scholarly journals Prevalence and clinical features of most frequent phenotypes in the Italian COPD population: the CLIMA Study

2021 ◽  
Vol 16 ◽  
Author(s):  
Roberto W. Dal Negro ◽  
Mauro Carone ◽  
Giuseppina Cuttitta ◽  
Luca Gallelli ◽  
Massimo Pistolesi ◽  
...  
Keyword(s):  
Lung Function ◽  
Smoking Habit ◽  
Daily Practice ◽  
Chronic Obstructive ◽  
Blood Eosinophil ◽  
Chi Square ◽  
Recurrent Wheezing ◽  
Total Blood ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease

Background: Chronic obstructive pulmonary disease (COPD) is a complex, progressive respiratory condition characterized by heterogeneous clinical presentations (phenotypes). The aim of this study was to assess the prevalence of the main COPD phenotypes and match each phenotype to the most fitting clinical and lung function profile.Methods: The CLIMA (Clinical Phenotypes in Actual Clinical Practice) study was an observational, cross-sectional investigation involving twenty-four sites evenly distributed throughout Italy. Patients were tentatively grouped based on their history and claimed prevailing symptoms at recruitment: chronic cough (CB, suggesting chronic bronchitis); dyspnoea (possible emphysema components, E); recurrent wheezing (presuming asthma components, A). Variables collected were: anagraphics; smoking habit; history of asthma; claim of >1 exacerbations in the previous year; blood eosinophil count; total blood IgE and alpha1 anti-trypsin (α1-AT) levels; complete lung function, and the chest X-ray report. mMRC, CAT, BCS, EQ5d-5L were also used. The association between variables and phenotypes were checked by Chi-square test and multinomial logistic regression.Results: The CB phenotype was prevalent (48.3%), followed by the E and the A phenotypes (38.8% and 12.8%, respectively). When dyspnea was the prevailing symptom, the probability of belonging to the COPD-E phenotype was 3.40 times higher. Recurrent wheezing was mostly related to the COPD-A phenotype. Lung function proved more preserved in the COPD-CB phenotype. Smoke; n. exacerbations/year; VR, and BODE index were positively correlated with the COPD-E phenotype, while SpO2, FEV1/FVC, FEV1/VC, and FEV1 reversibility were negatively correlated. Lower DLco values were highly probative for the COPD-E phenotype (p<0.001). Conversely, smoke, wheezing, plasma eosinophils, FEV1 reversibility, and DLco were positively correlated with the COPD-A phenotype. The probability of belonging to the COPD-A phenotype raised by 2.71 times for any increase of one unit in % plasma eosinophils (p<0.001). Also multiparametrical scores contributed to discriminate the three phenotypes.Conclusion: the recognition of the main phenotypes of COPD can be effectively pursued by means of a few clinical and instrumental parameters, easy to obtain also in current daily practice. The phenotypical approach is crucial in the management of COPD as it allows to individualize the therapeutic strategy and to obtain more effective clinical outcomes

HUBUNGAN FAKTOR RESIKO DENGAN KEJADIAN PADA PENYAKIT PARU OBSTRUKSI KRONIK DI PUSKESMAS MANDALA

2019 ◽  
Vol 1 (2) ◽  
pp. 43-47
Author(s):  
Alamsyah Lukito
Keyword(s):  
Health Center ◽  
Smoke Inhalation ◽  
Chronic Obstructive ◽  
Test Results ◽  
Chi Square ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Chi Square Test ◽  
Analytical Research ◽  
Exposure To Secondhand Smoke

The main cause of Chronic Obstructive Pulmonary Disease is smoking or exposure to secondhand smoke from active smokers or smoke inhalation in passive smokers. Other causes are air pollution, workplace exposure, and genetic factors. This type of research is analytical research with a cross sectional approach which aims to study the existence of a variable relationship dynamics. In this study, the sample was 30 patients from the Mandala Health Center. Generally, COPD sufferers are those aged 45 years to 65 years where 21 of the 30 people suffer from risk. The chi-square test results show that there is a relationship between risk factors and the incidence of COPD in the Tembung Mandala 2018 Health Center Working Area.

scholarly journals Prevalence of smoking and chronic obstructive pulmonary disease amongst teachers working in Kocaeli, Turkey

