Features of the immune status in patients with chronic and complicated pyodermas: choice of a therapeutic correction method

Introduction: To compare the features of the immune status in patients with chronic and complicated pyoderma in the course of complex pharmacotherapy using immunomodulators based on transfer factors and glucosaminylmuramyldipeptide. Materials and methods: A clinical examination of 107 patients with pyoderma, divided into three groups, was carried out. All individuals underwent immunological examination before and after etiopathogenetic treatment. The patients of the first group were additionally treated with a drug containing signaling immunoactive molecules (transfer factor) as an immunomodulator; the patients of the second group received glucosaminylmuramyldipeptide; and the patients of the third group received standard antibacterial therapy. Results and discussion: Prior to the beginning of pathogenetic therapy, the patients were found to lack non-specific mechanisms of antimicrobial protection; there was a decrease in the activity and intensity of phagocytosis: phagocytic index and phagocytic number of neutrophils by 1.2 and 1.3 times; the production of proinflammatory cytokines IL-6 increased by 2.3 times, IL-8 –by 2.1 times, and TNFa – by 2.4 times. The study of immunological parameters after the inclusion of immunomodulators into the therapy revealed an increase in the phagocytic activity of neutrophils, and the indicators of the NST test were close to the control ones. The production of proinflammatory cytokines in the blood serum was restored to the level of the healthy individuals. Normalization of the number of CD4+-, CD8+-, CD19+-cells was observed in 86.0 ± 3% of the patients. At the same time, against the background of the use of glucosaminylmuramyldipeptide, a more intensive recovery of all links of anti-infectious immunity was recorded in comparison with the group where transfer factor molecules were used. Conclusion: A drug based on glucosaminylmuramyldipeptide can be recommended as the drug of choice in non-specific immunocorrection for complex pharmacotherapy of pyoderma accompanied by secondary immune insufficiency, in comparison with a drug containing transfer factors.

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Immunologic features of chronic granulomatous mucocutaneous candidiasis before and after treatment with transfer factor

Archives of Dermatology ◽

10.1001/archderm.115.2.180 ◽

1979 ◽

Vol 115 (2) ◽

pp. 180-184 ◽

Cited By ~ 2

Author(s):

M. Horsmanheimo

Keyword(s):

Transfer Factor ◽

Mucocutaneous Candidiasis ◽

Before And After

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ASMANEX TWISTHALER - THE DRUG OF CHOICE AMONG INHALED CORTICOSTEROIDS

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja632 ◽

2013 ◽

Vol 10 (6) ◽

pp. 51-57

Author(s):

T V Latysheva ◽

E A Latysheva ◽

O V Shubina

Keyword(s):

Bronchial Asthma ◽

Inhaled Corticosteroids ◽

Control Methods ◽

Efficacy And Safety ◽

Prior Therapy ◽

Asthma Symptoms ◽

Drug Of Choice ◽

Systemic Corticosteroids ◽

Before And After ◽

Baseline Therapy

Goals. To reveal the clinical efficacy and safety of Asmanex in patients with moderate and severe bronchial asthma (BA), treated with inhaled and/or systemic glucocorticosteroids (GCS), depending on the severity and level of control. Methods. 40 patients (age 18 to 65 years) were treated with Asmanex with equivalent to prior therapy with inhaled corticosteroids (ICS) doses or in combination with systemic corticosteroids prior therapy (without increasing the dose of systemic corticosteroids) for 3 months. Efficacy was assessed before and after the treatment on a background of Asmanex treatment by the need of additional using of agonists of β 2-adrenoreceptors, severity of daytime and nighttime asthma symptoms, dynamics of spirometry parameters. The efficacy of Asmanex was compared with the original baseline therapy of other inhaled corticosteroids at equivalent doses using the new delivery system.

