scholarly journals Serum Micronutrients as related to Childhood Pneumonia Severity and Outcome in a Nigerian Health Facility

2021 ◽  
Vol 15 (07) ◽  
pp. 953-961
Author(s):  
Bankole Peter Kuti ◽  
Hammed Hassan Adetola ◽  
Oyeku Akibu Oyelami
Keyword(s):  
Indoor Air Pollution ◽  
Health Centre ◽  
Severe Pneumonia ◽  
Zn Deficiency ◽  
Pneumonia Severity ◽  
Childhood Pneumonia ◽  
Nigerian Children ◽  
And Zn Deficiency ◽  
Optimal Health ◽  
Low Serum

Introduction: Micronutrients are essential minerals and vitamins needed for optimal health. There are however conflicting reports about the roles of micronutrients in severity and outcomes of childhood pneumonia. This study aims to determine the socio-demographic and serum micronutrients – Zinc (Zn), Selenium (Se), Vitamins (Vit) A, C and E status of Nigerian children with or without pneumonia and relate these to pneumonia severity and outcome. Methodology: Children aged two months to 14 years with severe and non-severe pneumonia were recruited with age and sex-matched controls over 12 month period in a Nigerian tertiary health centre. Relevant history and serum micronutrients were compared in the two groups and related to pneumonia severity and length of hospitalisation (LOH). Results: One hundred and forty-four children (72 for each group) were recruited with median (IQR) age 1.6 (0.6 – 4.0) years and fifty-six (38.8%) had severe pneumonia. Pneumonia incidence was associated with undernutrition, inappropriate immunisation and Zn deficiency (p < 0.05). Hypovitaminosis A [60.8(22.2)µg/dl vs. 89.5(34.7)µg/dl; p < 0.001], low serum Zn [71.6(32.5)µg/dl vs. 92.6(24.6)µg/dl; p=0.019] and indoor air pollution (IAP) were associated with pneumonia severity. However, only IAP (OR = 4.529; 95%CI 1.187–17.284; p=0.027) and Zn deficiency (OR=6.144; 95%CI 1.157–32.617; p=0.033) independently predicted severe pneumonia. No significant correlation between serum micronutrients and LOH. Conclusions: Exposure to IAP and low serum micronutrients particularly Zn and Vit A were associated with pneumonia incidence and severity in Nigerian children. Routine micronutrient supplementation may assist to reduce the burden of childhood pneumonia in developing countries.

scholarly journals Determinants of Oxygen Therapy in Childhood Pneumonia in a Resource-Constrained Region

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Bankole Peter Kuti ◽  
Samuel Ademola Adegoke ◽  
Benard E. Ebruke ◽  
Stephen Howie ◽  
Oyeku Akibu Oyelami ◽  
...  
Keyword(s):  
Oxygen Therapy ◽  
Health Centre ◽  
Severe Pneumonia ◽  
Childhood Pneumonia ◽  
Oxygen Administration ◽  
Primary Health ◽  
Head Nodding ◽  
Primary Health Centres ◽  
Life Saving ◽  
The World

Childhood pneumonia is a leading cause of morbidity and mortality among underfives particularly in the resource-constraint part of the world. A high proportion of these deaths are due to lack of oxygen, thereby making oxygen administration a life-saving adjunctive when indicated. However, many primary health centres that manage most of the cases often lack the adequate manpower and facilities to decide which patient should be on oxygen therapy. Therefore, this study aimed to determine factors that predict hypoxaemia at presentation in children with severe pneumonia. Four hundred and twenty children aged from 2 to 59 months (40% infants) with severe pneumonia admitted to a health centre in rural Gambia were assessed at presentation. Eighty-one of them (19.30%) had hypoxaemia (oxygen saturation < 90%). Children aged 2–11 months, with grunting respiration, cyanosis, and head nodding, and those with cardiomegaly on chest radiograph were at higher risk of hypoxaemia (P<0.05). Grunting respiration (OR=5.210, 95% CI 2.287–7.482) and cyanosis (OR=83.200, 95% CI 5.248–355.111) were independent predictors of hypoxaemia in childhood pneumonia. We conclude that children that grunt and are centrally cyanosed should be preferentially commenced on oxygen therapy even when there is no facility to confirm hypoxaemia.

scholarly journals Relationship between serum 25-hydroxyvitamin D, total antioxidant capacity and pneumonia incidence, severity and outcome in Nigerian children

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Bankole Peter Kuti ◽  
Alex Ifeoluwa Akinwumi ◽  
Demilade Kehinde Kuti ◽  
Kazeem Olanrewaju Amoo
Keyword(s):  
Vitamin D ◽  
Total Antioxidant Capacity ◽  
Serum Vitamin ◽  
Severe Pneumonia ◽  
Lower Serum ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Nigerian Children ◽  
Total Antioxidant ◽  
25 Hydroxyvitamin D

