scholarly journals Comparison of acid-fast stain and culture for Mycobacterium tuberculosis in pre- and post-bronchoscopy sputum and bronchoalveolar lavage in HIV-infected patients with atypical chest X-ray in Ethiopia

2007 ◽  
Vol 2 (4) ◽  
pp. 154 ◽  
Author(s):  
Getachew Aderaye ◽  
Haimanot G/Egziabher ◽  
Abraham Aseffa ◽  
Alemayehu Worku ◽  
Lars Lindquist
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Bronchoalveolar Lavage ◽  
X Ray ◽  
Chest X Ray

scholarly journals Early chest X-ray in persons with presumptive tuberculosis increases Xpert® MTB/RIF diagnostic yield and efficiency

2020 ◽  
Vol 10 (1) ◽  
pp. 17-20
Author(s):  
Z. Nadiah ◽  
R. C. Koesoemadinata ◽  
S. M. McAllister ◽  
G. Putriyani ◽  
L. Chaidir ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Diagnostic Yield ◽  
Content Type ◽  
X Ray ◽  
Acid Fast Bacilli ◽  
Number Needed To Screen ◽  
Sputum Microscopy ◽  
Chest X Ray

Adult presumptive tuberculosis (TB) patients (n = 1690) were screened for TB using a questionnaire, chest X-ray (CXR) and sputum microscopy for acid-fast bacilli (AFB); <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> culture was performed for 74% of the patients and Xpert® MTB/RIF was done for 17.2%. Among patients recruited, 943 (55.8%) were diagnosed with TB, of whom 870 (92.3%) were bacteriologically confirmed and 73 (7.7%) were clinically diagnosed on the basis of CXR. Using CXR prior to culture or Xpert testing reduces the number needed to screen from 7.6 to 5.0. Using CXR to triage for culture or Xpert testing reduces the number of missed cases and increases the efficiency of culture and Xpert testing.

scholarly journals 757. Community Prevalence of Bacteriologically Confirmed Pulmonary Tuberculosis: A 7-Year Retrospective Study

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S272-S272
Author(s):  
Nandini Sethuraman ◽  
M a Thirunarayan ◽  
R Subbulakshmi ◽  
V Lakshmisree ◽  
Udhaya Balasubramanian
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Large Scale ◽  
Health Check ◽  
Prior History ◽  
First Line ◽  
X Ray ◽  
Chest X Ray ◽  
Culture Positive ◽  
Line Drug

Abstract Background It is estimated that about 40% of the Indian population is infected with Mycobacterium tuberculosis (TB), the vast majority of whom have latent TB. However, asymptomatic pulmonary carriage of the TB bacteria contributes to sustenance of the disease in the community and subsequent transmission. The present study was carried out to see the prevalence of culture positive pulmonary tuberculosis in apparently asymptomatic individuals from the community. Methods The study population consisted of individuals wishing to migrate to the USA/UK/Canada/Australia and submitting for the mandatory health check prior to obtaining the Visa. Chest X-ray was the initial screening test for diagnosis of tuberculosis. Individuals with any X-ray abnormalities were directed to submit three sputum samples for microscopy and culture which was done on automated culture systems (BacTALERT and MGIT). First-line drug susceptibility (INH, Rifampicin, Pyrazinamide, Ethambutol, Streptomycin) testing data were retrieved wherever available. Data were obtained for a period of 7 years from August 2010 to July 2017. Results A total of 140,499 individuals presented for the health check. Of these, 1,002 (0.7%) were further investigated using sputum microscopy and culture based on chest X-ray findings. Of these, 42 (0.4%) individuals were sputum culture positive for Mycobacterium tuberculosis. Except two, none had any respiratory complaints. Eleven (27.5%) of them were smear positive for acid fast bacilli. Most of the patients (30%) belonged to the age group of 18–25 years. Eighty-four percent had no prior history of tuberculosis or treatment for TB. Fifty-nine percent isolates were sensitive to all first-line drugs (Isoniazid, rifampicin, pyrazinamide, ethambutol and streptomycin). Twenty-seven percent were resistant to pyrazinamide alone. Fourteen percent were resistant to more than one first-line drug. There were no cases of multidrug resistance. Conclusion This is a unique large-scale study which assesses prevalence of culture positive pulmonary tuberculosis in the urban Indian community. It stresses the need for more stringent public health measures to curb transmission of the disease in such a high endemic region such as India. Disclosures All authors: No reported disclosures.

