scholarly journals Seropositivity of Hepatitis B and C among Syrian Multitransfused Patients

2016 ◽  
Vol 8 ◽  
pp. e2016046 ◽  
Author(s):  
Widad Yazaji ◽  
Wafa Habbal ◽  
Fawza Monem
Keyword(s):  
Blood Transfusion ◽  
Hepatitis B ◽  
Viral Hepatitis ◽  
Surgical Procedure ◽  
Immune Status ◽  
Blood Transfusions ◽  
Immunosorbant Assay ◽  
Hbv Vaccine ◽  
Window Period ◽  
Enzyme Linked Immunosorbant Assay

Background and objectives: Blood transfusion is a lifesaving therapy for patients with hemoglobinopathies. However, the need of frequent transfusion carries the risk of transmitting hepatitis B and C infections which are intermediately prevalent in Syria. Despite screening blood donations with sensitive methods, the risk of transmission is still present when infectious blood is donated within the window period. This study aimed to investigate the incidence of HBV and HCV seropositivity, and its association with multiple transfusions among Syrian hemoglobinopathies patients.Materials and Methods: HBsAg, anti-HBc, anti-HBs and anti-HCV were tested for 159 Syrian multitransfused patients by Enzyme Linked Immunosorbant Assay (ELISA).Results: Thirty-nine of 159 (24.5%) multitransfused patients were HBsAg/anti-HBc or anti-HCV positive, 26 (16%) of which never visited the dentist, and they either tested postsurgically negative for HBsAg and anti-HCV or never underwent a surgical procedure. On the contrary of anti-HCV seropositivity, HBsAg/anti-HBc seropositivity was significantly associated with the number of blood transfusions, number of blood units and age (P < 0.001).Conclusion: About one-sixth of our patients most likely acquired HBV/HCV infection via blood transfusion. Administering HBV vaccine, ensuring the immune status, and monitoring hepatitis markers might considerably minimize the incidence of viral hepatitis among multitransfused patients.

scholarly journals HEPATITIS B, C & HIV

2006 ◽  
Vol 13 (04) ◽  
pp. 632-636
Author(s):  
MOHAMMAD FAYYAZ ◽  
Muhammad Ayub Khan ◽  
MASROOR ALI QAZI ◽  
Ghulam Mohyud Din `Chaudhary ◽  
GULZAR AHMED
Keyword(s):  
Blood Transfusion ◽  
Hepatitis B ◽  
Past History ◽  
Hepatitis B Surface Antigen ◽  
Immunosorbant Assay ◽  
Human Immuno Deficiency Virus ◽  
History Of ◽  
Enzyme Linked Immunosorbant Assay ◽  
Age Range ◽  
Anti Hiv

Objective: To determine the prevalence of HBV, HCV and HIV in healthyblood donors in Blood Transfusion Services, Bahawal Victoria Hospital, Bahawalpur. Design: Prospective observationalstudy. Setting: Blood Transfusion Services, Bahawal Victoria Hospital (BVH), affiliated with Quaid-e-Azam medicalCollege Bahawalpur. Period: From 1 January t st o 31st December 2005. Methods and Materials: All the personscoming for blood donations , at the BVH facility, were included. Clinically anaemic, ill, past history of jaundice and ageof less than 18 or more than 50 years were excluded. All the donors (27938) from various areas of Bahawalpur,Bahawalnagar, Lodhran, Vehari and Rahim Yar Khan districts, were screened for hepatitis B surface antigen (HBs)Antigen, hepatitis C antibody (Anti HCV) & Human Immuno-deficiency Virus Antibody (Anti-HIV)on sera by one StepTest Device. All the positives cases were confirmed by Enzyme Linked Immunosorbant Assay. Results: Out of total27938, 25420(91%) were male. Mean age was 28 years with age range 18-50. No HIV positive case was detected.HBV was 2.69%, slightly more than HCV, 2.52%. Males were significantly (p<0.02) more infected than females.Conclusion: Risk of transmission of viral hepatitis is a major problem of blood transfusion. Frequency of viral hepatitisin blood donors is higher in our area as compared to rest of the world. HIV infection is very low. Preventive strategiesinclude good blood transfusion services along with safe sex and other measures.

