scholarly journals Ewing’s sarcoma: an uncommon breast tumor

2014 ◽  
Vol 4 (2) ◽  
Author(s):  
Sawsen Meddeb ◽  
Mohamed Salah Rhim ◽  
Mouna Kouira ◽  
Sarra Mestiri ◽  
Mohamed Bibi ◽  
...  
Keyword(s):  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Histopathological Examination ◽  
Radical Mastectomy ◽  
Lower Limbs ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Diagnostic Challenge ◽  
Children And Young Adults ◽  
Lymph Nodes Dissection

Ewing’s sarcoma/primitive neuroectodermal tumors (EWS/PNET) are rare malignant and aggressive tumors, usually seen in the trunk and lower limbs of children and young adults. They are uncommon in the breast. We report a case of a 43-year-old woman who developed a painless breast mass. An initial core needle biopsy concluded to a fibrocystic dystrophy contrasting with a rapidly growing mass; thus a large lumpectomy was done. Diagnosis of primary PNET of the breast was established, based on both histopathological examination and immunohistochemical findings. Surgical margins were positive, therefore, left modified radical mastectomy with axillary lymph nodes dissection was performed. The patient was given 6 cycles of adjuvant chemotherapy containing cyclophosphamide, adriamycin and vincristine. Twenty months later, she is in life without recurrence or metastasis. EWS/PNET may impose a diagnostic challenge. Indeed, mammography and ultrasonography features are non specific. The histopathological pattern is variable depending on the degree of neuroectodermal differentiation. Immuno-phenotyping is necessary and genetic study is the only confirmatory tool of diagnosis showing a characteristic cytogenetic anomaly; t (11; 22) translocation.

Primary nasal cavity Ewing’s sarcoma in pediatric practice: A clinical case

2021 ◽  
Vol 59 (1) ◽  
pp. 39-42
Author(s):  
А. Bekisheva ◽  
A. Makhneva ◽  
E. Satbaeva ◽  
G. Abyov ◽  
M. Remkulova
Keyword(s):  
Nasal Cavity ◽  
Clinical Case ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Histopathological Examination ◽  
Neck Region ◽  
Diagnostic Techniques ◽  
Tumor Type ◽  
Head And Neck Region ◽  
Tumor Remission

Ewing’s sarcoma is an aggressive tumor rarely found in the head and neck region and extremely rare in the nasal cavity or paranasal sinuses (2-3% of all Ewing’s sarcomas). Purpose: The article presents a clinical diagnostic case of nasal cavity Ewing’s sarcoma finally verified only by IHC test. Results: The presented clinical case describes Ewing’s sarcoma of the nasal cavity in a 14-year-old girl and presents the clinical picture, the results of MRI and CT examination of the sinuses, histopathological and IHC tests. Adequate diagnostical tools made it possible to establish a diagnosis. Timely determined treatment tactics, taking into account the tumor localization and possible postoperative complications, led to tumor remission. At present, the patient is under dynamic observation. Conclusion: The presented clinical case confirms that a primary nasal cavity Ewing’s sarcoma diagnostic largely depends on histopathological examination since visual diagnostic techniques do not provide reliable information on the tumor type.

scholarly journals Ewing’s sarcoma of sinonasal tract: a rare case

2020 ◽  
Vol 6 (3) ◽  
pp. 565
Author(s):  
Ankur Gupta ◽  
Ancy S. Sofia ◽  
Kanwar Sen
Keyword(s):  
Multidisciplinary Approach ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Histopathological Examination ◽  
Malignant Tumour ◽  
Rare Entity ◽  
Round Cell ◽  
First Line ◽  
Cytogenetic Studies ◽  
Immunohistochemical Studies

<p class="abstract">Extra skeletal Ewing’s sarcoma (EES) is a rare, rapidly growing, round cell malignant tumour that can develop in the soft tissue at any location. Involvement of the paranasal sinus is a very rare entity. Nearly 80% of patients are younger than 20 years. Diagnosis is made after histopathological examination, immunohistochemical studies and cytogenetic studies. Treatment includes a multidisciplinary approach with surgery as the first line followed by chemotherapy and radiotherapy.</p><p class="abstract"> </p>

Patterns of Relapse and Survival in Operable Breast Carcinoma with Positive and Negative Axillary Nodes

1978 ◽  
Vol 64 (3) ◽  
pp. 241-258 ◽  
Author(s):  
Pinuccia Valagussa ◽  
Gianni Bonadonna ◽  
Umberto Veronesi
Keyword(s):  
Primary Tumor ◽  
Postoperative Radiotherapy ◽  
Menopausal Status ◽  
Survival Rates ◽  
Radical Mastectomy ◽  
Risk Groups ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Axillary Nodes ◽  
Prognostic Importance