Abstract Background The pathologic basis of childhood community-acquired pneumonia (CAP) involves the generation of reactive oxygen species by immune cells leading to cellular damage and lung congestion. Serum antioxidants and vitamin D with immunomodulatory properties therefore hold prospects in the prevention and management of pneumonia in children. This case–control study set out to compare the serum 25-hydroxyvitamin D (25-OHD) and total antioxidant capacity (TAC) in Nigerian children with CAP and age- and sex-matched controls and to relate these parameters with pneumonia severity and outcome—length of hospital stay (LOH). Results A total of 160 children (80 each for CAP and controls) were recruited. The median (IQR) age was 1.8 (0.6–4.0) years, male:female 1.7:1, 63 (78.8%) and 11 (13.8%) of CAP group had severe pneumonia and parapneumonic effusions, respectively. Serum 25-OHD (33.8 (18.3) ng/ml vs. 41.9 (12.3) ng/ml; p = 0.010) and TAC (6.1 (4.4–8.1) ng/dl vs. 7.2 (4.7–17.5) ng/dl; p = 0.023) were lower in children with CAP than controls. Lower serum 25-OHD was observed in severe than non-severe pneumonia (30.5(17.1) ng/ml vs. 46.3 (17.6) ng/ml; p = 0.001) but LOH did not correlate with serum 25-OHD and TAC. Conclusion Children with CAP had lower serum vitamin D and antioxidants than controls, and severe pneumonia was significantly associated with suboptimal serum vitamin D. They however were not related to pneumonia outcome. Optimal serum vitamin D and antioxidants may play a role in reducing the incidence of childhood CAP in Nigerian children.

Methods of early diagnostics of severe pneumonia in children

2020 ◽  
Vol 03 (04) ◽  
pp. 43-46
Author(s):  
Sabir Nurgalam Amiraliev ◽  
Keyword(s):  
Young Children ◽  
Key Words ◽  
Lung Tissue ◽  
Tissue Damage ◽  
Severe Pneumonia ◽  
Early Diagnostics ◽  
Key Words Pneumonia ◽  
Pneumonia Severity ◽  
Acute Pneumonia ◽  
Lung Tissue Damage

Studies have shown that the severity and outcome of acute pneumonia largely depends on the prevalence of the focus of inflammation in the lung tissue, which is determined radiologically. We analyzed and determined a statistically significant effect of the degree of lung tissue damage on the severity and prognosis of pneumonia in young children, taking into account the conditions of infection. In pneumonia, χ² = 47.13 (p <0.001), indicates that the greater the degree of damage, the greater the likelihood of a severe course and unfavorable outcome of pneumonia. Key words: pneumonia, severity of the course, outcome, young children

Barriers to seeking timely treatment for severe childhood pneumonia in rural Bangladesh

2021 ◽  
pp. archdischild-2021-321993
Author(s):  
Kamal Ibne Amin Chowdhury ◽  
Ishrat Jabeen ◽  
Mahfuzur Rahman ◽  
Abu Syed Golam Faruque ◽  
Nur H Alam ◽  
...  
Keyword(s):  
Severe Pneumonia ◽  
Medical Attention ◽  
Long Distance ◽  
Childhood Pneumonia ◽  
Delayed Treatment ◽  
Rural Bangladesh ◽  
Tertiary Hospitals ◽  
Household Heads ◽  
Facility Level ◽  
Rural Mothers

ObjectiveDelays in seeking medical attention for childhood pneumonia may lead to increased morbidity and mortality. This study aimed at identifying the drivers of delayed seeking of treatment for severe childhood pneumonia in rural Bangladesh.MethodsWe conducted a formative study from June to September 2015 in one northern district of Bangladesh. In-depth interviews were conducted with 20 rural mothers of children under 5 years with moderate or severe pneumonia. We analysed the data thematically.ResultsWe found that mothers often failed to assess severity of pneumonia accurately due to lack of knowledge or misperception about symptoms of pneumonia. Several factors delayed timely steps that could lead to initiation of appropriate treatment. They included time lost in consultation with non-formal practitioners, social norms that required mothers to seek permission from male household heads (eg, husbands) before they could seek healthcare for their children, avoiding community-based public health centres due to their irregular schedules, lack of medical supplies, shortage of hospital beds and long distance of secondary or tertiary hospitals from households. Financial hardships and inability to identify a substitute caregiver for other children at home while the mother accompanied the sick child in hospital were other factors.ConclusionsThis study identified key social, economic and infrastructural factors that lead to delayed treatment for childhood pneumonia in the study district in rural Bangladesh. Interventions that inform mothers and empower women in the decision to seek healthcare, as well as improvement of infrastructure at the facility level could lead to improved behaviour in seeking and getting treatment of childhood pneumonia in rural Bangladesh.