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Keçiboynuzu (Ceratonia siliqua) Şurubunun Tilapia (Oreochromis mossambicus) Balıklarında Büyüme Performansı, Hematolojik, Serum Biyokimyası ve Bağışıklık Parametrelerine Etkisi

Turkish Journal of Agriculture - Food Science and Technology ◽

10.24925/turjaf.v6i12.1820-1826.2184 ◽

2018 ◽

Vol 6 (12) ◽

pp. 1820 ◽

Cited By ~ 1

Author(s):

Sevdan Yılmaz ◽

Sebahattin Ergün ◽

Ekrem Şanver Çelik

Keyword(s):

Growth Performance ◽

Oreochromis Mossambicus ◽

Serum Glucose ◽

Phagocytic Index ◽

Ceratonia Siliqua ◽

Feed Conversion ◽

Immunological Parameters ◽

Immune Parameters ◽

Cholesterol Levels ◽

Serum Biochemical

The present study investigated the effects of dietary carob (Ceratonia siliqua) syrup supplementation on growth performance, haematological, serum biochemical and immunological parameters of tilapia, Oreochromis mossambicus. Five isonitrogenous and isoenergetic diets were formulated to contain carob syrup at levels of 0%, 5%, 2.5%, 1.25%, and 0.625%. Fish were fed experimental diets for 60 days. There were no particular differences in weight gain, feed conversion ratio, specific growth rate, red blood cell count, haematocrit ratio (%), serum total protein, albumin, and globulin levels of fish fed experimental diets. However, dietary carob syrup especially with 1.25% incorporation significantly decreased serum glucose, triglyceride, cholesterol levels. The dietary carob syrup especially at 1.25% significantly increased the phagocytic activity, phagocytic index, respiratory burst and potential killing activity. In conclusion, findings of the present study indicate that feeding tilapia with a diet containing 1.25% carob syrup over a period of 60 days might be adequate to improve immune parameters and serum biochemical variables without any adverse effect on growth performance and haematological parameters of fish.

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Multi-level assessment of obsessive-compulsive disorder (OCD) reveals relations between neural and neurochemical levels

BMC Psychiatry ◽

10.1186/s12888-020-02913-5 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Kathrin Viol ◽

Günter Schiepek ◽

Martin Kronbichler ◽

Arnulf Hartl ◽

Carina Grafetstätter ◽

...

Keyword(s):

Symptom Severity ◽

Anterior Cingulate ◽

Linear Modeling ◽

Obsessive Compulsive ◽

Time Intervals ◽

Immunological Parameters ◽

Compulsive Disorder ◽

Before And After ◽

Treatment Changes ◽

Open Question

Abstract Background While considerable progress has been made in exploring the psychological, the neural, and the neurochemical dimensions of OCD separately, their interplay is still an open question, especially their changes during psychotherapy. Methods Seventeen patients were assessed at these three levels by psychological questionnaires, fMRI, and venipuncture before and after inpatient psychotherapy. Seventeen controls were scanned at comparable time intervals. First, pre/post treatment changes were investigated for all three levels separately: symptom severity, whole-brain and regional activity, and the concentrations of cortisol, serotonin, dopamine, brain-derived neurotrophic factor (BDNF), and immunological parameters (IL-6, IL-10, TNFα). Second, stepwise linear modeling was used to find relations between the variables of the levels. Results The obsessive-compulsive, depressive, and overall symptom severity was significantly reduced after psychotherapy. At the neural level, the activity in the anterior cingulate cortex (ACC), in frontal regions, in the precuneus, and in the putamen had significantly decreased. No significant changes were found on the neurochemical level. When connecting the levels, a highly significant model was found that explains the decrease in neural activity of the putamen by increases of the concentrations of cortisol, IL-6, and dopamine. Conclusion Multivariate approaches offer insight on the influences that the different levels of the psychiatric disorder OCD have on each other. More research and adapted models are needed.

