scholarly journals Synthesis, Spectroscopic Characterization and Biological Applications of Novel Zinc Complexes with Schiff Bases

2018 ◽  
Vol 778 ◽  
pp. 293-300
Author(s):  
Mehrine Rehman ◽  
Saqib Ali ◽  
Khurram Shahzad Munawar
Keyword(s):  
Spectroscopic Characterization ◽  
Diffusion Method ◽  
Drug Candidates ◽  
H Nmr ◽  
Oxygen Donor ◽  
Field Shift ◽  
Ft Ir ◽  
Treatment Of Diabetes ◽  
Toxic Drugs ◽  
Azomethine Proton

Schiff base ligands, having nitrogen and oxygen donor sites and their zinc (II) complexes have been prepared by using methanol as a solvent. Purity of the compounds has been tested by TLC and are characterized by FT-IR, multinuclear NMR (1H and13C). FT-IR spectra suggested the binding of precursors and their chelation with zinc (II) moieties by showing characteristics peaks in particular regions.1H-NMR also approves the synthesis of compounds by showing characteristics peaks of azomethine proton (HC=N) and phenolic proton (-OH). On complexation phenolic proton was disappeared while a down field shift was observed in azomethine proton.13C-NMR data further supports the formation of compounds by the displaying and shifting of characteristic peaks of azomethine carbon (HC=N).The DNA binding ability of all the synthesized ligands was studied by UV-Visible spectroscopy. A hypochromic affect was observed showing that ligands interacted with DNA by intercalation. The results implied that these synthesized compounds can be employed for the formulation of Anticancer and Antitumor drugs in future with less toxic side effects to normal cells (unlike toxic drugs presently used) .Moreover they were found to have antifungal and antibacterial activity by Disc Diffusion method. Zinc containing complexes have been investigated a lot recently for the treatment of Diabetes Mellitus. Thus, these synthesized compounds are potential drug candidates for research if explored .

scholarly journals SYNTHESIS AND STRUCTURAL ELUCIDATION OF AMINO ACETYLENIC AND THIOCARBAMATES DERIVATIVES FOR 2-MERCAPTOBENZOTHIAZOLE AS ANTIMICROBIAL AGENTS

2017 ◽  
Vol 9 (2) ◽  
pp. 192
Author(s):  
Aseel Alsarahni ◽  
Zuhair Muhi Eldeen ◽  
Elham Al-kaissi ◽  
Ibrahim Al- Adham ◽  
Najah Al-muhtaseb
Keyword(s):  
Antimicrobial Activity ◽  
Elemental Analysis ◽  
Antimicrobial Agents ◽  
Diffusion Method ◽  
Benzothiazole Derivatives ◽  
H Nmr ◽  
Ft Ir ◽  
Potential Antimicrobial Activity ◽  
C Nmr

<p><strong>Objective: </strong>To design and synthesize amino acetylenic and thiocarbonate of 2-mercapto-1,3-benthiazoles as potential antimicrobial agents.</p><p><strong>Methods: </strong>A new series of 2-{[4-(t-amino-1-yl) but-2-yn-1-yl] sulfanyl}-1,3-benzothiazole derivatives (AZ1-AZ6), and S-1,3-benzothiazol-2-yl-O-alkyl carbonothioate derivatives were synthesised, with the aim that the target compounds show new and potential antimicrobial activity. The elemental analysis was indicated by the EuroEA elemental analyzer, and biological characterization was via IR, <sup>1</sup>H-NMR, [13]C-NMR, DSC were determined with the aid of Bruker FT-IR and Varian 300 MHz spectrometer using DMSO-d<sub>6</sub> as a solvent.<em> </em><em>In vitro </em>antimicrobial activity, evaluation was done for the synthesised compounds, by agar diffusion method and broth dilution test. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined. <em></em></p><p><strong>Results: </strong>The IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, DSC and elemental analysis were consistent with the assigned structures. Compound of 2-{[4-(4-methylpiperazin-1-yl)but-2-yn-1-yl] sulfanyl}-1,3-benzothiazole (AZ1), 2-{[4-(2-methylpiperidin-1-yl)but-2-yn-1-yl]sulfanyl}-1,3-benzothiazole (AZ2), 2-{[4-(piperidin-1-yl) but-2-yn-1-yl]sulfanyl}-1, 3-benzothiazole (AZ6), S-1,3-benzothiazol-2-yl-O-ethyl carbonothioate (AZ7), and S-1,3-benzothiazol-2-yl-O-(2-methylpropyl) carbonothioate (AZ9) showed the highest antimicrobial activity against <em>Pseudomonas aeruginosa </em>(<em>P. aeruginosa</em>), AZ-9 demonstrated the highest antifungal activity against <em>Candida albicans </em>(<em>C. albicans</em>), with MIC of 31.25 µg/ml.</p><p><strong>Conclusion: </strong>These promising results promoted our interest to investigate other structural analogues for their antimicrobial activity further.</p>

scholarly journals Computational and Spectral Discussion of Some Substituted Chalcone Derivatives

