scholarly journals Was it a case of acute disseminated encephalomyelitis? A rare association following dengue fever

2013 ◽  
Vol 04 (03) ◽  
pp. 318-321 ◽  
Author(s):  
Ritu Karoli ◽  
Zeba Siddiqi ◽  
Jalees Fatima ◽  
Sumit Maini
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Febrile Illness ◽  
Complete Recovery ◽  
Acute Disseminated Encephalomyelitis ◽  
Neurological Complications ◽  
Methyl Prednisolone ◽  
Immune Mediated ◽  
Atypical Manifestations ◽  
Lag Period

ABSTRACTDengue infection, caused by a flavivirus is endemic in more than hundred countries, mostly in the developing world. Recent observations indicate that the clinical profile of dengue is changing, and that atypical manifestations are being reported more frequently. The exact incidence of various neurological complications is variable. Acute disseminated encephalomyelitis (ADEM) is a neurological manifestation rarely described in association with dengue. We present a patient, 32-year-old female who was diagnosed as a case of dengue fever initially after an acute febrile illness and two weeks later admitted in emergency with seizures and altered sensorium. Although MRI did not show typical lesions suggestive of ADEM, the lag period between initial dengue infection and neurological manifestations and complete recovery with methyl prednisolone point towards immune mediated demyelinating illness.

scholarly journals Oculogyric Crisis – Atypical Presentation in Patient with Dengue Fever

2021 ◽  
pp. 19-23
Author(s):  
Saurabh Rajkumar Jain ◽  
Jitendra D. Lakhani ◽  
Pramod R. Jha
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Neurological Complications ◽  
Oculogyric Crisis ◽  
Co Morbidity ◽  
Wide Range ◽  
Chief Complaints ◽  
Plasma Leakage ◽  
Multi Organ Dysfunction Syndrome ◽  
Rule Out

Here we are presenting a case of dengue fever presented with an atypical symptom of “oculogyric crisis” with features of multi organ dysfunction syndrome. Increased vascular permeability, plasma leakage, haemorrhagic manifestations, and thrombocytopenia are charecteristics of dengue fever.  A 19 year old male patient, with no co-morbidity came to Dhiraj hospital with chief complaints of  fever which was high grade & intermittent, it is associated with chills & rigours for 5 days. Also complain of abdominal pain over epigastric region, dull aching non radiating associated with decreased appetite since 5 days. Dengue infection has a wide range of clinical features. Neurological complications can occur in any spectrum of dengue infection.  The diagnosis of oculogyric crisis is majorly clinical and it requires a focused detailed history and detailed physical examination to find out possible triggers for the crisis and to rule out other reasons for abnormal eye movements.

scholarly journals Movement Disorders Associated with COVID-19

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Mehri Salari ◽  
Bahareh Zaker Harofteh ◽  
Masoud Etemadifar ◽  
Nahad Sedaghat ◽  
Hosein Nouri
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Movement Disorders ◽  
Viral Infections ◽  
De Novo ◽  
Complete Recovery ◽  
Neurological Complications ◽  
Causal Link ◽  
Immune Mediated

As neurological complications associated with COVID-19 keep unfolding, the number of cases with COVID-19-associated de novo movement disorders is rising. Although no clear pathomechanistic explanation is provided yet, the growing number of these cases is somewhat alarming. This review gathers information from 64 reports of de novo movement disorders developing after/during infection with SARS-CoV-2. Three new cases with myoclonus occurring shortly after a COVID-19 infection are also presented. Treatment resulted in partial to complete recovery in all three cases. Although the overall percentage of COVID-19 patients who develop movement disorders is marginal, explanations on a probable causal link have been suggested by numerous reports; most commonly involving immune-mediated and postinfectious and less frequently hypoxic-associated and ischemic-related pathways. The current body of evidence points myoclonus and ataxia out as the most frequent movement disorders occurring in COVID-19 patients. Some cases of tremor, chorea, and hypokinetic-rigid syndrome have also been observed in association with COVID-19. In particular, parkinsonism may be of dual concern in the setting of COVID-19; some have linked viral infections with Parkinson’s disease (PD) based on results from cerebrospinal fluid analyses, and PD is speculated to impact the outcome of COVID-19 in patients negatively. In conclusion, the present paper reviewed the demographic, clinical, and treatment-associated information on de novo movement disorders in COVID-19 patients in detail; it also underlined the higher incidence of myoclonus and ataxia associated with COVID-19 than other movement disorders.

