Structure and In Vitro Bioactivity of Si Enriched Hydroxyapatite/TiO2 Coatings on Pure Titanium by Micro-Arc Oxidation

2007 ◽  
pp. 1596-1598
Author(s):  
Rong Rong Nie ◽  
Feng Zhu ◽  
Li Ru Shen ◽  
Zhi Qing Chen ◽  
Xiao Yu Li ◽  
...  
Keyword(s):  
Pure Titanium ◽  
In Vitro Bioactivity ◽  
Micro Arc Oxidation

Structure and In Vitro Bioactivity of Si Enriched Hydroxyapatite/TiO2 Coatings on Pure Titanium by Micro-Arc Oxidation

2007 ◽  
Vol 336-338 ◽  
pp. 1596-1598
Author(s):  
Rong Rong Nie ◽  
Feng Zhu ◽  
Li Ru Shen ◽  
Zhi Qing Chen ◽  
Xiao Yu Li ◽  
...  
Keyword(s):  
Cell Attachment ◽  
Composite Coatings ◽  
Composite Films ◽  
Pure Titanium ◽  
In Vitro Bioactivity ◽  
Si Doping ◽  
Amorphous Silicon Dioxide ◽  
Pdl Cells ◽  
Micro Arc Oxidation

The effect of Si doping on the bioactivity and characteristics of hydroxyapatite/TiO2 composite films was investigated. Pure titanium plates were treated to form Ca, P and Si enriched titania-based films by using micro-arc oxidation (MAO). Then, some specimens were undergone a further hydrothermal treatment to produce a thin outermost layer of hydroxyapatite (HA). Experiments revealed that that the film, which was about 10μm thick, was composed of amorphous silicon dioxide, amorphous calcium phosphate, rutile and anatase. The film was porous and uneven, with the pore size of 1-4μm. No obvious cracks exist on the surface. In order to investigate the cytocompatibility of the films, periodontal ligament (PDL) cells were seeded onto the surface of the films. It was concluded that the Si ion did not influence the characters of MAO film but Si enriched hydroxyapatite/ TiO2 composite coatings exhibited an effect on cell attachment.

scholarly journals In vitro biological and antimicrobial properties of chitosan-based bioceramic coatings on zirconium

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Salim Levent Aktug ◽  
Salih Durdu ◽  
Selin Kalkan ◽  
Kultigin Cavusoglu ◽  
Metin Usta
Keyword(s):  
Antimicrobial Properties ◽  
Dip Coating ◽  
In Vitro Bioactivity ◽  
Thermal Cracks ◽  
Coating Method ◽  
Micro Arc Oxidation ◽  
Edx Analyses ◽  
Dip Coating Method ◽  
Bioceramic Coatings

AbstractCa-based porous and rough bioceramic surfaces were coated onto zirconium by micro-arc oxidation (MAO). Subsequently, the MAO-coated zirconium surfaces were covered with an antimicrobial chitosan layer via the dip coating method to develop an antimicrobial, bioactive, and biocompatible composite biopolymer and bioceramic layer for implant applications. Cubic ZrO2, metastable Ca0.15Zr0.85O1.85, and Ca3(PO4)2 were detected on the MAO surface by powder-XRD. The existence of chitosan on the MAO-coated Zr surfaces was verified by FTIR. The micropores and thermal cracks on the bioceramic MAO surface were sealed using a chitosan coating, where the MAO surface was porous and rough. All elements such as Zr, O, Ca, P, and C were homogenously distributed across both surfaces. Moreover, both surfaces indicated hydrophobic properties. However, the contact angle of the MAO surface was lower than that of the chitosan-based MAO surface. In vitro bioactivity on both surfaces was investigated via XRD, SEM, and EDX analyses post-immersion in simulated body fluid (SBF) for 14 days. In vitro bioactivity was significantly enhanced on the chitosan-based MAO surface with respect to the MAO surface. In vitro microbial adhesions on the chitosan-based MAO surfaces were lower than the MAO surfaces for Staphylococcus aureus and Escherichia coli.

scholarly journals Zn- or Cu-containing CaP-Based Coatings Formed by Micro-Arc Oxidation on Titanium and Ti-40Nb Alloy: Part II—Wettability and Biological Performance

Materials ◽  
2020 ◽  
Vol 13 (19) ◽  
pp. 4366
Author(s):  
Ekaterina G. Komarova ◽  
Yurii P. Sharkeev ◽  
Mariya B. Sedelnikova ◽  
Oleg Prymak ◽  
Matthias Epple ◽  
...  
Keyword(s):  
Surface Energy ◽  
Pure Titanium ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Contact Angles ◽  
Polar Component ◽  
Micro Arc Oxidation ◽  
Main Component ◽  
Biological Performance

