Development of a Novel CaP-Containing Mesoporous Silica-Based Xerogels Used as Hemostatic Material with Good Biodegradability and Low Heat Generation

A novel Ca/P-containing mesoporous silica-based xerogels (CaMSX) with good degradability and low heat generation were synthesized for hemorrhage control by a modified sol-gel process and physicochemically characterized. The mesoporous silica-based xerogels without Ca/P (MSX) was also prepared as comparison. The in vitro whole blood coagulation time, activated partial thromboplastin time (APTT) and prothrombin time (PT) of the CaMSX were measured with MSX, Chinese traditional medicin-Yunnan medical powder (YM) and traditional zeolite. In vivo bleeding model was tested with rabbit’ ear side veins. The results illustrated that the CaMSX could remarkably promote the intrinsic and extrinsic blood coagulation processes which greatly depend on the dosage and the content of Ca in the CaMSX. The CaMSX had better efficiency in promoting coagulation process than that of MSX, YM and zeolite.

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Drug Loaded Porous Hydroxyapatite and Its In Vitro Release

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.284-286.423 ◽

2005 ◽

Vol 284-286 ◽

pp. 423-426 ◽

Cited By ~ 2

Author(s):

Y. Kim ◽

B.G. Song ◽

Soo Ryong Kim ◽

Kwang Jin Kim

Keyword(s):

Mesoporous Silica ◽

Body Fluid ◽

Sol Gel ◽

In Vitro Release ◽

Controlled Drug Delivery ◽

Porous Hydroxyapatite ◽

Sol Gel Process ◽

The Matrix ◽

Vitro Release

Porous hydroxyapatite coated with mesoporous silica has been utilized as the matrix for controlled drug delivery. TEM observation confirms the pore size of mesoporous silica scatters about 50 Å. Porous hydroxyapatite was coated with mesoporous silica via sol-gel process. Ibuprofen and was loaded into the pores of mesoporous silica, and controlled release profiles were studied by soaking the samples in a simulated body fluid using a UV-VIS spectrophotometer.

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Differently sized drug-loaded mesoporous silica nanoparticles elicit differential gene expression in MCF-7 cancer cells

Nanomedicine ◽

10.2217/nnm-2020-0375 ◽

2021 ◽

Author(s):

Baranya Murugan ◽

Uma Maheswari Krishnan

Keyword(s):

Gene Expression ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Cancer Cells ◽

Mesoporous Silica Nanoparticles ◽

Sol Gel ◽

Anticancer Efficacy ◽

Mcf 7

Aim: This study investigates the effects of different sized unmodified and chemo-responsive mesoporous silica nanocarriers on MCF-7 cancer cells. Materials & methods: Unmodified and thiol-functionalized large and small-sized mesoporous MCM-41 silica nanoparticles prepared using templated sol-gel process were characterized for their physicochemical properties and in vitro and in vivo anticancer efficacy. Microarray analysis was carried out to assess their differential effect on gene expression. Results: Thiol-functionalized nanoparticles displayed chemo responsive release and greater cytotoxicity to cancer cells when compared with unmodified carriers. Microarray studies showed distinct differences in genes differentially regulated by sMCM-41and lMCM-41 carriers when compared with the free drug. Conclusion: The small chemo-responsive carrier was more effective in suppressing oncogenes and genes involved in proliferation, invasion and survival while the large carrier mainly altered membrane-associated pathways.

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The Natural Course of Defibrination Syndrome Caused by Echis Colorata Venom in Man

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649181 ◽

1974 ◽

Vol 31 (03) ◽

pp. 420-428 ◽

Cited By ~ 3

Author(s):

M Fainaru ◽

S Eisenberg ◽

N Manny ◽

C Hershko

Keyword(s):

Factor Viii ◽

Blood Coagulation ◽

Major Bleeding ◽

Renal Damage ◽

Specific Treatment ◽

Natural Course ◽

Factor V ◽

Thrombocyte Count

SummaryThe natural course of defibrination syndrome caused by Echis colorata venom (ECV) in five patients is reported. All patients developed afibrinogenemia within six hours after the bite. Concomitantly a depression in factor V was recorded. Factor VIII and thrombocyte count in blood were normal in most patients. In the light of the known effects of ECV on blood coagulation in vivo and in vitro it is concluded that the afibrinogenemia is due to intravascular clotting.Four patients had transient renal damage, manifested by oliguria, azotemia, albuminuria and cylindruria, ascribed to microthrombi in the renal glomeruli.After the bite, the natural course was benign, no major bleeding was observed, and all signs of coagulopathy reverted to normal within 7 days. Therefore we recommend no specific treatment for this condition. In the case of heavily bleeding patients, administration of antiserum against ECV and/or heparin should be considered.

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Tantalum Oxide Nanoparticles as Versatile Contrast Agents for X-ray Computed Tomography

10.26434/chemrxiv.11845572.v1 ◽

2020 ◽

Author(s):

Shatadru Chakravarty ◽

Jeremy Hix ◽

Kaitlyn Wieweora ◽

Maximilian Volk ◽

Elizabeth Kenyon ◽

...

