Reduction of Locomotor and Brain Activity of Wistar Rats after Serial Administration of Titanium Dioxide

2015 ◽  
Vol 1085 ◽  
pp. 400-405
Author(s):  
Marina Khodanovich ◽  
Anna Zelenskaya ◽  
Elizaveta Gul ◽  
Dmitry Sukhanov ◽  
Elena Krutenkova
Keyword(s):  
Particle Size ◽  
Titanium Dioxide ◽  
Wistar Rats ◽  
Neuronal Damage ◽  
Titanium Dioxide Nanoparticles ◽  
Brain Activity ◽  
Open Field Behavior ◽  
Low Frequencies ◽  
The Central Nervous System ◽  
Electroencephalogram Eeg

Nanoparticles of titanium dioxide (TiO2) are widely used nanomaterial with particle size below 100 nanometers TiO2 is applied as a pigment to provide whiteness to such products as paints, paper, foodstuffs, medicines, toothpastes, etc. However, neurotropic properties of titanium dioxide remains unclear. This work aimed evaluation of neurotoxic effects of titanium dioxide nanoparticles (12 nm particle size) serially administered to Wistar rats in dose of 250 mg/kg for 7 days. Behavioral and physiological observations were registered immediately after treatment. Results showed that nanoTiO2 particles caused reducing of general motor activity in rats and a shift of the electroencephalogram (EEG) power toward low frequencies of (EEG), while aggressive behavior, and open field behavior did not change. The depressive effect of titanium dioxide nanoparticles on the central nervous system (CNS) observed in our study might be related to neuronal damage caused by an increase in reactive oxygen species (ROS) as well as the impairment of synaptic transmission.

The influence of titanium dioxide (TiO2) nanoparticles on the structure, optical and dielectric properties of polyvinyl chloride (PVC)

2020 ◽  
Vol 34 (28) ◽  
pp. 2050310
Author(s):  
M. A. Ramazanov ◽  
A. M. Rahimli ◽  
F. V. Hajiyeva
Keyword(s):  
Particle Size ◽  
Titanium Dioxide ◽  
Dielectric Properties ◽  
Surface Area ◽  
Titanium Dioxide Nanoparticles ◽  
Inorganic Nanoparticles ◽  
Nanocomposite Films ◽  
Slight Reduction ◽  
Insulation Systems ◽  
Nanoparticle Content

The tendency to improve the properties of insulating materials by incorporating inorganic nanoparticles has become necessary in order to design new insulation systems. In this study, PVC/TiO2-based nanocomposites with different loadings (3, 5 and 10 wt.%) of TiO2 nanoparticles were prepared by the solution mixing method. The morphology of the prepared nanocomposites was studied by Atomic Force Microscope (AFM). Experimentally, it was found that as the concentration increases, the size of the surface structural elements and particle size increases. Photoluminescence (PL) analysis of samples shows improvement compared to the pristine polymer. Furthermore, PL intensity for nanocomposites increases depending on the concentration and saturation occurs at a certain amount of titanium dioxide nanoparticles. The increase in luminescence intensity till a certain nanoparticle content is due to the growth of the luminescent surface area. Further saturation is explained by the increase in particle size with no increase or a slight reduction in surface area. Dielectric properties of nanocomposites were studied. It was found that dielectric permittivity of the materials increases as the nanoparticle volume content increases and it reaches at its highest value for the nanocomposites with 3% nanoparticle content. The optical properties of the polymer and nanocomposite films were studied in the region 200 nm to 600 nm. It was found that the PVC/TiO2 nanocomposites showed enhancement in the absorbance intensities which was more significant for the nanocomposites with higher nanoparticle content compared to the pristine polymer. Furthermore, absorption spectra were used to calculate the optical bandgap of the prepared nanocomposite films and redshift observed in the calculated values of bandgap for nanocomposites. Consequently, it was proved that by incorporating TiO2 nanoparticles into the polymer matrix, the spectral region of the samples can be expanded resulting in broadened application of such systems in various fields of science and technology.

scholarly journals Inhalation Exposure Study of Titanium Dioxide Nanoparticles with a Primary Particle Size of 2 to 5 nm

2007 ◽  
Vol 115 (3) ◽  
pp. 397-402 ◽  
Author(s):  
Vicki H. Grassian ◽  
Patrick T. O’Shaughnessy ◽  
Andrea Adamcakova-Dodd ◽  
John M. Pettibone ◽  
Peter S. Thorne
Keyword(s):  
Particle Size ◽  
Titanium Dioxide ◽  
Primary Particle ◽  
Titanium Dioxide Nanoparticles ◽  
Inhalation Exposure ◽  
Primary Particle Size ◽  
Exposure Study

scholarly journals Titanium Dioxide, but Not Zinc Oxide, Nanoparticles Cause Severe Transcriptomic Alterations in T98G Human Glioblastoma Cells

2021 ◽  
Vol 22 (4) ◽  
pp. 2084
Author(s):  
Encarnación Fuster ◽  
Héctor Candela ◽  
Jorge Estévez ◽  
Eugenio Vilanova ◽  
Miguel A. Sogorb
Keyword(s):  
Zinc Oxide ◽  
Titanium Dioxide ◽  
Proteomic Analysis ◽  
Zinc Oxide Nanoparticles ◽  
Titanium Dioxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
The Central Nervous System ◽  
Human Glioblastoma Cells

Titanium dioxide and zinc oxide are two of the most widely used nanomaterials. We assessed the effects of noncytotoxic doses of both nanomaterials on T98G human glioblastoma cells by omic approaches. Surprisingly, no effects on the transcriptome of T98G cells was detected after exposure to 5 µg/mL of zinc oxide nanoparticles during 72 h. Conversely, the transcriptome of the cells exposed to 20 µg/mL of titanium dioxide nanoparticles during 72 h revealed alterations in lots of biological processes and molecular pathways. Alterations to the transcriptome suggests that exposure to titanium dioxide nanoparticles might, potentially, compromise the integrity of the blood brain barrier integrity and cause neuroinflammation. The latter issue was further confirmed phenotypically with a proteomic analysis and by recording the release of interleukin 8. Titanium dioxide also caused autophagy, which was demonstrated through the increase in the expression of the autophagy-related 3 and microtubule associated protein 1 light chain 3 alpha genes. The proteomic analysis revealed that titanium dioxide nanoparticles might have anticancerigen properties by downregulating genes involved in the detoxication of anthracyclines. A risk assessment resulting from titanium dioxide exposure, focusing on the central nervous system as a potential target of toxicity, is necessary.

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