The medical records of 716 consecutive patients with infiltrating mammary carcinoma and treated during a 4-year period (January 1964-January 1968) were reviewed. Patients were randomized between conventional radical or extended radical mastectomy. No postoperative radiotherapy or other specific treatments were given without documented evidence of recurrence. The intent of this retrospective analysis was to identify, on a clinical basis, the high-risk groups that could be candidates for systemic adjuvant treatment. The most reliable prognostic discriminant was found to be the histological status of axillary lymph nodes. The 10-year relapse rate for patients with negative axillary nodes (N−) was 27.9 % compared to 75.5 % for patients with positive axillary nodes (N+). The corresponding 10-year survival rates were 81.9 % and 39.6 %, respectively. The number of involved nodes was also of particular prognostic importance (relapse rates at 10 years: 1 to 3 nodes, 66.5 %; more than 3 nodes, 83.6 %; survival rates: 53.7 % and 25.6 %, respectively). Other clinical variables (location of primary tumor and menopausal status) failed to significantly affect the results of mastectomy, except for the extent of primary tumor in N+ patients. In this subgroup, relapse and survival rates were directly proportional to tumor size. In both groups, the highest incidence of recurrence was detected in distant organs and tissues, and it progressively increased with time. In contrast, 77.3 % of all local-regional recurrences were documented during the first three years from radical surgery.

Immunohistochemical Investigation of Axillary Lymph Nodes for Micrometastases in Patients with Breast Cancer Using E29

1989 ◽  
Vol 75 (6) ◽  
pp. 563-565 ◽  
Author(s):  
Antonio Cavaliere ◽  
Brunangelo Falini ◽  
Giacomo Antonini
Keyword(s):  
Breast Cancer ◽  
Monoclonal Antibody ◽  
Epithelial Cells ◽  
Lymph Nodes ◽  
Histological Examination ◽  
Mammary Carcinoma ◽  
Radical Mastectomy ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Immunohistochemical Investigation

The axillary lymph nodes from 31 mammary carcinoma patients who had undergone radical mastectomy and were negative for metastases at routine histologic examination of hilar sections, were investigated with E29, an anti-epithelial monoclonal antibody, to detect the presence of neoplastic epithelial cells. In 4 of 433 lymph nodes examined (0.9 %) this antibody revealed the presence of epithelial metastatic foci which had not been observed at routine histological examination or interpreted as histiocytes. The 4 lymph nodes belonged to 4 different patients.

Massive inflammatory reaction following the removal of a ruptured silicone implant masking the invasive breast cancer – case report and literature review

2016 ◽  
Vol 88 (1) ◽  
Author(s):  
Piotr Nowaczyk ◽  
Aleksandra Budnicka ◽  
Mateusz Wichtowski ◽  
Paweł Kurzawa ◽  
Dawid Murawa
Keyword(s):  
Breast Cancer ◽  
Histopathological Examination ◽  
Breast Implants ◽  
Breast Cancer Case ◽  
Left Breast ◽  
Cancer Case ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Breast Cancers ◽  
Inflammatory Infiltration

AbstractThis paper presents a case of a patient with invasive ductal breast cancer following breast augmentation. Following breast implants rupture in March 2013 the breast implants have been removed – histopathological examination revealed leaked silicone with inflammatory infiltration, without evidence of cancerous lesions. Diagnostic imaging revealed multiple encapsulated silicone particles and clusters of post-inflammatory macrocalcifications in both breasts. In January 2014 the patient presented with symptoms of massive inflammation of the left breast. Following surgical consultation the patient had undergone radical left-sided mastectomy with lymphadenectomy. Postoperative histopathological examination revealed a multifocal advanced invasive ductal cancer G3 pT3pN3a (vascular invasion, metastases in 11 of 12 examined axillary lymph nodes). Following surgery the patient was qualified for further treatment – chemotherapy, radiotherapy, hormone therapy. The discussion includes a review of literature on the risk evaluation of co-occurrence of breast cancers in women with silicone breast implants and presents diagnostic challenges of breast cancer in this patient group.

scholarly journals Development and validation of a nomogram to predict drainage duration in patients with breast cancer treated with modified radical mastectomy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Song Wu ◽  
Zechang Xin ◽  
Daxing Sui ◽  
Zhengli Ou ◽  
Haotian Bai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Radical Mastectomy ◽  
Postoperative Management ◽  
The Body ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Modified Radical Mastectomy ◽  
Suction Drain ◽  
Postoperative Drainage

AbstractAppropriate drainage duration is vital for the postoperative rehabilitation of patients with breast cancer (BC) undergoing modified radical mastectomy (MRM). To provide better and individualized postoperative management for these patients, this study explored independent predictors of postoperative drainage duration in patients with BC. This was a single-center retrospective cohort study. Patients diagnosed with BC and treated with MRM from May 2016 to April 2020 were randomly divided into training (n = 729) and validation (n = 243) cohorts. Univariate and multivariate Cox analyses revealed that the body mass index, serum albumin level, hypertension, number of total dissected axillary lymph nodes, and ratio of positive axillary lymph nodes were independent predictors of postoperative drainage duration in the training cohort. Based on independent predictors, a nomogram was constructed to predict the median postoperative drainage duration and the probability of retaining the suction drain during this period. This nomogram had good concordance and discrimination both in the training and validation cohorts and could effectively predict the probability of retaining the suction drain during drainage, thus assisting clinicians in predicting postoperative drainage duration and providing individualized postoperative management for patients with BC.