This work describes the wettability and biological performance of Zn- and Cu-containing CaP-based coatings prepared by micro-arc oxidation on pure titanium (Ti) and novel Ti-40Nb alloy. Good hydrophilic properties of all the coatings were demonstrated by the low contact angles with liquids, not exceeding 45°. An increase in the applied voltage led to an increase of the coating roughness and porosity, thereby reducing the contact angles to 6° with water and to 17° with glycerol. The free surface energy of 75 ± 3 mJ/m2 for all the coatings were determined. Polar component was calculated as the main component of surface energy, caused by the presence of strong polar PO43− and OH− bonds. In vitro studies showed that low Cu and Zn amounts (~0.4 at.%) in the coatings promoted high motility of human adipose-derived multipotent mesenchymal stromal cells (hAMMSC) on the implant/cell interface and subsequent cell ability to differentiate into osteoblasts. In vivo study demonstrated 100% ectopic bone formation only on the surface of the CaP coating on Ti. The Zn- and Cu-containing CaP coatings on both substrates and the CaP coating on the Ti-40Nb alloy slightly decreased the incidence of ectopic osteogenesis down to 67%. The MAO coatings showed antibacterial efficacy against Staphylococcus aureus and can be arranged as follows: Zn-CaP/Ti > Cu-CaP/TiNb, Zn-CaP/TiNb > Cu-CaP/Ti.

Structure and in vitro bioactivity of titania-based films by micro-arc oxidation

2003 ◽  
Vol 168 (2-3) ◽  
pp. 249-258 ◽  
Author(s):  
Yong Han ◽  
Seong-Hyeon Hong ◽  
Kewei Xu
Keyword(s):  
In Vitro Bioactivity ◽  
Micro Arc Oxidation

Temulawak (Curcuma  xanthorrhizaRoxb.) belongs to the family Zingiberaceae, has been empirically used as herbal medicines. The research was aimed to evaluate three promising lines of Temulawak based on their high bioactive contents (xanthorrhizol and curcuminoid) and its in vitro bioactivity (antioxidant and toxicity), and to obtain information on agrobiophysic environmental condition which produced high bioactive compounds. The xanthorrhizol and curcuminoid contents were measured by HPLC. In vitro antioxidant and toxicity were determined by DPPH (1,1-diphenyl-2-picryl-hydrazyl) method and BSLT (Brine Shrimp Lethality Test). The result showed that promising line A produced the highest yield of bioactive and bioactivity, i.e. 0.157 and 0.056 g plant-1of xanthorrizol and curcuminoid respectively. The IC50 of antioxidant activity was 65.09 mg L-1and LC50of toxicity was 69.05 mg L-1. In this study, Cipenjo had the best temulawak performance than two other locations. According to the agrobiophysic parameters, Cipenjo environmental condition was suitable for temulawak cultivation with temperature 28-34 ºC, rainfall ± 223.97 mm year-1 and sandy clay soil. Keywords: antioxidant, curcuminoid, promising lines, temulawak, xanthorrhizol

1970 ◽  
Vol 40 (2) ◽  
Author(s):  
Waras Nurcholis ◽  
Edy Djauhari Purwakusumah ◽  
Mono Rahardjo ◽  
Latifah K. Darusman
Keyword(s):  
Antioxidant Activity ◽  
Bioactive Compounds ◽  
Brine Shrimp ◽  
Clay Soil ◽  
Herbal Medicines ◽  
Environmental Condition ◽  
In Vitro Bioactivity ◽  
The Family ◽  
Promising Line

Temulawak (Curcuma  xanthorrhizaRoxb.) belongs to the family Zingiberaceae, has been empirically used as herbal medicines. The research was aimed to evaluate three promising lines of Temulawak based on their high bioactive contents (xanthorrhizol and curcuminoid) and its in vitro bioactivity (antioxidant and toxicity), and to obtain information on agrobiophysic environmental condition which produced high bioactive compounds. The xanthorrhizol and curcuminoid contents were measured by HPLC. In vitro antioxidant and toxicity were determined by DPPH (1,1-diphenyl-2-picryl-hydrazyl) method and BSLT (Brine Shrimp Lethality Test). The result showed that promising line A produced the highest yield of bioactive and bioactivity, i.e. 0.157 and 0.056 g plant-1of xanthorrizol and curcuminoid respectively. The IC50 of antioxidant activity was 65.09 mg L-1and LC50of toxicity was 69.05 mg L-1. In this study, Cipenjo had the best temulawak performance than two other locations. According to the agrobiophysic parameters, Cipenjo environmental condition was suitable for temulawak cultivation with temperature 28-34 ºC, rainfall ± 223.97 mm year-1 and sandy clay soil. Keywords: antioxidant, curcuminoid, promising lines, temulawak, xanthorrhizol

