Fumonisins and their modified forms, a matter of concern in future scenario?

2016 ◽  
Vol 9 (5) ◽  
pp. 727-739 ◽  
Author(s):  
C. Dall’Asta ◽  
P. Battilani

Masked mycotoxins are found in grains and derived foods as a result of plant phase II metabolism. Recently, masked mycotoxins senso strictu, together with other covalently or non-covalently conjugated forms, even formed upon processing, have been classified as modified mycotoxins. In this context, the issue of modified fumonisins is of great interest, on account of the wide range of factors affecting their formation and accumulation in maize pre- and postharvest. Fumonisins, indeed, may undergo modification in plants, along the growing season, but also during storage and drying of maize kernels, and upon processing. All these modifications strongly affect the analytical outcome, thus making more difficult the assessment of maize compliance. Since the ratio between free and modified fumonisins is affected by maize composition and environmental factors, a deeper knowledge on the phenomena driving the production and accumulation of free and modified forms in plants may support the selection of resistant hybrids. This review provides a critical picture of the state of the art on this topic, mainly focusing on those events occurring in field, identified as crucial in determining amount and partitioning of contamination. Nevertheless, knowledge on modified fumonisins is still in its dawn, on account of the wide range of factors involved. Anyway, reported results, taking altogether, clearly indicate that modified fumonisins should be included in the monitoring plans to have an overview of the possible contribution to human exposure. Furthermore, next efforts should focus on the events occurring in field and on the cross-talk between the plant and the fungus, to support the identification of resistant hybrids and to provide data for predictive models, the most suitable tool to forecast what is going to happens in the future changing climate.

2020 ◽  
Vol 21 (4) ◽  
pp. 438-477
Author(s):  
Bryan R Early ◽  
Menevis Cilizoglu

Abstract Policymakers employ economic sanctions to deal with a wide range of international challenges, making them an indispensable foreign policy tool. While scholarship on sanctions has tended to focus on the factors affecting their success, newer research programs have emerged that explore the reasons for why sanctions are threatened and initiated, the ways they are designed and enforced, and their consequences. This scholarship has yielded a wealth of new insights into how economic sanctions work, but most of those insights are based on sanctions observations from the 20th Century. The ways that policymakers employ sanctions have fundamentally changed over the past two decades, though, raising concerns about whether historically derived insights are still relevant to contemporary sanctions policies. In this forum, the contributors discuss the scholarly and policy-relevant insights of existing research on sanctions and then explore what gaps remain in our knowledge and new trends in sanctions policymaking. This forum will inform readers on the state of the art in sanctions research and propose avenues for future research.


2006 ◽  
Vol 46 (7) ◽  
pp. 921 ◽  
Author(s):  
D. J. Westmoreland ◽  
A. C. Schlink ◽  
J. C. Greeff

A benchtop scouring procedure was used to evaluate the ability of conventional detergent scouring systems to adequately clean fleece samples from a selection of Western Australian Merino wools. Sixteen fleeces were selected from the Western Australian Department of Agriculture resource flocks, covering a wide range in yield (49.2 to 77.5%), wax (7.3 to 26.9%), suint (4.9 to 11.6%), and dust (1.4 to 16.3%) contents. Using a simple detergent-based system, 50% of the fleeces were classified as effectively scoured, based on residual wax content. When scouring liquor was not refreshed between subsamples drawn from the same fleece, wool wax, staple length and dust content in the greasy fleece accounted for 93% of the variation in the rate of residual wax increase observed in sequential 10 g samples of wool. Residual ash content also increased but the greasy fleece parameters measured were not statistically significant predictors of residual ash changes. The rate of scoured wool colour change, when sequential samples of greasy wool from the same fleece were scoured without liquor change, could be predicted from greasy fleece yields. The scouring efficiency of the more difficult to scour wools was improved by the addition of sodium carbonate to the main scouring bowls.


Toxins ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 110 ◽  
Author(s):  
Tim Birr ◽  
Tolke Jensen ◽  
Nils Preußke ◽  
Frank D. Sönnichsen ◽  
Marthe De Boevre ◽  
...  

