Clean Meat

2019 ◽  
pp. 85-97
Author(s):  
Kurt Schmidinger
Keyword(s):  
Tissue Engineering ◽  
Meat Products ◽  
Consumer Acceptance ◽  
Cultured Meat ◽  
In Vitro Meat ◽  
Conventional Animal

This chapter presents the production of real animal meat, which is grown outside of an animal. Starting cells are grown to meat products with the aid of tissue engineering techniques, a process with many names: “Lab meat,” “in vitro meat,” “cultured meat,” or “clean meat.” The chapter gives an overview of the technology and—maybe even more interesting for many readers—shows who were and who are the major players behind clean meat, with many well-known persons among them. Finally, the chapter shows in which ways clean meat could outperform conventional animal-derived meat and so overcome the obstacles of little consumer acceptance, which can be expected initially.

scholarly journals TENDÊNCIAS E DESAFIOS NA PRODUÇÃO DE “CARNE LIMPA”: UMA REVISÃO UTILIZANDO A METHODI ORDINATIO

2021 ◽  
Vol 6 (2) ◽  
Author(s):  
Mayara Scheffer ◽  
Alessandra C. Novak Sydney ◽  
Sabrina Ávila Rodrigues
Keyword(s):  
Food Security ◽  
Web Of Science ◽  
Cultured Meat ◽  
In Vitro Meat

Os sistemas de produção e consumo de carne são alvos de estudos, críticas e questionamentos há bastante tempo. A tendência crescente de consumo de carne acompanhada do aumento da população mundial sugere a busca por alternativas para os sistemas produtivos convencionais de alimentos para que, no futuro, segurança e qualidade nutricional sejam garantidos a população. Neste contexto, as carnes cultivadas em laboratório, também chamadas de “carne in vitro” ou “carne limpa”, fazem parte de um novo campo de estudo que pretende atrair consumidores mais críticos com relação aos danos ambientais da produção convencional. Esta revisão sistemática de literatura foi elaborada utilizando a Methodi Ordinatio para obtenção dos artigos de maior relevância sobre o tema considerando fatores como o número de citações, ano de publicação e fator de impacto. Os dados foram extraídos das bases de dados Science Direct, Scopus e Web of Science e a seguinte combinação de palavras-chave e operadores booleanos foi utilizada (“in vitro meat” OR “cultivated meat” OR “cultured meat”) AND (“sustainability” OR “food security”). As 20 publicações resultantes foram gerenciadas utilizando o Mendeley e uma análise de tendência baseada na recorrência de palavras-chave foi feita utilizando o VOSviewer. Os resultados forneceram um panorama sobre os principais driversde consumo de carne, um breve histórico sobre as carnes in vitro e suas principais técnicas de produção. Mesmo com o avanço da tecnologia, a indústria da “carne limpa” ainda enfrenta alguns entraves com relação ao uso de matérias-primas livres componentes animais para o cultivo, o custo e a palatabilidade do produto final, a produção em larga escala, além da comprovação da sustentabilidade ambiental do processo. A carne in vitro é, portanto, uma área de fronteira da biotecnologia, o que propicia um campo amplo para o desenvolvimento de pesquisas e de novas técnicas para se tornar um produto palpável.Palavras-chave: carnes in vitro, sustentabilidade, segurança alimentar, agricultura celular, inovação.

scholarly journals The Epic of In Vitro Meat Production—A Fiction into Reality

Foods ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1395
Author(s):  
Balamuralikrishnan Balasubramanian ◽  
Wenchao Liu ◽  
Karthika Pushparaj ◽  
Sungkwon Park
Keyword(s):  
Tissue Engineering ◽  
Muscle Development ◽  
Development Program ◽  
Meat Production ◽  
The Public ◽  
In Vitro Meat ◽  
Pivotal Study ◽  
Computer Fluid Dynamics

Due to a proportionally increasing population and food demands, the food industry has come up with wide innovations, opportunities, and possibilities to manufacture meat under in vitro conditions. The amalgamation of cell culture and tissue engineering has been the base idea for the development of the synthetic meat, and this has been proposed to be a pivotal study for a futuristic muscle development program in the medical field. With improved microbial and chemical advancements, in vitro meat matched the conventional meat and is proposed to be eco-friendly, healthy, nutrient rich, and ethical. Despite the success, there are several challenges associated with the utilization of materials in synthetic meat manufacture, which demands regulatory and safety assessment systems to manage the risks associated with the production of cultured meat. The role of 3D bioprinting meat analogues enables a better nutritional profile and sensorial values. The integration of nanosensors in the bioprocess of culture meat eased the quality assessment throughout the food supply chain and management. Multidisciplinary approaches such as mathematical modelling, computer fluid dynamics, and biophotonics coupled with tissue engineering will be promising aspects to envisage the future prospective of this technology and make it available to the public at economically feasible rates.

Decellularized bone extracellular matrix in skeletal tissue engineering

2020 ◽  
Vol 48 (3) ◽  
pp. 755-764
Author(s):  
Benjamin B. Rothrauff ◽  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Animal Studies ◽  
Tumor Resection ◽  
Regenerative Capacity ◽  
Skeletal Tissue ◽  
Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

On visions and promises — ethical aspects of in vitro meat

2019 ◽  
Vol 3 (6) ◽  
pp. 753-758
Author(s):  
Silvia Woll
Keyword(s):  
Animal Welfare ◽  
Environmental Issues ◽  
Meat Production ◽  
Ethical Aspects ◽  
Existing Problems ◽  
In Vitro Meat ◽  
Production And Consumption ◽  
Production Conditions

Innovators of in vitro meat (IVM) are convinced that this approach is the solution for problems related to current meat production and consumption, especially regarding animal welfare and environmental issues. However, the production conditions have yet to be fully clarified and there is still a lack of ethical discourses and critical debates on IVM. In consequence, discussion about the ethical justifiability and desirability of IVM remains hypothetical and we have to question those promises. This paper addresses the complex ethical aspects associated with IVM and the questions of whether, and under what conditions, the production of IVM represents an ethically justifiable solution for existing problems, especially in view of animal welfare, the environment, and society. There are particular hopes regarding the benefits that IVM could bring to animal welfare and the environment, but there are also strong doubts about their ethical benefits.

