scholarly journals Is There Any Association Between Uric Acid to High-density Lipoprotein Cholesterol Ratio and Erectile Dysfunction?

2021 ◽  
Author(s):  
Dilay Karabulut ◽  
Mustafa Gürkan Yenice
Keyword(s):  
Uric Acid ◽  
Erectile Dysfunction ◽  
High Density Lipoprotein ◽  
Roc Curve ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
Roc Curve Analysis ◽  
Cholesterol Ratio ◽  
Group 3

Objective: Elevated uric acid (UA) and low levels of high-density lipoprotein (HDL) cholesterol are associated with cardiovascular events and mortality. Erectile dysfunction (ED) has been considered an early marker of cardiovascular disease (CVD). Therefore, this study aimed to investigate the uric acid/ HDL ratio (UHR) as a nowel marker in patients with ED. Materials and Methods: The study included 147 patients with a mean age of 50 years (range 32-76 years). Retrospective analyses were performed on the patients who were admitted to urology outpatient clinics. The laboratory parameter results were retrieved from the hospital medical records, and the UHR value was calculated. Patients were categorized into three groups according to the International Index of Erectile Function (IIEF) score. UHR was compared between groups, and its predictive value was evaluated using regression analysis and ROC curve analysis. Results: Age was found to be significantly different in all three groups (Groups 1-2, p=0.001; Groups 1-3, p=0.000; Groups 2-3, p=0.001). It was observed that the degree of ED increased with age. The values of UA and HDL were similar in all groups (p>0.05). In contrast, the UHR value was statistically significantly higher 0.15 (0.083-0.288, p =0.047) in the moderate-severe ED (Group 3). ROC curve analyses revealed that UHR predicted severe ED (IIEF 5-11) with 42.9% sensitivity and 87.3% specificity (AUC:0.66, CI 95% 0.538-0.781, p=0.019). Conclusion: UHR may serve as a severe ED indicator in patients admitted to the cardiology outpatient clinic since it has a significant association with a low IIEF score.

Effects of Smoking on Oral Fat Tolerance and High Density Lipoprotein Cholesterol

1983 ◽  
Vol 65 (6) ◽  
pp. 669-672 ◽  
Author(s):  
R. S. Elkeles ◽  
S. R. Khan ◽  
V. Chowdhury ◽  
M. B. Swallow
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Fatty Meal ◽  
Cholesterol Ratio ◽  
Average Serum

1. Changes in serum triglyceride and high density lipoprotein (HDL) cholesterol after a fatty meal have been studied in smokers and non-smokers. 2. Average serum triglyceride during the study was higher in smokers than in non-smokers. 3. In non-smokers there was a rise in the HDL2/HDL3 cholesterol ratio after oral fat, but not in smokers. 4. These findings are compatible with the hypothesis that smoking interferes with the lipolysis of triglyceride rich lipoproteins and the conversion of HDL3 into HDL2.

scholarly journals Increased Oxidized High-Density Lipoprotein/High-Density Lipoprotein–Cholesterol Ratio as a Potential Indicator of Disturbed Metabolic Health in Overweight and Obese Individuals

2019 ◽  
Vol 51 (1) ◽  
pp. 24-33
Author(s):  
Jelena M Janac ◽  
Aleksandra Zeljkovic ◽  
Zorana D Jelic-Ivanovic ◽  
Vesna S Dimitrijevic-Sreckovic ◽  
Jelena Vekic ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Metabolic Health ◽  
High Density ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cholesterol Ratio ◽  
Amyloid A ◽  
Potential Indicator ◽  
Metabolically Healthy

AbstractBackgroundWe evaluated the qualitative characteristics of high-density lipoprotein (HDL) particles in metabolically healthy and unhealthy overweight and obese subjects.MethodsThe study involved 115 subject individuals classified as metabolically healthy and unhealthy, as in overweight and obese groups. Commercial enzyme-linked immunosorbent assay (ELISA) kits were used to measure oxidized HDL (OxHDL) and serum amyloid A (SAA) concentrations. Lipoprotein subfractions were separated using nondenaturing gradient gel electrophoresis.ResultsAn independent association was shown between increased OxHDL/HDL-cholesterol ratio and the occurrence of metabolically unhealthy phenotype in the overweight and obese groups. The OxHDL/HDL-cholesterol ratio showed excellent and acceptable diagnostic accuracy in determination of metabolic health phenotypes (overweight group, AUC = 0.881; obese group, AUC = 0.765). Accumulation of smaller HDL particles in metabolically unhealthy subjects was verified by lipoprotein subfraction analysis. SAA concentrations did not differ significantly between phenotypes.ConclusionsIncreased OxHDL/HDL-cholesterol ratio may be a potential indicator of disturbed metabolic health in overweight and obese individuals.

scholarly journals Higher High Density Lipoprotein 2 (HDL2) to Total HDL Cholesterol Ratio Is Associated with a Lower Risk for Incident Hypertension

2019 ◽  
Vol 43 (1) ◽  
pp. 114 ◽  
Author(s):  
You-Cheol Hwang ◽  
Wilfred Y. Fujimoto ◽  
Steven E. Kahn ◽  
Donna L. Leonetti ◽  
Edward J. Boyko
Keyword(s):  
High Density Lipoprotein ◽  
Lower Risk ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
Incident Hypertension ◽  
Cholesterol Ratio