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Potential Differences between Local and Systemic Allergic Rhinitis Induced by Birch Pollen

International Archives of Allergy and Immunology ◽

10.1159/000509438 ◽

2020 ◽

Vol 181 (11) ◽

pp. 831-838

Author(s):

Andrzej Bozek ◽

Jolanta Zalejska Fiolka ◽

Anna Krajewska Wojtys ◽

Beata Galuszka ◽

Anna Cudak

Keyword(s):

Allergic Rhinitis ◽

Birch Pollen ◽

Provocation Test ◽

Basophil Activation Test ◽

Specific Ige ◽

Immunological Parameters ◽

Local Allergic Rhinitis ◽

Before And After ◽

Intermittent Allergic Rhinitis ◽

Bet V1

Introduction: Different endotypes of rhinitis are known, but its pathomechanism has not been conclusively established. For example, the precise difference between systemic allergic rhinitis (SAR) and local allergic rhinitis (LAR) is still being checked. Comparison of patients with LAR and with allergies to birch of those with intermittent allergic rhinitis, same allergy, or with non-allergic rhinitis (NAR) was the purpose of this study. Methods: Twenty-six patients with LAR, 18 with SAR and allergy to birch, and 21 with NAR were included. Patients who met the inclusion criteria were selected to undergo the following procedures at baseline: medical examinations, nasal provocation test (NPT), detection of nasal-specific IgE to birch as well as basophil activation test (BAT). All immunological parameters were detected before and after NPT. Results: Concentration of nasal IgE to Bet v1 increased comparably in the LAR and SAR groups after NPT to birch as follows: in 21 (81%) patients with LAR, 14 (78%) with SAR, and in everyone in the NAR group. Serum concentration of allergen-specific IgE to Bet v1 increased significantly from a median of 20.7 (25–75% interval: 11.2–35.6) IU/mL to 29.9 (13.6–44.1) (p = 0.028) after NPT in patients with SAR. Allergen-specific IgE to Bet v1 was absent in all patients with LAR and NAR before and after NPT. BAT with Bet v1 was positive in 22 (85%) patients with LAR, in 14 (78%) with SAR, and 2 (9.5%) with NAR. Conclusion: These obtained data suggest there are no potential mechanisms that could explain LAR compared to SAR.

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Comparative studies on the effects of lincomycin and bacitracin on hematobiochemical and immunological parameters in broiler chickens

International Journal of Pharmacology and Toxicology ◽

10.14419/ijpt.v7i1.28033 ◽

2019 ◽

Vol 7 (1) ◽

pp. 1

Author(s):

Ashraf A. Elkomy ◽

Enas Farag ◽

Elshahat I. Elgharbawy ◽

Mohamed Elbadawy

Keyword(s):

Broiler Chickens ◽

Phagocytic Index ◽

Control Group ◽

Broiler Chicks ◽

Growth Promoters ◽

Serum Total Protein ◽

Immunological Parameters ◽

Hematobiochemical Parameters ◽

Serum Total Lipid ◽

Immunological Alterations

A total of 100 one-day-old healthy broiler chicks were used to study the effects of lincomycin and bacitracin on some hematobiochemical and immunological parameters. Chicks were divided into four equal groups, 25 each. The first group was kept as control; the 2nd group was received 0.5 g of lincomycin per liter; the 3rd group was received 100 mg bacitracin per liter and the 4th group was administered both lincomycin and bacitracin, each at the above-mentioned dose. Drugs were given in drinking water for 5 successive days from 20th to 25th day of age. Bodyweight was recorded at the beginning of the experiment and at 1st-day post administration where body performance was recorded. One day post administration, blood samples were collected for estimation of hematobiochemical and immunological alterations. The obtained results revealed that broiler chicks administered lincomycin or bacitracin or both revealed a marked increase in bodyweight, weight gain, phagocytic activity, phagocytic index, erythrocytic count, hemoglobin level, packed cell volume, total leukocytic count, serum total protein, albumin, total globulin, α, β and γ globulin. Furthermore, a significant elevation in malondialdehyde associated with a marked reduction in albumin-globulin ratio, serum total lipid, cholesterol and triglyceride and a significant decrease in catalase and superoxide dismutase, were recorded, compared with the control group. In conclusion, lincomycin and bacitracin either alone or in combination have positive impacts on growth performance, immunological and hematobiochemical parameters of broiler chickens. So, it is recommended to use both drugs as growth promoters in broiler chickens.

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