2019 ◽  
Vol 6 ◽  
Author(s):  
Serap A. Barış ◽  
Füsun Yıldız ◽  
İlknur Başyiğit ◽  
Haşim Boyacı ◽  
Ahmet Ilgazlı
Keyword(s):  
Pulmonary Function ◽  
Pulmonary Function Test ◽  
Smoking Habit ◽  
Cross Sectional Study ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Progressive Decline ◽  
Function Test ◽  
Progression Of Disease

Aim: To evaluate smoking and COPD prevalence amongst teachers working in the schools of Kocaeli City, Turkey.Method: In this cross-sectional study, a questionnaire focusing on respiratory symptoms and smoking habits was adminis- tered to all participants who accepted to join the study. All sub- jects also underwent a physical examination and a pulmonary function test performed with portable spirometer. According to GOLD criteria, subjects who had post-bronchodilator FEV1/FVC < 70% and negative reversibility test were classi- fied as COPD. Results: A total of 685 teachers were included [female n = 307 (45%), male n = 378 (55%)] with mean age 38.9 ± 8.9 years. Smoking habit was evaluated in 660 subjects: 291 (44.1%) were smokers, 252 (38.2%) were non-smokers and 117 (17.7%) were ex-smokers. Pulmonary function test was available in 651 subjects and 510 (78.3%) were defined as normal on spirometric analysis. Small airway obstruction was found in 115 of the cases (17.7%) in whom FEF25-75 level was found to be lower than 70% predicted. FEV1/FVC level was lower than 70% in 16 subjects (2.5%). Five subjects who had positive reversibility test were excluded from the study. The remaining 11 subjects who were considered as COPD consisted of 2 (18%) females and 9 (82%) males. Six of these subjects were aged over 40 years. Conclusion: Spirometry has an important role in early diagno- sis of COPD. Spirometric evaluation of cases with risk factors for COPD could be helpful in diagnosing patients before the progressive decline in lung function begins. Further studies are needed to evaluate whether the interventional strategies at this stage such as smoking cessation could prevent the progression of disease.

scholarly journals Pulmonary impairment after tuberculosis in a South African population

2016 ◽  
Vol 72 (1) ◽  
Author(s):  
Gibwa Cole ◽  
Duncan Miller ◽  
Tasneem Ebrahim ◽  
Tannith Dreyden ◽  
Rory Simpson ◽  
...  
Keyword(s):  
Lung Function ◽  
Pulmonary Tuberculosis ◽  
South African ◽  
Pulmonary Rehabilitation ◽  
Population Based ◽  
Forced Expiratory Volume ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Predicted Values

Background: In South Africa, pulmonary tuberculosis (PTB) remains a problem of epidemic proportions. Despite evidence demonstrating persistent lung impairment after PTB cure, few population-based South African studies have investigated this finding. Pulmonary rehabilitation post-cure is not routinely received.Objectives: To determine the effects of PTB on lung function in adults with current or past PTB. To determine any association between PTB and chronic obstructive pulmonary disease (COPD). Methods: This study was observational and cross-sectional in design. Participants (n = 55) were included if they were HIV positive on treatment, had current PTB and were on treatment, and/or had previous PTB and completed treatment or if they were healthy adult subjects with no history of PTB. A sample of convenience was used with participants coming from a similar socio-economic background and undergoing spirometry testing. Multiple regression analyses were conducted on each lung function variable.Results: Compared to normal percentage-predicted values, forced expiratory volume in 1 second (FEV1 ), forced vital capacity (FVC) and FEV1 :FVC were significantly reduced in those with current PTB by 23.39%, 15.99% and 6.4%, respectively. Both FEV1 and FVC were significantly reduced in those with past PTB by 11.76% and 10.79%, respectively. There was no association between PTB and COPD – those with previous PTB having a reduced FEV1 :FVC (4.88% less than the norm), which was just short of significance (p = 0.059).Conclusions: Lung function is reduced both during and after treatment for PTB and these deficits may persist. This has implications regarding the need for pulmonary rehabilitation even after medical cure.Keywords: Lung function, pulmonary, tuberculosis

scholarly journals HUBUNGAN FAKTOR RESIKO DENGAN KEJADIAN PADA PENYAKIT PARU OBSTRUKSI KRONIK DI PUSKESMAS MANDALA

2019 ◽  
Vol 1 (2) ◽  
pp. 43-47
Author(s):  
Alamsyah Lukito
Keyword(s):  
Health Center ◽  
Smoke Inhalation ◽  
Chronic Obstructive ◽  
Test Results ◽  
Chi Square ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Chi Square Test ◽  
Analytical Research ◽  
Exposure To Secondhand Smoke

