Enterprise Digital Twin

2020 ◽  
pp. 68-89
Author(s):  
Souvik Barat
Keyword(s):  
Control Measure ◽  
Dynamic Environment ◽  
Cost Effective ◽  
Control Measures ◽  
Effective Control ◽  
Digital Twin ◽  
The Core ◽  
Specific Objective ◽  
Effective Manner ◽  
Predictive Analyses

Enterprises constantly aim to maximise their objectives while operating in a competitive and dynamic environment. This necessitates an enterprise to be efficient, adaptive, and amenable for transformation. However, understanding a complex enterprise and identifying effective control measure, adaptation choice, or transformation option to realise specific objective is not a trivial task. The digital twin that imitates the real enterprise provides an environment to conduct the necessary interrogative and predictive analyses to evaluate various control measures, adaptation choices, and transformation options in a safe and cost-effective manner without compromising the analysis precision. This chapter reflects on the core concept of the digital twin, evaluates the state-of-the-art modelling and analysis technologies, and presents a pragmatic approach to develop high-fidelity digital twin for large complex enterprises.

A model of cholera transmission with hyperinfectivity and its optimal vaccination control

2017 ◽  
Vol 10 (06) ◽  
pp. 1750084 ◽  
Author(s):  
Chairat Modnak
Keyword(s):  
Optimal Control Theory ◽  
Control Measure ◽  
Cost Effective ◽  
Control Measures ◽  
Equilibrium Analysis ◽  
Time Dependent ◽  
Effective Control ◽  
Health Control ◽  
Vaccination Strategies ◽  
Constant Control

The use of cholera vaccines has been increasingly recognized as an effective control measure in cholera endemic countries. Also, the disease transmissions are getting more complicated and thus comprehensive strategies to implement public health control measures are worthwhile to be investigated. In this paper, we aim to better understand the effects of HI states of vibrios from the environment and from human contacts that cause cholera outbreaks. We also present and analyze our cholera mathematical model with vaccine incorporated. Equilibrium analysis is conducted in the case with constant control for both epidemic and endemic dynamics. Optimal control theory is applied to seek cost-effective solutions of time-dependent vaccination strategies against cholera outbreaks. Our results show that using vaccination during cholera outbreaks at the very beginning of the onset can reduce the number of infections significantly.

scholarly journals Community Knowledge and Attitudes about the Transmission of Dengue Haemorrhagic Fever and Its Relationship to Prevention Behaviour in Palembang, South Sumatra, Indonesia

2021 ◽  
Vol 9 (E) ◽  
pp. 1534-1543
Author(s):  
Minarti Minarti ◽  
Chairil Anwar ◽  
Irfannuddin Irfannuddin ◽  
Chandra Irsan
Keyword(s):  
Vector Control ◽  
Control Measure ◽  
Public Awareness ◽  
Cost Effective ◽  
Hemorrhagic Fever ◽  
Control Measures ◽  
Good Knowledge ◽  
Effective Control ◽  
Control Practice ◽  
Prevention Behavior

BACKGROUND: PSN 3 M Plus is a long-running program in Indonesia for the prevention and control of dengue hemorrhagic fever (DHF). AIM: This study aimed to determine the knowledge, behavior, attitudes, and beliefs of the community toward PSN 3 M Plus in preventing and controlling the spread of DHF. METHODS: A cluster random sampling method was used to recruit 200 respondents in endemic areas and 100 respondents in sporadic locations of Indonesia from August 2020 to February 2021. The respondents were interviewed directly by interviewers and the relationships between demographics and characteristics with the practice of PSN 3M Plus prevention behavior on the incidence of DHF were analyzed. RESULTS: Most respondents had good knowledge regarding the cause of DHF. Although respondents recognized and understood the dangers of and how to control DHF, most did not follow PSN 3 M Plus and believed that fogging was the most effective control measure. There was a significant relationship between the characteristics of the respondents in terms of education, occupation, and attitude on vector control practice. CONCLUSION: Although community environmental modifications can be a cost-effective approach to reduce the incidence of DHF, there is a need to raise public awareness regarding preventive vector control measures as good knowledge does not guarantee good compliance with PSN 3M Plus recommendations.

