High Serum Cartilage Oligomeric Matrix Protein Determines the Subset of Patients with Early-Stage Rheumatoid Arthritis with High Serum C-Reactive Protein, Matrix Metalloproteinase-3, and MRI-Proven Bone Erosion

2009 ◽  
Vol 36 (6) ◽  
pp. 1126-1129 ◽  
Author(s):  
KEITA FUJIKAWA ◽  
ATSUSHI KAWAKAMI ◽  
MAMI TAMAI ◽  
MASATAKA UETANI ◽  
SHOICHIRO TAKAO ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Bone Erosion ◽  
Early Stage ◽  
High Serum ◽  
C Reactive Protein ◽  
Matrix Metalloproteinase 3 ◽  
Reactive Protein ◽  
Mri Features

Objective.To identify the significance of serum cartilage oligomeric matrix protein (COMP), a marker of cartilage turnover, in patients with early-stage rheumatoid arthritis (RA) in relation to other serologic variables and magnetic resonance imaging (MRI) features.Methods.Ninety-eight patients with early-stage RA, whose disease duration from onset was less than 2 years, were enrolled. The objective measures at baseline were Disease Activity Score (DAS28), serum C-reactive protein (CRP), serum matrix metalloproteinase-3 (MMP-3), serum antibodies against cyclic citrullinated peptide (anti-CCP), and MRI features of both wrist and finger joints. The MRI features included the number of sites scored positive for synovitis, bone edema, and bone erosion.Results.Serum COMP concentration was not different among groups identified with low, moderate, and high DAS28-CRP values. However, COMP values were statistically high in subjects positive for bone erosions on MRI compared with the subjects who were negative for bone erosions. A positive correlation of COMP with CRP and with MMP-3 values was also identified.Conclusion.Elevation of COMP may reflect joint damage that is dependent on the synovial inflammatory process in early-stage RA.

Thrombin-cleaved Osteopontin Is Increased in Urine of Patients with Rheumatoid Arthritis

2010 ◽  
Vol 37 (4) ◽  
pp. 704-710 ◽  
Author(s):  
KIORI SHIO ◽  
HIROKO KOBAYASHI ◽  
TOMOYUKI ASANO ◽  
RIE SAITO ◽  
HARUYO IWADATE ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Disease Activity Score ◽  
Tender Joint Count ◽  
Healthy Controls ◽  
C Reactive Protein ◽  
Tender Joint ◽  
Matrix Metalloproteinase 3 ◽  
Reactive Protein ◽  
Urine Levels

Objective.To measure concentrations of the thrombin-cleaved isoform of osteopontin (OPN) in urine and plasma of patients with rheumatoid arthritis (RA), and to assess whether levels of thrombin-cleaved OPN are associated with measures of RA.Methods.Subjects comprised 70 patients with RA, 20 patients with osteoarthritis (OA), and 46 healthy controls. RA disease activity was evaluated by tender joint count, swollen joint count, patient’s global assessment of disease activity, erythrocyte sedimentation rate (ESR), and levels of C-reactive protein (CRP), matrix metalloproteinase-3 (MMP-3), and rheumatoid factor (RF), as well as 28-joint count Disease Activity Score (DAS28). OPN levels in plasma and urine were measured by ELISA.Results.Median levels of thrombin-cleaved OPN in urine (U-half) were significantly higher in RA patients (143.5 pmol/mmol Cr) than in healthy controls (67.9 pmol/mmol Cr) or OA patients (69.8 pmol/mmol Cr). Thrombin-cleaved OPN was not detected in plasma. U-half levels correlated significantly with levels of CRP (r = 0.26, p = 0.03), ESR (r = 0.26, p = 0.03), and RF (r = 0.28, p = 0.03). Median U-half levels were significantly higher in patients with stage III (249.9 pmol/mmol Cr) and IV (251.6 pmol/mmol Cr) disease than in patients with stage I (98.6 pmol/mmol Cr) disease.Conclusion.Our results suggest that urine levels of the thrombin-cleaved isoform of OPN may reflect the severity of active inflammatory arthritis in patients with RA.