scholarly journals Coinfection of SARS-CoV-2 and MTB: how not to miss the wood for the trees

2021 ◽  
Vol 14 (7) ◽  
pp. e240581
Author(s):  
Jeny Jacob ◽  
Rajesh Venkataram ◽  
Giridhar Belur Hosmane
Keyword(s):  
Multiple Sclerosis ◽  
Mycobacterium Tuberculosis ◽  
Nucleic Acid ◽  
Young Woman ◽  
Nucleic Acid Amplification Test ◽  
Nucleic Acid Amplification ◽  
Intensive Phase ◽  
X Ray ◽  
Chest X Ray ◽  
Scarce Data

Scarce data exist about the coinfection of SARS‐CoV‐2 and Mycobacterium tuberculosis (MTB). A young woman who was undergoing treatment for multiple sclerosis was brought to our hospital with a COVID-19 positive status. On further evaluation, her chest X-ray showed right upper and mid-zone opacity, which lead to the suspicion of MTB. Her sputum came positive for acid-fast bacilli (AFB) staining and cartridge-based nucleic acid amplification test (CBNAAT) confirmed it, and rifampicin resistance was not detected. She was started on an antitubercular regimen. She was discharged, and by the end of the intensive phase of treatment, her symptoms subsided, but her sputum CBNAAT still showed the presence of TB bacillus.

scholarly journals Ensemble deep learning for tuberculosis detection

2020 ◽  
Vol 17 (2) ◽  
pp. 1014
Author(s):  
Mohd Hanafi Ahmad Hijazi ◽  
Leong Qi Yang ◽  
Rayner Alfred ◽  
Hairulnizam Mahdin ◽  
Razali Yaakob
Keyword(s):  
Infectious Disease ◽  
Machine Learning ◽  
Lung Cancer ◽  
Mycobacterium Tuberculosis ◽  
Deep Learning ◽  
Tubercle Bacillus ◽  
X Ray ◽  
Initial Stage ◽  
The World ◽  
Chest X Ray

Tuberculosis (TB) is one of the deadliest infectious disease in the world. TB is caused by a type of tubercle bacillus called Mycobacterium Tuberculosis. Early detection of TB is pivotal to decrease the morbidity and mortality. TB is diagnosed by using the chest x-ray and a sputum test. Challenges for radiologists are to avoid confused and misdiagnose TB and lung cancer because they mimic each other. Semi-automated TB detection using machine learning found in the literature requires identification of objects of interest. The similarity of tissues, veins and small nodules presenting the image at the initial stage may hamper the detection. In this paper, an approach to detect TB, that does not require segmentation of objects of interest, based on ensemble deep learning, is presented. Evaluation on publicly available datasets show that the proposed approach produced a model that recorded the best accuracy, sensitivity and specificity of 91.0%, 89.6% and 90.7% respectively.

Comparative Study Between Using QuantiFERON, Acid Fast Bacilliand Chest X-ray In Diagnosis Of Mycobacterium Tuberculosis Infection In Al-Mansoura Hospital-Libya

2017 ◽  
pp. 1
Author(s):  
مرفوعة صالح ◽  
سليمة رزق الله اقوديدر ◽  
وسام محمد محارب ◽  
محمد عبدالرسول المبروك
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Comparative Study ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
X Ray ◽  
Chest X Ray

scholarly journals Ensemble deep learning for tuberculosis detection using chest X-ray and canny edge detected images

2019 ◽  
Vol 8 (4) ◽  
pp. 429 ◽  
Author(s):  
Mohd Hanafi Ahmad Hijazi ◽  
Stefanus Kieu Tao Hwa ◽  
Abdullah Bade ◽  
Razali Yaakob ◽  
Mohammad Saffree Jeffree
Keyword(s):  
Lung Cancer ◽  
Mycobacterium Tuberculosis ◽  
Deep Learning ◽  
Detection Rate ◽  
Early Stage ◽  
X Ray ◽  
Different Types ◽  
Chest X Ray ◽  
Canny Edge ◽  
New Type