Characterizing the effectiveness of COVID-19 mitigation measures: A data-centric approach (Preprint)

2020 ◽  
Author(s):  
Lukman Olagoke ◽  
Ahmet E. Topcu
Keyword(s):  
Control Measure ◽  
Control Measures ◽  
World Health ◽  
Mitigation Measures ◽  
Effective Control ◽  
The World ◽  
Decision Making Processes ◽  
And Performance ◽  
Health Organization ◽  
The Impact

BACKGROUND COVID-19 represents a serious threat to both national health and economic systems. To curb this pandemic, the World Health Organization (WHO) issued a series of COVID-19 public safety guidelines. Different countries around the world initiated different measures in line with the WHO guidelines to mitigate and investigate the spread of COVID-19 in their territories. OBJECTIVE The aim of this paper is to quantitatively evaluate the effectiveness of these control measures using a data-centric approach. METHODS We begin with a simple text analysis of coronavirus-related articles and show that reports on similar outbreaks in the past strongly proposed similar control measures. This reaffirms the fact that these control measures are in order. Subsequently, we propose a simple performance statistic that quantifies general performance and performance under the different measures that were initiated. A density based clustering of based on performance statistic was carried out to group countries based on performance. RESULTS The performance statistic helps evaluate quantitatively the impact of COVID-19 control measures. Countries tend show variability in performance under different control measures. The performance statistic has negative correlation with cases of death which is a useful characteristics for COVID-19 control measure performance analysis. A web-based time-line visualization that enables comparison of performances and cases across continents and subregions is presented. CONCLUSIONS The performance metric is relevant for the analysis of the impact of COVID-19 control measures. This can help caregivers and policymakers identify effective control measures and reduce cases of death due to COVID-19. The interactive web visualizer provides easily digested and quick feedback to augment decision-making processes in the COVID-19 response measures evaluation. CLINICALTRIAL Not Applicable

Water safety plans for small systems: a model for applying HACCP concepts for cost-effective monitoring in developing countries

2003 ◽  
Vol 47 (3) ◽  
pp. 215-220 ◽  
Author(s):  
G. Howard
Keyword(s):  
Risk Factors ◽  
Water Quality ◽  
Cost Effective ◽  
Control Measures ◽  
Effective Control ◽  
Performance Limits ◽  
Water Safety ◽  
Small Systems ◽  
Water Safety Plans ◽  
Contamination Events

The development of water safety plans (WSPs) for small systems should be based on a thorough understanding of the relationships between risk factors and contamination events. This can be achieved through the use of well-designed assessments of water quality that provide better evidence to support the identification of control measures, performance limits, monitoring parameters and verification procedures. Training of community operators is critical to the success of the WSP and the understanding gained from the assessments provides a sound basis for addressing these needs. The WSP approach provides for more effective control of water quality and the use of targeted assessments is cost-effective in improving the design of WSPs.

scholarly journals Development of a Sanitation Safety Plan for improving the sanitation system in peri-urban areas of Iringa, Tanzania

2017 ◽  
Vol 7 (2) ◽  
pp. 340-348 ◽  
Author(s):  
M. Domini ◽  
G. Langergraber ◽  
L. Rondi ◽  
S. Sorlini ◽  
S. Maswaga
Keyword(s):  
Urban Areas ◽  
Cost Effective ◽  
Control Measures ◽  
Effective Control ◽  
Safety Plan ◽  
First Results ◽  
Assessment Matrix ◽  
Planning Methodology ◽  
The Given

The Sanitation Safety Planning methodology is implemented within a cooperation project in Iringa, Tanzania. The study presents the methodology and its adaptation and use for the given context, in order to assess risks and to support stakeholders in improving the current sanitation system and validate the design of an improved one. First results of the application of the methodology, obtained in one of the four peri-urban wards of Iringa, demonstrated its efficacy and utility in prioritising risks and identifying cost-effective control measures. Risks were assessed by the use of a semi-quantitative approach, and a simplified risk assessment matrix was developed for the case study. A sensitivity analysis was carried out in order to evaluate criteria for prioritising control measures to be selected for the development of an achievable improvement plan.

