Analyzing Intraductal Papillary Mucinous Neoplasms Using Artificial Neural Network Methodologic Triangulation

2022 ◽  
pp. 867-880
Author(s):  
Steven Walczak ◽  
Jennifer B. Permuth ◽  
Vic Velanovich
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Pancreatic Cancer ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Methodological Triangulation ◽  
Average Survival ◽  
Mucinous Neoplasms ◽  
Artificial Neural ◽  
The Impact ◽  
Malignant Ipmn

Intraductal papillary mucinous neoplasms (IPMN) are a type of mucinous pancreatic cyst. IPMN have been shown to be pre-malignant precursors to pancreatic cancer, which has an extremely high mortality rate with average survival less than 1 year. The purpose of this analysis is to utilize methodological triangulation using artificial neural networks and regression to examine the impact and effectiveness of a collection of variables believed to be predictive of malignant IPMN pathology. Results indicate that the triangulation is effective in both finding a new predictive variable and possibly reducing the number of variables needed for predicting if an IPMN is malignant or benign.

Analyzing Intraductal Papillary Mucinous Neoplasms Using Artificial Neural Network Methodologic Triangulation

2019 ◽  
Vol 14 (4) ◽  
pp. 21-32 ◽  
Author(s):  
Steven Walczak ◽  
Jennifer B. Permuth ◽  
Vic Velanovich
Keyword(s):  
Neural Network ◽  
Pancreatic Cancer ◽  
Pancreatic Cyst ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Methodological Triangulation ◽  
Average Survival ◽  
Mucinous Neoplasms ◽  
Artificial Neural ◽  
The Impact ◽  
Malignant Ipmn

Intraductal papillary mucinous neoplasms (IPMN) are a type of mucinous pancreatic cyst. IPMN have been shown to be pre-malignant precursors to pancreatic cancer, which has an extremely high mortality rate with average survival less than 1 year. The purpose of this analysis is to utilize methodological triangulation using artificial neural networks and regression to examine the impact and effectiveness of a collection of variables believed to be predictive of malignant IPMN pathology. Results indicate that the triangulation is effective in both finding a new predictive variable and possibly reducing the number of variables needed for predicting if an IPMN is malignant or benign.

Operations-based classification of the bullwhip effect

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Sachin Gupta ◽  
Anurag Saxena
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Logistic Regression ◽  
Supply Chain ◽  
Discriminant Analysis ◽  
Bullwhip Effect ◽  
Content Type ◽  
Operational Variables ◽  
Artificial Neural ◽  
The Impact

Purpose Present study deals with the most discussed rather than addressed yet still an unsolved problem of supply chain known as the bullwhip effect. Operational variables affecting the bullwhip effect are identified and their role in causing the bullwhip effect has been explored using artificial neural networks. The purpose of this study is to analyze the impact of identified operational reasons that affect the bullwhip effect and to analyze the bunch of variables that are more prominent in explaining the phenomenon of the bullwhip effect. Design/methodology/approach Ten major sectors of the Indian economy are analyzed for the bullwhip effect in the present study, and the operational variables affecting the bullwhip effect in these sectors are identified. The bullwhip metric is developed as the ratio of variance in production to the variance in the demand. The impact of identified operation variables on the bullwhip effect has been discussed using the artificial neural network technique known as multilayer perceptron. The classification is also performed using neural network, logistic regression and discriminant analysis. Findings The operation variables are found to be varying with respect to sectors. The study emphasizes that analyzing the right set of operation variables with respect to the sector is required to deal with the complex problem, the bullwhip effect. The operational variables affecting the bullwhip effect are identified. The classification result of the neural network is compared with those of the logistic regression and discriminant analysis, and it is found that the dynamism present in the bullwhip effect is better classified by neural network. Research limitations/implications The study used 11 years of observations to analyze the bullwhip effect on the basis of operational variables. The bullwhip effect is a complex phenomenon, and it is explained on the basis of an extensive set of operational variables which is not exhaustive. Further, the behavioral aspect (bullwhip because of decision-making) is not explored in the present study. Practical implications The operational aspect plays a gigantic role to explain and deal with the bullwhip effect. Strategies to mitigate the bullwhip effect must be in accordance with the operational variables impacting the sector. Originality/value The study suggests a novel approach to study the bullwhip effect in supply chain management using the application of neural networks in which operational variables are taken as predictor variables.

scholarly journals Comparison of Artificial Neural Network (ANN) Model Development Methods for Prediction of Macroinvertebrate Communities in the Zwalm River Basin in Flanders, Belgium

