scholarly journals Association of Circulating COMP and YKL-40 as Markers of Metabolic Changes of Cartilage with Adipocytokines in Juvenile Idiopathic Arthritis

Metabolites ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 61
Author(s):  
Katarzyna Winsz-Szczotka ◽  
Kornelia Kuźnik-Trocha ◽  
Anna Gruenpeter ◽  
Magdalena Wojdas ◽  
Klaudia Dąbkowska ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Clinical Improvement ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Metabolic Changes ◽  
C Reactive Protein ◽  
Human Cartilage ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Before And After

The aim of this study was to evaluate the association of circulating cartilage oligomeric matrix protein (COMP) and human cartilage glycoprotein-39 (YKL-40) as markers of metabolic changes of cartilage, with leptin, adiponectin, and resistin in juvenile idiopathic arthritis (JIA) patients before and after treatment. A significant decrease of COMP and an increase of YKL-4 were found in blood of untreated patients. JIA treatment leading to clinical improvement resulted in normalization of COMP levels only. Concentrations of both markers in treated patients, while showing no clinical improvement, differed from those in controls and patients with remission. The leptin level decreased (p < 0.05) in untreated patients; however, concentrations of adiponectin and resistin increased (p < 0.05) as compared to controls. JIA treatment resulted in normalization of adipocytokine levels in remissive patients but not those with active JIA. Untreated patients showed a correlation between COMP and leptin, adiponectin, and body mass index (BMI) and between YKL-40 and leptin, adiponectin, BMI, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). In inactive JIA, a correlation between YKL-40 and leptin was shown. Treated patients with an active JIA demonstrated a correlation between COMP and adiponectin and between YKL-40 and leptin, adiponectin, BMI, CRP, and ESR. The results of this work indicate that leptin and adiponectin but not resistin may be involved in the development and progression of joint dysfunction in JIA. Additionally, we suggest that YKL-40 may be a useful biomarker of disease activity and may be used to assess treatment towards remission, as compared to COMP.

Serum C-reactive protein and erythrocyte sedimentation rate changes in children after adenotonsillectomy

2021 ◽  
Vol 42 (6) ◽  
pp. 684-691
Author(s):  
Mehrnoosh Mousavi Aghdas ◽  
Nikzad Shahidi ◽  
Shahin Abdollahi Fakhim
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Protein Level ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Obstructive Sleep ◽  
Before And After

Background: Sleep-disordered breathing is a common problem in children and is associated with increased cardiovascular morbidity. The circulating level of C-reactive protein, a pro-inflammatory protein, is associated with increased risk for atherosclerosis. The aim of this study was the comparison of C-reactive protein level and erythrocyte sedimentation rate in children with tonsillar hypertrophy before and after adenotonsillectomy. Methods: All patients aged between 4 to 10 years who had underwent adenotonsillectomy due to obstructive sleep apnea were enrolled. Serum C-reactive protein and erythrocyte sedimentation rate were measured before and after adenotonsillectomy. Data were analyzed with SPSS version 19. Results: In this study, 384 patients were enrolled. The average age of the patients was 6.7 years. The C-reactive protein level in 91 patients (23.7 %) was decreased and in 286 patients (74.5%) did not change and in 7 patients (1.8%) it was increased. Decreasing serum C-reactive protein level and erythrocyte sedimentation rate was statistically significant after adenotonsillectomy (P-value < 0.05). Conclusion: Obstructive sleep apnea induces a systemic inflammatory response so frequently associated with an increase in serum C-reactive protein and erythrocyte sedimentation rate that is reversible with surgery and if left untreated may lead to cardiovascular morbidity.

PSV-B-28 Late-Breaking: Development and validation of a Total Inflammation Index™ for identifying inflammation in Labrador Retrievers using a pressure walkway

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 383-384
Author(s):  
Jessica L Varney ◽  
Craig N Coon
Keyword(s):  
Creatine Kinase ◽  
Gait Analysis ◽  
Interleukin 6 ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Low Grade ◽  
C Reactive Protein ◽  
Inflammatory Biomarker ◽  
Reactive Protein ◽  
Labrador Retrievers