scholarly journals A Cross-sectional Study on Hepatitis B Immune Status among Vaccinated Healthcare Workers in Khartoum, Sudan

2020 ◽  
pp. 35-42
Author(s):  
Abdullahi Elsheikh Mahgoub ◽  
Yassir Hamadalnil ◽  
Osama Mohammed ◽  
Rasha Nakhleh ◽  
Musa Mohamed Khair
Keyword(s):  
Immune Response ◽  
Hepatitis B ◽  
Health Personnel ◽  
Healthcare Workers ◽  
Immune Status ◽  
Cross Sectional Study ◽  
Easy Access ◽  
Cross Sectional ◽  
Post Vaccination ◽  
Hbv Vaccine

Background: Hepatitis B virus (HBV) infection can lead to chronic hepatitis, liver cirrhosis, and Hepatocellular Carcinoma (HCC). Vaccination against the virus plays an important role in its prevention. Health personnel at risk of infection are recommended to receive the vaccine and to check their immune status thereafterObjective:   To determine Hepatitis B Immune status among vaccinated health personnel in Khartoum state, Sudan.A total of 106 health personnel from different hospitals and doctors’mess in Khartoum and from different jobs were surveyed and their HBV surface antibodies levels were determined by HBsAb (Quantitative) ELISA Kits.Methods: Of the 106 participants in this study, the majority were females 72.6%. The mean age of those involved was 27.69 years, and nurses made for more than 50% of those surveyed. About 56.6% (60) of the health personnel involved took three or more doses of HBV vaccine while the rest received one or two doses. The results of the participants who received three or more doses of the vaccine represented immunity by 70%. In general, about 47.2% (50) of the participants in this study did show excellent immune response (> 100 mIU/mL) and 18.9% (20) had weak protective levels (between 10 and 100 mIU/mL)So, we concluded that HBV post-vaccination immunity status of health personnel in Khartoum state is lower than post-vaccination HBV immunity in other parts of the world. There is an urgent need for a national protocol of HBV vaccination to improve the immunization status of health personnel with a regular checkup of HBV immunity and easy access to a good-quality vaccine. Keywords: hepatitis B vaccines; healthcare workers; immune response

scholarly journals Knowledge, attitude and practice on hepatitis-B infection among infected patients in a Homoeopathy Medical Center in Dhaka City, Bangladesh

2016 ◽  
Vol 6 (1) ◽  
pp. 27-31
Author(s):  
Sazia Huq ◽  
Sarder Mahmud Hossain ◽  
Syed Mohammad Tanjilul Haque ◽  
Selina Akter
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Drug Users ◽  
Medical Center ◽  
Sampling Technique ◽  
Statistical Association ◽  
Cross Sectional ◽  
Hbv Vaccine ◽  
Attitude And Practice ◽  
Knowledge Attitude And Practice

Viral hepatitis is the commonest liver disease in Bangladesh. About 10 million people in Bangladesh have been suffering from hepatitis B. Hepatitis B is a potentiality life threatening liver infection caused by HBV. It is a major global health problem and the most serious type of viral hepatitis. The aim of this study is to assess the knowledge, attitude and practice on Hepatitis B Virus infection among the selected patients in Essence Homoeopathy Medical Center, Dhaka. A descriptive type of cross sectional study was carried out among 150 samples by using non-randomized purposive sampling technique and by the help of pretested modified questionnaire. Statistical association was calculated by chi-square test and all the Hepatitis B related data were analyzed by the help of SPSS (version 16). The study showed that 73.3% of the respondents’ age ranged from 15-35 years with mean age (32.44±10.54) and of them 96.7% was found to be Muslims. Among injectable drug users (IDUs) (19.3%), 27.6% was sharing same needle. Approximately 5% of the respondents had a history of taking unscreened blood among 28% of the respondents who experienced blood transfusion. Another concerning issue was that 77% of the respondents practiced polygamy sex and among them only 38.8% used protecting device during sexual activity. Majority (70.7%) of the respondents did not take HBV vaccine. Significant statistical association was found between education and vaccination against HBV (p-0.000). To prevent this deadly disease mass awareness has to be created among the people of active age group through media education and policy implementation.South East Asia Journal of Public Health Vol.6(1) 2016: 27-31

scholarly journals Assessing the level of awareness and vaccination status of Hepatitis B among young female community of Pakistan