2002 ◽  
Vol 2 ◽  
pp. 96-104 ◽  
Author(s):  
Andy P. Dedecker ◽  
Peter L.M. Goethals ◽  
Niels De Pauw
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Artificial Neural Networks ◽  
River Basin ◽  
Structural Characteristics ◽  
Sensitivity Analyses ◽  
Macroinvertebrate Communities ◽  
Predictive Variables ◽  
Artificial Neural ◽  
The Impact

Modelling has become an interesting tool to support decision making in water management. River ecosystem modelling methods have improved substantially during recent years. New concepts, such as artificial neural networks, fuzzy logic, evolutionary algorithms, chaos and fractals, cellular automata, etc., are being more commonly used to analyse ecosystem databases and to make predictions for river management purposes. In this context, artificial neural networks were applied to predict macroinvertebrate communities in the Zwalm River basin (Flanders, Belgium). Structural characteristics (meandering, substrate type, flow velocity) and physical and chemical variables (dissolved oxygen, pH) were used as predictive variables to predict the presence or absence of macroinvertebrate taxa in the headwaters and brooks of the Zwalm River basin. Special interest was paid to the frequency of occurrence of the taxa as well as the selection of the predictors and variables to be predicted on the prediction reliability of the developed models. Sensitivity analyses allowed us to study the impact of the predictive variables on the prediction of presence or absence of macroinvertebrate taxa and to define which variables are the most influential in determining the neural network outputs.

Possibility of detecting intraductal papillary mucinous neoplasms using metabolite biomarkers for pancreatic cancer

2020 ◽  
Vol 14 (11) ◽  
pp. 1009-1020
Author(s):  
Ryota Nakano ◽  
Shin Nishiumi ◽  
Takashi Kobayashi ◽  
Takuya Ikegawa ◽  
Yuzo Kodama ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
High Risk ◽  
Multiple Logistic Regression Analysis ◽  
High Sensitivity ◽  
Plasma Samples ◽  
Multiple Logistic Regression ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Detection Model ◽  
High Risk Factors ◽  
Mucinous Neoplasms

Aim: The aim of this study was to identify whether metabolite biomarker candidates for pancreatic cancer (PC) could aid detection of intraductal papillary mucinous neoplasms (IPMN), recognized as high-risk factors for PC. Materials & methods: The 12 metabolite biomarker candidates, which were found to be useful to detect PC in our previous study, were evaluated for plasma samples from patients with PC (n = 44) or IPMN (n = 24) or healthy volunteers (n = 46). Results: Regarding the performance of individual biomarkers of PC and PC high-risk IPMN, lysine exhibited the best performance (sensitivity: 67.8%; specificity: 86.9%). The multiple logistic regression analysis-based detection model displayed high sensitivity and specificity values of 92.5 and 90.6%, respectively. Conclusion: Metabolite biomarker candidates for PC are useful for detecting high-risk IPMN, which can progress to PC.

scholarly journals The Budapest Amyloid Predictor and Its Applications

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 500
Author(s):  
László Keresztes ◽  
Evelin Szögi ◽  
Bálint Varga ◽  
Viktor Farkas ◽  
András Perczel ◽  
...  
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Artificial Neural Networks ◽  
Support Vector ◽  
User Needs ◽  
Computational Technique ◽  
Linear Support Vector Machine ◽  
Β Sheets ◽  
Artificial Neural ◽  
Amorphous Aggregation

The amyloid state of proteins is widely studied with relevance to neurology, biochemistry, and biotechnology. In contrast with nearly amorphous aggregation, the amyloid state has a well-defined structure, consisting of parallel and antiparallel β-sheets in a periodically repeated formation. The understanding of the amyloid state is growing with the development of novel molecular imaging tools, like cryogenic electron microscopy. Sequence-based amyloid predictors were developed, mainly using artificial neural networks (ANNs) as the underlying computational technique. From a good neural-network-based predictor, it is a very difficult task to identify the attributes of the input amino acid sequence, which imply the decision of the network. Here, we present a linear Support Vector Machine (SVM)-based predictor for hexapeptides with correctness higher than 84%, i.e., it is at least as good as the best published ANN-based tools. Unlike artificial neural networks, the decisions of the linear SVMs are much easier to analyze and, from a good predictor, we can infer rich biochemical knowledge. In the Budapest Amyloid Predictor webserver the user needs to input a hexapeptide, and the server outputs a prediction for the input plus the 6 × 19 = 114 distance-1 neighbors of the input hexapeptide.

scholarly journals Artificial neural network, predictor variables and sensitivity threshold for DNA methylation-based age prediction using blood samples