Abstract The objective of this trial was to develop an index system to identify inflammation in Labrador Retrievers using a pressure walkway system. Gait analysis data can be difficult to interpret between treatment groups or for identifying low grade inflammation. To calculate the Total Inflammation Index™, the distance away from the ideal score was calculated for four parameters for each dog, including gait lameness score, total pressure index, step/stride ratio, and hind reach. These values were equally weighted and added together to produce the Total Inflammation Index™. For validation, the Total Inflammation Index™ values were compared to biomarker data for inflammation including cartilage oligomeric matrix protein, interleukin-6, creatine kinase, and c-reactive protein. Forty Labrador Retrievers (20 male/20 female) were used in this trial. All dogs were passed over the pressure walkway (Gait4Dogs; CIR Systems, Inc) to obtain gait analysis at baseline, 24h prior to the first 5km run, 24h after the first 5km run, 24h prior to the final 16km run, and 24h after the final 16km run. All biomarkers and the Total Inflammation Index™ were both significantly lower at the pre-exercise timepoints and elevated after post-exercise timepoints (P &lt; 0.01). The Total Inflammation Index™ had significant correlation between timepoints and all biomarkers, including cartilage oligomeric matrix protein (P &lt; 0.01), interleukin-6 (P &lt; 0.05), creatine kinase (P &lt; 0.01), and c-reactive protein (P &lt; 0.05). The Total Inflammation Index™ appears to be a valid assay to evaluate generalized inflammation in Labrador Retrievers, and is in agreement with inflammatory biomarker values.

scholarly journals Effects of balneotherapy on the reactants of acute inflammation phase in Ankylosing spondylitis

2009 ◽  
Vol 137 (5-6) ◽  
pp. 255-258 ◽  
Author(s):  
Bojana Stamenkovic ◽  
Aleksandra Stankovic ◽  
Jovan Nedovic ◽  
Sonja Stojanovic ◽  
Aleksandar Dimic ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Serum Concentrations ◽  
C Reactive Protein ◽  
Acid Glycoprotein ◽  
Reactive Protein ◽  
Medication Therapy ◽  
Erythrocyte Sedimentation ◽  
Before And After

Introduction. Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects sacroiliac joints, spinal column and peripheral joints. Beside medication therapy, physical and balneotherapy play an important role in its complex treatment. Objective. The aim of the research was to establish serum concentrations of C-reactive protein (CRP), ? 1-acid glycoprotein (? 1-AGP), ceruloplasmine (CP) and erythrocyte sedimentation rate (SE) before and after the balneotherapy in ankylosing spondylitis. Methods. The research included 50 AS patients according to the revised New York criteria, of mean age 43 years, who were treated for 14 days on the average at the Clinic for Rheumatology of the Institute 'Niska Banja'. All the patients received medications and balneotherapy (radioactive oligomineral baths, peloid, massage, kinesitherapy); the serum concentrations of CRP, ?1-AGP, CP and SE were measured before and after balneotherapy. Serum proteins were determined using original Nor Partigen plates Boehringer. Erythrocyte sedimentation rate was measured by Westergreen method. Balneotherapy was applied individually, intensively or mildly, depending on the AS stage and activity phase. Results. After dosed balneotherapy, a significant decrease in the concentrations of CP (p<0.05), ?1-AGP (p<0.01) and CRP (p<0.05) was registered in the serums of AS patients. ESR was not significantly reduced. Conclusion. The research proved that ? 1-acid glycoprotein, ceruloplasmine and C-reactive protein represent more sensitive inflammation markers as compared to erythrocyte sedimentation rate. The identification of acute phase reactants is important in the evaluation of dosed balneotherapy efficiency in the treatment of ankylosing spondylitis.

High Serum Cartilage Oligomeric Matrix Protein Determines the Subset of Patients with Early-Stage Rheumatoid Arthritis with High Serum C-Reactive Protein, Matrix Metalloproteinase-3, and MRI-Proven Bone Erosion

2009 ◽  
Vol 36 (6) ◽  
pp. 1126-1129 ◽  
Author(s):  
KEITA FUJIKAWA ◽  
ATSUSHI KAWAKAMI ◽  
MAMI TAMAI ◽  
MASATAKA UETANI ◽  
SHOICHIRO TAKAO ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Bone Erosion ◽  
Early Stage ◽  
High Serum ◽  
C Reactive Protein ◽  
Matrix Metalloproteinase 3 ◽  
Reactive Protein ◽  
Mri Features

