Evaluation of antibiotic usage in skin and soft-tissue infections and its antimicrobial susceptibility testing: A hospital-based cross-sectional study

2021 ◽  
Vol 8 (1) ◽  
pp. 27
Author(s):  
Mohammed Fareedullah ◽  
Zareen Unnisa ◽  
Shajiya Khan ◽  
Fakeha Fatima ◽  
Afifa Khan ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Antimicrobial Susceptibility ◽  
Susceptibility Testing ◽  
Cross Sectional Study ◽  
Antibiotic Usage ◽  
Antimicrobial Susceptibility Testing ◽  
Soft Tissue Infections ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Group B Streptococcal infections among nonpregnant adults: A cross sectional study from a Tertiary care teaching hospital in South India

2021 ◽  
Vol 7 (4) ◽  
pp. 274-278
Author(s):  
Rosmi Jose ◽  
Ann George ◽  
Sathiavathy K A ◽  
Chithra Valsan
Keyword(s):  
Diabetes Mellitus ◽  
Soft Tissue ◽  
Antibiotic Susceptibility ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Soft Tissue Infections ◽  
Streptococcal Infections ◽  
Sectional Study ◽  
Cross Sectional ◽  
Group B

To understand the epidemiology of Group B Streptococcal infections among nonpregnant adults and to study the antibiotic susceptibility profile of GBS isolates.: A cross sectional study conducted in the department of microbiology in a tertiary care teaching hospital during December 2018 to May 2020. Group B Streptococcal (GBS) isolates from clinical samples of nonpregnant adults were included in the study. Identification and antibiotic susceptibility testing of GBS isolates were performed according to standard microbiology techniques. Patient’s demographic features and clinical details were collected from medical records. : A total of 58 GBS isolates were obtained from nonpregnant adults during the study period. There was a female (60.3%) predominance among the study group. Mean age of the study subjects was 51.4 years. In our study GBS were commonly isolated from urine 50% (n=29) and wound swabs 46.6% (n=27). One isolate each (1.7%) was obtained from blood culture, urethral swab and high vaginal swab. Common GBS infections noted in this study were Urinary tract infections (50%) and skin and soft tissue infections (46.6%). Diabetes mellitus (58.6%) was the most common risk factor noted in our study. All the isolates were sensitive to Penicillin, Linezolid and Vancomycin. Erythromycin and clindamycin resistance of 13.8% and 6.9% respectively were noted. A shifting trend of GBS infections from pregnant women and neonates to non-pregnant adults was observed in the present study. In patients with diabetes mellitus GBS could be considered as causative agent of skin and soft tissue infections.

scholarly journals 1365. Profiling Extrapulmonary Nontuberculous Mycobacteria Infections and Predictors for rapid-growing Species: A Multi-Center Retrospective Study

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S494-S494
Author(s):  
Jung Ho Kim ◽  
Woon Ji Lee ◽  
Hye Seong ◽  
In Young Jung ◽  
Eun Jin Kim ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Antimicrobial Susceptibility ◽  
Susceptibility Testing ◽  
Nontuberculous Mycobacteria ◽  
Joint Infection ◽  
Tertiary Care ◽  
Antimicrobial Susceptibility Testing ◽  
Soft Tissue Infections ◽  
Joint Infections ◽  
Bone And Joint Infections

Abstract Background Nontuberculous mycobacteria (NTM) disease is increasing worldwide and is an important cause of morbidity and mortality. It is found that 20 to 30% of NTM isolates are of extrapulmonary origin. However, Studies about extrapulmonary NTM infections have been limited. Thus, we aim to describe the diversity of NTM infections and correlate these observations with clinical data. Methods We analyzed all symptomatic patients with positive NTM cultures in sterile extrapulmonary sites at three tertiary care centers in South Korea between January 2006 and June 2018. We collected patient information including predisposing factors, diversity of NTM isolates, antimicrobial susceptibility testing, treatment regimens, and outcomes. Results A total of 117 patients (46 males vs. 71 females) were included. The median age of the patients was 54 years. There are a lot of infections associated with medical procedures like surgery, but about half of cases (54.7%) are unknown origin. Skin and soft-tissue infections predominated (34.2%), followed by bone and joint infections (28.2%). Of 117 NTM isolates, 66 NTM subspecies were identified. Mycobacterium intracellulare (34.8%) was the most common species identified, followed rapid-growing NTM (RGM) species such as M. fortuitum complex (21.2%), M. abscessus (15.2%), M. massiliense (10.6%), and M. chelonae (9.1%). In skin and soft-tissue infections, RGM species were predominantly identified (26/28, 92.9%), whereas slow-growing NTM (SGM) species were mainly identified in bone and joint infections (18/26, 69.2%). The difference of isolated sites was verified by post hoc test and female sex (OR 4.72; P < 0.001) and skin and soft-tissue infections (OR 25.33; P < 0.001) were identified as predictors of RGM by logistic regression analysis. Based on antimicrobial susceptibility testing, fluoroquinolone and macrolide were mainly used for RGM treatment, and rifamycin-ethambutol-macrolide-based regimen was predominantly used for SGM treatment. Conclusion Skin and soft-tissue infection were predominantly caused by RGM, whereas bone and joint infection is mainly caused by SGM. Species-specific and region-specific data that integrate clinical and microbiologic information is crucial in determining treatment direction. Disclosures All authors: No reported disclosures.