Limited Adverse Occurrence Screening: A Program with Significant Benefits for the Medical Record Department

1992 ◽  
Vol 22 (3) ◽  
pp. 98-101 ◽  
Author(s):  
Catherine Dooling ◽  
Alan Wolff
Keyword(s):  
Patient Care ◽  
Medical Record ◽  
Screening Program ◽  
Cost Effective ◽  
Effective Control ◽  
Screening Process ◽  
Daily Work ◽  
Medical Quality ◽  
Effective Manner ◽  
Care Problems

Quality is a major issue in industry. However, the performance of hospitals is predominantly measured by quantity. There is little accurate measurement of, and control over, the quality of patient care provided. Traditional medical quality assurance methods do not meet the basic criteria of an effective control system as defined in management theory. Occurrence screening is a method of medical quality control that overcomes many of these deficiencies. It detects adverse patient occurrences by screening medical records using outcome criteria and selective medical record review. The implementation of an occurrence screening program using a small number of criteria and retrospective review in the Medical Record Department of a 200 bed base hospital is described. Screening has been integrated into daily work practices in an efficient and cost effective manner. Medical record staff have become more aware of the importance of complete documentation and the profile of the department in the hospital has risen. Significant patient care problems have been detected by the screening process.

Ecology of the maize stalk borer, Busseola fusca (Fuller) (Lepidoptera: Noctuidae)

1987 ◽  
Vol 77 (2) ◽  
pp. 255-269 ◽  
Author(s):  
J. B. J. Van Rensburg ◽  
M. C. Walters ◽  
J. H. Giliomee
Keyword(s):  
Plant Development ◽  
Busseola Fusca ◽  
Cost Effective ◽  
Control Measures ◽  
Effective Control ◽  
Planting Dates ◽  
Plant Parts ◽  
New Information ◽  
Repeated Sampling ◽  
Definite Pattern

AbstractNew information on the intraseasonal progression of larval infestations of Busseola fusca (Fuller) in South Africa was obtained through repeated sampling in maize plantings of different planting dates over various seasons. Due to the occurrence of distinct periods of moth flight, variation in planting date had a marked influence on levels of larval infestation. Also, plants were found to be most attractive as sites for oviposition between three and five weeks after emergence, resulting in a definite pattern in the time distribution of different larval instars in different plant parts. In the pre-tassel stage of plant development, most larvae occurred in localized groups within the whorls, reaching maximum numbers eight weeks after plant emergence. The emergence of the tassel forced some larvae to migrate to adjacent plants, resulting in an increase of internally damaged plants without an increase in larval numbers. It is shown that scouting for eggs over a limited period of plant development can lead to better timing of spray applications and thus to more cost-effective control measures.

scholarly journals Predicting spread and effective control measures for African swine fever– should we blame the boars?

2019 ◽  
Author(s):  
Rachel A. Taylor ◽  
Tomasz Podgórski ◽  
Robin R. L. Simons ◽  
Sophie Ip ◽  
Paul Gale ◽  
...  
Keyword(s):  
At Risk ◽  
Wild Boar ◽  
Control Strategies ◽  
Control Measure ◽  
African Swine Fever ◽  
Control Measures ◽  
Effective Control ◽  
Risk Of Infection ◽  
Long Distance ◽  
Baltic Countries

SummaryAfrican swine fever (ASF) has been causing multiple outbreaks in Russia, Poland and the Baltic countries in recent years and is currently spreading westwards throughout Europe and eastwards into China, with cases occurring in wild boar and domestic pigs. Curtailing further spread of ASF requires full understanding of the transmission pathways of the disease. Wild boars have been implicated as a potential reservoir for the disease and one of the main modes of transmission within Europe. We developed a spatially explicit model to estimate the risk of infection with ASF in boar and pigs due to the natural movement of wild boar that is applicable across the whole of Europe. We demonstrate the model by using it to predict the probability that early cases of ASF in Poland were caused by wild boar dispersion. The risk of infection in 2015 is computed due to wild boar cases in Poland in 2014, compared against the reported cases in 2015 and then the procedure is repeated for 2015-2016. We find that long- and medium-distance spread of ASF (i.e. >30km) is very unlikely to have occurred due to boar dispersal, due in part to the generally short distances boar will travel (<20km on average). We also predict what the relative success of different control strategies would have been in 2015, if they were implemented in 2014. Results suggest that hunting of boar reduces the number of new cases, but a larger region is at risk of ASF compared to no control measure. Alternatively, introducing boar-proof fencing reduces the size of the region at risk in 2015, but not the total number of cases. Overall, our model suggests wild boar movement is only responsible for local transmission of disease, thus other pathways are more dominant in medium and long distance spread of the disease.

