Higher High Density Lipoprotein 2 (HDL2) to Total HDL Cholesterol Ratio Is Associated with a Lower Risk for Incident Hypertension

Objective: Elevated uric acid (UA) and low levels of high-density lipoprotein (HDL) cholesterol are associated with cardiovascular events and mortality. Erectile dysfunction (ED) has been considered an early marker of cardiovascular disease (CVD). Therefore, this study aimed to investigate the uric acid/ HDL ratio (UHR) as a nowel marker in patients with ED. Materials and Methods: The study included 147 patients with a mean age of 50 years (range 32-76 years). Retrospective analyses were performed on the patients who were admitted to urology outpatient clinics. The laboratory parameter results were retrieved from the hospital medical records, and the UHR value was calculated. Patients were categorized into three groups according to the International Index of Erectile Function (IIEF) score. UHR was compared between groups, and its predictive value was evaluated using regression analysis and ROC curve analysis. Results: Age was found to be significantly different in all three groups (Groups 1-2, p=0.001; Groups 1-3, p=0.000; Groups 2-3, p=0.001). It was observed that the degree of ED increased with age. The values of UA and HDL were similar in all groups (p>0.05). In contrast, the UHR value was statistically significantly higher 0.15 (0.083-0.288, p =0.047) in the moderate-severe ED (Group 3). ROC curve analyses revealed that UHR predicted severe ED (IIEF 5-11) with 42.9% sensitivity and 87.3% specificity (AUC:0.66, CI 95% 0.538-0.781, p=0.019). Conclusion: UHR may serve as a severe ED indicator in patients admitted to the cardiology outpatient clinic since it has a significant association with a low IIEF score.

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Abstract P175: High-density Lipoprotein Cholesterol and Mortality Prior to Age 90 in a Cohort of Male Physicians

Circulation ◽

10.1161/circ.125.suppl_10.ap175 ◽

2012 ◽

Vol 125 (suppl_10) ◽

Author(s):

Catherine Rahilly-Tierney ◽

Howard D Sesso ◽

J. Michael Gaziano ◽

Luc Djousse

Keyword(s):

High Density Lipoprotein ◽

Lower Risk ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Cox Proportional Hazards ◽

High Density ◽

Health Study ◽

Inverse Association ◽

Cvd Mortality

BACKGROUND: Few studies have examined prospectively the relationship between baseline high-density lipoprotein (HDL) cholesterol and longevity. OBJECTIVES: We sought to examine whether higher HDL levels were associated with lower risk of all-cause, cardiovascular (CVD), and non-CVD mortality prior to age 90 in the Physicians’ Health Study (PHS). METHODS: We considered a baseline cohort of 1351 PHS participants who provided bloods between 1997 and 2001 and were old enough to reach age 90 by March 4, 2009. Included subjects had complete baseline data on HDL and total cholesterol; lifestyle factors including smoking, exercise, alcohol consumption, and BMI; and comorbidities including hypertension, diabetes mellitus, congestive heart failure, cancer, and stroke. We used Cox proportional hazards to determine the HRs and 95% CIs for all-cause, CVD, and non-CVD mortality prior to age 90, adjusting for baseline age, co-morbidities, and non-HDL cholesterol. RESULTS: At baseline, the cohort had a mean (SD) age of 81.9 (2.9) years and a mean (SD) HDL cholesterol of 44.8(16.5) mg/dL. After a mean follow-up of 6.8 years (maximum 12.3 years), 501 (37.1%) of men died prior to age 90. In multi-variable adjusted analyses, men in the highest HDL-C quartile (≥54.1 mg/dL) had a 28% lower risk (HR 0.72, 95% CI 0.55-0.95) of all-cause mortality prior to age 90 compared to men in the lowest HDL-C quartile (<32.8 mg/dL). From the lowest to highest HDL quartile, age-adjusted HR(95%CI) for CVD mortality prior to age 90 were 0.66 (0.44-0.99), 0.58 (0.38-0.90), and 0.53 (0.34-0.82) (p for trend 0.004). There was no significant association between baseline HDL cholesterol and non-CVD death. CONCLUSION: In a cohort of older male physicians with long-term follow-up, baseline HDL cholesterol was inversely associated with the risk of dying prior to age 90, largely explained by an inverse association between HDL and CVD mortality.

