemic of 2003, the H1N1 or “swine flu” pandemic of 2012, and the ongoing COVID-19 pandemic. Each public health crisis exposed specific systemic shortfalls and provided public health lessons for future events. The Spanish flu revealed a nursing shortage and led to a great appreciation of nursing as a profession. SARS showed the importance of having frontline clinicians be able to work with regulators and those producing guidelines. H1N1 raised questions about the nature of a global organization such as the World Health Organization in terms of the benefits and potential disadvantages of leading the fight against a long-term global public health threat. In the era of COVID-19, it seems apparent that we are learning about both the blessing and curse of social media.


2021 ◽  
Vol 15 (03) ◽  
pp. 366-369
Author(s):  
Rooh Ullah ◽  
Muhammad Suleman Rana ◽  
Mehmood Qadir ◽  
Muhammad Usman ◽  
Niaz Ahmed

Pandemic of novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections in China is now become global public health crisis. At present 87.64% of the world is infected by this deadly illness. The risk from this epidemic depends on the nature of the virus, including how well it transmits from person to person, and the complications resulting from this current illness. The novel coronavirus has killed thousands of people in China and other countries as well; its rate of mortality is increasing day by day. There is an urgent need to control the virus by developing vaccine or any other antiviral drugs to save the world from this deadly viral infection.


According to the World Health Organization (WHO), viral diseases continue to emerge and represent a serious issue to public health. In the last twenty years, several viral epidemics such as the severe acute respiratory syndrome coronavirus (SARS-CoV) from 2002 to 2003, and H1N1 influenza in 2009, have been recorded. The new coronavirus, formed a clade within the subgenus Orthocoronavirinae, sarbecovirus subfamily. The first time these cases were published, they were classified as “pneumonia of unknown etiology.” The question then became: are future epidemic risks amenable to forecast from identifiable triggers? Of immediate concern was the integrated research on closed spaces; where they in fact favorable or not to virus transmission subject to certification? We are currently opening diverse research in viral Medical Geology studies, as a new discipline. At present, there appears to be an emergent need for society to be educated on both existing in a world with Covid-19, while simultaneously learning how to prevent the spread of the pandemic. It is certainly important, yet has become insufficient, to impose physical distancing among people, isolation of patients, coughing “vampire” style into your elbow or continuing the usage of hand disinfectants and hand washing. The goal of this most recent work is to prepare a safety certificate for closed spaces which allows us to mandate the minimum number of people who may be present (altogether) with the minimum risk in values of viral transmission. It analyzes four key parameters in the propagation of Covid-19. The Viral Transmission in selected enclosed spaces was calculated according to the mathematical algorithm proposed by Prof. Dr. Luis CRUZ RODRIGUEZ. The Covid-19 pandemic has led to a true global public health crisis as well as a devastating financial recession, affecting the entire world. Here we have proposed a certification entitled: “Elidan Certificate”, depicting prolonged safety within enclosed areas, such as inside of buildings or relating to various modes of transportation, suggesting a safe number of people who may occupy those particular places. Our aim is to better understand potential dormant repositories of outbreaks and the potential spread of those repositories, together with potential geological-geogenic terrain factors in closed space and their triggers. Integrated research on closed spaces, whether favorable or not to the virus transmission, would be subject to certification, along with the imminent opening of diversity research in viral Medical Geology studies, as a new discipline is anticipated. In this regard, UVC is a well-known disinfectant for air, water and surfaces, which can help reduce the risk of acquiring Covid-19 when applied correctly. By the way, the IUVA has been given the task of bringing together a group of experts, leaders in the field, from various parts of the world with the aim of developing guides that contribute to an effective use of UVC Technologies (ELIDAN dynamic LLC).


2020 ◽  
Vol 18 (2) ◽  
pp. 151-158 ◽  
Author(s):  
Pradip Gyanwali ◽  
Sitasma Sharma ◽  
Suman Pant ◽  
Pallavi Koirala ◽  
Kriti Adhikari ◽  
...  

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the strain of coronavirus that causes coronavirus disease 2019 (COVID-19), a respiratory illness. COVID-19 has now become a global public health crisis causing alarming numbers of morbidity and mortality. Ever since the COVID-19 pandemic started scientists, researchers, universities, companies, and institutions all around the world have been endeavoring to discover a potential treatment for COVID-19. Numerous studies and clinical trials on vaccines and drugs for the prevention and treatment of COVID-19 are underway across the world. However, the uncertainty around the efficacy and safety of various treatment regimens have become one of the biggest challenges in the battle against the SARS-CoV-2. This paper is a narrative review of articles regarding the various treatments and vaccines being tested for the SARS-CoV-2, available in the PubMed database along with Google Scholar. There are ongoing clinical trials on potential drugs such as remdesivir, favipiravir, lopinavir/ritonavir, chloroquine, and hydroxychloroquine, corticosteroids tocilizumab, azithromycin, anakinra, etc. and other therapeutic modalities like convalescent plasma therapy. Likewise, vaccines against SARS-CoV-2 are being developed and tested, including mRNA, non-replicating viral vector, DNA, protein subunit candidate vaccines, etc. Although some early-stage clinical trials and studies on these drugs and vaccines have shown positive results, definitive and conclusive results are yet to be obtained. Keywords: COVID-19; antiviral drugs; COVID-19 treatment; COVID-19 vaccine; SARS-CoV-2