Keyword(s):

Computed Tomography ◽

Contrast Agents ◽

Mesoporous Silica Nanoparticles ◽

Sol Gel ◽

Tantalum Oxide ◽

High Signal ◽

Drug Delivery Vehicles ◽

X Ray Computed

Here we describe the synthesis, characterization and in vitro and in vivo performance of a series of tantalum oxide (TaOx) based nanoparticles (NPs) for computed tomography (CT). Five distinct versions of 9-12 nm diameter silane coated TaOx nanocrystals (NCs) were fabricated by a sol-gel method with varying degrees of hydrophilicity and with or without fluorescence, with the highest reported Ta content to date (78%). Highly hydrophilic NCs were left bare and were evaluated in vivo in mice for micro-CT of full body vasculature, where following intravenous injection, TaOx NCs demonstrate high CT contrast, circulation in blood for ~ 3 h, and eventual accumulation in RES organs; and following injection locally in the mammary gland, where the full ductal tree structure can be clearly delineated. Partially hydrophilic NCs were encapsulated within mesoporous silica nanoparticles (MSNPs; TaOx@MSNPs) and hydrophobic NCs were encapsulated within poly(lactic-co-glycolic acid) (PLGA; TaOx@PLGA) NPs, serving as potential CT-imagable drug delivery vehicles. Bolus intramuscular injections of TaOx@PLGA NPs and TaOx@MSNPs to mimic the accumulation of NPs at a tumor site produce high signal enhancement in mice. In vitro studies on bare NCs and formuated NPs demonstrate high cytocompatibility and low dissolution of TaOx. This work solidifies that TaOx-based NPs are versatile contrast agents for CT.

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Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

Materials ◽

10.3390/ma14123337 ◽

2021 ◽

Vol 14 (12) ◽

pp. 3337

Author(s):

Sara Hooshmand ◽

Sahar Mollazadeh ◽

Negar Akrami ◽

Mehrnoosh Ghanad ◽

Ahmed El-Fiqi ◽

...

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Skin Regeneration ◽

Bioactive Molecules ◽

Wound Management ◽

Bioactive Glasses ◽

Wide Range

Exploring new therapies for managing skin wounds is under progress and, in this regard, mesoporous silica nanoparticles (MSNs) and mesoporous bioactive glasses (MBGs) offer great opportunities in treating acute, chronic, and malignant wounds. In general, therapeutic effectiveness of both MSNs and MBGs in different formulations (fine powder, fibers, composites etc.) has been proved over all the four stages of normal wound healing including hemostasis, inflammation, proliferation, and remodeling. The main merits of these porous substances can be summarized as their excellent biocompatibility and the ability of loading and delivering a wide range of both hydrophobic and hydrophilic bioactive molecules and chemicals. In addition, doping with inorganic elements (e.g., Cu, Ga, and Ta) into MSNs and MBGs structure is a feasible and practical approach to prepare customized materials for improved skin regeneration. Nowadays, MSNs and MBGs could be utilized in the concept of targeted therapy of skin malignancies (e.g., melanoma) by grafting of specific ligands. Since potential effects of various parameters including the chemical composition, particle size/morphology, textural properties, and surface chemistry should be comprehensively determined via cellular in vitro and in vivo assays, it seems still too early to draw a conclusion on ultimate efficacy of MSNs and MBGs in skin regeneration. In this regard, there are some concerns over the final fate of MSNs and MBGs in the wound site plus optimal dosages for achieving the best outcomes that deserve careful investigation in the future.

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Antimicrobial and antibiofilm activities of meropenem loaded-mesoporous silica nanoparticles against carbapenem-resistant Pseudomonas aeruginosa

Journal of Biomaterials Applications ◽

10.1177/08853282211003848 ◽

2021 ◽

pp. 088532822110038

Author(s):

Mohammad Yousef Memar ◽

Mina Yekani ◽

Hadi Ghanbari ◽

Edris Nabizadeh ◽

Sepideh Zununi Vahed ◽

...

Keyword(s):

Pseudomonas Aeruginosa ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Carbapenem Resistant ◽

Toxicity In Vitro ◽

Different Levels

The aims of the present study were the determination of antimicrobial and antibiofilm effects of meropenem-loaded mesoporous silica nanoparticles (MSNs) on carbapenem resistant Pseudomonas aeruginosa ( P. aeruginosa) and cytotoxicity properties in vitro. The meropenem-loaded MSNs had shown antibacterial and biofilm inhibitory activities on all isolates at different levels lower than MICs and BICs of meropenem. The viability of HC-04 cells treated with serial concentrations as MICs and BICs of meropenem-loaded MSNs was 92–100%. According to the obtained results, meropenem-loaded MSNs display the significant antibacterial and antibiofilm effects against carbapenem resistant and biofilm forming P. aeruginosa and low cell toxicity in vitro. Then, the prepared system can be an appropriate option for the delivery of carbapenem for further evaluation in vivo assays.

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