scholarly journals How Interventions Might Improve Cognition in Healthy Older Adults

2013 ◽  
Vol 5 (3) ◽  
pp. 72-82
Author(s):  
Elizabeth M. Zelinski
Keyword(s):  
Functional Assessment ◽  
Functional Ability ◽  
Cognitive Skills ◽  
Functional Outcomes ◽  
Healthy Aging ◽  
Narrow Range ◽  
Cognitive Tasks ◽  
Healthy Older Adults ◽  
The Third ◽  
Everyday Activities

Many of the cognitive declines in healthy aging are moderated by experience, suggesting that interventions may be beneficial. Goals for aging outcomes include improving performance on untrained tasks, remediating observed cognitive declines, and ensuring preservation of functional ability. This selective review evaluates current progress towards these goals. Most research focuses on untrained tasks. Interventions associated with this outcome include games and exercises practicing specific cognitive skills, as well as aerobic exercise, and modestly benefit a relatively narrow range of cognitive tasks. Few studies have directly tested improvements in tasks on which individuals have been shown to experience longitudinal decline, so this goal has not been realized, though remediation can be examined rather easily. Little work has been done to develop psychometrically strong functional outcomes that could be used to test preservation of independence in everyday activities. Virtual reality approaches to functional assessment show promise for achieving the third goal.

Games and Other Training Interventions to Improve Cognition in Healthy Older Adults

2016 ◽  
pp. 192-205
Author(s):  
Elizabeth M. Zelinski
Keyword(s):  
Older Adults ◽  
Virtual Reality ◽  
Aerobic Exercise ◽  
Functional Assessment ◽  
Functional Ability ◽  
Cognitive Skills ◽  
Healthy Aging ◽  
Healthy Older Adults ◽  
Training Interventions ◽  
The Third

Many of the cognitive declines in healthy aging are moderated by experience, suggesting that interventions may be beneficial. Goals for aging outcomes include improving performance on untrained tasks, remediating observed cognitive declines, and ensuring preservation of functional ability. This selective review evaluates current progress towards these goals. Most research focuses on untrained tasks. Interventions associated with this outcome include games and exercises practicing specific cognitive skills, as well as aerobic exercise, and modestly benefit a relatively narrow range of cognitive tasks. Few studies have directly tested improvements in tasks on which individuals have been shown to experience longitudinal decline, so this goal has not been realized, though remediation can be examined rather easily. Little work has been done to develop psychometrically strong functional outcomes that could be used to test preservation of independence in everyday activities. Virtual reality approaches to functional assessment show promise for achieving the third goal.

scholarly journals Effect of erenumab on functional outcomes in patients with episodic migraine in whom 2–4 preventives were not useful: results from the LIBERTY study

2021 ◽  
pp. jnnp-2020-324396
Author(s):  
Michel Lanteri-Minet ◽  
Peter J Goadsby ◽  
Uwe Reuter ◽  
Shihua Wen ◽  
Peggy Hours-Zesiger ◽  
...  
Keyword(s):  
Functional Outcomes ◽  
Impact Test ◽  
Work Productivity ◽  
Placebo Treatment ◽  
Episodic Migraine ◽  
Activity Impairment ◽  
Everyday Activities ◽  
Point Reduction ◽  
Patient Reported ◽  
Headache Impact

ObjectiveTo evaluate the effect of erenumab on patient-reported, functional outcomes in patients with episodic migraine (EM) in whom 2–4 preventives were not useful from the Phase 3b LIBERTY study.MethodsAs previously reported, 246 patients with EM with 2–4 prior failed preventives were randomised 1:1 to subcutaneous erenumab 140 mg or placebo every 4 weeks for 12 weeks. This analysis evaluated Migraine Physical Function Impact Diary (MPFID), Headache Impact Test (HIT-6) and Work Productivity and Activity Impairment (WPAI) scores at Week 12. P values were nominal without multiplicity adjustment.ResultsErenumab significantly improved MPFID-Physical Impairment (PI) and Everyday Activities (EA) scores versus placebo (treatment difference (TD) (95% CI) MPFID-PI: −3.5 (−5.7 to –1.2) (p=0.003); MPFID-EA: −3.9 (−6.1 to –1.7)) (p<0.001) at 12 weeks. Patients on erenumab were more likely to have a ≥5-point reduction in MPFID score (OR vs placebo (95% CI) MPFID-EA: 2.1 (1.2 to 3.6); MPFID-PI: 2.5 (1.4 to 4.5)). A similar trend was observed for HIT-6 (TD: −3.0; p<0.001); significantly higher proportions of patients on erenumab reported a ≥5-point reduction (OR (95% CI): 2.4 (1.4 to 4.1)). In three out of four WPAI domains, erenumab showed improvement versus placebo.ConclusionAt 12 weeks, erenumab was efficacious on functional outcomes in patients with EM in whom 2–4 preventives were not useful.Trial registration detailsClinicalTrials.gov identifier: NCT03096834.