Tuberculosis (TB) is a disease caused by Mycobacterium Tuberculosis. Detection of TB at an early stage reduces mortality. Early stage TB is usually diagnosed using chest x-ray inspection. Since TB and lung cancer mimic each other, it is a challenge for the radiologist to avoid misdiagnosis. This paper presents an ensemble deep learning for TB detection using chest x-ray and Canny edge detected images. This method introduces a new type of feature for the TB detection classifiers, thereby increasing the diversity of errors of the base classifiers. The first set of features were extracted from the original x-ray images, while the second set of features were extracted from the edge detected image. To evaluate the proposed approach, two publicly available datasets were used. The results show that the proposed ensemble method produced the best accuracy of 89.77%, sensitivity of 90.91% and specificity of 88.64%. This indicates that using different types of features extracted from different types of images can improve the detection rate.

scholarly journals Tuberkulosis Serviks pada Penderita Tuberkulosis Paru

2019 ◽  
Vol 2 (2) ◽  
pp. 41
Author(s):  
Renny Irviana Eka Tantri ◽  
Ida Bagus Ngurah Rai
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Inflammatory Process ◽  
Normal Limit ◽  
Mycobacterium Tuberculosis Complex ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Tuberculosis Complex ◽  
X Ray ◽  
Cervical Biopsy ◽  
Chest X Ray

Background: Tuberculosis (TB) is a disease caused by infection of Mycobacterium tuberculosis complex. Global Tuberculosis Report 2011 stated the incidence of TB cases reached 8.7 million (1.1 million co-infected with HIV) and 990,000 people died because of TB. Twenty five percent of extrapulmonary TB occurs in cervix, which is 0.1 to 0.65% of all TB cases, and 5-24% of TB in urogenital tract. Case: We report the case of a woman, aged 28 years admitted with complaint hematuria since 6 months. With UTI treatment, Patient didn’t get improved. Gynecology examination within normal limit. The results of cervical biopsy were granulomatous chronic inflammation with suppuratif inflammatory process. Patient were diagnose with cervical TB. Patiens also complaint chronic cough with decrease of appetite and night sweating. Chest x-ray showed Lung TB with thickening of upper left pleural. AFB sputum examination with positive result, patient diagnosed with Lung TB. Patient got therapy ATD first chategory and after 2 weeks of therapy patient showed clinical improvement. Conclusion: Cervical TB is more common in women of childbearing age between 20-40 years. In this case, the possibility of Cervical TB occurs because through hematogenous dissemination of pulmonary tuberculosis.

scholarly journals Long-Incubation-Time Gamma Interferon Release Assays in Response to Purified Protein Derivative, ESAT-6, and/or CFP-10 for the Diagnosis of Mycobacterium tuberculosis Infection in Children

2013 ◽  
Vol 21 (2) ◽  
pp. 111-118 ◽  
Author(s):  
K. Schepers ◽  
F. Mouchet ◽  
V. Dirix ◽  
I. De Schutter ◽  
K. Jotzo ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Incubation Time ◽  
Gamma Interferon ◽  
Skin Tests ◽  
Mycobacterium Tuberculosis Infection ◽  
Content Type ◽  
X Ray ◽  
Purified Protein Derivative ◽  
Chest X Ray ◽  
Ifn Γ

ABSTRACTThe diagnosis of childhood active tuberculosis (aTB) and latentMycobacterium tuberculosis(M. tuberculosis) infection (LTBI) remains a challenge, and the replacement of tuberculin skin tests (TST) with commercialized gamma interferon (IFN-γ) release assays (IGRA) is not currently recommended. Two hundred sixty-six children between 1 month and 15 years of age, 214 of whom were at risk of recentM. tuberculosisinfection and 51 who were included as controls, were prospectively enrolled in our study. According to the results of a clinical evaluation, TST, chest X ray, and microbiological assessment, each children was classified as noninfected, having LTBI, or having aTB. Long-incubation-time purified protein derivative (PPD), ESAT-6, and CFP-10 IGRA were performed and evaluated for their accuracy in correctly classifying the children. Whereas both TST and PPD IGRA were suboptimal for detecting aTB, combining the CFP-10 IGRA with a TST or with a PPD IGRA allowed us to detect all the children with aTB with a specificity of 96% for children who were positive for the CFP-10 IGRA. Moreover, the combination of the CFP-10 IGRA and PPD IGRA detected 96% of children who were eventually classified as having LTBI, but a strong IFN-γ response to CFP-10 (defined as >500 pg/ml) was highly suggestive of aTB, at least among the children who were <3 years old. The use of long-incubation-time CFP-10 IGRA and PPD IGRA should help clinicians to quickly identify aTB or LTBI in young children.

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