Automatization of the Cable-Routing-Process within the Automated Production of Wiring Systems

2017 ◽  
Vol 871 ◽  
pp. 186-192 ◽  
Author(s):  
Paul Heisler ◽  
Patrick Steinmetz ◽  
In Seong Yoo ◽  
Jörg Franke
Keyword(s):  
Early Years ◽  
Efficient Production ◽  
Production Methods ◽  
Wiring Harness ◽  
Automated Production ◽  
Passenger Vehicles ◽  
3D Printed ◽  
Cost Efficient ◽  
Production Cell ◽  
Wiring System

The wiring system is one of the most important and one of the most expensive part of modern passenger vehicles. It ́s production is done manually to nearly 100% since the early years of car manufacturing. Until today it wasn ́t possible to automatize these cost-intensive step of the car production in an effective and cost efficient way. This paper shows how the routing process of the wiring harness as a part of the whole production process can be automatized with easy and cost efficient production methods. Collaborative robots and 3D-printed prototypes of cable grippers were used to treat with the complexity of the job and to finally create a sustainable and cost efficient production system. Further the routing concept has been brought to a prototypical production cell which has been tested in various routing experiments at the institute’s laboratory. Finally, a discussion of the results brings up the strengths and weaknesses of the concept and shows possible solutions.

Comparative characteristics of provisional crowns made by CAD/CAM milling and 3D printing

2020 ◽  
pp. 45-49
Author(s):  
A.V. Stomatov ◽  
D.V. Stomatov ◽  
P.V. Ivanov ◽  
V.V. Marchenko ◽  
E.V. Piitsky ◽  
...  
Keyword(s):  
3D Printing ◽  
Good Alternative ◽  
Digital Model ◽  
Dental Practice ◽  
Production Methods ◽  
Automated Production ◽  
3D Printing Technology ◽  
Cad Cam ◽  
Milling Method ◽  
Technology Comparison

In this work, the authors studied and compared the two main methods used in dental practice for the automated production of orthopedic structures: the widely used CAD / CAM milling method and the 3D printing technology. As an object of research, temporary crowns were used, which were made on the basis of the same digital model: a) by the method of CAD / CAM milling from polymethylmethacrylate disks; b) by 3D printing from photopolymer resin based on LCD technology. Comparison of production methods and finished designs was carried out according to the following characteristics: strength, durability, aesthetic qualities, accuracy of orthopedic designs, etc. According to the results of the study, it was concluded that 3D printing can be a good alternative to CAD / CAM milling in solving problems of temporary prosthetics.

scholarly journals Dissecting cellobiose metabolic pathway and its application in biorefinery through consolidated bioprocessing in Myceliophthora thermophila

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Jingen Li ◽  
Shuying Gu ◽  
Zhen Zhao ◽  
Bingchen Chen ◽  
Qian Liu ◽  
...  
Keyword(s):  
Malic Acid ◽  
Plant Biomass ◽  
Consolidated Bioprocessing ◽  
Cellulase Activity ◽  
Industrial Applications ◽  
Efficient Production ◽  
Myceliophthora Thermophila ◽  
Final Strain ◽  
Cellobiose Metabolism ◽  
Cost Efficient

Abstract Background Lignocellulosic biomass has long been recognized as a potential sustainable source for industrial applications. The costs associated with conversion of plant biomass to fermentable sugar represent a significant barrier to the production of cost-competitive biochemicals. Consolidated bioprocessing (CBP) is considered a potential breakthrough for achieving cost-efficient production of biomass-based fuels and commodity chemicals. During the degradation of cellulose, cellobiose (major end-product of cellulase activity) is catabolized by hydrolytic and phosphorolytic pathways in cellulolytic organisms. However, the details of the two intracellular cellobiose metabolism pathways in cellulolytic fungi remain to be uncovered. Results Using the engineered malic acid production fungal strain JG207, we demonstrated that the hydrolytic pathway by β-glucosidase and the phosphorolytic pathway by phosphorylase are both used for intracellular cellobiose metabolism in Myceliophthora thermophila, and the yield of malic acid can benefit from the energy advantages of phosphorolytic cleavage. There were obvious differences in regulation of the two cellobiose catabolic pathways depending on whether M. thermophila JG207 was grown on cellobiose or Avicel. Disruption of Mtcpp in strain JG207 led to decreased production of malic acid under cellobiose conditions, while expression levels of all three intracellular β-glucosidase genes were significantly up-regulated to rescue the impairment of the phosphorolytic pathway under Avicel conditions. When the flux of the hydrolytic pathway was reduced, we found that β-glucosidase encoded by bgl1 was the dominant enzyme in the hydrolytic pathway and deletion of bgl1 resulted in significant enhancement of protein secretion but reduction of malate production. Combining comprehensive manipulation of both cellobiose utilization pathways and enhancement of cellobiose uptake by overexpression of a cellobiose transporter, the final strain JG412Δbgl2Δbgl3 produced up to 101.2 g/L and 77.4 g/L malic acid from cellobiose and Avicel, respectively, which corresponded to respective yields of 1.35 g/g and 1.03 g/g, representing significant improvement over the starting strain JG207. Conclusions This is the first report of detailed investigation of intracellular cellobiose catabolism in cellulolytic fungus M. thermophila. These results provide insights that can be applied to industrial fungi for production of biofuels and biochemicals from cellobiose and cellulose.