2021 ◽  
Vol 12 (6) ◽  
pp. 7159-7176
Keyword(s):  
Geometry Optimization ◽  
Spectroscopic Characterization ◽  
Diffusion Method ◽  
Geometrical Parameters ◽  
1H And 13C Nmr ◽  
Chalcone Derivatives ◽  
Ft Ir ◽  
Experimental Values ◽  
Antibacterial And Antifungal ◽  
Homo Lumo

The substituted chalcone derivatives 1–7 have been synthesized, and spectroscopic characterization were done as done using the experimental FT-IR, UV-Vis, GC-MS, 1D NMR spectroscopy. The favored conformation of substituted chalcone 3 was predicted theoretically by geometry optimization structure selected geometrical parameters and molecular properties such as NBO, AIM, HOMO-LUMO, MEP surface, and atomic charges were derived from optimized structures. The 1H and 13C NMR spectral data had been additionally computed using the Gaussian-09 package and compared with the experimental values. The antibacterial and antifungal activity was derived by the disc diffusion method.

Calcium-bis[N,N'-bis(trimethylsilyl)benzamidinat]-THF (1/2) - Synthese, spektroskopische Charakterisierung und Struktur/Calcium-bis[N,N'-bis(trimethylsilyl)benzamidinate]-THF (1/2) - Syntheses, Spectroscopic Characterization and Structure

1992 ◽  
Vol 47 (4) ◽  
pp. 453-459 ◽  
Author(s):  
Matthias Westerhausen ◽  
Wolfgang Schwarz
Keyword(s):  
Title Compound ◽  
High Field ◽  
Spectroscopic Characterization ◽  
Calcium Atom ◽  
Space Group ◽  
Bond Lengths ◽  
H Nmr ◽  
Distorted Octahedral ◽  
Anionic Charge ◽  
Field Shift

The reaction of calcium-bis[bis(trimethylsilyl)amide]-THF (1/2) with benzonitrile in THF nearly quantitatively yields the title compound calcium-bis[N,N'-bis(trimethylsilyl)- benzamidinate]-THF (1/2). Under similar conditions pivalonitrile substitutes an ether ligand of calcium-bis[bis(trimethylsilyl)amide]-DME (1/2) without the formation of the corresponding amidinate derivative. The calcium-di(benzamidinate) [H5C6-C(NSiMe3)2]2Ca · 2THF crystallizes in the space group Pbcn with {a = 188.8(6); b = 1286.0(3); c = 1802.5(5) pm; Z = 4}. The calcium atom is hexa-coordinate with a distorted octahedral trans-configuration and with Ca - O and Ca - N bond distances of 238 and 243 pm, respectively. The bond lengths within the NCN moiety with values of 132 pm are characteristic of a diazaallylic system. The short N - Si bond lengths of about 170.5 pm as well as the high field shift of the 29Si{1H} NMR signal are evidence for an effective backdonation of the anionic charge from the nitrogen to the silicon atoms.

scholarly journals Synthesis and Spectroscopic Characterization of Some New Biological Active Azo–Pyrazoline Derivatives

2012 ◽  
Vol 9 (3) ◽  
pp. 1613-1622 ◽  
Author(s):  
Farouq E. Hawaiz ◽  
Mohammad K. Samad
Keyword(s):  
Addition Reaction ◽  
Coupling Reaction ◽  
Spectroscopic Characterization ◽  
Hydroxyl Group ◽  
Significant Activity ◽  
H Nmr ◽  
Ft Ir ◽  
High Yields ◽  
C Nmr

A number of 3-[4-(benzyloxy)-3-(2-Chlorophenylazo)-phenyl]-5-(substituted-phenyl)-1-substituted-2-pyrazolines( 4a-j) and (5a-j) have been synthesized by diazotization of 2-chloroaniline and its coupling reaction with 4-hydroxy acetophenone, followed by benzyloxation of the hydroxyl group to give the substrate [4-benzyloxy-3-(2-chlorophenylazo)-acetophenone (1)].The prepared starting material (1) has been reacted with different substituted benzaldehydes to give a new series of chalcone derivatives 1-[(4-benzyloxy)-3-(2-chloro-phenylazo)-phenyl]-3-(substituted phenyl)-2-propen-1-one (3a-j), in high yields and in a few minutes, and the later compounds were treated with hydrazine hydrate according to Michael addition reaction to afford a new biolological active target compounds (4a-j) and (5a-j). Furthermore, The structures of the newly synthesized compounds were confirmed by FT-IR,13C-NMR,13C-DEPT &1H-NMR spectral data. The chalcone and pyrazoline derivatives were evaluated for their anti bacterial activity againstEscherichia colias gram negative andStaphylococcus aureusas gram positive, the results showed significant activity against both types of bacteria.