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Effects of Smoking on Oral Fat Tolerance and High Density Lipoprotein Cholesterol

Clinical Science ◽

10.1042/cs0650669 ◽

1983 ◽

Vol 65 (6) ◽

pp. 669-672 ◽

Cited By ~ 19

Author(s):

R. S. Elkeles ◽

S. R. Khan ◽

V. Chowdhury ◽

M. B. Swallow

Keyword(s):

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Density Lipoprotein ◽

Serum Triglyceride ◽

Hdl Cholesterol ◽

High Density ◽

Lipoprotein Cholesterol ◽

Fatty Meal ◽

Cholesterol Ratio ◽

Average Serum

1. Changes in serum triglyceride and high density lipoprotein (HDL) cholesterol after a fatty meal have been studied in smokers and non-smokers. 2. Average serum triglyceride during the study was higher in smokers than in non-smokers. 3. In non-smokers there was a rise in the HDL2/HDL3 cholesterol ratio after oral fat, but not in smokers. 4. These findings are compatible with the hypothesis that smoking interferes with the lipolysis of triglyceride rich lipoproteins and the conversion of HDL3 into HDL2.

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Increased Oxidized High-Density Lipoprotein/High-Density Lipoprotein–Cholesterol Ratio as a Potential Indicator of Disturbed Metabolic Health in Overweight and Obese Individuals

Laboratory Medicine ◽

10.1093/labmed/lmz017 ◽

2019 ◽

Vol 51 (1) ◽

pp. 24-33

Author(s):

Jelena M Janac ◽

Aleksandra Zeljkovic ◽

Zorana D Jelic-Ivanovic ◽

Vesna S Dimitrijevic-Sreckovic ◽

Jelena Vekic ◽

...

Keyword(s):

High Density Lipoprotein ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Metabolic Health ◽

High Density ◽

Enzyme Linked Immunosorbent Assay ◽

Cholesterol Ratio ◽

Amyloid A ◽

Potential Indicator ◽

Metabolically Healthy

AbstractBackgroundWe evaluated the qualitative characteristics of high-density lipoprotein (HDL) particles in metabolically healthy and unhealthy overweight and obese subjects.MethodsThe study involved 115 subject individuals classified as metabolically healthy and unhealthy, as in overweight and obese groups. Commercial enzyme-linked immunosorbent assay (ELISA) kits were used to measure oxidized HDL (OxHDL) and serum amyloid A (SAA) concentrations. Lipoprotein subfractions were separated using nondenaturing gradient gel electrophoresis.ResultsAn independent association was shown between increased OxHDL/HDL-cholesterol ratio and the occurrence of metabolically unhealthy phenotype in the overweight and obese groups. The OxHDL/HDL-cholesterol ratio showed excellent and acceptable diagnostic accuracy in determination of metabolic health phenotypes (overweight group, AUC = 0.881; obese group, AUC = 0.765). Accumulation of smaller HDL particles in metabolically unhealthy subjects was verified by lipoprotein subfraction analysis. SAA concentrations did not differ significantly between phenotypes.ConclusionsIncreased OxHDL/HDL-cholesterol ratio may be a potential indicator of disturbed metabolic health in overweight and obese individuals.

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Association of triglycerides to high-density lipoprotein-cholesterol ratio with risk of incident hypertension

Hypertension Research ◽

10.1038/s41440-020-0439-8 ◽

2020 ◽

Vol 43 (9) ◽

pp. 948-955

Author(s):

Dechen Liu ◽

Li Guan ◽

Yang Zhao ◽

Yu Liu ◽

Xizhuo Sun ◽

...

Keyword(s):

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Incident Hypertension ◽

Cholesterol Ratio

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High-Density Lipoprotein Particles and Their Relationship to Posttransplantation Diabetes Mellitus in Renal Transplant Recipients

Biomolecules ◽

10.3390/biom10030481 ◽

2020 ◽

Vol 10 (3) ◽

pp. 481

Author(s):

Sara Sokooti ◽

Tamas Szili-Torok ◽

Jose L. Flores-Guerrero ◽

Maryse C. J. Osté ◽

António W. Gomes-Neto ◽

...