scholarly journals Applications of Additively Manufactured Tools in Abrasive Machining—A Literature Review

Materials ◽  
2021 ◽  
Vol 14 (5) ◽  
pp. 1318
Author(s):  
Mariusz Deja ◽  
Dawid Zieliński ◽  
Aini Zuhra Abdul Kadir ◽  
Siti Nur Humaira
Keyword(s):  
Rapid Tooling ◽  
Rapid Manufacturing ◽  
Abrasive Machining ◽  
Production Methods ◽  
Industrial Environment ◽  
Hard And Brittle Materials ◽  
3D Printed ◽  
Abrasive Tools ◽  
Machine Parts ◽  
Further Development

High requirements imposed by the competitive industrial environment determine the development directions of applied manufacturing methods. 3D printing technology, also known as additive manufacturing (AM), currently being one of the most dynamically developing production methods, is increasingly used in many different areas of industry. Nowadays, apart from the possibility of making prototypes of future products, AM is also used to produce fully functional machine parts, which is known as Rapid Manufacturing and also Rapid Tooling. Rapid Manufacturing refers to the ability of the software automation to rapidly accelerate the manufacturing process, while Rapid Tooling means that a tool is involved in order to accelerate the process. Abrasive processes are widely used in many industries, especially for machining hard and brittle materials such as advanced ceramics. This paper presents a review on advances and trends in contemporary abrasive machining related to the application of innovative 3D printed abrasive tools. Examples of abrasive tools made with the use of currently leading AM methods and their impact on the obtained machining results were indicated. The analyzed research works indicate the great potential and usefulness of the new constructions of the abrasive tools made by incremental technologies. Furthermore, the potential and limitations of currently used 3D printed abrasive tools, as well as the directions of their further development are indicated.

scholarly journals perekonomian indonesa

2019 ◽  
Author(s):  
Pricyllia
Keyword(s):  
Sugar Industry ◽  
Raw Material ◽  
Efficient Production ◽  
Internal Conflicts ◽  
Beverage Industry ◽  
Self Sufficiency ◽  
Food And Beverage Industry ◽  
Food And Beverage ◽  
Cost Efficient ◽  
The Cost

The 1930s was the heyday of the Indonesian sugarindustry that is capable of exporting to manycountries and has become the country an exporterof sugar to two after Cuba, but the situation isreversed since 1967 in which Indonesia wouldimport sugar from Brazil, India, and Thailand inorder to meet the needs raw material consumptionand food and beverage industry. The resultsshowed that the cost of sugar production isvery uneconomical because of inefficiency thatstretches from the cultivation to processing inthe factory so difficult to obtain profit margins.Target and beyond sugar self-sufficiency can notbe achieved because highly regulated, there is nosynergy and tends to conflicts of interests amongministries or agencies, and internal conflicts oftenoccur between the sugar mill and the disharmonybetween sugarcane farmers by the sugar millofficials.In the competition of the sugar industry aremore stringent, in the era of the Asean EconomicCommunity, it means the level of efficiency of sugarfactories in the country need special attention,the same thing also applies to industrial users ofsugar, and sugar as a raw material componentscontribute to the creation of products food andbeverage efficient so as to compete with similarproducts from other countries. Observing howthe intense competition in the Asean EconomicCommunity is based on free trade, the yield ofsugar that’s a cost efficient production is veryimportant and urgent at this time, including workto improve the welfare of farmers.

Enhancement of the Compressive Strength of 3D-Printed Polylactic Acid(PLA) by Controlling Internal Pattern

2021 ◽  
Vol 1023 ◽  
pp. 75-81
Author(s):  
Aappo Mustakangas ◽  
Atef Hamada ◽  
Antti Järvenpää
Keyword(s):  
Compressive Strength ◽  
3D Printing ◽  
Polylactic Acid ◽  
Optical Microscope ◽  
Fused Filament Fabrication ◽  
Loading Direction ◽  
Compressive Flow ◽  
3D Printed ◽  
Cost Efficient ◽  
Loading Axis

Cost-efficient 3D-printing can create a lot of new opportunities in engineering as it enables rapid prototyping of models and functional parts. In the present study, Polylactic acid (PLA) cubic specimens with different types of infill patterns (IPs), rectilinear, grid and cuboid, were additively manufactured by Fused Filament Fabrication 3D-printing. The PLA cubes are fabricated with one perimeter and different IPs density (10, 20, and 30%). Subsequently, the compressive strengths of the PLA materials were measured in two loading directions, i.e., the layers building direction is parallel (PD) to the loading axis and perpendicular (ND) to the loading direction. An optical microscope was used to examine the deformed IPs in both loading directions. The compressive flow stress curves of the PLA cubes infilled with rectilinear and grid patterns exhibited strong fluctuations with lower compressive strengths in the loading direction along ND. The PLA with 30% grid IP revealed a superior strength of ~12 kN in the loading direction along PD. On the contrary, the same material exhibited a worst compressive strength 3 kN along ND.

