Surface Characteristics and Osteoinductivity of Biphasic Calcium Phosphate Ceramics with Different Sintering Temperature

2006 ◽  
Vol 309-311 ◽  
pp. 1299-1302 ◽  
Author(s):  
Hong Song Fan ◽  
Toshiyuki Ikoma ◽  
C.Y. Bao ◽  
H.L. Wang ◽  
Ling Li Zhang ◽  
...  
Keyword(s):  
Phase Composition ◽  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Sintering Temperature ◽  
Surface Characteristics ◽  
Affecting Factors ◽  
Micro Structure ◽  
Factors Affecting ◽  
Distinct Temperature

Calcium phosphate (Ca-P) biomaterials have been proved to show osteoinductivity, however the affecting factors and mechanism are still unclear now. In this study, the surface characteristics of biphasic Ca-P ceramics (hydroxyapatite/tricalcium phosphate; HA/TCP) sintered at the distinct temperature were investigated and the mechanism of the osteoinductivity was discussed. The osteoinductivity of HA/TCP ceramics increased with decreasing the sintering temperature. The different surface micro-structure resulted from different sintering temperature includes phase composition, surface micro-structure, and surface potential. These characteristics should be the important factors affecting osteoinductivity.

scholarly journals Sintering Behavior and Mechanical Properties of Biphasic Calcium Phosphate Ceramics

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Mehmet Yetmez
Keyword(s):  
Mechanical Properties ◽  
Compressive Strength ◽  
Calcium Phosphate ◽  
Grain Growth ◽  
Vickers Hardness ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Sintering Temperature ◽  
Sintering Behavior ◽  
Microstructure Observation

The sintering behavior and the mechanical properties of a mechanical mixture of hydroxyapatite and tricalcium phosphate (BCP) ceramics with the composition of 30% HA and 70% TCP are experimentally investigated in the temperature range between 1000°C and 1300°C. The results show that consolidation, grain growth, and Vickers hardness generally increase with increasing sintering temperature up to 1200°C. However, microstructure observation indicates that cracks are formed along the grain boundaries as well as in the bulk of the grains after sintering at 1200°C. Moreover, the best values of compressive strength, modulus of elasticity, and toughness are achieved in the samples sintered at 1100°C. These properties at 1100°C decay with sintering at 1200°C and increase again after sintering at 1300°C.

Effect of Sintering Temperature on Biphasic Calcium Phosphate (BCP) Biocomposite

2015 ◽  
Vol 1087 ◽  
pp. 475-478 ◽  
Author(s):  
Shah Rizal Kasim ◽  
Nor Firdaus Muhamad ◽  
Sivakumar Ramakrishan
Keyword(s):  
Calcium Phosphate ◽  
Mathematical Models ◽  
Design Of Experiment ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Sintering Temperature ◽  
Present Report ◽  
Tcp Phases ◽  
Different Temperatures ◽  
Formation Porosity

The present report aims to fabricate biphasic calcium phosphate (BCP) biocomposite in order to study the effects of sintering temperature on the sintered BCP biocomposite characteristics (phase’s formation, porosity and hardness properties). These effects were quantified using design of experiment (DOE) to develop mathematical models. BCP biocomposite pellets (60 wt% HA) were fabricated using mixing, pressing and sintered at two different temperatures (1100°C and 1250°C). The experiment was run by following the run order suggested by DOE software (Minitab 16) through randomization stage. Results show that sintering temperature will affect the formation of α-tricalcium phosphate (α-TCP) and the porosity of the samples. The formation of α-TCP phases will reduce the hardness value of BCP biocomposite.

Comparison of Biphasic Calcium Phosphate Bioceramics Fabricated Using Different Techniques

2011 ◽  
Vol 222 ◽  
pp. 255-258
Author(s):  
Kristine Salma ◽  
Zilgma Irbe ◽  
Dmitrijs Jakovlevs ◽  
Natalija Borodajenko ◽  
Liga Berzina-Cimdina
Keyword(s):  
Phase Composition ◽  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Mechanical Mixture ◽  
Preparation Technique ◽  
Homogeneous Microstructure ◽  
Intimate Mixture ◽  
Sintering Properties ◽  
Preparation Techniques

In this work three different preparation techniques of biphasic calcium phosphate (BCP) bioceramics (consisting of both hydroxyapatite (HAp) and β-tricalcium phosphate (TCP)) are compared: sintering of synthetic calcium-deficient apatites (CDAs) (intimate mixture of HAp and TCP - SBCP), sintering of mechanical mixture of synthetic HAp and apatitic tricalcium phosphate (Ap-TCP) - MBCP and sintering of mechanical mixture of synthetic HAp and calcium metaphosphate glass (CMG) - GBCP. Two different HAp/TCP phase ratios were investigated: 20/80 and 60/40. Phase composition, microstructure, sintering properties and microporosity of obtained BCP bioceramics were investigated. The open porosity of prepared BCP bioceramics is strongly influenced by phase composition and preparation technique. BCP bioceramics SBCP and MBCP have homogeneous microstructure, whereas GBCP has inhomogeneous inclusions of dense TCP. High content of hydroxyapatite (HAp) phase in MBCP and SBCP correlates with high microporosity.

