Joint FAO/WHO Expert Committee on Food Additives (JECFA)

2012 ◽  
Author(s):  
Kelly Boyer Sagert
Keyword(s):  
Food Additives ◽  
Expert Committee

scholarly journals Characterization and Lifetime Dietary Risk Assessment of Eighteen Pyrrolizidine Alkaloids and Pyrrolizidine Alkaloid N-Oxides in New Zealand Honey

Toxins ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 843
Author(s):  
Andrew J. Pearson ◽  
Jeane E. F. Nicolas ◽  
Jane E. Lancaster ◽  
C. Wymond Symes
Keyword(s):  
New Zealand ◽  
Pyrrolizidine Alkaloids ◽  
Pyrrolizidine Alkaloid ◽  
Food Additives ◽  
Dietary Exposure ◽  
World Health ◽  
Exposure Model ◽  
Average Lifetime ◽  
Expert Committee ◽  
Dietary Risk

Pyrrolizidine alkaloids (PAs) are a large group of botanical toxins of concern, as they are considered genotoxic carcinogens, with long-term dietary exposure presenting an elevated risk of liver cancer. PAs can contaminate honey through honeybees visiting the flowers of PA-containing plant species. A program of monitoring New Zealand honey has been undertaken over several years to build a comprehensive dataset on the concentration, regional and seasonal distribution, and botanical origin of 18 PAs and PA N-oxides. A bespoke probabilistic exposure model has then been used to assess the averaged lifetime dietary risk to honey consumers, with exposures at each percentile of the model characterized for risk using a margin of exposure from the Joint World Health Organization and United Nations Food and Agriculture Organization Expert Committee on Food Additives (JECFA) Benchmark Dose. Survey findings identify the typical PA types for New Zealand honey as lycopsamine, echimidine, retrorsine and senecionine. Regional and seasonal variation is evident in the types and levels of total PAs, linked to the ranges and flowering times of certain plants. Over a lifetime basis, the average exposure an individual will receive through honey consumption is considered within tolerable levels, although there are uncertainties over high and brand-loyal consumers, and other dietary contributors. An average lifetime risk to the general population from PAs in honey is not expected. However, given the uncertainties in the assessment, risk management approaches to limit or reduce exposures through honey are still of value.

Total Mercury and Methylmercury Content in Edible Fish from the Mediterranean Sea

2003 ◽  
Vol 66 (2) ◽  
pp. 300-303 ◽  
Author(s):  
M. M. STORELLI ◽  
R. GIACOMINELLI STUFFLER ◽  
A. STORELLI ◽  
G. O. MARCOTRIGIANO
Keyword(s):  
European Commission ◽  
Mediterranean Sea ◽  
Total Mercury ◽  
Food Additives ◽  
World Health ◽  
Expert Committee ◽  
Blue Whiting ◽  
Commission Decision ◽  
Wet Weight ◽  
The Mediterranean

The objective of this study was to determine the current levels of total mercury and methyl mercury in the muscle tissues of different fish species caught in the Mediterranean Sea to ascertain whether these concentrations exceed the maximum level stipulated by the European Commission Decision. Total mercury concentrations in the muscles of skates ranged from 0.18 to 1.85 mg/kg (wet weight) (average, 1.00 mg/kg) while levels of 0.11 to 1.92 mg/kg (wet weight) (average, 0.70 mg/kg) and 0.21 to 1.74 mg/kg (wet weight) (average, 0.70 mg/kg) were recorded for blue whiting and red mullet, respectively. For 66.7% of long nose skate samples, 61.4% of thornback ray samples, 42.8% of winter skate samples, and 38% of starry ray samples, the total mercury concentrations exceeded the prescribed legal limit (1.0 mg/kg [wet weight]). Concentrations exceeding the maximum total mercury level stipulated by the European Commission Decision (0.5 mg/kg [wet weight]) were observed in 63.6 and 40% of blue whiting and striped mullet samples, respectively. Mercury was present in the different species almost completely in the methylated form at 55 to 100%. Weekly intakes were estimated and compared with the provisional tolerable weekly intake recommended by the Joint Food and Agriculture Organization/World Health Organization Expert Committee on Food Additives.