In vitro Behaviour of Alumina-Hydroxiapatite Composites Coatings

2018 ◽  
Vol 69 (6) ◽  
pp. 1416-1418
Author(s):  
Alexandru Szabo ◽  
Ilare Bordeasu ◽  
Ion Dragos Utu ◽  
Ion Mitelea
Keyword(s):  
Pure Titanium ◽  
Titanium Substrate ◽  
High Strength ◽  
Biological Properties ◽  
Commercially Pure Titanium ◽  
Hvof Spraying ◽  
Before And After ◽  
Sbf Solution ◽  
Oxygen Fuel

Hydroxyapatite (HA) is a very common material used for biomedical applications. Usually, in order to improve its poor mechanical properties is combined or coated with other high-strength materials.The present paper reports the manufacturing and the biocompatibility behaviour of two different biocomposite coatings consisting of alumina (Al2O3) and hydroxyapatite (HA) using the high velocity oxygen fuel (HVOF) spraying method which were deposited onto the surface of a commercially pure titanium substrate. The biological properties of the Al2O3-HA materials were evaluated by in vitro studies. The morphology of the coatings before and after their immersing in the simulated body fluid (SBF) solution was characterized by scanning electron microscopy (SEM). The results showed an important germination of the biologic hydroxyapatite crystallite on the surface of both coatings.

Chemical Characterization and In Vitro Bioactivity of Apple Bark Extracts Obtained by Subcritical Water

2021 ◽  
Author(s):  
Jaroslava Švarc-Gajić ◽  
Víctor Cerdà ◽  
Cristina Delerue-Matos ◽  
Pavle Mašković ◽  
Sabrina Clavijo ◽  
...  
Keyword(s):  
Subcritical Water ◽  
Chemical Characterization ◽  
In Vitro Bioactivity

Phytochemical investigations and in vitro bioactivity screening on Melia azedarach L. leaves extract from Nepal

2021 ◽  
Author(s):  
Stefano Dall'Acqua ◽  
Shyam Sharan Shrestha ◽  
Irene Ferrarese ◽  
Stefania Sut ◽  
Gokhan Zengin ◽  
...  
Keyword(s):  
Melia Azedarach ◽  
In Vitro Bioactivity

scholarly journals Synthesis and Characterization of Silver–Strontium (Ag-Sr)-Doped Mesoporous Bioactive Glass Nanoparticles

Gels ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 34
Author(s):  
Shaher Bano ◽  
Memoona Akhtar ◽  
Muhammad Yasir ◽  
Muhammad Salman Maqbool ◽  
Akbar Niaz ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Composite Coatings ◽  
Antibacterial Properties ◽  
Bone Diseases ◽  
Osteogenic Potential ◽  
Diffusion Method ◽  
Charge Composition ◽  
In Vitro Bioactivity ◽  
Mesoporous Bioactive Glass

Biomedical implants are the need of this era due to the increase in number of accidents and follow-up surgeries. Different types of bone diseases such as osteoarthritis, osteomalacia, bone cancer, etc., are increasing globally. Mesoporous bioactive glass nanoparticles (MBGNs) are used in biomedical devices due to their osteointegration and bioactive properties. In this study, silver (Ag)- and strontium (Sr)-doped mesoporous bioactive glass nanoparticles (Ag-Sr MBGNs) were prepared by a modified Stöber process. In this method, Ag+ and Sr2+ were co-substituted in pure MBGNs to harvest the antibacterial properties of Ag ions, as well as pro-osteogenic potential of Sr2 ions. The effect of the two-ion concentration on morphology, surface charge, composition, antibacterial ability, and in-vitro bioactivity was studied. Scanning electron microscopy (SEM), X-Ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) confirmed the doping of Sr and Ag in MBGNs. SEM and EDX analysis confirmed the spherical morphology and typical composition of MBGNs, respectively. The Ag-Sr MBGNs showed a strong antibacterial effect against Staphylococcus carnosus and Escherichia coli bacteria determined via turbidity and disc diffusion method. Moreover, the synthesized Ag-Sr MBGNs develop apatite-like crystals upon immersion in simulated body fluid (SBF), which suggested that the addition of Sr improved in vitro bioactivity. The Ag-Sr MBGNs synthesized in this study can be used for the preparation of scaffolds or as a filler material in the composite coatings for bone tissue engineering.

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