Serenoa repens and its effects on male sexual function. A systematic review and meta-analysis of clinical trials

Background: Serenoa repens (SR) is a plant used to treat benign prostatic hyperplasia and prostatitis. We know that SR act as a 5α-reductase inhibitor, moreover, several studies have proved that SR has anti-inflammatory and antioxidant properties. There is some belief among patients that SR may negatively impact male sexual function. Such belief is circulating in non-medical social networks and is perhaps maintained by patients as a result of incorrect web surfing. However, it is also possible that SR may exert a “nocebo” effect thus negatively impacting on the general well-being of patients. Objective: The aim of this study is to investigate whether SR is causing negative effects on male sexual function. Methods: To ascertain the effect of SR on male sexual function, we conducted a systematic review and meta-analysis, by performing an electronic database search in accordance with the PRISMA guidelines. Results: Out of 20 included papers, 8 papers reported comparisons of SR with placebo, and 7 studies reported comparisons of SR with tamsulosin. The standardized mean difference of changes from baseline scores of sexual function was not significantly different between SR and placebo (SMD: 0.43, 95% CI: 0.18 to 1.05; I^2 = 95%). Similarly, no significant mean differences in the Male Sexual Function-4 (MSF-4) test scores were found between SR and tamsulosin (SMD: -0.31, 95% CI: -0.82 to 0.19; I^2 = 90%). Conclusions: We found no statistically significant differences between negative effects on sexual function in patients treated with SR compared to patients who received placebo. The results of our meta-analysis are similar to those of other systematic reviews. Studies are warranted to ascertain whether any such effects might occur as a result of a nocebo effect.

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The State of Interventions for Sibling Conflict and Aggression: A Systematic Review

Trauma Violence & Abuse ◽

10.1177/1524838015622438 ◽

2015 ◽

Vol 18 (4) ◽

pp. 396-406 ◽

Cited By ~ 14

Author(s):

Corinna Jenkins Tucker ◽

David Finkelhor

Keyword(s):

Systematic Review ◽

Social Skills ◽

Meta Analysis ◽

Well Being ◽

Sibling Relationship ◽

Control Group ◽

Sibling Conflict ◽

Negative Effects ◽

Online Databases ◽

Children's Social Skills

Sibling conflict and aggression is often a pervasive part of family life that parents want help managing and can have negative effects on children’s well-being. The purpose of this systematic review is to evaluate current research regarding programs to reduce sibling conflict and aggression and promote positive sibling relationships. Online databases, reference lists, and Google Scholar were searched using key words and inclusion/exclusion criteria were applied. The search located five unique studies of programs focused on school-aged children. Heterogeneity of the studies precluded meta-analysis, but characteristics of the studies were systematically described. Three interventions were aimed at directly improving children’s social skills and two interventions trained parents on mediation techniques to use during sibling conflicts. Overall, of the four studies that included assessment of children’s social skills, the results were positive. Two of the three studies that evaluated sibling relationship quality demonstrated improved sibling interactions compared with the control group. With further research and evidentiary support, these programs have promise to modify sibling behaviors as part of current parenting education programs or as a stand-alone program to address sibling conflict and aggression.

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Women’s well-being and functioning after evidence-based antenatal care: a protocol for a systematic review of intervention studies

BMJ Open ◽

10.1136/bmjopen-2020-042667 ◽

2021 ◽

Vol 11 (2) ◽

pp. e042667

Author(s):

Carla Betina Andreucci ◽

Veronique Filippi ◽

Jose Guilherme Cecatti

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Experimental Studies ◽

Well Being ◽

Screening Strategy ◽

Evidence Based ◽

Human Beings ◽

Negative Effects ◽

Statistical Measures ◽

Quasi Experimental

IntroductionThe 2016 WHO antenatal guidelines propose evidence-based recommendations to improve maternal outcomes. We aim to complement these recommendations by describing and estimating the effects of the interventions recommended by WHO on maternal well-being or functioning.Methods and analysisWe will conduct a systematic review of experimental and quasi-experimental studies evaluating women’s well-being or functioning following the implementation of evidence-based antenatal interventions, published in peer-reviewed journals through a 15-year interval (2005–2020). The lead reviewer will screen all records identified at MEDLINE, EMBASE, CINAHL Plus, LILACS and SciELO. Two other reviewers will control screening strategy quality. Quality and risk of bias will be assessed using a specially designed instrument. Data synthesis will consider the instruments applied, how often they were used, conditions/interventions for positive or negative effects documented, statistical measures used to document effectiveness and how results were presented. A random-effects meta-analysis comparing frequently used instruments may be conducted.Ethics and disseminationThe study will be a systematic review with no human beings’ involvement, therefore not requiring ethical approval. Findings will be disseminated through peer-reviewed publication and scientific events.PROSPERO registration numberCRD42019143436.

