Fabrication and Characterization of PCL/GE-Based Electrospun Nanofibers for Tissue Engineering and Drug Delivery Application

2014 ◽  
Vol 695 ◽  
pp. 195-198
Author(s):  
Lor Huai Chong ◽  
Mim Mim Lim ◽  
Naznin Sultana
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Average Pore Size ◽  
Weight Ratio ◽  
Electrospun Nanofibers ◽  
Average Pore ◽  
X Ray ◽  
Fabrication And Characterization ◽  
The Relationship

Tissue engineering (TE) provides an alternative option to solve limitation of organ and tissue transplantation issues. Fabrication of scaffold is a major challenge because it needs to provide a suitable medium for cell growing and drug delivery which enhances cell transplantation efficiency. The porosity, biodegradability and biocompatibility are the important properties in fabricating a scaffold. Our previous work had found that electrospinning of Polycarprolactone (PCL)/ Gelatin (GE)-based nanofibers in 14% w/v polymer solution in 18kV showed the best results in morphology, average diameters, average pore size and hydrophilicity. Hence, in this project, we are interested to study the relationship between weight ratio of PCL and GE in the same concentration (14%) to the morphology, degradation rate and porosity of nanofibers. Experimental results showed that PCL with 1.2g and GE with 0.2g was able to produce better nanofibers. The sample was then further deployed in drug (tetracycline hydrochloride) loading and it was successfully loaded proven by Energy Dispersive X-Ray (EDX) Spectrum. These nanofibers are predicted to be potentially useful for drug delivery and TE application.

Fabrication and characterization of chitosan/kefiran electrospun nanofibers for tissue engineering applications

2021 ◽  
pp. 50547
Author(s):  
Shabnam Shokraei ◽  
Esmaeil Mirzaei ◽  
Nasim Shokraei ◽  
Mohammad Ali Derakhshan ◽  
Hossein Ghanbari ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Electrospun Nanofibers ◽  
Engineering Applications ◽  
Fabrication And Characterization

Fabrication and characterization of electrospun nanofibers composed of decellularized meniscus extracellular matrix and polycaprolactone for meniscus tissue engineering

2017 ◽  
Vol 5 (12) ◽  
pp. 2273-2285 ◽  
Author(s):  
Shuang Gao ◽  
Weimin Guo ◽  
Mingxue Chen ◽  
Zhiguo Yuan ◽  
Mingjie Wang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Electrospun Nanofibers ◽  
Meniscus Tissue ◽  
Fabrication And Characterization ◽  
Meniscus Scaffolds

Decellularized meniscus extracellular matrix (DMECM) and polycaprolactone (PCL) were electrospun into nanofibers to make meniscus scaffolds with good mechanical properties.

scholarly journals Fabrication and Characterization of Electrospun Poly(acrylonitrile-co-Methyl Acrylate)/Lignin Nanofibers: Effects of Lignin Type and Total Polymer Concentration

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 992
Author(s):  
Suchitha Devadas ◽  
Saja M. Nabat Al-Ajrash ◽  
Donald A. Klosterman ◽  
Kenya M. Crosson ◽  
Garry S. Crosson ◽  
...  
Keyword(s):  
Methyl Acrylate ◽  
Lignin Content ◽  
Polymer Concentration ◽  
Weight Ratio ◽  
Electrospun Nanofibers ◽  
Polymer Content ◽  
Blend Ratio ◽  
Blend Ratios ◽  
Poly Acrylonitrile

Lignin macromolecules are potential precursor materials for producing electrospun nanofibers for composite applications. However, little is known about the effect of lignin type and blend ratios with synthetic polymers. This study analyzed blends of poly(acrylonitrile-co-methyl acrylate) (PAN-MA) with two types of commercially available lignin, low sulfonate (LSL) and alkali, kraft lignin (AL), in DMF solvent. The electrospinning and polymer blend solution conditions were optimized to produce thermally stable, smooth lignin-based nanofibers with total polymer content of up to 20 wt % in solution and a 50/50 blend weight ratio. Microscopy studies revealed that AL blends possess good solubility, miscibility, and dispersibility compared to LSL blends. Despite the lignin content or type, rheological studies demonstrated that PAN-MA concentration in solution dictated the blend’s viscosity. Smooth electrospun nanofibers were fabricated using AL depending upon the total polymer content and blend ratio. AL’s addition to PAN-MA did not affect the glass transition or degradation temperatures of the nanofibers compared to neat PAN-MA. We confirmed the presence of each lignin type within PAN-MA nanofibers through infrared spectroscopy. PAN-MA/AL nanofibers possessed similar morphological and thermal properties as PAN-MA; thus, these lignin-based nanofibers can replace PAN in future applications, including production of carbon fibers and supercapacitors.

scholarly journals Biomedical application of photo-crosslinked gelatin hydrogels

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Lei Xiang ◽  
Wenguo Cui
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Application ◽  
Biomedical Field ◽  
Or Gene ◽  
Tunable Mechanical Properties ◽  
Bio Compatibility ◽  
Regeneration Of Bone ◽  
Development Prospects

Abstract During the past decades, photo-crosslinked gelatin hydrogel (methacrylated gelatin, GelMA) has gained a lot of attention due to its remarkable application in the biomedical field. It has been widely used in cell transplantation, cell culture and drug delivery, based on its crosslinking to form hydrogels with tunable mechanical properties and excellent bio-compatibility when exposed to light irradiation to mimic the micro-environment of native extracellular matrix (ECM). Because of its unique biofunctionality and mechanical tenability, it has also been widely applied in the repair and regeneration of bone, heart, cornea, epidermal tissue, cartilage, vascular, peripheral nerve, oral mucosa, and skeletal muscle et al. The purpose of this review is to summarize the recent application of GelMA in drug delivery and tissue engineering field. Moreover, this review article will briefly introduce both the development of GelMA and the characterization of GelMA. Finally, we discuss the challenges and future development prospects of GelMA as a tissue engineering material and drug or gene delivery carrier, hoping to contribute to accelerating the development of GelMA in the biomedical field. Graphical abstract

Altering the characterization of nanofibers by changing the electrospinning parameters and their application in tissue engineering, drug delivery, and gene delivery systems

2021 ◽  
Vol 32 (5) ◽  
pp. 1924-1950
Author(s):  
Amir Ghaderpour ◽  
Zohreh Hoseinkhani ◽  
Reza Yarani ◽  
Sina Mohammadiani ◽  
Farshid Amiri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Gene Delivery ◽  
Delivery Systems

Preparation and Characterization of Chitosan-Based Scaffolds for Biomedical Applications

2006 ◽  
Vol 514-516 ◽  
pp. 1005-1009 ◽  
Author(s):  
José V. Araújo ◽  
J.A. Lopes da Silva ◽  
Margarida M. Almeida ◽  
Maria Elisabete V. Costa
Keyword(s):  
Biomedical Applications ◽  
Freeze Drying ◽  
Average Pore Size ◽  
Composite Scaffolds ◽  
Average Pore ◽  
Chitosan Matrix ◽  
Freeze Dried ◽  
Porous Chitosan ◽  
Interconnected Structure

Porous chitosan/brushite composite scaffolds were prepared by a freeze-drying technique, starting from brushite suspensions in chitosan solutions. The obtained scaffolds showed a regular macroporous and interconnected structure with brushite particles uniformly distributed in the chitosan matrix. The variation of the brushite concentration affected the microstructure of the final freeze-dried scaffold, in particular, its porosity and its average pore size. The yield strengths of the composite scaffolds could also be improved by the increase of the brushite content.

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