Fabrication of Porous Structure of BCP Sintered Bodies Using Microwave Assisted Synthesized HAp Nano Powder

2007 ◽  
Vol 534-536 ◽  
pp. 49-52 ◽  
Author(s):  
Min Ho Youn ◽  
Rajat Kanti Paul ◽  
Ho Yeon Song ◽  
Byong Taek Lee
Keyword(s):  
Calcium Phosphate ◽  
Porous Structure ◽  
Relative Density ◽  
Polymethyl Methacrylate ◽  
Biphasic Calcium Phosphate ◽  
Sintering Temperature ◽  
Microwave Assisted ◽  
Nano Powder ◽  
Maximum Value ◽  
Porous Biphasic Calcium Phosphate

Using microwave synthesized HAp nano powder and polymethyl methacrylate (PMMA) as a pore-forming agent, the porous biphasic calcium phosphate (BCP) ceramics were fabricated depending on the sintering temperature. The synthesized HAp powders was about 70-90 nm in diameter. In the porous sintered bodies, the pores having 150-180 μm were homogeneously dispersed in the BCP matrix. Some amounts of pores interconnected due the necking of PMMA powders which will increase the osteoconductivity and ingrowth of bone-tissues while using as a bone substrate. As the sintering temperature increased, the relative density increased and showed the maximum value of 79.6%. From the SBF experiment, the maximum resorption of Ca2+ ion was observed in the sample sintered at 1000°C.

scholarly journals Composite Bioceramics/Polymer Electrospun Scaffolds for Regenerative Medicine

2012 ◽  
Vol 529-530 ◽  
pp. 441-446
Author(s):  
Thomas Miramond ◽  
Pascal Borget ◽  
Caroline Colombeix ◽  
Serge Baroth ◽  
G. Daculsi
Keyword(s):  
Cell Adhesion ◽  
Calcium Phosphate ◽  
Regenerative Medicine ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Electrospun Scaffolds ◽  
Mineral Particles

The main goal of this study was to succeed in the relevant association of well-known osteoconductive biphasic calcium phosphate (BCP) made of Hydroxyapatite (20% HA) and β-Tricalcium Phosphate (80% β-TCP) crystallographic phases and resorbable poly (L-lactide-co-D,L-lactide)(PLDLLA) 3D matrices synthesized by electrospinning. Two types of mineral particles were obtained, BCP new hollow granules, and classical BCP particles. It appeared that hollow shells/PLDLLA composite 3D matrices allowed higher cell adhesionin vitro,thanks to internal concavities and are promising scaffolds in terms of cell carrying.

Bimodal Porous Bi-Phasic Calcium Phosphate Ceramics and Its Dissolution in SBF Solution

2007 ◽  
Vol 330-332 ◽  
pp. 91-94 ◽  
Author(s):  
Y. Zhang ◽  
Yoshiyuki Yokogawa ◽  
Tetsuya Kameyama
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Reaction Rate ◽  
Ceramic Materials ◽  
Calcium Phosphate Ceramics ◽  
Fine Powders ◽  
Beta Tricalcium Phosphate ◽  
Sbf Solution ◽  
New Phase

Biphasic calcium phosphate (BCP) ceramics, a mixture of hydroxyapatite (HAp) and beta-tricalcium phosphate (β-TCP), of varying HAp/β-TCP ratios were prepared from fine powders. Porous BCP ceramic materials with HAp/β-TCP weight rations of 20/80, 40/60, and 80/20 were prepared. In this study, the bioactivity is reduced at a larger HAp content rate, which is likely related to the high driving pore for the formation of a new phase, and the reaction rate was proportional to the β-TCP. The porous BCP ceramics having a bigger porosity rate can easily under up dissolution. The powder having a larger β-TCP content rate can easily generate a new phase. The dissolution results confirmed that the biodegradation of calcium phosphate ceramics could be controlled by simply adjusting the amount of HAp or β-TCP in the ceramics and porosity rate.

Impact of Biphasic Calcium Phosphate Bioceramics on Osteoporotic Hip Bone Mineralization In Vivo Six Months after Implantation

2016 ◽  
Vol 721 ◽  
pp. 229-233 ◽  
Author(s):  
Sandris Petronis ◽  
Janis Locs ◽  
Vita Zalite ◽  
Mara Pilmane ◽  
Andrejs Skagers ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Mineralization ◽  
Bone Substitutes ◽  
Tissue Response ◽  
Control Group ◽  
Osteoporotic Bone ◽  
Local Recovery