2015 ◽  
Vol 14 (4) ◽  
pp. 376-383 ◽  
Author(s):  
Sadia Shakeel ◽  
Wajiha Iffat ◽  
Hina Rehman ◽  
Nadia Jamil ◽  
Faiza Nazeer ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Medical Science ◽  
Educational Status ◽  
Vaccination Status ◽  
Hbv Infection ◽  
P Value ◽  
Cross Sectional ◽  
Hbv Vaccine ◽  
Validated Questionnaire

Objectives: Hepatitis B virus (HBV) infection is a global health problem with about 2 billion infected persons. Pakistan is one of the endemic areas for viral hepatitis B. Prevention is merely a safe approach rather than curing against high incidence of viral hepatitis. Therefore, the aim of the present study was to assess the knowledge and awareness of HBV infection, its prevention and transmission, perception of HBV vaccine and vaccination status among young females of Karachi, Pakistan. Methods: This cross sectional study was conducted from Oct till Dec 2014 by adopting a pre-validated questionnaire distributed to female individuals in Karachi, Pakistan. Descriptive statistics were used to demonstrate students’ demographic information and their response to the questionnaire items. Kruskal Wallis H test was executed to evaluate the association of age and educational status of the respondents with their response. A p-value <0.05 was considered as significant. Results: Out of 550 survey questionnaires, only 434 were returned back in useable form. Hence the response rate was 78.9%. More than 90% had knowledge of HBV infection and 85.94% knew that HBV infection can be prevented by vaccination. However, only 17% had received HBV vaccination during childhood. 67.05% and 54.60% knew that HBV can be transmitted from mother to infant and an infected mother may transmit hepatitis B to her newborn baby through breast milk respectively. Only 24% had been tested for HBV in adulthood. General excuses for not having their HBV status tested, were lack of motivation (36.76%) and lack of time to check (21.54%). Conclusion: It indicates that majority of respondents showed some awareness of HBV and its related consequences. Yet, there are some misapprehensions regarding the attitudes that imitate a fallacy perception of the disease. It identifies a more standardized approach coupled with the well-structured health education programs pointing out such misconceptions.Bangladesh Journal of Medical Science Vol.14(4) 2015 p.376-383

Interferon in the treatment of viral hepatitis. The interferon was discovered 50 years ago

2007 ◽  
Vol 148 (33) ◽  
pp. 1539-1543 ◽  
Author(s):  
János Fehér ◽  
Gabriella Lengyel
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Interferon Gamma ◽  
Interferon Beta ◽  
Interferon Alfa

Az interferonok heterogén összetételű glycoproteinek, melyeket a vírusfertőzés hatására, az immunválasz során, az élő sejtek termelnek. Felfedezésük éppen fél évszázaddal ezelőtt történt. Daganatellenes, antivirális és immunmoduláns hatásúak. A terápiában használatos interferonok görög betűkkel jelölt formái utalnak az eredetre: az interferon-alfa leukocita-eredetű, az interferon-béta fibroblastokból származó, az interferon-gamma pedig lymphocyta-eredetű immuninterferon. A humán gyógyászatban a természetes és rekombináns interferonokat egyaránt alkalmazzák. A polietilén-glikollal történő összekapcsolás az interferonkészítmény tartós hatását biztosítja. Jelenleg a klinikumban leginkább hepatitis B és C vírus okozta krónikus hepatitisben a vírus eliminálására, valamint az onkológiában daganatprogresszió gátlására alkalmazzák.

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