Micturition Disturbance: A Predominant Feature of Acute Disseminated Encephalomyelitis

2021 ◽  
Author(s):  
Sandesh Kini ◽  
Ramesh Y. Bhat ◽  
Lakshmikanth Halegubbi Karegowda
Keyword(s):  
Urinary Retention ◽  
Supportive Therapy ◽  
Febrile Illness ◽  
Complete Recovery ◽  
Acute Disseminated Encephalomyelitis ◽  
Bladder Function ◽  
Neurological Deficits ◽  
Long Time ◽  
Characteristic Features ◽  
Magnetic Resonance Imaging Mri

AbstractUrinary retention in children can have varied etiology ranging from anatomic to functional causes. Functional causes include neuropathies, including rare central nervous system (CNS) involvement, such as acute disseminated encephalomyelitis (ADEM). ADEM is usually preceded by acute viral infection and commonly presents with multifocal neurological deficits. The ADEM diagnosis is mainly based on the clinical presentation and its correlation with characteristic CNS findings on magnetic resonance imaging (MRI). Here, we report an adolescent boy who presented with acute urinary retention preceded by an acute febrile illness. The patient was worked up thoroughly, including an MRI of the brain and spine, which revealed ADEM's characteristic features. The bladder function was evaluated periodically. The voiding dysfunction persisted for a long time. Treatment with steroids and other supportive therapy ultimately lead to a complete recovery over 6 months.

Study on Clinical Spectrum, Laboratory Profile and Outcome of Dengue Fever in Adults

Mediscope ◽  
2021 ◽  
Vol 8 (1) ◽  
pp. 33-39
Author(s):  
Muhammad Ashraful Kabir ◽  
Syed Didarul Haque ◽  
Baishakhi Islam ◽  
Hasan Imam
Keyword(s):  
Abdominal Pain ◽  
Pleural Effusion ◽  
Dengue Fever ◽  
Laboratory Finding ◽  
Dengue Infection ◽  
Febrile Illness ◽  
Clinical Spectrum ◽  
Structural Protein ◽  
Careful Clinical Examination ◽  
Laboratory Profile

Background: Dengue infection is a major health burden, which can result in mild self-limited febrile illness to highly fatal haemorrhagic disease. Infection is caused by Dengue virus, which is transmitted by the Aedes aegypti mosquito. Objective: The aim of the study was to see the clinical spectrum, laboratory profile and outcome of dengue fever in adult. Methods: This prospective observational study was carried out on 75 patients in the department of medicine of Bangabandhu Sheikh Mujib Medical University, Dhaka from 11/07/2019 to 20/10/2019. All patients above 18 years with confirmed dengue, who were either hospitalized or managed as outdoor patients with NS1 (non-structural protein) antigen and/ or IgM dengue antibody positive were included in the study. The patients with concomitant malaria, typhoid and leptospirosis were excluded from the study. Detailed history and careful clinical examination were performed on each patient. Results: In this study, all patients (100%) had fever. Among them, 70 (93.3%) was suffering from headache, 66 (88.0%) myalgia, 32 (42.7%) abdominal pain, 30 (40.0%) conjuctival suffusion, 29 (38.7%) nausea/vomiting, 27 (36.0%) skin rashes, 14 (18.7%) pleural effusion, 13 (17.3%) ascites, 13 (17.3%) retro-orbital pain, 11 (14.7%) itching, 8 (10.7%) hepatomegaly, 7 (9.3%) splenomegaly. Death occurred in 3 (4.0%) patients. Rate of cure was 58 (77.3%) and ICU admission was required in 14 (18.7%), they were ultimately cured. Conclusion: Fever associated with headache and myalgia were the most common symptoms. Other common clinical features were abdominal pain, conjunctival suffusion, nausea/vomiting, skin rashes and pleural effusion. Regarding laboratory finding, platelet count has little role in management of dengue patients. Mediscope Vol. 8, No. 1: January 2021, Page 33-39

scholarly journals Dengue: a new challenge for neurology

2012 ◽  
Vol 4 (3) ◽  
pp. 15 ◽  
Author(s):  
Marzia Puccioni-Sohler ◽  
Marco Orsini ◽  
Cristiane N. Soares
Keyword(s):  
Dengue Infection ◽  
Hemorrhagic Fever ◽  
Acute Disseminated Encephalomyelitis ◽  
Neurological Complications ◽  
Immunoglobulin M ◽  
Neurological Manifestations ◽  
Dengue Vaccine ◽  
Autoimmune Reaction ◽  
Viral Antigens ◽  
The World