scholarly journals P110 Sex differences in hand osteoarthritis symptoms and function

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_1) ◽  
Author(s):  
Brona Dinneen ◽  
David Heath ◽  
Mohammed Tauseef Ghaffar ◽  
Miriam O'Sullivan ◽  
Carmel Silke ◽  
...  
Keyword(s):  
Sex Differences ◽  
Pain Intensity ◽  
Motor Skills ◽  
Functional Assessment ◽  
Functional Ability ◽  
Fine Motor ◽  
Hand Osteoarthritis ◽  
Fine Motor Skills ◽  
Males And Females ◽  
And Function

Abstract Background/Aims  There is currently no consensus regarding sex-related differences in pain intensity and functional abilities among patients with hand osteoarthritis (OA). In this study we determine sex-related differences in pain intensity and functional ability among patients with hand OA, as assessed by a self-report questionnaire and by performance-based tests. Methods  Using the AUSCAN tool for symptom and functional assessment of hand OA with dynamometry we prospectively accessed patients meeting the ACR criteria for hand osteoarthritis. Using this analysis, assessments of pain and function were compared in male and female patients. The outcome measures included self-reported pain measures, functional assessment and dynamometry measures. Results  The study population included 106 patients (90 females and 16 males) with a mean age of males 48.44 (7.48) and females 52.67 (9.43). All patients with symptomatic hand osteoarthritis meeting ACR Criteria. When accessing difference between sexes, men were found to be significantly heavier (p = 0.003) and have greater grip and pinch strength.As part of function and pain assessments there was a significant correlation between difficulty with fine motor skills such as difficulty doing buttons, difficulty when doing jewellery, or peeling vegetables associated with pain when turning objects e.g. doorknobs, taps and faucets for men in comparison to women. Difficulty in these fine motor skills also correlated with stiffness on wakening and pain on lifting heavy objects regardless of sex. A Mann-Whitney U test was run on 106 participants to determine if there were differences in pain or functional scores between males and females. This reviled Median score for males () and females () was statistically significantly different,There were sex differences noted in the correlation associated with pain with rotational movements e.g. turning objects and functional difficulty with fine motor movements including difficulty when doing up buttons ( Males r(14) = -0.109, p = 0.698, Females r(88) =0.489, p = &lt;0.01 value.= ), difficulty when doing jewellery ( Males r(14) =-0.265, p = 0.339.= Females r(88) = 0.570, p = &lt;0.01) , difficulty peeling vegetables ( Males r(14) = -0.207, p = 0.458 Females r(88) = 0.519, &lt;0.01 ) Conclusion  The results demonstrate the presence of sex differences in patients suffering from hand osteoarthritis self-reported functional ability and pain scales. These differences indicate the need for further studies to explore the mechanisms of hand OA and to understanding the specific impact of gender on the development and progression of disease. With further understanding we can obtain the proper strategy to provide better individualised treatment. It also highlights that rehabilitation programs should consider these differences and each patients’ performance limitations in order to address the specific needs of each individual patient. In doing so, improved pain and functional status will improve morbidity in hand OA Disclosure  B. Dinneen: None. D. Heath: None. M. Ghaffar: None. M. O'Sullivan: None. C. Silke: None. B. Whelan: None.