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Impact of Exposure to Natural and Built Environments on Positive and Negative Affect: A Systematic Review and Meta-Analysis

Frontiers in Public Health ◽

10.3389/fpubh.2021.758457 ◽

2021 ◽

Vol 9 ◽

Author(s):

Wenfei Yao ◽

Fei Chen ◽

San Wang ◽

Xiaofeng Zhang

Keyword(s):

Systematic Review ◽

Negative Affect ◽

Natural Environment ◽

Meta Analysis ◽

Well Being ◽

Convincing Evidence ◽

Built Environments ◽

Natural Environments ◽

Negative Effects ◽

Study Region

There is increasing evidence that the natural environment provides substantial benefits to human emotional well-being. The current study synthesized this body of research using the meta-analysis and assessed the positive and negative effects of exposure to both the natural and built environments. We searched four databases and 20 studies were included in the review. The meta-analysis results showed the most convincing evidence that exposure to the natural environment could increase positive affect (standardized mean difference, SMD = 0.61, 95% CI 0.41, 0.81) and decreased negative affect (SMD = −0.47, 95% CI −0.71, −0.24). However, there was extreme heterogeneity between the studies, and the risk of bias was high. According to the subgroup analysis, study region, study design, mean age of the sample, sample size, and type of natural and built environment were found to be important factors during exposure to the natural environment. The implications of these findings for the existing theory and research are discussed. These findings will help convince the health professionals and policymakers to encourage the residents to increase their time spent in the natural environment. These findings of this systematic review also suggested that the creation, maintenance, and enhancement of accessible greenspaces or existing natural environments may form part of a multidimensional approach to increasing emotional well-being of the local populations.

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Effect of Bariatric Surgery on Male Sexual Function: A Meta-Analysis and Systematic Review

Sexual Medicine ◽

10.1016/j.esxm.2019.06.003 ◽

2019 ◽

Vol 7 (3) ◽

pp. 270-281 ◽

Cited By ~ 8

Author(s):

Jiangnan Xu ◽

Qian Wu ◽

Yuhui Zhang ◽

Changsong Pei

Keyword(s):

Systematic Review ◽

Bariatric Surgery ◽

Sexual Function ◽

Meta Analysis ◽

Male Sexual Function

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Effectiveness of Nutritional Education for Obese Older Adults With Frailty: A Systematic Review and Meta-Analysis

Innovation in Aging ◽

10.1093/geroni/igaa057.1291 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 401-401

Author(s):

Yue-Heng Yin ◽

Liu Yat Justina

Keyword(s):

Systematic Review ◽

Physical Function ◽

Meta Analysis ◽

Experimental Studies ◽

Well Being ◽

Risk Of Bias ◽

Cochrane Library ◽

Nutritional Education ◽

Hand Search ◽

Education Interventions

Abstract Obesity has been shown to intensify the decline of physical function and lead to frailty. Nutrition is an important method in managing obesity and frailty, while seldom reviews have ever explored the effects of nutritional education interventions. We conducted a systematic review (PROSPERO: CRD42019142403) to explore the effectiveness of nutritional education interventions in managing body composition and physio-psychosocial parameters related to frailty. Randomized controlled trials and quasi-experimental studies were searched in CINAHL, Cochrane Library, EMBASE, MEDLINE, PsycINFO, PubMed and Scopus from 2001 to 2019. Hand search for the reference lists of included papers was conducted as well. We assessed the quality of included studies by Cochrane risk of bias tool. Meta-analyses and narrative synthesis were used to analyse the data. Two studies with low risk of bias were screened from 180 articles, which involved 177 older people with an average age of 69.69±4.08 years old. The results showed that nutritional education was significantly effective in reducing body weight and fat mass than exercises, and it was beneficial to enhancing physical function and psychosocial well-being. But the effects of nutritional education in increasing muscle strength were not better than exercises. The combined effects of nutritional education and exercises were superior than either exercises or nutritional education interventions solely in preventing the loss of lean mass and bone marrow density, and in improving physical function. Due to limited numbers of relevant studies, the strong evidence of effectiveness of nutritional education interventions on reversing frailty is still lacking.

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The effectiveness of hope-fostering interventions in palliative care: A systematic review and meta-analysis

Palliative Medicine ◽

10.1177/0269216321994728 ◽

2021 ◽

pp. 026921632199472

Author(s):