Dengue infection is a leading cause of illness and death in tropical and subtropical regions of the world. Forty percent of the world’s population currently lives in these areas. The clinical picture resulting from dengue infection can range from relatively minor to catastrophic hemorrhagic fever. Recently, reports have increased of neurological manifestations. Neuropathogenesis seems to be related to direct nervous system viral invasion, autoimmune reaction, metabolic and hemorrhagic disturbance. Neurological manifestations include encephalitis, encephalopathy, meningitis, Guillain-Barré syndrome, myelitis, acute disseminated encephalomyelitis, polyneuropathy, mononeuropathy, and cerebromeningeal hemorrhage. The development of neurological symptoms in patients with positive Immunoglobulin M (IgM) dengue serology suggests a means of diagnosing the neurological complications associated with dengue. Viral antigens, specific IgM antibodies, and the intrathecal synthesis of dengue antibodies have been successfully detected in cerebrospinal fluid. However, despite diagnostic advancements, the treatment of neurological dengue is problematic. The launch of a dengue vaccine is expected to be beneficial.

scholarly journals Clinical profile of dengue infection at a teaching hospital in North India

2011 ◽  
Vol 6 (07) ◽  
pp. 551-554 ◽  
Author(s):  
Ritu Karoli ◽  
Jalees Fatima ◽  
Zeba Siddiqi ◽  
Khursheed I Kazmi ◽  
Amit R Sultania
Keyword(s):  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Indian Subcontinent ◽  
Dengue Infection ◽  
Hemorrhagic Fever ◽  
North India ◽  
World Health ◽  
Health Concern ◽  
Neurological Involvement ◽  
Atypical Manifestations

Introduction: Dengue viral infections are among the most important mosquito-borne diseases of the Indian subcontinent and have become a major global public health concern. Spread of disease has led to increased recognition of atypical manifestations apart from the classical clinical features of dengue infection. Methodology: A cross-sectional study of admitted patients suspected to have dengue infection was conducted during the monsoon and post-monsoon seasons in the year 2010. Patients who had serological confirmation of dengue infection were classified according to World Health Organization definitions of dengue fever and dengue hemorrhagic fever. Clinical and biochemical parameters were compared between the two groups. Results: Out of 356 patients with suspected dengue fever enrolled in the study, 138 (39%) had serologically confirmed dengue infection. Eighty (58%) patients were males and 58 (42%) were females. Ninety-six (70%) patients had classical dengue fever while 42 (30%) had dengue hemorrhagic fever. The most common symptoms were headache (105, 76%), abdominal pain (87, 63%), vomiting (80, 58%), rash (36, 26%), and cutaneous hypersensitivity (22, 16%). Hemorrhagic manifestations were present in 55 (40%) patients. Atypical manifestations were recorded. Notably, 14% of patients had neurological involvement and 4% had acute hepatic failure. Overall mortality was 6% and all fatal cases were due to multi-organ failure. Conclusion: Dengue infection poses a huge burden to the health-care system; its spectrum ranges from mild self-limiting illness to severe fatal disease. It can have varied and multi-systemic manifestations which can go unrecognized. Clinicians should have a high index of suspicion for atypical manifestations.

scholarly journals ASSESSMENT OF KNOWLEDGE, ATTITUDES AND PRACTICE TOWARD DENGUE FEVER AMONG UNIVERSITY STUDENTS IN MALAYSIA

2021 ◽  
Vol 3 (1) ◽  
pp. 289-300
Keyword(s):  
University Students ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Febrile Illness ◽  
Simple Random Sampling ◽  
Health Concern ◽  
P Value ◽  
Cross Sectional ◽  
Level Of Knowledge ◽  
Dengue Prevention