Conservatism and liberalism predict performance in two nonideological cognitive tasks

2017 ◽  
Vol 36 (2) ◽  
pp. 49-59 ◽  
Author(s):  
Rodolpho Talaisys Bernabel ◽  
Amâncio Oliveira
Keyword(s):  
Cognitive Skills ◽  
Cognitive Tasks ◽  
Intuitive Thinking ◽  
Experimental Findings ◽  
Cognitive Environment

Intuitive thinking would argue that political or ideological orientation does not correlate with nonpolitical decisions, and certainly not with nonideological cognitive tasks. However, that is what happens in some cases. Previous neuropolitics studies have found that liberals are more adept at dealing with novel information than conservatives. This finding suggests that conservatives and liberals possess different cognitive skills. For the purposes of this article, two studies were executed to test whether this difference remained in alternative environmental settings. To this end, two novel cognitive tasks were designed in which one type of ideology or another was privileged according to the cognitive environment created by the tasks. Experimental findings indicate that liberals committed fewer errors than conservatives in one kind of cognitive environment, while conservatives scored higher in another.

scholarly journals Mindful awareness in early childhood education

2016 ◽  
Vol 6 (1) ◽  
pp. 9
Author(s):  
Suvi H. Nieminen ◽  
Nina Sajaniemi
Keyword(s):  
Early Childhood ◽  
Peer Relationships ◽  
Self Regulation ◽  
Evidence Base ◽  
Stress Regulation ◽  
Mindful Awareness ◽  
Childhood Education ◽  
The Third ◽  
Everyday Activities ◽  
Excessive Stress

<p>This study is a literature review, drawing mainly on the nine significant and good quality studies (i.e. published in peer-reviewed journals) that make up the evidence base for mindful awareness practices in early childhood. Mindful awareness practices in this context means an individual’s awareness of her own body and her inner emotions or tensions. Increased awareness can decrease if individuals tend to impulsiveness or excessive stress. Self-regulation and mindful awareness skills are associated not only with stress regulation but also peer relationships and social skills. This systematic review attempts to look at the research of mindful awareness activities, programmes or interventions used as routine everyday activities. The second aim of this review is to examine the research design that has been used. The third aim of this study is to analyse the main themes and methods of these pieces of research.</p>

scholarly journals Quality of life after ischaemic stroke—accent on patients with thrombolytic therapy

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Mihael Emilov Tsalta-Mladenov ◽  
Silva Peteva Andonova
Keyword(s):  
Quality Of Life ◽  
Ischemic Stroke ◽  
Thrombolytic Therapy ◽  
Functional Outcomes ◽  
Intravenous Thrombolysis ◽  
Treatment Method ◽  
The Third ◽  
Related Quality ◽  
Health Related

Abstract Background Intravenous thrombolysis is a widely approved treatment method for acute ischemic stroke (AIS). Nevertheless, there is a growing interest in its impact on functional outcomes and Health-related Quality of life (HR-QoL). We aimed to evaluate and compare the HR-QoL in patients receiving intravenous thrombolysis (IVT) and in those without thrombolytic therapy during the first 3-month post-stroke in a defined Bulgarian population. Results Patients treated with IVT have simillar functional outcomes and HR-QoL on the third month as the group with conservative treatment, besides their higher NIHSS on admission. Patients with IVT had better self-assessed recovery after the AIS. The higher NIHSS and mRS scores and the lower HR-QoL on discharge are reliable predictors for a poor functional outcome on the third month. A door-to-needle of 60 min or less, and the absence of pathological neuroimaging findings 24-h post IVT predict more beneficial HR-QoL outcome. Conclusion There were no significant differences in HR-QoL and functional outcomes between the groups. Nevertheless, IVT is a treatment option with great importance for improving the clinical outcomes after ischemic stroke, which should be performed in well selected patients.

scholarly journals Phylogenetic partitioning of the third-largest vertebrate genus in the world, Cyrtodactylus Gray, 1827 (Reptilia; Squamata; Gekkonidae) and its relevance to taxonomy and conservation

2021 ◽  
Vol 71 ◽  
pp. 101-154 ◽  
Author(s):  
L. Lee Grismer ◽  
Perry L. Wood, Jr. ◽  
Nikolay A. Poyarkov ◽  
Minh D. Le ◽  
Fred Kraus ◽  
...  
Keyword(s):  
Conservation Management ◽  
Narrow Range ◽  
Small Islands ◽  
Rate Data ◽  
Ecological Studies ◽  
The Third ◽  
True Number ◽  
The World ◽  
Species Groups ◽  
Mitochondrial Phylogeny