Forage maize is often infected by mycotoxin-producing Fusarium fungi during plant growth, which represent a serious health risk to exposed animals. Deoxynivalenol (DON) and zearalenone (ZEN) are among the most important Fusarium mycotoxins, but little is known about the occurrence of their modified forms in forage maize. To assess the mycotoxin contamination in Northern Germany, 120 natural contaminated forage maize samples of four cultivars from several locations were analysed by liquid chromatography-high resolution mass spectrometry (LC-HRMS) for DON and ZEN and their modified forms deoxynivalenol-3-glucoside (DON3G), the sum of 3- and 15-acetyl-deoxynivalenol (3+15-AcDON), α- and β-zearalenol (α-ZEL, β-ZEL). DON and ZEN occurred with high incidences (100 and 96%) and a wide range of concentrations, reaching levels up to 10,972 and 3910 µg/kg, respectively. Almost half of the samples (46%) exceeded the guidance value in complementary and complete feeding stuffs for ZEN (500 µg/kg), and 9% for DON (5000 µg/kg). The DON related mycotoxins DON3G and 3+15-AcDON were also present in almost all samples (100 and 97%) with amounts of up to 3038 and 2237 µg/kg and a wide range of concentrations. For the ZEN metabolites α- and β-ZEL lower incidences were detected (59 and 32%) with concentrations of up to 423 and 203 µg/kg, respectively. Forage maize samples were contaminated with at least three co-occurring mycotoxins, whereby 95% of all samples contained four or more mycotoxins with DON, DON3G, 3+15-AcDON, and ZEN co-occurring in 93%, together with α-ZEL in 57% of all samples. Positive correlations were established between concentrations of the co-occurring mycotoxins, especially between DON and its modified forms. Averaged over all samples, ratios of DON3G/DON and 3+15-AcDON/DON were similar, 20.2 and 20.5 mol%; cultivar-specific mean ratios ranged from 14.6 to 24.3 mol% and 15.8 to 24.0 mol%, respectively. In total, 40.7 mol% of the measured DON concentration was present in the modified forms DON3G and 3+15-AcDON. The α-ZEL/ZEN ratio was 6.2 mol%, ranging from 5.2 to 8.6 mol% between cultivars. These results demonstrate that modified mycotoxins contribute substantially to the overall mycotoxin contamination in forage maize. To avoid a considerable underestimation, it is necessary to analyse modified mycotoxins in future mycotoxin monitoring programs together with their parent forms.


1983 ◽  
Vol 10 (3) ◽  
pp. 527-537
Author(s):  
M. D. Haug ◽  
Paul Kozicki

Slurry trench cutoff walls have been employed for over three decades and are becoming increasingly popular for controlling seepage of groundwater and hazardous wastes. They are also gaining acceptance for construction of underground facilities. The technique involves the excavation of a narrow trench in the presence of a bentonitic fluid or slurry. The slurry acts to support the open trench until it is backfilled with an impermeable material. The increase in popularity of these walls has been aided by the development of new construction techniques. These techniques offer the designer a wide range of engineering properties for the cutoff wall. However, there are few published guidelines on the selection of slurry trench cutoffs. This has resulted in situations where the cutoff wall selected was originally designed for a totally different application. The net effect in these cases has been poor performance and an unsatisfactory cutoff wall.This paper examines the principal methods of constructing slurry trench cutoffs, establishes their engineering characteristics, and presents a procedure for selecting a slurry trench cutoff. The factors which influence the selection are identified and discussed. The methodology of the selection process is reviewed with an example. This review and examination of the selection procedure demonstrates that it is an effective method of compiling and systematically analyzing the relevant factors affecting selection of slurry trench cutoffs.


Author(s):  
Phil McCash ◽  
Tristram Hooley ◽  
Peter J. Robertson

This chapter introduces readers to The Oxford Handbook of Career Development and to the field of career development. The origins of the field are discussed in relation to vocational guidance, differential psychology, interactionist sociology, and life course development. The selection of the term career development for this volume is explained with regard to three interlocking themes: the broader contexts of career development, including government policy; the wide range of theory concerned with career-related experiences, phenomena, and behaviour; and the broad spectrum of career helping practices, including one-to-one work and group work. The inspiration and aims for the volume are set out, and the challenges associated with terminology in the field are acknowledged. The editors seek to provide a state-of-the-art reference point for the field of career development, and engender a transdisciplinary and international dialogue that explores key current ideas, debates, and controversies. The volume is divided into three sections. The first explores the economic, educational, and public policy contexts for practice. The second section focuses on concepts and explores the rich theoretical landscape of the field. The third section turns to practice, and the translation of ideas into action to support individuals and groups with their career development.