Controlled Release of Bi-Layered Malvidin Tablets Using 3D Printing Techniques

2021 ◽  
pp. 70-78
Author(s):  
Tejinder Kaur ◽  
Suruchi Singh
Keyword(s):  
Controlled Release ◽  
3D Printing ◽  
Fruits And Vegetables ◽  
Physical And Mechanical Properties ◽  
3D Printer ◽  
Anti Cancer ◽  
Printing Cost ◽  
3D Printed ◽  
Cost Efficient ◽  
3D Printing Technique

Malvidin belongs to the class of anthocyanidin, a pigment compound present in fruits and vegetables like the colored berries, flowers, and vegetables which have pigments on it and it is available commercially as malvidin chloride. Malvidin is known to possess many medicinal characteristics like anti-microbial, anti-diabetic, anti-inflammatory, anti-obesity, and anti-cancer. In this research paper, a 3D printing technique is used which evolves a 3D printer based on desktop that extrudes tablets comprising the active drug which here is malvidin our main ingredient and the other excipients which are used as binders and disintegrants. Methods which are adapted here for the formulation of 3D printed tablet make the tablets appropriate for immediate and sustained release with its definite physical and mechanical properties like hardness, friability, and weight. Tablets that are extruded by the 3D printer are controlled release bi-layer tablets. Due to involvement of 3D printer, printing cost for the bi-layered tablets found very low that makes our method as cost efficient.

scholarly journals Accuracy Assessment of Molded, Patient-Specific Polymethylmethacrylate Craniofacial Implants Compared to Their 3D Printed Originals

2020 ◽  
Vol 9 (3) ◽  
pp. 832 ◽  
Author(s):  
Dave Chamo ◽  
Bilal Msallem ◽  
Neha Sharma ◽  
Soheila Aghlmandi ◽  
Christoph Kunz ◽  
...  
Keyword(s):  
Computer Aided Design ◽  
Accuracy Assessment ◽  
Three Dimensional ◽  
Production Costs ◽  
Patient Specific ◽  
Patient Specific Implants ◽  
3D Printed ◽  
Cost Efficient ◽  
Craniofacial Implants ◽  
Aided Design

The use of patient-specific implants (PSIs) in craniofacial surgery is often limited due to a lack of expertise and/or production costs. Therefore, a simple and cost-efficient template-based fabrication workflow has been developed to overcome these disadvantages. The aim of this study is to assess the accuracy of PSIs made from their original templates. For a representative cranial defect (CRD) and a temporo-orbital defect (TOD), ten PSIs were made from polymethylmethacrylate (PMMA) using computer-aided design (CAD) and three-dimensional (3D) printing technology. These customized implants were measured and compared with their original 3D printed templates. The implants for the CRD revealed a root mean square (RMS) value ranging from 1.128 to 0.469 mm with a median RMS (Q1 to Q3) of 0.574 (0.528 to 0.701) mm. Those for the TOD revealed an RMS value ranging from 1.079 to 0.630 mm with a median RMS (Q1 to Q3) of 0.843 (0.635 to 0.943) mm. This study demonstrates that a highly precise duplication of PSIs can be achieved using this template-molding workflow. Thus, virtually planned implants can be accurately transferred into haptic PSIs. This workflow appears to offer a sophisticated solution for craniofacial reconstruction and continues to prove itself in daily clinical practice.

scholarly journals Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Mathias Vormehr ◽  
Barbara Schrörs ◽  
Sebastian Boegel ◽  
Martin Löwer ◽  
Özlem Türeci ◽  
...  
Keyword(s):  
Target Selection ◽  
Efficient Production ◽  
Patient Centered ◽  
Sequencing Technologies ◽  
Cost Efficient ◽  
Potent Drug ◽  
Personalized Cancer ◽  
The Cost ◽  
Synthetic Mrna ◽  
Selection Of

Advances in nucleic acid sequencing technologies have revolutionized the field of genomics, allowing the efficient targeting of mutated neoantigens for personalized cancer vaccination. Due to their absence during negative selection of T cells and their lack of expression in healthy tissue, tumor mutations are considered as optimal targets for cancer immunotherapy. Preclinical and early clinical data suggest that synthetic mRNA can serve as potent drug format allowing the cost efficient production of highly efficient vaccines in a timely manner. In this review, we describe a process, which integrates next generation sequencing based cancer mutanome mapping,in silicotarget selection and prioritization approaches, and mRNA vaccine manufacturing and delivery into a process we refer to as MERIT (mutanome engineered RNA immunotherapy).

Sign in / Sign up

Export Citation Format

Share Document