Keyword(s):

Diabetes Mellitus ◽

Renal Transplant ◽

High Density Lipoprotein ◽

Lower Risk ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

High Density ◽

Renal Transplant Recipients ◽

Transplant Recipients ◽

Cox Regression Analysis

High concentrations of high-density lipoprotein (HDL) cholesterol are likely associated with a lower risk of posttransplantation diabetes mellitus (PTDM). However, HDL particles vary in size and density with yet unestablished associations with PTDM risk. The aim of our study was to determine the association between different HDL particles and development of PTDM in renal transplant recipients (RTRs). We included 351 stable outpatient adult RTRs without diabetes at baseline evaluation. HDL particle characteristics and size were measured by nuclear magnetic resonance (NMR) spectroscopy. During 5.2 (IQR, 4.1‒5.8) years of follow-up, 39 (11%) RTRs developed PTDM. In multivariable Cox regression analysis, levels of HDL cholesterol (hazard ratio [HR] 0.61, 95% confidence interval [CI] 0.40–0.94 per 1SD increase; p = 0.024) and of large HDL particles (HR 0.68, 95% CI 0.50–0.93 per log 1SD increase; p = 0.017), as well as larger HDL size (HR 0.58, 95% CI 0.36–0.93 per 1SD increase; p = 0.025) were inversely associated with PTDM development, independently of relevant covariates including, age, sex, body mass index, medication use, transplantation-specific parameters, blood pressure, triglycerides, and glucose. In conclusion, higher concentrations of HDL cholesterol and of large HDL particles and greater HDL size were associated with a lower risk of PTDM development in RTRs, independently of established risk factors for PTDM development.

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Effect on High Density Lipoprotein Cholesterol of Atenolol and Oxprenolol in Patients with Mild Essential Hypertension

Clinical Science ◽

10.1042/cs063463s ◽

1982 ◽

Vol 63 (s8) ◽

pp. 463s-465s ◽

Cited By ~ 3

Author(s):

S. E. Kjeldsen ◽

I. Eide ◽

P. Leren ◽

O. P. Foss

Keyword(s):

Essential Hypertension ◽

High Density Lipoprotein ◽

Blood Pressure Reduction ◽

Density Lipoprotein ◽

Clinical Importance ◽

Hdl Cholesterol ◽

High Density ◽

Cholesterol Ratio ◽

Group I ◽

Effect Of Treatment

1. Nineteen healthy men aged 50 years, with untreated, mild essential hypertension WHO group I, were randomized into two groups to study the effect of treatment (18 weeks) with oxprenolol (n = 10) and atenolol (n = 9) on serum cholesterol fractions, total triglycerides and uric acid. 2. Oxprenolol lowered high density lipoprotein (HDL) cholesterol by 11.4% (P < 0.02) and cholesterol ratio (HDL cholesterol × 100/LDL + VLDL cholesterol) by 13.7% (P < 0.05). Atenolol lowered HDL cholesterol by 16.5% (P < 0.02) and cholesterol ratio by 19.2% (P < 0.01). 3. Oxprenolol and atenolol raised total triglycerides by 20.0% and 17.9% respectively. Only with atenolol was this increment statistically significant (P < 0.05). 4. The HDL cholesterol lowering effect of oxprenolol and atenolol observed in the present study may have clinical importance, since such metabolic side effects have been postulated to counteract the beneficial effect of blood pressure reduction on development of atherosclerosis and coronary heart disease in mild essential hypertension.

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Triglycerides and triglycerides to high-density lipoprotein cholesterol ratio are strong predictors of incident hypertension in Middle Eastern women

Journal of Human Hypertension ◽

10.1038/jhh.2011.70 ◽

2011 ◽

Vol 26 (9) ◽

pp. 525-532 ◽

Cited By ~ 31

Author(s):

M Tohidi ◽

M Hatami ◽

F Hadaegh ◽

F Azizi

Keyword(s):

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Middle Eastern ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Incident Hypertension ◽

Cholesterol Ratio ◽

Middle Eastern Women

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Alcohol Intake and Incident Myocardial Infarction: The Role of High-density Lipoprotein Cholesterol (P18-020-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz039.p18-020-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Shue Huang ◽

Zhe Huang ◽

Gregory Shearer ◽

Shanshan Li ◽

Shuohua Chen ◽

...