PSV-B-28 Late-Breaking: Development and validation of a Total Inflammation Index™ for identifying inflammation in Labrador Retrievers using a pressure walkway

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 383-384
Author(s):  
Jessica L Varney ◽  
Craig N Coon
Keyword(s):  
Creatine Kinase ◽  
Gait Analysis ◽  
Interleukin 6 ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Low Grade ◽  
C Reactive Protein ◽  
Inflammatory Biomarker ◽  
Reactive Protein ◽  
Labrador Retrievers

Abstract The objective of this trial was to develop an index system to identify inflammation in Labrador Retrievers using a pressure walkway system. Gait analysis data can be difficult to interpret between treatment groups or for identifying low grade inflammation. To calculate the Total Inflammation Index™, the distance away from the ideal score was calculated for four parameters for each dog, including gait lameness score, total pressure index, step/stride ratio, and hind reach. These values were equally weighted and added together to produce the Total Inflammation Index™. For validation, the Total Inflammation Index™ values were compared to biomarker data for inflammation including cartilage oligomeric matrix protein, interleukin-6, creatine kinase, and c-reactive protein. Forty Labrador Retrievers (20 male/20 female) were used in this trial. All dogs were passed over the pressure walkway (Gait4Dogs; CIR Systems, Inc) to obtain gait analysis at baseline, 24h prior to the first 5km run, 24h after the first 5km run, 24h prior to the final 16km run, and 24h after the final 16km run. All biomarkers and the Total Inflammation Index™ were both significantly lower at the pre-exercise timepoints and elevated after post-exercise timepoints (P < 0.01). The Total Inflammation Index™ had significant correlation between timepoints and all biomarkers, including cartilage oligomeric matrix protein (P < 0.01), interleukin-6 (P < 0.05), creatine kinase (P < 0.01), and c-reactive protein (P < 0.05). The Total Inflammation Index™ appears to be a valid assay to evaluate generalized inflammation in Labrador Retrievers, and is in agreement with inflammatory biomarker values.

Circulating Dickkopf-1 and Radiological Progression in Patients with Early Rheumatoid Arthritis Treated with Etanercept

2008 ◽  
Vol 35 (12) ◽  
pp. 2313-2315 ◽  
Author(s):  
PATRICK GARNERO ◽  
NADINE CHARNI-BEN TABASSI ◽  
NATHALIE VOORZANGER-ROUSSELOT
Keyword(s):  
Rheumatoid Arthritis ◽  
Inflammatory Arthritis ◽  
Bone Erosion ◽  
C Reactive Protein ◽  
Radiological Progression ◽  
Reactive Protein ◽  
Important Mediator ◽  
Risk Of Progression ◽  
Radiological Damage ◽  
Dickkopf 1

ObjectiveDickkopf-1 (Dkk-1) regulates bone remodeling in animal models of inflammatory arthritis, but its role in patients with rheumatoid arthritis (RA) remains unclear.MethodsBaseline circulating Dkk-1 was measured in 113 patients with RA (< 3 yrs) who received etanercept (10 or 25 mg twice/week, n = 63) or methotrexate alone (n = 40) for 1 year. Progression was assessed by changes in radiological Sharp score.ResultsIncreased Dkk-1 was associated with a higher risk of progression of bone erosion, independently of age, sex, baseline radiological damage, C-reactive protein, and disease activity in patients treated with etanercept.ConclusionDkk-1 may be an important mediator of bone erosion in patients with RA.

scholarly journals Association of Circulating COMP and YKL-40 as Markers of Metabolic Changes of Cartilage with Adipocytokines in Juvenile Idiopathic Arthritis

Metabolites ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 61
Author(s):  
Katarzyna Winsz-Szczotka ◽  
Kornelia Kuźnik-Trocha ◽  
Anna Gruenpeter ◽  
Magdalena Wojdas ◽  
Klaudia Dąbkowska ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Clinical Improvement ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Metabolic Changes ◽  
C Reactive Protein ◽  
Human Cartilage ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Before And After

The aim of this study was to evaluate the association of circulating cartilage oligomeric matrix protein (COMP) and human cartilage glycoprotein-39 (YKL-40) as markers of metabolic changes of cartilage, with leptin, adiponectin, and resistin in juvenile idiopathic arthritis (JIA) patients before and after treatment. A significant decrease of COMP and an increase of YKL-4 were found in blood of untreated patients. JIA treatment leading to clinical improvement resulted in normalization of COMP levels only. Concentrations of both markers in treated patients, while showing no clinical improvement, differed from those in controls and patients with remission. The leptin level decreased (p < 0.05) in untreated patients; however, concentrations of adiponectin and resistin increased (p < 0.05) as compared to controls. JIA treatment resulted in normalization of adipocytokine levels in remissive patients but not those with active JIA. Untreated patients showed a correlation between COMP and leptin, adiponectin, and body mass index (BMI) and between YKL-40 and leptin, adiponectin, BMI, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). In inactive JIA, a correlation between YKL-40 and leptin was shown. Treated patients with an active JIA demonstrated a correlation between COMP and adiponectin and between YKL-40 and leptin, adiponectin, BMI, CRP, and ESR. The results of this work indicate that leptin and adiponectin but not resistin may be involved in the development and progression of joint dysfunction in JIA. Additionally, we suggest that YKL-40 may be a useful biomarker of disease activity and may be used to assess treatment towards remission, as compared to COMP.

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