Author(s):  
Alyshia Gálvez

In the two decades since the North American Free Trade Agreement (NAFTA) went into effect, Mexico has seen an epidemic of diet-related illness. While globalization has been associated with an increase in chronic disease around the world, in Mexico, the speed and scope of the rise has been called a public health emergency. The shift in Mexican foodways is happening at a moment when the country’s ancestral cuisine is now more popular and appreciated around the world than ever. What does it mean for their health and well-being when many Mexicans eat fewer tortillas and more instant noodles, while global elites demand tacos made with handmade corn tortillas? This book examines the transformation of the Mexican food system since NAFTA and how it has made it harder for people to eat as they once did. The book contextualizes NAFTA within Mexico’s approach to economic development since the Revolution, noticing the role envisioned for rural and low-income people in the path to modernization. Examination of anti-poverty and public health policies in Mexico reveal how it has become easier for people to consume processed foods and beverages, even when to do so can be harmful to health. The book critiques Mexico’s strategy for addressing the public health crisis generated by rising rates of chronic disease for blaming the dietary habits of those whose lives have been upended by the economic and political shifts of NAFTA.


2020 ◽  
pp. 1-11
Author(s):  
Pratik DIXIT

There is no time more opportune to review the workings of the International Health Regulations (IHR) than the present COVID-19 crisis. This article analyses the theoretical and practical aspects of international public health law (IPHL), particularly the IHR, to argue that it is woefully unprepared to protect human rights in times of a global public health crisis. To rectify this, the article argues that the IHR should design effective risk reduction and response strategies by incorporating concepts from international disaster law (IDL). Along similar lines, this article suggests that IDL also has a lot to learn from IPHL in terms of greater internationalisation and institutionalisation. Institutionalisation of IDL on par with IPHL will provide it with greater legitimacy, transparency and accountability. This article argues that greater cross-pollination of ideas between IDL and IPHL is necessary in order to make these disciplines more relevant for the future.


2021 ◽  
pp. 19-23
Author(s):  
Donizete Tavares Da Silva ◽  
Priscila De Sousa Barros Lima ◽  
Renato Sampaio Mello Neto ◽  
Gustavo Magalhães Valente ◽  
Débora Dias Cabral ◽  
...  

In March 2020, the World Health Organization (1) declared COVID-19 as a pandemic and a threat to global public health (2). The virus mainly affects the lungs and can cause acute respiratory distress syndrome (ARDS). In addition, coronavirus 2 severe acute respiratory syndrome (SARSCOV2) also has devastating effects on other important organs, including the circulatory system, brain, gastrointestinal tract, kidneys and liver


2014 ◽  
Vol 27 (3) ◽  
pp. 511-529 ◽  
Author(s):  
Sudeepa Abeysinghe

ArgumentScientific uncertainty is fundamental to the management of contemporary global risks. In 2009, the World Health Organization (WHO) declared the start of the H1N1 Influenza Pandemic. This declaration signified the risk posed by the spread of the H1N1 virus, and in turn precipitated a range of actions by global public health actors. This article analyzes the WHO's public representation of risk and examines the centrality of scientific uncertainty in the case of H1N1. It argues that the WHO's risk narrative reflected the context of scientific uncertainty in which it was working. The WHO argued that it was attempting to remain faithful to the scientific evidence, and the uncertain nature of the threat. However, as a result, the WHO's public risk narrative was neither consistent nor socially robust, leading to the eventual contestation of the WHO's position by other global public health actors, most notably the Council of Europe. This illustrates both the significance of scientific uncertainty in the investigation of risk, and the difficulty for risk managing institutions in effectively acting in the face of this uncertainty.


2019 ◽  
Vol 34 (4) ◽  
Author(s):  
Amy Moran-Thomas

Long-accepted models of causality cast diseases into the binary of either “contagious” or “non-communicable,” typically with institutional resources focused primarily on interrupting infectious disease transmission. But in southern Belize, as in much of the world today, epidemic diabetes has become a leading cause of death and a notorious contributor to organ failure and amputated limbs. This ethnographic essay follows caregivers’ and families’ work to survive in-between public health categories, and asks what responses a bifurcated model of infectious versus non-communicable disease structures or incapacitates in practice. It proposes an alternative focus on diabetes as a “para-communicable” condition—materially transmitted as bodies and ecologies intimately shape each other over time, with unequal and compounding effects for historically situated groups of people. The article closes by querying how communicability relates to community, and why it matters to reframe narratives about contributing causalities in relation to struggles for treatment access.


2021 ◽  
Vol 9 ◽  
Author(s):  
Debanjan Banerjee ◽  
K. S. Meena

The Coronavirus disease 2019 (COVID-19) pandemic has emerged as a significant and global public health crisis. Besides the rising number of cases and fatalities, the outbreak has also affected economies, employment and policies alike. As billions are being isolated at their homes to contain the infection, the uncertainty gives rise to mass hysteria and panic. Amidst this, there has been a hidden epidemic of “information” that makes COVID-19 stand out as a “digital infodemic” from the earlier outbreaks. Repeated and detailed content about the virus, geographical statistics, and multiple sources of information can all lead to chronic stress and confusion at times of crisis. Added to this is the plethora of misinformation, rumor and conspiracy theories circulating every day. With increased digitalization, media penetration has increased with a more significant number of people aiding in the “information pollution.” In this article, we glance at the unique evolution of COVID-19 as an “infodemic” in the hands of social media and the impact it had on its spread and public reaction. We then look at the ways forward in which the role of social media (as well as other digital platforms) can be integrated into social and public health, for a better symbiosis, “digital balance” and pandemic preparedness for the ongoing crisis and the future.


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