Natalia Salamanca-Balen ◽

Thomas V Merluzzi ◽

Man Chen

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Palliative Care ◽

Meta Analysis ◽

Symptom Burden ◽

Well Being ◽

Medium Effect ◽

Spiritual Well Being ◽

Quasi Experimental

Background: The concept of hope is an important theme in chronic illness and palliative care and has been associated with increased psycho-spiritual well-being and quality of life. Psycho-spiritual interventions have been described in this population, but no systematic review of hope-enhancing interventions or hopelessness-reducing interventions has been conducted for persons with palliative care diseases. Aim: To describe and assess the effectiveness of interventions in palliative care that measure hope and/or hopelessness as an outcome. Design: This systematic review and meta-analysis was pre-registered (Prospero ID: CRD42019119956). Data sources: Electronic databases, journals, and references were searched. We used the Cochrane criteria to assess the risk of bias within studies. Results: Thirty-five studies (24 randomized controlled trials, 5 quasi-experimental, 6 pre-post studies) involving a total of 3296 palliative care patients were included. Compared with usual/standard cancer care alone, interventions significantly increased hope levels at a medium effect size ( g = 0.61, 95% confidence interval (CI) = 0.28–0.93) but did not significantly reduce hopelessness ( g = −0.08, 95% CI = −0.18 to 0.02). It was found that interventions significantly increase spirituality ( g = 0.70, 95% CI = 0.02–1.37) and decrease depression ( g = −0.29, 95% CI = −0.51 to −0.07), but had no significant effect over anxiety, quality of life, and symptom burden. Overall, quality of evidence across the included studies was rated as low. Conclusions: Evidence suggests that interventions can be effective in increasing hope in palliative care patients.

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Relationship of postoperative vaginal anatomy and sexual function: a systematic review with meta-analysis

International Urogynecology Journal ◽

10.1007/s00192-021-04829-4 ◽

2021 ◽

Author(s):

Shunaha Kim-Fine ◽

Danielle D. Antosh ◽

Ethan M. Balk ◽

Kate V. Meriwether ◽

Gregg Kanter ◽

...

Keyword(s):

Systematic Review ◽

Sexual Function ◽

Meta Analysis ◽

Vaginal Anatomy ◽

Relationship Of

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Updated systematic review and meta-analysis of studies examining the relationship between reported racism and health and well-being for children and youth: a protocol

BMJ Open ◽

10.1136/bmjopen-2020-043722 ◽

2021 ◽

Vol 11 (6) ◽

pp. e043722

Author(s):

Naomi Priest ◽

Kate Doery ◽

Mandy Truong ◽

Shuaijun Guo ◽

Ryan Perry ◽

...

Keyword(s):

Systematic Review ◽

Health Outcomes ◽

Research Policy ◽

Meta Analysis ◽

Well Being ◽

Children And Youth ◽

Effect Sizes ◽

Future Research ◽

Critical Determinant ◽

Health And Well Being

IntroductionRacism is a critical determinant of health and health inequities for children and youth. This protocol aims to update the first systematic review conducted by Priest et al (2013), including a meta-analysis of findings. Based on previous empirical data, it is anticipated that child and youth health will be negatively impacted by racism. Findings from this review will provide updated evidence of effect sizes across outcomes and identify moderators and mediators of relationships between racism and health.Methods and analysisThis systematic review and meta-analysis will include studies that examine associations between experiences of racism and racial discrimination with health outcomes of children and youth aged 0–24 years. Exposure measures include self-reported or proxy reported systemic, interpersonal and intrapersonal racism. Outcome measures include general health and well-being, physical health, mental health, biological markers, healthcare utilisation and health behaviours. A comprehensive search of studies from the earliest time available to October 2020 will be conducted. A random effects meta-analysis will examine the average effect of racism on a range of health outcomes. Study-level moderation will test the difference in effect sizes with regard to various sample and exposure characteristics. This review has been registered with the International Prospective Register of Systematic Reviews.Ethics and disseminationThis review will provide evidence for future research within the field and help to support policy and practice development. Results will be widely disseminated to both academic and non-academic audiences through peer-review publications, community summaries and presentations to research, policy, practice and community audiences.PROSPERO registration numberCRD42020184055.

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Individual Resilience Interventions: A Systematic Review in Adult Population Samples over the Last Decade

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18147564 ◽

2021 ◽

Vol 18 (14) ◽

pp. 7564

Author(s):

Mafalda Ferreira ◽

António Marques ◽

Paulo Veloso Gomes

Keyword(s):

Systematic Review ◽

Methodological Quality ◽

Meta Analysis ◽

Statistical Significance ◽

Adult Population ◽

Well Being ◽

Eligibility Criteria ◽

Individual Resilience ◽

Literature Searches ◽

Great Heterogeneity

Resilience interventions have been gaining importance among researchers due to their potential to provide well-being and reduce the prevalence of mental disorders that are becoming an increasing concern, especially in Western countries, because of the costs associated. The purpose of this systematic review is to identify the intervention studies carried out in the last decade in adult population samples, evaluate their methodological quality and highlight the trends of these types of interventions. This review was performed using systematic literature searches in the following electronic databases: B-on, PubMed, PsycNet and Science Direct. The application of eligibility criteria resulted in the inclusion of 38 articles, of which 33 were randomized controlled trials and the other five were nonrandomized controlled studies. Although most studies showed statistical significance for their results, these were constrained by the great heterogeneity of the studies, the lack of power of the samples and their fair methodological quality. Therefore, it is important to consolidate the theoretical basis and standardize certain methodologies so that the effects of the interventions can be compared through a meta-analysis.

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