The main cause of Chronic Obstructive Pulmonary Disease is smoking or exposure to secondhand smoke from active smokers or smoke inhalation in passive smokers. Other causes are air pollution, workplace exposure, and genetic factors. This type of research is analytical research with a cross sectional approach which aims to study the existence of a variable relationship dynamics. In this study, the sample was 30 patients from the Mandala Health Center. Generally, COPD sufferers are those aged 45 years to 65 years where 21 of the 30 people suffer from risk. The chi-square test results show that there is a relationship between risk factors and the incidence of COPD in the Tembung Mandala 2018 Health Center Working Area.

scholarly journals Analysis of Risk Factors Affecting The Occurrence of Chronic Obstructive Pulmonary Disease in Indonesia

2021 ◽  
Vol 9 (1) ◽  
pp. 18
Author(s):  
Nurul Layly Firdausi ◽  
Kurnia Dwi Artanti ◽  
Chung-Yi Li
Keyword(s):  
Risk Factors ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Urban Areas ◽  
Airflow Limitation ◽  
Chronic Obstructive ◽  
Chi Square ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Factors Affecting

Background: Chronic obstructive pulmonary disease (COPD) is a lung disease caused by the occurrence of airflow limitation in the lungs and also causes 60% of all deaths in Indonesia. Purpose: This study aimed to analyze the risk factors that affect the incidence of COPD in Indonesia. Methods: This study was conducted in July–August 2019 in Indonesia as an analytic research study with a cross-sectional design, using data from the Indonesia Family Life Survey-5. The sample consisted of respondents aged >15 years, giving a total of 34,231 respondents. Data analysis was partially carried out using the chi-square test to analyze the relationships between the variables. Results: The majority of respondents were female, were aged <40 years, and had a low level of education. Risk factors for the development of COPD included, among others, an age of >40 years (p = 0.02; PR = 1.20; 95% CI = 1.02–1.41), male gender (p = 0.01; PR = 1.26; 95% CI = 1.07–1.49), smoking (p = 0.01; PR = 1.22 ; 95% CI = 1.03–1.44), first smoking age < 40 years (p = 0.02; PR = 1.22; 95% CI = 1.03–1.44), residence in urban areas (p = 0.01; PR = 1.43; 95% CI = 1.20–1.70), being underweight (p = 0.01; PR = 2.17; 95% CI = 1.76–2.66). Conclusions: The risk factors that affect the incidence of COPD include being aged >40 years, being male, smoking, taking up smoking when aged <40 years, urban residence, and being underweight.

scholarly journals Correlation between FEV1% Predicted and Blood Eosinophils in Patients with Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)

2021 ◽  
Vol 7 (2) ◽  
pp. 59
Author(s):  
Alfian Nurfaizi ◽  
Isnin Anang Marhana ◽  
Gadis Meinar Sari ◽  
Arief Bakhtiar
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Blood Eosinophil ◽  
Normal Body Mass Index ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Copd Exacerbations ◽  
Blood Eosinophils ◽  
Eosinophil Counts

Introduction: Chronic obstructive pulmonary disease (COPD) exacerbations are still the leading causes of mortality. Eosinophil counts were recommended in assessing the risk of exacerbations. This additional examination was preferred rather than the pulmonary function test (PFT), which was considered less precise and had vast differences. Therefore, an analysis of the correlation between the FEV1% predicted and blood eosinophil counts were needed as a reference in the diagnosis of COPD exacerbation. This study aimed to determine the correlation between FEV1% predicted and blood eosinophils counts in patients with COPD exacerbations.Methods: This was a retrospective cross-sectional study by analyzing medical records of patients with COPD exacerbations at Dr. Soetomo General Hospital, Surabaya, from 2017 to 2018.Results: The characteristics of patients with exacerbations of COPD consisted of 91.7% male patients. Most of them were in the age group of 61-70 years old, 58.3% were in the private sector, 75% had a high school diploma, and 41.7% had normal body mass index (BMI). The percentage of the FEV1% predicted is directly proportional to the percentage of blood eosinophils with weak and statistically insignificant strength.Conclusion: The FEV1% predicted and blood eosinophil counts had a very weak correlation and statistically insignificant strength. Thus, it could not be used as a reference for diagnosis using one of the variables. Further research is needed with sputum eosinophils and biopsy as consideration for more accurate results.