scholarly journals Estimating the basic reproduction number for the 2015 bubonic plague outbreak in Nyimba district of Eastern Zambia

2020 ◽  
Vol 14 (11) ◽  
pp. e0008811
Author(s):  
Joseph Sichone ◽  
Martin C. Simuunza ◽  
Bernard M. Hang’ombe ◽  
Mervis Kikonko
Keyword(s):  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Cost Effective ◽  
Control Measures ◽  
Effective Control ◽  
Infectious Period ◽  
Bubonic Plague ◽  
Infectious Individual ◽  
Susceptible Population ◽  
The Basic Reproduction Number

Background Plague is a re-emerging flea-borne infectious disease of global importance and in recent years, Zambia has periodically experienced increased incidence of outbreaks of this disease. However, there are currently no studies in the country that provide a quantitative assessment of the ability of the disease to spread during these outbreaks. This limits our understanding of the epidemiology of the disease especially for planning and implementing quantifiable and cost-effective control measures. To fill this gap, the basic reproduction number, R0, for bubonic plague was estimated in this study, using data from the 2015 Nyimba district outbreak, in the Eastern province of Zambia. R0 is the average number of secondary infections arising from a single infectious individual during their infectious period in an entirely susceptible population. Methodology/Principal findings Secondary epidemic data for the most recent 2015 Nyimba district bubonic plague outbreak in Zambia was analyzed. R0 was estimated as a function of the average epidemic doubling time based on the initial exponential growth rate of the outbreak and the average infectious period for bubonic plague. R0 was estimated to range between 1.5599 [95% CI: 1.382–1.7378] and 1.9332 [95% CI: 1.6366–2.2297], with average of 1.7465 [95% CI: 1.5093–1.9838]. Further, an SIR deterministic mathematical model was derived for this infection and this estimated R0 to be between 1.4 to 1.5, which was within the range estimated above. Conclusions/Significance This estimated R0 for bubonic plague is an indication that each bubonic plague case can typically give rise to almost two new cases during these outbreaks. This R0 estimate can now be used to quantitatively analyze and plan measurable interventions against future plague outbreaks in Zambia.

scholarly journals Transmission Dynamics of Corynebacterium spp. Within Two Danish Dairy Cattle Herds

2021 ◽  
Vol 8 ◽  
Author(s):  
Carsten Kirkeby ◽  
Tariq Halasa ◽  
Michael Farre ◽  
Galal Nazih Chehabi ◽  
Kaare Græsbøll
Keyword(s):  
Dairy Cattle ◽  
Transmission Rate ◽  
Cost Effective ◽  
Control Measures ◽  
Transmission Dynamics ◽  
Effective Control ◽  
Indirect Transmission ◽  
The Mean ◽  
Cattle Herds ◽  
Danish Dairy

Intramammary infections (IMI) can cause mastitis, a prevalent and costly infectious disease in dairy cattle worldwide. The IMI is caused by a range of bacteria, including Corynebacterium spp. Knowledge of the transmission dynamics of pathogens is generally sparse but essential to support decision-making; such as input to bioeconomic models. In this observational study, we explored the transmission dynamics of Corynebacterium spp. in two different Danish dairy cattle herds by testing monthly quarter-level milk samples of all lactating cows for 1 year. We estimated the prevalence for herd 1 and 2 to 24 and 11.7%, respectively, and the mean quarter-level incidence to be 8 and 6.5% per month, respectively. We compared a model for indirect transmission via the environment with a model with the direct contagious transmission and found that the latter model best explained the data. We estimated the daily mean quarter-level transmission rate to be 0.016 and 0.018 cases/quarter-day for herd 1 and 2, respectively. The mean recovery rate was 0.012 and 0.016 for herd 1 and 2, respectively. Consequently, the basic reproduction number for herd 1 and 2 was 1.27 and 1.10, respectively. This study highlights that Corynebacterium spp. can be prevalent within a herd and transmit directly between cows. Thus, future studies should investigate cost-effective control measures against Corynebacterium spp.

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