Synthesis and Characterization of Palladium(II) Schiff Base and their Catalytic Activities for Heck Reaction

2012 ◽  
Vol 554-556 ◽  
pp. 736-740 ◽  
Author(s):  
Amalina Mohd Tajuddin ◽  
Hadariah Bahron ◽  
Karimah Kassim ◽  
Wan Nazihah Wan Ibrahim ◽  
Hoong Kun Fun
Keyword(s):  
Schiff Base ◽  
Coupling Reaction ◽  
Spectroscopic Characterization ◽  
Heck Coupling ◽  
Schiff Base Ligands ◽  
H Nmr ◽  
Catalytic Potential ◽  
Physico Chemical ◽  
Ft Ir

The syntheses, physico-chemical and spectroscopic characterization of ovan-type Schiff-base ligands (L1, L2) and their novel mononuclear Pd(II) complexes (PdL1, PdL2) are reported herein. Elemental analysis, FT-IR,1H NMR as well as magnetic susceptibility measurements characterised the compounds. The catalytic potential of the Pd(II) complexes for Heck coupling reaction were investigated and monitored using GC. It was observed that both Pd(II) complexes displayed properties of good catalysts for the reaction, indicated by 100% conversion of the starting materials to the subtituted alkene product after 6 hours of reaction time at 100°C in inert conditions. The catalytic activity was compared with the reaction without Pd(II) complexes.

scholarly journals Synthesis, spectroscopic characterization and pharmacological evaluation of oxazolone derivatives

2013 ◽  
Vol 78 (8) ◽  
pp. 1127-1134 ◽  
Author(s):  
Ghulam Fareed ◽  
Nighat Afza ◽  
Ali Versiani ◽  
Nazia Fareed ◽  
Rasheed Mughal ◽  
...  
Keyword(s):  
Spectroscopic Characterization ◽  
Significant Inhibition ◽  
Diffusion Method ◽  
Urease Inhibition ◽  
Inhibition Activity ◽  
Mueller Hinton ◽  
Excellent Activity ◽  
Mueller Hinton Agar ◽  
Ft Ir ◽  
Urease Inhibition Activity

A series of 4-aryl methylidene-2-phenyl/methyl-5-(4H)-oxazolone derivatives (2-7) have been synthesized using the reported method by condensation of aldehydes with N-benzoyl / N-acetyl glycine in the presence of zinc oxide as a catalyst and acetic anhydride at room temperature in ethanol. The compounds (2-6) are new derivatives. The structures of compounds were evaluated on the basis of 1H-NMR, 13C-NMR, EIMS, FT-IR and elemental analysis. All the compounds were screened for their antibacterial and urease inhibition activity. Antibacterial activity was tested by agar well diffusion method using Mueller Hinton Agar medium. Compound (2) showed excellent activity against S. aureus which has 16 mm (80%) inhibition and above 24 mm (70%) against S. typhi. The most active compound against E. coli was compound (6) having 20 mm (80%) inhibition followed by compound (5) having above 18 mm (70%) inhibition. Urease inhibition activity of all the compounds was determined by indophenol method. Compounds (3, 6) and (7) showed significant inhibition against Jacks bean urease.

scholarly journals Facile synthesis of new pyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidin-5(1H)-ones via the tandem intramolecular Pinner–Dimroth rearrangement and their antibacterial evaluation

2019 ◽  
Vol 74 (2) ◽  
pp. 175-181
Author(s):  
Nadieh Dorostkar-Ahmadi ◽  
Abolghasem Davoodnia ◽  
Niloofar Tavakoli-Hoseini ◽  
Hossein Behmadi ◽  
Mahboobeh Nakhaei-Moghaddam
Keyword(s):  
Staphylococcus Epidermidis ◽  
Diffusion Method ◽  
Dimroth Rearrangement ◽  
Disk Diffusion Method ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Ft Ir ◽  
High Yields ◽  
Aliphatic Carboxylic Acids ◽  
C Nmr

AbstractSome new 7-alkyl-4,6-dihydropyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidin-5(1H)-ones were prepared through heterocyclization of 6-amino-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles with aliphatic carboxylic acids in the presence of phosphoryl chloride under reflux in high yields. The suggested mechanism involves a tandem intramolecular Pinner–Dimroth rearrangement. The products were characterized on the basis of FT-IR, 1H NMR, and 13C NMR spectral and microanalytical data and evaluated for their antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) using the disk diffusion method.