Bioreaktoren für Knochen-Tissue-Engineering

2013 ◽  
Vol 22 (03) ◽  
pp. 188-195 ◽  
Author(s):  
H.-H. Hsu ◽  
C. Goepfert ◽  
R. Pörtner
Keyword(s):  
Tissue Engineering

ZusammenfassungZur medizinischen Behandlung großer Knochendefekte oder Verletzungen werden als Alternative zu etablierten Behandlungs-methoden neue Konzepte des Tissue Engineering (TE) diskutiert. Beim Knochen-TE ist es das Ziel, eine mit Zellen besiedelte drei-dimensionale (3D), biologisch abbaubare Struktur am Ort der Verletzung zu implantieren. Techniken für die organotypische Kultivierung von Knochenzellen in vitro beruhen auf der Kultivierung von Gewebezellen in Bioreaktoren in einem definierten Kultur-medium auf porösen Matrizes (Scaffolds), um ein gewebeähnliches Wachstum in 3D-Strukturen zu ermöglichen. Ein wichtiger Faktor für die erfolgreiche 3D-Kultur ist die Schaffung adäquater Strömungsbedingungen, die wiederum Einfluss auf die biochemischen und biophysikalischen (z. B. mechanische) Reize haben, denen die Zellen ausgesetzt sind. Hier müssen neben Schereffekten auch Stofftransportlimitierungen berücksichtigt werden. Der Beitrag fasst den aktuellen Stand bei der Entwicklung von Bioreaktoren für die Generierung von Knochenersatzmaterialien zusammen.

In vitro- / in vivo- Untersuchungen zur Biokompatibilität und Bioresorption amorpher Kieselgelfaser für das Tissue engineering humaner Knorpelgewebe

2004 ◽  
Vol 83 (02) ◽  
Author(s):  
A Haisch ◽  
A Evers ◽  
K Jöhrens-Leder ◽  
S Jovanovic ◽  
B Sedlmaier ◽  
...  
Keyword(s):  
Tissue Engineering

Needleless electrospinning of PVP/PGS fibrous scaffolds for skin tissue engineering applications

2018 ◽  
Author(s):  
Antonios Keirouz ◽  
Giuseppino Fortunato ◽  
Anthony Callanan ◽  
Norbert Radacsi
Keyword(s):  
Tissue Engineering ◽  
Tensile Modulus ◽  
Dermal Fibroblasts ◽  
Skin Tissue ◽  
Skin Substitute ◽  
Electrospinning Technique ◽  
Skin Tissue Engineering ◽  
Needleless Electrospinning ◽  
High Concentrations

Scaffolds and implants used for tissue engineering need to be adapted for their mechanical properties with respect to their environment within the human body. Therefore, a novel composite for skin tissue engineering is presented by use of blends of Poly(vinylpyrrolidone) (PVP) and Poly(glycerol sebacate) (PGS) were fabricated via the needleless electrospinning technique. The formed PGS/PVP blends were morphologically, thermochemically and mechanically characterized. The morphology of the developed fibers related to the concentration of PGS, with high concentrations of PGS merging the fibers together plasticizing the scaffold. The tensile modulus appeared to be affected by the concentration of PGS within the blends, with an apparent decrease in the elastic modulus of the electrospun mats and an exponential increase of the elongation at break. Ultraviolet (UV) crosslinking of PGS/PVP significantly decreased and stabilized the wettability of the formed fiber mats, as indicated by contact angle measurements. In vitro examination showed good viability and proliferation of human dermal fibroblasts over the period of a week. The present findings provide important insights for tuning the elastic properties of electrospun material by incorporating this unique elastomer, as a promising future candidate for skin substitute constructs.

Surface Modification by Nanobiomaterials for Vascular Tissue Engineering Applications

2020 ◽  
Vol 27 (10) ◽  
pp. 1634-1646 ◽  
Author(s):  
Huey-Shan Hung ◽  
Shan-hui Hsu
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Thrombus Formation ◽  
Vascular Grafts ◽  
Vascular Tissue Engineering ◽  
Great Success ◽  
Natural Polymers ◽  
Vascular Biomaterials

Treatment of cardiovascular disease has achieved great success using artificial implants, particularly synthetic-polymer made grafts. However, thrombus formation and restenosis are the current clinical problems need to be conquered. New biomaterials, modifying the surface of synthetic vascular grafts, have been created to improve long-term patency for the better hemocompatibility. The vascular biomaterials can be fabricated from synthetic or natural polymers for vascular tissue engineering. Stem cells can be seeded by different techniques into tissue-engineered vascular grafts in vitro and implanted in vivo to repair the vascular tissues. To overcome the thrombogenesis and promote the endothelialization effect, vascular biomaterials employing nanotopography are more bio-mimic to the native tissue made and have been engineered by various approaches such as prepared as a simple surface coating on the vascular biomaterials. It has now become an important and interesting field to find novel approaches to better endothelization of vascular biomaterials. In this article, we focus to review the techniques with better potential improving endothelization and summarize for vascular biomaterial application. This review article will enable the development of biomaterials with a high degree of originality, innovative research on novel techniques for surface fabrication for vascular biomaterials application.

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