scholarly journals Assessment of Available Micronutrients Status in the Soils of Melur Block, Madurai District, Tamil Nadu, Using GIS and GPS Techniques

2021 ◽  
pp. 108-116
Author(s):  
P. Ramamoorthy ◽  
P. Christy Nirmala Mary ◽  
P. Saravanapandian ◽  
A. Gurusamy ◽  
K. Kumutha
Keyword(s):  
Tamil Nadu ◽  
Nutrient Status ◽  
Micronutrient Deficiency ◽  
Soil Samples ◽  
Zn Deficiency ◽  
Soil Resource ◽  
And Zn Deficiency ◽  
Standard Procedures ◽  
Resource Inventory ◽  
Critical Limits

A soil resource inventory was conducted at village level in the Melur block of Madurai district, Tamil Nadu to assess the micronutrients status in the soils and to prepare fertility maps depicting the extent of soil micronutrient deficiency/sufficiency using GIS and GPS techniques. Soil samples were collected at revenue village wise along with geo coordinates and analysed for available micronutrients such as Zn, Fe, Cu and Mn by adopting standard procedures. Based on the nutrient status, the soils were grouped as deficient or sufficient using the critical limits. Per cent deficiency of micronutrients in Melur block was worked out and the thematic maps showing status of different available micronutrients were generated. The results indicated that, Fe and Zn  deficiency is most prevalent in the soils of Melur block  in Madurai district to an extent of more than 35 per cent, followed by Cu (1.1%) and Mn (10%).

scholarly journals Impact of the trace element status on the course of ankylosing spondylitis in the Orenburg Region patients

2019 ◽  
Vol 13 (4) ◽  
pp. 66-74
Author(s):  
U. A. Yakubova ◽  
O. V. Bugrova ◽  
S. I. Krasikov ◽  
N. P. Setko ◽  
R. I. Saifutdirov
Keyword(s):  
Ankylosing Spondylitis ◽  
Inflammatory Diseases ◽  
Clinical Manifestations ◽  
Atomic Absorption Spectrophotometry ◽  
Zn Deficiency ◽  
Orenburg Region ◽  
And Zn Deficiency ◽  
Trace Element Status ◽  
The Impact

The role of trace elements (TEs) and their imbalance in the physiology of bone tissue and in the development of inflammatory diseases of the joints and spine has been discussed in recent years; however, there is no evidence for the TE status of patients with ankylosing spondylitis (AS) and its possible impact on the course of the disease.Objective: to investigate the impact of the TE status of patients with AS on the course, clinical manifestations, and activity of the disease.Patients and methods. Examinations were made in 58 patients (39 men and 19 women), residents of the Orenburg Region, with a reliable diagnosis of AS, the duration of which was 16 [11; 26] years. The patients’ mean age was 38 [31; 48] years. HLA-B27 antigen was detected in 91.4% of cases. In addition to the generally accepted examination, atomic absorption spectrophotometry was used to determine the hair levels of 9 TEs: Cu, Zn, Fe, Mn, Cr, Co, Ni, Pb, and Cd in all the patients.Results and discussion. The AS patients living in the Orenburg Region showed TE imbalance manifested by Cu and Zn deficiency and Ni, Cr, and Mn accumulation in the hair. Multidirectional correlations were found between the values of these TEs and the presence of extra-axial (peripheral arthritis, dactylitis) and extra-skeletal (uveitis) manifestations of AS, its activity, and severity of functional disorders.Conclusion. The preliminary results may suggest that the emerging imbalance of TEs can affect the course of AS, maintaining and increasing its activity.

scholarly journals A Comparative Study of the Bioavailability of Fe, Cu and Zn from Gluten-Free Breads Enriched with Natural and Synthetic Additives

Foods ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1853
Author(s):  
Anna Rogaska ◽  
Julita Reguła ◽  
Joanna Suliburska ◽  
Zbigniew Krejpcio
Keyword(s):  
Mineral Content ◽  
Control Diet ◽  
Nutritional Intervention ◽  
Zn Deficiency ◽  
Gluten Free ◽  
Factors Affecting ◽  
And Zn Deficiency ◽  
High Bioavailability ◽  
Cu And Zn ◽  
Natural And Synthetic

The aim of this study was to compare the bioavailability of iron, copper and zinc from newly designed gluten-free breads enriched with natural and synthetic additives. The study was conducted on rats with induced Fe, Cu and Zn deficiency. The nutritional intervention with diets supplemented with a 70% addition of gluten-free breads enriched with natural additives and organic compounds to the control diet AIN-93M lasted 40 days. After the intervention, the rats were euthanized, the organs were collected and their mineral content was measured. Chemical analysis of diets with the addition of fortified gluten-free breads showed significantly higher amounts of iron, zinc and copper in diets with the addition of fortified breads compared to diets with the addition of unenriched breads. The type of additives did not influence the amount of minerals in diets. It is necessary to conduct further research to explain the interactions of ingredients and the factors affecting the bioavailability of Fe, Cu and Zn from gluten-free breads in order to obtain a product with a high bioavailability of these ingredients.