Keyword(s):

Myocardial Infarction ◽

Alcohol Consumption ◽

High Density Lipoprotein ◽

Lower Risk ◽

Alcohol Intake ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

High Density ◽

Penn State

Abstract Objectives The aim of this study is to test the hypothesis that the lower risk of myocardial infarction (MI) associated with alcohol intake is through its effect on raising high-density lipoprotein (HDL) cholesterol. Methods This study included 81,827 Chinese men and women (mean age: 51 ± 12 yr.) from the Kailuan Study who were free of cardiovascular disease in 2006 (at baseline) and were followed up to Dec. 2016. At baseline, alcohol consumption was assessed via a questionnaire and the concentration of HDL cholesterol was measured. Incident MI at follow up was a first MI event, confirmed by medical record review. Multivariable Cox regression was used to model the association between habitual alcohol intake and risks of MI, adjusting for potential covariates including age, sex, education, monthly income, occupation, smoking status, physical activity, body mass index, waist circumferences, hypertension, diabetes and total cholesterol. Mediated effect through HDL cholesterol was assessed using a causal mediating analysis (SAS macro). Results During an average of 9.6 years of follow-up, we documented 1095 incident cases. The adjusted hazard ratio (HR) for MI was 0.64 (95% confidence interval (CI), 0.54–0.76) for current alcohol drinkers compared with never or former. The ratio changed very slightly, to 0.65 (95% CI, 0.55–0.76) after further adjustment of HDL cholesterol concentration. Mediation analysis showed that HDL cholesterol concentrations mediated a small, non-significant proportion (1.8%) of the effect of alcohol on MI. Conclusions Alcohol consumption was associated with a lower risk for MI incidence in a large Chinese cohort. Our results suggest that the benefits associated with moderate alcohol consumption is not related to the effects of alcohol on HDL cholesterol. Funding Sources Start-up grant from Penn State College of Health and Human Development, and Penn State CyberScience Seed Grant Program.

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The Effect of Insulin Delivery Route on Lipoproteins in Type I Diabetic Patients on CAPD

Peritoneal Dialysis International ◽

10.1177/089686089901900213 ◽

1999 ◽

Vol 19 (2) ◽

pp. 148-153 ◽

Cited By ~ 7

Author(s):

Pasi I. Nevalainen ◽

Jorma T. Lahtela ◽

Jukka Mustonen ◽

Marja-Riitta Taskinen ◽

Amos Pasternack

Keyword(s):

Peritoneal Dialysis ◽

Glycemic Control ◽

High Density Lipoprotein ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

High Density ◽

Diabetic Patients ◽

Type I ◽

Subcutaneous Insulin ◽

Cholesterol Ratio

Objective To evaluate the influence of subcutaneous and intraperitoneal (IP) insulin on plasma lipoproteins in type I diabetic (IDDM) patients with end-stage renal failure (ESRD) treated with continuous ambulatory peritoneal dialysis (CAPD). Design A before–after trial. Setting University hospital outpatient care. Participants Eleven IDDM patients with stabilized peritoneal dialysis, age 42.9 ± 2.9 (SEM) years and duration of diabetes 31.4 ± 3.4 years. Intervention Two treatment periods during stabilized CAPD. All patients were first treated with subcutaneous and then with IP insulin. The studies were performed after a median time of 3 months on each treatment. Main Outcome Measures Plasma lipids; apoproteins (Apo) A-I, A-II, and B; high-density lipoprotein (HDL) subfractions; glycemic status; and uremic status. Results After changing from subcutaneous insulin to IP insulin, plasma HDL cholesterol decreased (from 1.29 ± 0.13 mmol/L to 0.96 ± 0.06 mmol/L, p < 0.05), and the low density to high density lipoprotein (LDL/HDL) cholesterol ratio increased ( p < 0.05). The HDL cholesterol decreased in both HDL2 and HDL3 fractions, but significantly so only in HDL3 ( p < 0.01). ApoA-I ( p < 0.05) decreased while the ApoB/ApoA-I ratio ( p < 0.01) and the ApoA-I/HDL-cholesterol ratio ( p < 0.01) increased during IP insulin therapy. Intraperitoneal insulin resulted in significantly better glycemic control than subcutaneous insulin ( p < 0.01). Conclusions In diabetic patients on CAPD therapy, IP insulin, although inducing better glycemic control than subcutaneous insulin, was associated with lowered plasma HDL cholesterol and ApoA-I levels. The atherogenic potential is probably less than expected as the relative particle size of HDL remained unchanged.

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