scholarly journals OPEN ACCESS: Insights into UK farmers' attitudes towards cattle youngstock rearing and disease

Livestock ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 274-281
Author(s):  
Katharine Baxter-Smith ◽  
Robert Simpson
Keyword(s):  
Cross Sectional Study ◽  
Antibiotic Usage ◽  
Sectional Study ◽  
Dairy Farmers ◽  
Cross Sectional ◽  
Attitudes And Practices ◽  
Veterinary Surgeons ◽  
Veterinary Surgeon ◽  
Beef Suckler ◽  
Housing Facilities

There is increased industry focus on optimised welfare, productivity and antibiotic usage in cattle youngstock, however, little is known about UK farmers' attitudes and practices in rearing calves. In this cross-sectional study, 479 farmers were surveyed online about their cattle youngstock rearing approach and outcomes. Represented were 174 dairy farmers, 255 beef suckler farmers and 50 calf rearers. Farmers showed awareness of good youngstock rearing practices such as colostrum management and housing facilities. Morbidity and mortality from diarrhoea (82%, 48%) and bovine respiratory disease (BRD) (68%, 48%) were high on farms surveyed but farmers did not frequently consult their veterinary surgeon regarding these diseases. Farmers surveyed were not always aware of the efficacy of preventative methods such as vaccination, and frequently used antibiotic treatments (27% for diarrhoea and 40% for BRD) but not diagnostics when animals had disease. Veterinary surgeons could use these insights to better understand farmers' motivations and priorities, to make communication more efficient and align goals.

scholarly journals Cross-Sectional Study on Antibiotic Usage in Pigs in Germany

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119114 ◽  
Author(s):  
Lisa van Rennings ◽  
Christiane von Münchhausen ◽  
Henry Ottilie ◽  
Maria Hartmann ◽  
Roswitha Merle ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Antibiotic Usage ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Associations of metabolic factors and adipokines with pain in incipient upper extremity soft tissue disorders: a cross-sectional study

BMJ Open ◽  
2013 ◽  
Vol 3 (8) ◽  
pp. e003036 ◽  
Author(s):  
Martti Rechardt ◽  
Rahman Shiri ◽  
Harri Lindholm ◽  
Jaro Karppinen ◽  
Eira Viikari-Juntura
Keyword(s):  
Soft Tissue ◽  
Upper Extremity ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Metabolic Factors ◽  
Cross Sectional

scholarly journals Bacterial Tonsillitis and Antimicrobial Resistance Profiles Among Children Within Five Years of Age At Hargeisa Group of Hospital, Somaliland: A Cross-Sectional Study

2021 ◽  
Author(s):  
Hamda Hussein Darod ◽  
Addisu Melese ◽  
Mulugeta Kibret ◽  
Wondemagegn Mulu
Keyword(s):  
Drug Resistance ◽  
Antimicrobial Resistance ◽  
Antimicrobial Susceptibility ◽  
School Attendance ◽  
Bacterial Species ◽  
Cross Sectional Study ◽  
Diffusion Method ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of

Abstract Background Tonsillitis is the third most frequently diagnosed infection in the pediatrics age group around the world. It causes significant morbidity and loss of school attendance in children. The emergence of drug resistance in bacterial tonsillitis is getting higher every year. However, data on the drug resistance profiles of bacterial causes of tonsillitis among children within five years of age is not available in Somaliland.Therefore; this study determined the bacterial causes of tonsillitis and their antimicrobial resistance profiles among children within five years of age at Hargeisa Group of Hospital, Somaliland. Methods A cross-sectional study was conducted from March to July 2020. A total of 374 children within five years of age were included using convenient sampling method. Throat swabs were collected from children, processed and bacterial species were identified using standard bacteriological procedures. Antimicrobial susceptibility was done using disc diffusion method. Data on demographic variables and clinical profiles were collected using structured questionnaires. Logistic regression analysis was computed to identify factors associated with bacterial tonsillitis. P-values < 0.05 were taken as statistically significant. Results The median age of children included in the study was 4 years. Overall, 120(32.1%)(95% CI 27.4–36.8%) of children had culture confirmed bacterial tonsillitis. Of them,23(19.2%) had mixed infections.The most frequent bacterial isolates were Streptococcus pyogenes 78(55%), Staphylococcus aureus 42 (29%) and Streptococcus pneumoniae 10(7%). Isolates revealed 83.3–100 % rate of resistance to ampicillin. S. aureus was resistant to clarithromycin (38%) while 60% of S. pneumoniae isolates were resistant to gentamicin. The overall multidrug resistance (MDR) was 50.4% and 52.6% of S.pyogenes and 60% of S.pneumoniae were MDR. History of tonsillitis(AOR = 0.12; 95% CI = 0.06–0.21), difficulty of swallowing(AOR = 6.99; 95% CI = 3.56–13.73), weight loss (AOR = 0.33; 95% CI = 0.186–0.597) and attending school (AOR = 2.98; 95% CI = 1.64–5.42) were found to be associated with tonsillitis among children within five years of age. Conclusions Bacterial tonsillitis with high degree of ampicillin resistance, mixed infections and MDR isolates are major concerns in children within five years of age at Hargeisa, Somaliland. Therefore, treatment of cases should be guided by regular culture and antimicrobial susceptibility testing to prevent disease consequences and critical drug resistance.

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