Mortality and Prognostic Prediction in Very Elderly Patients With Severe Pneumonia

2019 ◽  
Vol 35 (12) ◽  
pp. 1405-1410 ◽  
Author(s):  
Moon Seong Baek ◽  
Sojung Park ◽  
Jeong-Hee Choi ◽  
Cheol-Hong Kim ◽  
In Gyu Hyun
Keyword(s):  
Elderly Patients ◽  
Hospital Mortality ◽  
Pneumonia Severity Index ◽  
Nursing Home Residents ◽  
Area Under The Curve ◽  
Severe Pneumonia ◽  
Operating Characteristics ◽  
Very Elderly ◽  
Pneumonia Severity ◽  
Prognostic Prediction

Introduction: Although prognostic prediction scores for pneumonia such as CURB-65 score or pneumonia severity index (PSI) are widely used, there were a few studies in very elderly patients. The aim of the study was to validate prognostic prediction scores for severe pneumonia and investigate risk factors associated with in-hospital mortality of severe pneumonia in very elderly patients. Methods: During the 6-year study period (from October 2012 to May 2018), 160 patients aged 80 or older admitted to medical intensive unit were analyzed retrospectively. Pneumonia severity was evaluated using CURB-65 score, PSI, Sequential Organ Failure Assessment (SOFA) scores, A-DROP, I-ROAD, UBMo index, SOAR score, and lactate. The outcome was in-hospital mortality. Results: The median age was 85 years (interquartile range: 82-88). Nursing home residents accounted for 71 (44.4%) and in-hospital mortality was 40 (25.0%). Logistic regression showed that chronic lung, mechanical ventilation, hemodialysis, and albumin were associated with in-hospital mortality of pneumonia. Using the receiver operating characteristics curve for predicting mortality, the area under the curve in pneumonia was 0.65 for the SOFA score, 0.61 for the CURB-65 score, 0.52 for the PSI, 0.58 for the A-DROP, 0.52 for the I-ROAD, 0.54 for UBMo index, 0.59 for SOAR score, and 0.65 for lactate. Conclusion: The performances of the CURB-65 and PSI are not excellent in very elderly patients with pneumonia. Further studies are needed to improve the performance of prognostic prediction scores in elderly patients.

Indoor Air Pollution and Childhood Pneumonia: Impact of Reduced Exposure on Severity and Clinical Features

Epidemiology ◽  
2007 ◽  
Vol 18 (Suppl) ◽  
pp. S136
Author(s):  
M K Dherani ◽  
A Diaz ◽  
A Jenny ◽  
L Thomsan ◽  
K Smith ◽  
...  
Keyword(s):  
Air Pollution ◽  
Clinical Features ◽  
Indoor Air ◽  
Indoor Air Pollution ◽  
Childhood Pneumonia

scholarly journals Zinc status of northern Tasmanian adults

2015 ◽  
Vol 4 ◽  
Author(s):  
Jeffrey M. Beckett ◽  
Madeleine J. Ball
Keyword(s):  
Cross Sectional Study ◽  
Health Concern ◽  
Zn Deficiency ◽  
Dietary Intakes ◽  
Cross Sectional ◽  
Serum Zn ◽  
Zinc Nutrition ◽  
Zn Status ◽  
Low Serum ◽  
Consultative Group

AbstractInformation regarding Zn status in the Australian population is very limited. Mild deficiencies in Zn have been associated with CVD, impaired immune function and poor healing. A cross-sectional study of 497 northern Tasmanian adults (24–82 years of age) was conducted to assess Zn status. Dietary intakes were assessed by FFQ and serum concentrations of Zn were evaluated using International Zinc Nutrition Consultative Group methodology. Mean Zn intakes were 12·6 (sd4·4) mg/d for men and 10·9 (sd3·6) mg/d for women. It was found that 52 % of men but only 9 % of women consumed less than the Australia/New Zealand estimated average requirement for Zn. Mean serum Zn was 13·0 (sd2·4) µmol/l in men and 13·0 (sd2·5) µmol/l in women. Overall, 15 % of men and 7 % of women had low serum Zn levels. Furthermore, low serum Zn was observed in 18 % of men 50 years or older and 30 % of men 70 years or older. The present results suggest that mild Zn deficiency may be prevalent in older Tasmanian adults, particularly men; and due to the importance of Zn in many areas of health, this could be of public health concern.

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