Limited efficacy and significant toxicities of lapatinib (Lap) plus chemotherapy as neoadjuvant therapy (NAC) for HER2-positive inflammatory breast cancer (IBC) patients (Pts).

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 594-594 ◽  
Author(s):  
Ricardo H. Alvarez ◽  
Massimo Cristofanilli ◽  
Joe Ensor ◽  
Anthony Lucci ◽  
Wei Tse Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Kinase Inhibitor ◽  
Locally Advanced Breast Cancer ◽  
Performance Status ◽  
Single Agent ◽  
Locally Advanced ◽  
Radical Mastectomy ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Severe Toxicity

594 Background: IBC is a rare disease but the most aggressive form of locally advanced breast cancer with a higher frequency of HER2 neu amplification (HER2+) compared to non-IBC. The EGFR pathways are also important therapeutic targets in IBC. (Zhang D, 2009). Lap is an oral reversible dual kinase inhibitor of epidermal growth factor receptor of EGFR and HER2. Our objective was to determine the efficacy of Lap in combination with paclitaxel as NAC in pts with previously untreated HER2+ IBC. The primary end-point was to determine the rate of pathological complete response (pCR) defined as no residual invasive disease in the breast and the axillary lymph nodes or Residual Cancer Burden (RCB) of 0. (Symmans FW, 2008). The second endpoint was to assess general safety and cardiac toxicity of this combination therapy. Methods: From October 2008 to May 2011, 15 chemo-naïve pts were treated with Lap 1,250 mg/day as a single agent for 2 weeks, followed by 12 weeks of paclitaxel (80 mg/m2 weekly) plus Lap (1,000 mg/day), and finally with 4 cycles of FEC-75 mg/m2 regimen plus Lap (1,000 mg/day) before surgery. Among 12 first pts enrolled, 6 pts had grade 3 diarrhea (CTCAC v3.0) and the protocol was amended to reduce the Lap dose to 750 mg/day. After modified radical mastectomy (MRM), patients received radiation therapy and one year of adjuvant trastuzumab. Results: Median age was 53.8 (range, 39 -70), performance status was 0 (13 pts), 1 (2 pts), 4 pts had metastatic disease at diagnosis. 10 of 15 pts had MRM. One pt achieved pCR. Five pts did not complete the NAC due to grade 2 cardiomyopathy (1), liver dysfunction (2), diarrhea (1), and insurance denial after pt started treatment (1). The trial was stopped early due to severe toxicity (>15%) and lack of efficacy. Conclusions: Lap in combination with chemotherapy as NAC has a limited anti-tumor activity in pts with HER2+ IBC with a pCR rate of 6.6%. Lap and paclitaxel was associated with severe diarrhea toxicity and required multiple dose reductions of Lap. With the recent promising results in HER2+ NAC studies, the role of Lap should continue to be explored in combination with other anti-HER2 agents in IBC patients.

scholarly journals Clinical presentations of carcinoma breast in rural population of North India: a prospective observational study

2019 ◽  
Vol 6 (5) ◽  
pp. 1622
Author(s):  
Gaurav Gupta ◽  
Rohit Dang ◽  
Sangeeta Gupta
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Radical Mastectomy ◽  
Treatment Compliance ◽  
Late Presentation ◽  
North India ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Carcinoma Breast

Background: There is an ever increasing incidence in cases of carcinoma breast in developing countries, however no definitive cause is found. Since it presents as painless lump, patients neglect the disease and come to hospital often in late stages. This study was planned to investigate the causes for late presentation of the patients with carcinoma breast in North Indian population.Methods: This is a prospective observational study; it included fifty cases of carcinoma breast proven by FNAC/Trucut biopsy. All these cases were admitted in the department of general surgery and thoroughly examined and investigated. The details of investigations, management, morbidity & mortality were noted down & results calculated with appropriate statistical analysis.Results: Most of the female patients were in the age group of 31-60 years. Maximum patients presented with breast lumps, but most of them had lump more than 5 cm (T3) in size with spread to axillary lymph nodes N1 or N2. Surgery in the form of Modified Radical Mastectomy (MRM), adjuvant & neo-adjuvant Chemotherapy as per the stage of the disease and hormonal therapy in the form of Tamoxifen was given.Conclusions: Poor treatment compliance in the form of irregularity to turn up for chemotherapy cycles has resulted in more number of mastectomies. Numbers of patients lost to follow up were more due to unaffordability of the cost incurred and lack of awareness. True mortality rate and recurrence rate could not be commented upon as a longer period of follow up was required.

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