2020 ◽  
Vol 7 (2) ◽  
pp. 34-41
Author(s):  
VLADIMIR NIKONOV ◽  
◽  
ANTON ZOBOV ◽  

The construction and selection of a suitable bijective function, that is, substitution, is now becoming an important applied task, particularly for building block encryption systems. Many articles have suggested using different approaches to determining the quality of substitution, but most of them are highly computationally complex. The solution of this problem will significantly expand the range of methods for constructing and analyzing scheme in information protection systems. The purpose of research is to find easily measurable characteristics of substitutions, allowing to evaluate their quality, and also measures of the proximity of a particular substitutions to a random one, or its distance from it. For this purpose, several characteristics were proposed in this work: difference and polynomial, and their mathematical expectation was found, as well as variance for the difference characteristic. This allows us to make a conclusion about its quality by comparing the result of calculating the characteristic for a particular substitution with the calculated mathematical expectation. From a computational point of view, the thesises of the article are of exceptional interest due to the simplicity of the algorithm for quantifying the quality of bijective function substitutions. By its nature, the operation of calculating the difference characteristic carries out a simple summation of integer terms in a fixed and small range. Such an operation, both in the modern and in the prospective element base, is embedded in the logic of a wide range of functional elements, especially when implementing computational actions in the optical range, or on other carriers related to the field of nanotechnology.


2012 ◽  
Vol 9 (1) ◽  
pp. 43 ◽  
Author(s):  
Hueyling Tan

Molecular self-assembly is ubiquitous in nature and has emerged as a new approach to produce new materials in chemistry, engineering, nanotechnology, polymer science and materials. Molecular self-assembly has been attracting increasing interest from the scientific community in recent years due to its importance in understanding biology and a variety of diseases at the molecular level. In the last few years, considerable advances have been made in the use ofpeptides as building blocks to produce biological materials for wide range of applications, including fabricating novel supra-molecular structures and scaffolding for tissue repair. The study ofbiological self-assembly systems represents a significant advancement in molecular engineering and is a rapidly growing scientific and engineering field that crosses the boundaries ofexisting disciplines. Many self-assembling systems are rangefrom bi- andtri-block copolymers to DNA structures as well as simple and complex proteins andpeptides. The ultimate goal is to harness molecular self-assembly such that design andcontrol ofbottom-up processes is achieved thereby enabling exploitation of structures developed at the meso- and macro-scopic scale for the purposes oflife and non-life science applications. Such aspirations can be achievedthrough understanding thefundamental principles behind the selforganisation and self-synthesis processes exhibited by biological systems.


1993 ◽  
Vol 32 (2) ◽  
pp. 226-228
Author(s):  
Zakir Hussain

The book; under review provides a valuable account of the issues and factors in managing the irrigation system, and presents a lucid and thorough discussion on the performance of the irrigation bureaucracies. It comprises two parts: the first outlines the factors affecting irrigation performance under a wide range of topics in the first five chapters. In Chapter One, the authors have attempted to assess the performance of the irrigation bureaucracies, conceptualise irrigation management issues, and build an empirical base for analysis while drawing upon the experience of ten country cases in Asia, Africa, and Latin America. The Second Chapter focuses on the variations in the management structures identified and the types of irrigation systems; and it defines the variables of the management structures. The activities and objectives of irrigation management are discussed in Chapter Three. The objectives include: greater production and productivity of irrigation projects; improved water distribution; reduction in conflicts; greater resource mobilisation and a sustained system performance. The authors also highlight the performance criterion in this chapter. They identify about six contextual factors which affect the objectives and the performance of irrigation, which are discussed in detail in Chapter Four. In Chapter Five, some organisational variables, which would lead to improvements in irrigation, are examined.


2018 ◽  
Vol 13 (1) ◽  
pp. 45-52
Author(s):  
Aynura Manaf kizi Ismayilova ◽  

2020 ◽  
Vol 26 (1) ◽  
pp. 86-93
Author(s):  
D. V. Slivinsky ◽  
I. A. Fomina ◽  
D. G. Menshikh

The presented study determines the role of business aviation in the modern economy and examines the specific features of its development in Russia.Aim. The study aims to analyze the development of business aviation in Russia and its correlation with economic development in general.Tasks. The authors determine the benefits of business aviation as a business tool, examine the specific features of the Russian business aviation market and problems of its development, and identify factors that affect the development of business aviation in Russia.Methods. This study uses the methods of comparative and retrospective analysis, cross-country comparison, systems approach, and expert analytics.Results. Business aviation is a new segment of civil aviation for Russia. Therefore, it is advisable to rely on foreign practices in the management of its development. In many countries, business aviation is a separate industry that specializes in providing transport services to a wide range of corporate clients and/or individuals. The development of this industry is associated with the economic growth rate and the development level of the national economy, and also depends on the national institutional specifics. This study describes the specific features of development of business aviation in Russia and problems arising in the organization and management of this type of business.Conclusions. The authors develop a system of factors affecting the development of business aviation in Russia, describe the major problems of this industry, and propose solutions. The results of this study can be used in the development (adjustment) of business aviation development strategies in Russia both at the industrial and corporate level, and in the implementation of the national policy in this field.


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