Introduction: Dengue fever is an acute febrile illness with a significant public health concern in tropical and subtropical countries. Population knowledge and practice play an essential role in the transmission and prevention of the disease. This study aims to evaluate the level of knowledge, attitudes, and practice regarding dengue fever among Malaysian university students. Methods: A cross-sectional descriptive study was conducted in twenty-five randomly selected universities across Malaysia. A total of 1520 respondents were approached by simple random sampling method. A previously validated and published questionnaire was used with little modification. The associations between the level of knowledge, Attitudes, and practice with different risk factors were calculated statistically and the significant association was considered with a p-value <0.05. Results: The data were analysed and showed that most of the students (56.3%, 46.2%, and 43.3%) has a moderate level of knowledge, attitude, and practice respectively toward dengue infection among the respondents. The result shows a significant association between the level of practice and knowledge (p-value <0.001) as well as between the level of practice and attitudes (p-value <0.001). Conclusion: The significant association between the practice and knowledge along with attitudes indicates the more knowledge and attitudes lead to better practice. This study highlighted the important role of university students in dengue prevention-based programs. They should be exposed more to improve and transfer their knowledge and attitude to other community population to reduce the incidence of dengue not only in Malaysia but globally.

Spontaneous Spinal Subarachnoid Haemorrhage: A Rare Complication of Dengue Fever

2017 ◽  
Vol 2 (2) ◽  
pp. 54
Author(s):  
Nur Hidayati Mohd Sharif ◽  
Nor Arisah Misnan ◽  
Norashikin Saidon ◽  
Phaik Yee Ooi ◽  
Hilwati Hashim
Keyword(s):  
Subarachnoid Haemorrhage ◽  
Lower Limb ◽  
Rare Complication ◽  
Dengue Infection ◽  
Febrile Illness ◽  
Neurological Complications ◽  
Sensory Function ◽  
Limb Weakness ◽  
Surgical Interventions ◽  
Lower Limb Weakness

A 37-year-old woman presented with a short history of fever and bilateral lower limb weakness. She also had impaired sensory function up to T4 spine level and lax anal tone. Laboratory investigations confirmed dengue infection with mild thrombocytopenia. MRI of the spine showed a spinal subarachnoid haemorrhage from the level of T4 till T9. Despite medical and surgical interventions, her lower limb weakness persists. A high index of suspicion is needed to recognise dengue-related neurological complications. This diagnosis should be considered in any patients from dengue endemic areas presenting with acute febrile illness with atypical neurological manifestations.

scholarly journals Frequency and Clinical Manifestations of Dengue in Urban Medellin, Colombia

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Berta Nelly Restrepo ◽  
Mark E. Beatty ◽  
Yenny Goez ◽  
Ruth E. Ramirez ◽  
G. William Letson ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Dengue Fever ◽  
Low Income ◽  
Dengue Infection ◽  
Diagnostic Testing ◽  
Clinical Manifestations ◽  
Febrile Illness ◽  
Hemorrhagic Fever ◽  
Dengue Virus Infection ◽  
Medical Facilities

A dengue fever surveillance study was conducted at three medical facilities located in the low-income district of San Javier in Medellin, Colombia. During March 2008 to 2009, 781 patients with fever regardless of chief complaint were recruited for acute dengue virus infection testing. Of the 781 tested, 73 (9.3%) were positive for dengue infection. Serotypes DENV-2 (77%) and -3 (23%) were detected by PCR. One patient met the diagnostic criteria for dengue hemorrhagic fever. Only 3 out of 73 (4.1%) febrile subjects testing positive for dengue infection were diagnosed with dengue fever by the treating physician. This study confirms dengue virus as an important cause of acute febrile illness in Medellin, Colombia, but it is difficult to diagnose without dengue diagnostic testing.

scholarly journals Dengue Fever as A Cause of Acute Disseminated Encephalomyelitis (ADEM)

1970 ◽  
Vol 12 (2) ◽  
pp. 185-187 ◽  
Author(s):  
RN Chowdhury ◽  
MR Siddiqui ◽  
MS Mahbub ◽  
OSI Hasan ◽  
A Talukder ◽  
...  
Keyword(s):  
Viral Infection ◽  
Dengue Fever ◽  
Acute Disseminated Encephalomyelitis ◽  
Neurological Complications ◽  
Urban Populations

Dengue fever is very common in Bangladesh. Every year a large number of urban populations suffer from this viral infection. Various presentations of dengue fever have been documented. Neurological complications in dengue fever are relatively uncommon. Among these, Acute Disseminated Encephalomyelitis (ADEM) has been observed in very few cases. Here we present a case of 13 year old girl suffering from ADEM following dengue fever. Keyword: Acute Disseminated Encephalomyelitis, Dengue fever, Neurological complication.DOI: http://dx.doi.org/10.3329/jom.v12i2.8428 JOM 2011; 12(2): 185-187

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