scholarly journals Anemia in Patients with Chronic Obstructive Pulmonary Disease in a Tertiary Care Hospital in Bangladesh

2014 ◽  
Vol 4 (3) ◽  
pp. 151-155
Author(s):  
Naser Ahmed ◽  
Rukhsana Parvin ◽  
Md Abul Kalam Azad
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Smoking Habit ◽  
Tertiary Care ◽  
Chronic Obstructive ◽  
Care Hospital ◽  
Anemia Of Chronic Disease ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients

Background: Chronic obstructive pulmonary disease (COPD) is usually associated with polycythemia. It is assumed that systemic inflammatory components of COPD can interfere with erythropoietin and can result in anemia of chronic disease which will impair the functional capacity of these patients and also increase morbidity and mortality. Objective: To evaluate anemia status in COPD patients. Materials and Methods: This cross-sectional study was conducted in clinically stable 50 COPD patients in the outpatient department of Medicine in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka during the period of July to December 2011. The demographic characteristics, smoking habit, duration of disease, types and severity of anemia, BMI and results of 6-minute walk test were recorded. Results: Out of 50 COPD patients, 76% were male and 24% were female. Among them 32% patients were anemic, 20% were polycythemic and 48% patients had normal hemoglobin. Among the anemic patients with COPD, 87% were male and 13% were female,75% were mildly anemic and 4% moderately anemic, 62.5% had normocytic and 37.5% had microcytic anemia. Conclusion: Anemia in COPD patients is often overlooked and underestimated. Clinicians should be aware of the presence of anemia in patients with COPD so that appropriate treatment could be initiated to improve the quality of life and prognosis DOI: http://dx.doi.org/10.3329/jemc.v4i3.20943 J Enam Med Col 2014; 4(3): 151-155

scholarly journals Previous tuberculosis disease as a risk factor for chronic obstructive pulmonary disease: a cross-sectional analysis of multicountry, population-based studies

Thorax ◽  
2021 ◽  
pp. thoraxjnl-2020-216500 ◽  
Author(s):  
Katarina Kamenar ◽  
Shakir Hossen ◽  
Akshay N Gupte ◽  
Trishul Siddharthan ◽  
Suzanne Pollard ◽  
...  
Keyword(s):  
Risk Factor ◽  
Lung Function ◽  
Low Income ◽  
Population Based ◽  
Forced Expiratory Volume ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Middle Income ◽  
Tuberculosis Disease

BackgroundRisk factors for COPD in high-income settings are well understood; however, less attention has been paid to contributors of COPD in low-income and middle-income countries (LMICs) such as pulmonary tuberculosis. We sought to study the association between previous tuberculosis disease and COPD by using pooled population-based cross-sectional data in 13 geographically diverse, low-resource settings.MethodsWe pooled six cohorts in 13 different LMIC settings, 6 countries and 3 continents to study the relationship between self-reported previous tuberculosis disease and lung function outcomes including COPD (defined as a postbronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) below the lower limit of normal). Multivariable regressions with random effects were used to examine the association between previous tuberculosis disease and lung function outcomes.ResultsWe analysed data for 12 396 participants (median age 54.0 years, 51.5% male); 332 (2.7%) of the participants had previous tuberculosis disease. Overall prevalence of COPD was 8.8% (range 1.7%–15.5% across sites). COPD was four times more common among those with previous tuberculosis disease (25.7% vs 8.3% without previous tuberculosis disease, p<0.001). The adjusted odds of having COPD was 3.78 times higher (95% CI 2.87 to 4.98) for participants with previous tuberculosis disease than those without a history of tuberculosis disease. The attributable fraction of COPD due to previous tuberculosis disease in the study sample was 6.9% (95% CI 4.8% to 9.6%). Participants with previous tuberculosis disease also had lower prebronchodilator Z-scores for FEV1 (−0.70, 95% CI −0.84 to −0.55), FVC (−0.44, 95% CI −0.59 to −0.29) and the FEV1:FVC ratio (−0.63, 95% CI −0.76 to −0.51) when compared with those without previous tuberculosis disease.ConclusionsPrevious tuberculosis disease is a significant and under-recognised risk factor for COPD and poor lung function in LMICs. Better tuberculosis control will also likely reduce the global burden of COPD.

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