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhonghui Thong ◽  
Jolena Ying Ying Tan ◽  
Eileen Shuzhen Loo ◽  
Yu Wei Phua ◽  
Xavier Liang Shun Chan ◽  
...  
Keyword(s):  
Neural Network ◽  
Artificial Neural Network ◽  
Regression Model ◽  
Sensitivity Threshold ◽  
Ann Model ◽  
Blood Samples ◽  
Ann Models ◽  
Artificial Neural ◽  
The Impact ◽  
Age Prediction

AbstractRegression models are often used to predict age of an individual based on methylation patterns. Artificial neural network (ANN) however was recently shown to be more accurate for age prediction. Additionally, the impact of ethnicity and sex on our previous regression model have not been studied. Furthermore, there is currently no age prediction study investigating the lower limit of input DNA at the bisulfite treatment stage prior to pyrosequencing. Herein, we evaluated both regression and ANN models, and the impact of ethnicity and sex on age prediction for 333 local blood samples using three loci on the pyrosequencing platform. Subsequently, we trained a one locus-based ANN model to reduce the amount of DNA used. We demonstrated that the ANN model has a higher accuracy of age prediction than the regression model. Additionally, we showed that ethnicity did not affect age prediction among local Chinese, Malays and Indians. Although the predicted age of males were marginally overestimated, sex did not impact the accuracy of age prediction. Lastly, we present a one locus, dual CpG model using 25 ng of input DNA that is sufficient for forensic age prediction. In conclusion, the two ANN models validated would be useful for age prediction to provide forensic intelligence leads.

scholarly journals Non-Destructive Micromagnetic Determination of Hardness and Case Hardening Depth Using Linear Regression Analysis and Artificial Neural Networks

Metals ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 18
Author(s):  
Rahel Jedamski ◽  
Jérémy Epp
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Regression Analysis ◽  
Artificial Neural Networks ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Case Hardening ◽  
Artificial Neural ◽  
Non Destructive

Non-destructive determination of workpiece properties after heat treatment is of great interest in the context of quality control in production but also for prevention of damage in subsequent grinding process. Micromagnetic methods offer good possibilities, but must first be calibrated with reference analyses on known states. This work compares the accuracy and reliability of different calibration methods for non-destructive evaluation of carburizing depth and surface hardness of carburized steel. Linear regression analysis is used in comparison with new methods based on artificial neural networks. The comparison shows a slight advantage of neural network method and potential for further optimization of both approaches. The quality of the results can be influenced, among others, by the number of teaching steps for the neural network, whereas more teaching steps does not always lead to an improvement of accuracy for conditions not included in the initial calibration.

scholarly journals Quantitative Dynamics Effects of Belt and Road Economies Trade Using Structural Gravity and Neural Networks

SAGE Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 215824402110326
Author(s):  
Koffi Dumor ◽  
Li Yao ◽  
Jean-Paul Ainam ◽  
Edem Koffi Amouzou ◽  
Williams Ayivi
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Network Analysis ◽  
Bilateral Trade ◽  
Belt And Road Initiative ◽  
Neural Network Analysis ◽  
Analysis Techniques ◽  
Belt And Road ◽  
The Impact ◽  
Trade Partners

Recent research suggests that China’s Belt and Road Initiative (BRI) would improve the bilateral trade between China and its partners. This article uses detailed bilateral export data from 1990 to 2017 to investigate the impact of China’s BRI on its trade partners using neural network analysis techniques and structural gravity model estimations. Our main findings suggest that the BRI countries would raise exports by a modest 5.053%. This indicates that export and network upgrades should be considered from economic and policy perspectives. The results also show that neural networks is more robust compared with structural gravity framework.

scholarly journals Optimal Artificial Neural Network Type Selection Method for Usage in Smart House Systems

Sensors ◽  
2020 ◽  
Vol 21 (1) ◽  
pp. 47
Author(s):  
Vasyl Teslyuk ◽  
Artem Kazarian ◽  
Natalia Kryvinska ◽  
Ivan Tsmots
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Artificial Neural Network ◽  
Artificial Neural Networks ◽  
Input Data ◽  
Optimization Criterion ◽  
Fuzzy Input ◽  
Different Types ◽  
Smart House ◽  
Artificial Neural

In the process of the “smart” house systems work, there is a need to process fuzzy input data. The models based on the artificial neural networks are used to process fuzzy input data from the sensors. However, each artificial neural network has a certain advantage and, with a different accuracy, allows one to process different types of data and generate control signals. To solve this problem, a method of choosing the optimal type of artificial neural network has been proposed. It is based on solving an optimization problem, where the optimization criterion is an error of a certain type of artificial neural network determined to control the corresponding subsystem of a “smart” house. In the process of learning different types of artificial neural networks, the same historical input data are used. The research presents the dependencies between the types of neural networks, the number of inner layers of the artificial neural network, the number of neurons on each inner layer, the error of the settings parameters calculation of the relative expected results.

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