2,2,3,3-Tetrafluoropropoxy substituted oxo-titanium phthalocyanines axially ligated with common MALDI matrix materials

2013 ◽  
Vol 17 (06n07) ◽  
pp. 548-554 ◽  
Author(s):  
Deniz Kutlu Tarakci ◽  
İlke Gürol ◽  
Vefa Ahsen
Keyword(s):  
Chlorogenic Acid ◽  
Caffeic Acid ◽  
Elemental Analysis ◽  
Ellagic Acid ◽  
Donor Ligands ◽  
Spectroscopic Techniques ◽  
H Nmr ◽  
Oxygen Donor ◽  
Ft Ir ◽  
New Compounds

The synthesis of tetra and octa 2,2,3,3-tetrafluoropropoxy substituted oxo-titanium phthalocyanines (TiOPc) are reported. Using strongly chelating oxygen donor ligands, the reactions of TiOPc with catecholate (1a, 2a), 4-nitrocatecholate (1b, 2b) and caffeic acid (1c, 2c), ellagic acid (1d, 2d) and chlorogenic acid (1e, 2e) are described. The new compounds were characterized by mass, 1 H NMR, FT-IR, and UV-vis spectroscopic techniques as well as elemental analysis.

scholarly journals Synthesis and antioxidant properties of 2-(3-(hydroxyimino)methyl)-1H-indol-1-yl)acetamide derivatives

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Chandravadivelu Gopi ◽  
Magharla Dasaratha Dhanaraju
Keyword(s):  
Antioxidant Activity ◽  
Condensation Reaction ◽  
Antioxidant Properties ◽  
Side Chain ◽  
Antioxidant Power ◽  
H Nmr ◽  
Antioxidant Agents ◽  
Phenyl Rings ◽  
Ferric Reducing Antioxidant Power ◽  
Ft Ir

Abstract Background The main aim of this work was to synthesise a novel N-(substituted phenyl)-2-(3-(hydroxyimino) methyl)-1H-indol-1-yl) acetamide derivatives and evaluate their antioxidant activity. These compounds were prepared by a condensation reaction between 1H-indole carbaldehyde oxime and 2-chloro acetamide derivatives. The newly synthesised compound structures were characterised by FT-IR, 1H-NMR, mass spectroscopy and elemental analysis. Furthermore, the above-mentioned compounds were screened for antioxidant activity by using ferric reducing antioxidant power (FRAP) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) methods. Result The antioxidant activity result reveals that most of the compounds were exhibiting considerable activity in both methods and the values are very closer to the standards. Among the synthesised compounds, compound 3j, 3a and 3k were shown remarkable activity at low concentration. Conclusion Compounds 3j, 3a and 3k were shown highest activity among the prepared analogues due to the attachment of halogens connected at the appropriate place in the phenyl ring. Hence, these substituted phenyl rings considered as a perfect side chain for the indole nucleus for the development of the new antioxidant agents.

Evaluation of antibacterial, teratogenicity and antibiofilm effect of sulfated chitosans extracted from marine waste against microorganism

2021 ◽  
pp. 088391152110142
Author(s):  
Velu Gomathy ◽  
Venkatesan Manigandan ◽  
Narasimman Vignesh ◽  
Aavula Thabitha ◽  
Ramachandran Saravanan
Keyword(s):  
Biofilm Formation ◽  
Pathogenic Bacteria ◽  
Antimicrobial Agents ◽  
Inhibitory Effect ◽  
Diffusion Method ◽  
Marine Litter ◽  
Ionization Time ◽  
Gram Positive Bacteria ◽  
Mineral Components ◽  
Ft Ir

Biofilms play a key role in infectious diseases, as they may form on the surface and persist after treatment with various antimicrobial agents. The Staphylococcus aureus, Klebsiella pneumoniae, S. typhimurium, P. aeruginosa, and Escherichia coli most frequently associated with medical devices. Chitosan sulphate from marine litter (SCH-MW) was extracted and the mineral components were determined using atomic absorption spectroscopy (AAS). The degree of deacetylation (DA) of SCH was predicted 50% and 33.3% in crab and shrimp waste respectively. The elucidation of the structure of the SCH-MW was portrayed using FT-IR and 1H-NMR spectroscopy. The molecular mass of SCH-MW was determined with Matrix-Assisted Laser Desorption/Ionization-Time of Flight (MALDI-TOF). The teratogenicity of SCH-MW was characterized by the zebrafish embryo (ZFE) model. Antimicrobial activity of SCH-MW was tested with the agar well diffusion method; the inhibitory effect of SCH-MW on biofilm formation was assessed in 96 flat well polystyrene plates. The result revealed that a low concentration of crab-sulfated chitosan inhibited bacterial growth and significantly reduced the anti-biofilm activity of gram-negative and gram-positive bacteria relatively to shrimp. It is potentially against the biofilm formation of pathogenic bacteria.

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