Objective.To identify the significance of serum cartilage oligomeric matrix protein (COMP), a marker of cartilage turnover, in patients with early-stage rheumatoid arthritis (RA) in relation to other serologic variables and magnetic resonance imaging (MRI) features.Methods.Ninety-eight patients with early-stage RA, whose disease duration from onset was less than 2 years, were enrolled. The objective measures at baseline were Disease Activity Score (DAS28), serum C-reactive protein (CRP), serum matrix metalloproteinase-3 (MMP-3), serum antibodies against cyclic citrullinated peptide (anti-CCP), and MRI features of both wrist and finger joints. The MRI features included the number of sites scored positive for synovitis, bone edema, and bone erosion.Results.Serum COMP concentration was not different among groups identified with low, moderate, and high DAS28-CRP values. However, COMP values were statistically high in subjects positive for bone erosions on MRI compared with the subjects who were negative for bone erosions. A positive correlation of COMP with CRP and with MMP-3 values was also identified.Conclusion.Elevation of COMP may reflect joint damage that is dependent on the synovial inflammatory process in early-stage RA.

scholarly journals The Association of Serum IL-10 Levels with the Disease Activity in Systemic-Onset Juvenile Idiopathic Arthritis Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yu Peng ◽  
Xiaohui Liu ◽  
Zhao Duan ◽  
Junkai Duan ◽  
Yulan Zhou
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Disease Activity ◽  
Sedimentation Rate ◽  
Serum Levels ◽  
Interleukin 10 ◽  
C Reactive Protein ◽  
Clinical Marker ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Systemic Onset

Objectives. Interleukin-10 (IL-10) has been suggested as a biomarker of disease activity in patients with adult-onset Still’s disease (AOSD). In this study, we evaluated the serum IL-10 levels and investigated its clinical relevance in systemic-onset juvenile idiopathic arthritis (SoJIA). Methods. IL-10 levels were determined in 21 patients diagnosed with SoJIA and 35 patients with fever diseases which were suspected as SoJIA, and IL-10 levels were compared between SoJIA patients with regard to disease activity, disease courses, and other biomarkers. Results. Patients with SoJIA had significantly higher levels of IL-10 compared to patients with other febrile diseases. The serum levels of IL-10 were significantly higher in active SoJIA compared to inactive and positively correlated with known disease activity markers such as erythrocyte sedimentation rate (ESR), C-reactive protein level (CRP), ferritin (FER), and IL-6 levels. Moreover, the levels of IL-10 at diagnosis were significantly higher in SoJIA patients with a nonmonocyclic pattern than in patients with a monocyclic pattern. Compared to CRP, ESR, FER, and IL-6, IL-10 levels were superior in predicting monocyclic patients from nonmonocyclic patients. Conclusion. Compared to other febrile diseases, SoJIA patients have markedly higher levels of IL-10 which may assist with diagnosis. And a clear association of serum IL-10 levels with disease activity and disease courses in SoJIA was found. These results suggest that serum IL-10 might be a reliable clinical marker in SoJIA.

Growth Velocity and Interleukin 6 Concentrations in Juvenile Idiopathic Arthritis

2008 ◽  
Vol 35 (11) ◽  
pp. 2265-2271 ◽  
Author(s):  
LETÍCIA S. SOUZA ◽  
SANDRA H. MACHADO ◽  
CLAITON V. BRENOL ◽  
JOÃO CARLOS T. BRENOL ◽  
RICARDO M. XAVIER
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Growth Velocity ◽  
Interleukin 6 ◽  
Negative Influence ◽  
World Health ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Secondary Factor ◽  
Health Organization

ObjectiveTo evaluate associations of growth velocity with inflammatory markers and cumulative dose of glucocorticoid in a cohort of patients with juvenile idiopathic arthritis (JIA) followed during 1 year.MethodsSeventy-nine patients were evaluated. Disease activity was evaluated by a pediatric rheumatologist. Anthropometric data were classified according to the World Health Organization standards. Tanner growth velocity curves were used; values below the Z-score≤ −2 were considered low growth velocity. Serum concentrations of interleukin 6 (IL-6) were measured by ELISA, and values > 1 pg/ml were considered elevated.ResultsThe prevalence of low growth velocity was 25.3%, and it was associated with active disease on followup visit, elevated IL-6, erythrocyte sedimentation rate and C-reactive protein, and higher cumulative glucocorticoid doses. In the multiple linear regression with growth velocity as the dependent variable, only elevated IL-6 level was independently and negatively associated with growth velocity.ConclusionLow growth velocity is highly prevalent in children with JIA. Elevated IL-6 levels seem to have an important negative influence on growth in these children, while total glucocorticoid exposure appears to be a secondary factor.

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