Calcium bone substitutes are successfully used for local recovery of osteoporotic bone and filling of bone defects. Previous studies revieled that biphasic calcium phosphate (BCP) show better bioactivity in compare to pure β-tricalcium phosphate or hydroxyapatite. Also increased porosity of material promotes better bone tissue response. Aim of this experiment was to evaluate immunohistologically response of osteoporotic bone of experimental animal to implantation of granules with hydroxyapatite/β-tricalcium phosphate (HAp/β-TCP) ratio of 90/10. Calcium phosphate (CaP) was synthesized by aqueous precipitation technique from calcium hydroxide and phosphoric acid. Bioceramic granules in size range from 1.0 to 1.4 mm were prepared with nanopore sizes around 200 nm. We used nine female rabbits with induced osteoporosis in this experiment. Six animals in study group underwent implantation of BCP in hip bone defect and three animals in control group left without BCP implantation. After 6 months animals were euthanized, bone samples collected and proceeded for detection of bone activity and repair markers: osteocalcin (OC), osteopontin (OP) and osteoprotegerin (OPG). Controls showed the presence of experimental bone osteoporosis. In experimental group bone showed partially resorbed bioceramic granules and in some samples new bone formation near the granuli was observed. Increase of OC and OPG up to twice as to compare to control group were detected as well. Implantation of BCP granules in osteoporotic rabbit bone increases expression of OC and OPG indicating the activation of osteoblastogenesis and bone mineralization in vivo.

scholarly journals Influence of low-temperature reaction time on morphology and phase composition of short calcium phosphate whiskers

2019 ◽  
Vol 13 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Monika Biernat ◽  
Zbigniew Jaegermann ◽  
Paulina Tymowicz-Grzyb ◽  
Gustaw Konopka
Keyword(s):  
Hydrogen Peroxide ◽  
Phase Composition ◽  
Reaction Time ◽  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Calcium Pyrophosphate ◽  
Temperature Reaction ◽  
Test Results ◽  
Lower Temperature ◽  
Hydrothermal Methods

The present work shows the results of the synthesis of multiphasic calcium phosphate whiskers from a mixture of biphasic calcium phosphate (?-tricalcium phosphate (?-TCP) and calcium pyrophosphate (CPP)) in the hydrogen peroxide solution-mediated process carried out in different time ranges. The process was performed at considerably lower temperature than typical hydrothermal methods used for obtaining of whiskers. Test results show that using the above-mentioned procedure triphasic calcium phosphate consisting of hydroxyapatite (HA),(?-TCP) and CPP can be obtained, where the whiskers are formed mainly from hydroxyapatite. It was found that morphology, phase composition and specific surface area of the reaction product can be controlled by changing the reaction time. The obtained triphasic HA/?-TCP/CPP short whiskers may be considered as a promising biocompatible and resorbable reinforcement in composites for bone tissue engineering with a faster resorption rate than that of HA.

scholarly journals Integrated 3D Information for Custom-Made Bone Grafts: Focus on Biphasic Calcium Phosphate Bone Substitute Biomaterials

2020 ◽  
Vol 17 (14) ◽  
pp. 4931
Author(s):  
Alessandra Giuliani ◽  
Maria Laura Gatto ◽  
Luigi Gobbi ◽  
Francesco Guido Mangano ◽  
Carlo Mangano
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Alveolar Bone ◽  
Sintering Temperature ◽  
Calcium Phosphates ◽  
Compressive Loading ◽  
Peak Temperature ◽  
X Ray Diffraction ◽  
X Ray ◽  
Custom Made

Purpose: Several studies showed that the sintering temperature of 1250 °C could affect the formation of α-Ca3(PO4)2, which is responsible for the reduction of the hardness value of biphasic calcium phosphate biocomposites, but they did not evaluate the inference of the sintering time at peak temperature on transition of β-Ca3(PO4)2 to α-Ca3(PO4)2. This analysis explored, in an innovative way, inferences and correlations between volumetric microstructure, mechanical properties, sintering temperature, and time at peak temperature in order to find the best sintering conditions for biphasic calcium phosphate composites grafted in severe alveolar bone defects. Methods: Sintered biphasic calcium phosphates (30%-hydroxyapatite/70%-tricalcium phosphate) were tested by microCT imaging for the 3D morphometric analysis, by compressive loading to find their mechanical parameters, and by X-ray diffraction to quantify the phases via Rietveld refinement for different sintering temperatures and times at the peak temperature. Data were analysed in terms of statistical inference using Pearson’s correlation coefficients. Results: All the studied scaffolds closely mimicked the alveolar organization of the jawbone, independently on the sintering temperatures and times; however, mechanical testing revealed that the group with peak temperature, which lasted for 2 hours at 1250 °C, showed the highest strength both at the ultimate point and at fracture point. Conclusion: The good mechanical performances of the group with peak temperature, which lasted for 2 hours at 1250 °C, is most likely due to the absence of the α-Ca3(PO4)2 phase, as revealed by X-ray diffraction. However, we detected its presence after sintering at the same peak temperature for longer times, showing the time-dependence, combined with the temperature-dependence, of the β-Ca3(PO4)2 to α-Ca3(PO4)2 transition.

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