The gekkonid genus Cyrtodactylus is the third most speciose vertebrate genus in the world, containing well over 300 species that collectively range from South Asia to Melanesia across some of the most diverse landscapes and imperiled habitats on the planet. A genus-wide phylogeny of the group has never been presented because researchers working on different groups were using different genetic markers to construct phylogenies that could not be integrated. We present here Maximum likelihood and Bayesian inference mitochondrial and mito-nuclear phylogenies incorporating of 310 species that include dozens of species that had never been included in a genus-wide analysis. Based on the mitochondrial phylogeny, we partition Cyrtodactylus into 31 well-supported monophyletic species groups which, if used as recommended herein, will increase the information content of future integrative taxonomic analyses that continue to add new species to this genus at an ever-increasing annual rate. Data presented here reiterate the outcome of several previous studies indicating that Cyrtodactylus comprises an unprecedented number of narrow-range endemics restricted to single mountain tops, small islands, or karst formations that still remain unprotected. This phylogeny can provide a platform for various comparative ecological studies that can be integrated with conservation management programs across the broad diversity of landscapes and habitats occupied by this genus. Additionally, these data indicate that the true number of Cyrtodactylus remains substantially underrepresented.

Isotopic-geochemical features of water-rock system by the example of Verkh-Tarskoe oil field

2020 ◽  
Author(s):  
Lyudmila G. Vakulenko ◽  
◽  
Dmitry A. Novikov ◽  
Ostap D. Nikolenko ◽  
Fedor F. Dultsev ◽  
...  
Keyword(s):  
Narrow Range ◽  
Oil Field ◽  
Isotopic Ratios ◽  
Third Generation ◽  
Rock System ◽  
Authigenic Minerals ◽  
The Third ◽  
Three Generations ◽  
Aquifer Complex ◽  
Comprehensive Study

The first data of a comprehensive study of the isotope-geochemical features of the water-rock system are presented on the example of the Yu 1 horizon of the Verkh-Tarsk oil field. It was established that the reservoir waters of the developed deposits are similar in the isotopic ratios and located in the same area with the waters of the Apt-Alb-Cenomanian aquifer complex (an agent for flooding). In the cement of silt-sandy rocks among the authigenic minerals most widely represented by calcite, three generations of it were established. A narrow range of δ 13 C values was revealed in the analysis of the δ 13 C - δ 18 О isotope pair. In waters it ranges from -10.5 to -9.1 ‰, and in calcites of the third generation from -10.7 to -9.1 ‰.

scholarly journals People With Autism Spectrum Conditions Make More Consistent Decisions

2017 ◽  
Vol 28 (8) ◽  
pp. 1067-1076 ◽  
Author(s):  
George D. Farmer ◽  
Simon Baron-Cohen ◽  
William J. Skylark
Keyword(s):  
Autistic Traits ◽  
Autism Spectrum ◽  
Consumer Products ◽  
Cognitive Tasks ◽  
Autism Spectrum Conditions ◽  
The Third ◽  
Adult Participants ◽  
Contextual Stimuli ◽  
Practical Implications

People with autism spectrum conditions (ASC) show reduced sensitivity to contextual stimuli in many perceptual and cognitive tasks. We investigated whether this also applies to decision making by examining adult participants’ choices between pairs of consumer products that were presented with a third, less desirable “decoy” option. Participants’ preferences between the items in a given pair frequently switched when the third item in the set was changed, but this tendency was reduced among individuals with ASC, which indicated that their choices were more consistent and conventionally rational than those of control participants. A comparison of people who were drawn from the general population and who varied in their levels of autistic traits revealed a weaker version of the same effect. The reduced context sensitivity was not due to differences in noisy responding, and although the ASC group took longer to make their decisions, this did not account for the enhanced consistency of their choices. The results extend the characterization of autistic cognition as relatively context insensitive to a new domain, and have practical implications for socioeconomic behavior.

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