Effect on High Density Lipoprotein Cholesterol of Atenolol and Oxprenolol in Patients with Mild Essential Hypertension

1982 ◽  
Vol 63 (s8) ◽  
pp. 463s-465s ◽  
Author(s):  
S. E. Kjeldsen ◽  
I. Eide ◽  
P. Leren ◽  
O. P. Foss
Keyword(s):  
Essential Hypertension ◽  
High Density Lipoprotein ◽  
Blood Pressure Reduction ◽  
Density Lipoprotein ◽  
Clinical Importance ◽  
Hdl Cholesterol ◽  
High Density ◽  
Cholesterol Ratio ◽  
Group I ◽  
Effect Of Treatment

1. Nineteen healthy men aged 50 years, with untreated, mild essential hypertension WHO group I, were randomized into two groups to study the effect of treatment (18 weeks) with oxprenolol (n = 10) and atenolol (n = 9) on serum cholesterol fractions, total triglycerides and uric acid. 2. Oxprenolol lowered high density lipoprotein (HDL) cholesterol by 11.4% (P < 0.02) and cholesterol ratio (HDL cholesterol × 100/LDL + VLDL cholesterol) by 13.7% (P < 0.05). Atenolol lowered HDL cholesterol by 16.5% (P < 0.02) and cholesterol ratio by 19.2% (P < 0.01). 3. Oxprenolol and atenolol raised total triglycerides by 20.0% and 17.9% respectively. Only with atenolol was this increment statistically significant (P < 0.05). 4. The HDL cholesterol lowering effect of oxprenolol and atenolol observed in the present study may have clinical importance, since such metabolic side effects have been postulated to counteract the beneficial effect of blood pressure reduction on development of atherosclerosis and coronary heart disease in mild essential hypertension.

Neutrophil and monocyte ratios to high-density lipoprotein-cholesterol and adiponectin as biomarkers of nascent metabolic syndrome

2020 ◽  
Vol 41 (2) ◽  
Author(s):  
Ishwarlal Jialal ◽  
Ganesh Jialal ◽  
Beverley Adams-Huet ◽  
Neeraj Ramakrishnan
Keyword(s):  
Metabolic Syndrome ◽  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
High Density ◽  
Roc Curve Analysis ◽  
The Usa ◽  
Complete Blood Counts ◽  
Atherosclerotic Cardiovascular Diseases

AbstractBackgroundMetabolic syndrome (MetS) continues to be a significant problem globally, affecting nearly 35% of adults in the USA. Whilst there is no ideal biomarker that captures this disorder, high sensitivity C-reactive protein (hsCRP) appears to be most widely accepted. We examined the ratios between neutrophils (PMNs) and monocytes to high-density lipoprotein (HDL)-cholesterol and adiponectin, two anti-inflammatory proteins, in patients with nascent MetS without the confounding of diabetes, atherosclerotic cardiovascular diseases (ASCVD), smoking or lipid therapy to determine if they were also valid biomarkers of MetS.Materials and methodsPatients with nascent MetS (n = 58) and matched controls (n = 44) were recruited from Sacramento County. Fasting blood samples were obtained for complete blood counts, basic metabolic panel, lipid profile, insulin and adiponectin. Ratios of PMNs and monocytes to HDL-C and adiponectin were calculated and compared statistically.ResultsThe PMN:HDL-C, monocyte:HDL-C, PMN:adiponectin and monocyte:adiponectin ratios were significantly increased in patients with MetS and increased with increasing severity of MetS. Receiver operating characteristic (ROC) curve analysis showed that both the PMN:HDL-C and monocyte:HDL-C areas under the curve (AUCs) significantly added to the CRP AUC. Also both the ratios correlated with cardio-metabolic features of MetS, hsCRP and insulin resistance.ConclusionsOur data indicates that ratios of neutrophils and monocytes to HDL-C are significantly increased in patients with nascent MetS and both ratios appear to be better predictors of MetS than hsCRP alone. These important preliminary findings need to be confirmed in large prospective databases.

The Association between Plasma Cholesterol, High-Density-Lipoprotein Cholesterol, Triglycerides and Uric Acid in Ethanol Consumers

1985 ◽  
Vol 22 (1) ◽  
pp. 62-66 ◽  
Author(s):  
J K Allen ◽  
M A Adena
Keyword(s):  
Uric Acid ◽  
Alcohol Consumption ◽  
High Density Lipoprotein ◽  
Cholesterol Synthesis ◽  
Plasma Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Epidemiological Data ◽  
High Density ◽  
The Relationship

The relationship between the concentrations of plasma cholesterol, high-density-lipoprotein (HDL) cholesterol, triglycerides and uric acid has been studied in relation to alcohol consumption in men attending a health-screening centre. Although it has been suggested that these metabolites are associated with each other by environmental factors, including ethanol consumption, the only correlation we have found between the variables which is statistically significantly related to alcohol consumption is that between total cholesterol and uric acid. A comparison of these correlations with epidemiological data suggests that assessment of cardiovascular risk is best done by using plasma cholesterol and uric acid levels, corrected for alcohol consumption. The correlation between HDL-cholesterol and the remaining fractions of plasma cholesterol is constant over all levels of alcohol consumption, and therefore the division of cholesterol between these fractions is apparently independent of both alcohol consumption and cholesterol synthesis.

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