scholarly journals Fusarium mycotoxins and human health

2011 ◽  
Vol 64 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Gordon Shephard
Keyword(s):  
Human Health ◽  
Food Additives ◽  
Expert Committee ◽  
Diverse Range ◽  
Endocrine Disrupting Chemical ◽  
Toxicological Effects ◽  
Naturally Occurring ◽  
Carcinogenic Potential ◽  
Endocrine Disrupting ◽  
Daily Intakes

Fusariummycotoxins and human healthSpecies within the genusFusariumproduce a diverse range of mycotoxins, many of which have significant impacts on human health. Of the five generally recognised major mycotoxins, three (fumonisins, deoxynivalenol (DON) and zearalenone (ZON)) are produced by Fusaria. Apart from DON, other trichothecenes such as T-2 toxin, have received considerable international attention due to their impact on human health. The fumonisins, which occur ubiquitously in maize and its products, have been linked to oesophageal cancer, liver cancer and neural tube defects. DON, a frequent contaminant of maize, wheat and their products, although showing no carcinogenic potential, is immunomodulatory and produces emesis and growth retardation in animals. ZON is a naturally occurring endocrine disrupting chemical. Acute exposure to these mycotoxins has in each case been linked to outbreaks of human disease - gastro-intestinal effects in the case of fumonisins and DON, and precocious pubertal changes in the case of ZON. Concern over their toxicological effects has led to risk assessments by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which has set maximum tolerable daily intakes (TDI) of 2 μg/ kg body weight (bw) for fumonisins and 0.5 μg/kg bw for ZON. The initial TDI set for DON, namely 1 μg/kg bw has recently been updated by JECFA to include both 3 - and 15-acetylDON. Apart from the above mycotoxins, a number of other secondary metabolites (moniliformin, beauvericin and fusaproliferin) are produced by different Fusaria and their effects on human health, either alone or in combination with other mycotoxins, is largely unexplored.

Contents and Risk Assessment of Heavy Metals in Marine Invertebrates from Korean Coastal Fish Markets

2014 ◽  
Vol 77 (6) ◽  
pp. 1022-1030 ◽  
Author(s):  
JONG SOO MOK ◽  
JI YOUNG KWON ◽  
KWANG TAE SON ◽  
WOO SEOK CHOI ◽  
SUNG RIM KANG ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Risk Assessment ◽  
Marine Invertebrates ◽  
Marine Invertebrate ◽  
Food Additives ◽  
Daily Intake ◽  
Hazard Index ◽  
Human Consumption ◽  
Expert Committee ◽  
Consumer Safety

The concentrations of the heavy metals cadmium (Cd), mercury (Hg), lead (Pb), chromium, silver, nickel, copper, and zinc in the edible portions of 105 marine invertebrates representing 16 mollusk and crustacean species were accurately determined to evaluate their hazard for human consumption. The samples were collected in 2011 from major fish markets on the coast of Korea and analyzed for Hg using a direct Hg analyzer and for other metals using inductively coupled plasma mass spectrometry. Estimated dietary exposure (EDE) was determined, and a risk assessment was made of the heavy metals to provide information concerning consumer safety. The Cd concentrations, which were the highest for the three hazardous metals (Cd, Hg, and Pb), were significantly higher (P < 0.05) in the bivalves and crabs than in the gastropods and cephalopods. However, the concentrations of these metals in all samples were within the regulatory limits set by Korea and other countries. The EDE was compared with the provisional tolerable daily intake (PTDI) adopted by the Joint FAO/WHO Expert Committee on Food Additives or the U.S. Environmental Protection Agency. The EDE of Cd, Hg, and Pb for each class of marine invertebrate were 0.07 to 2.64, 0.01 to 0.43, and 0.001 to 0.16% of the PTDI, respectively. The total EDE of Cd, Hg, and Pb for marine invertebrates accounted for 4.03, 0.96, and 0.21%, respectively, of the PTDI. The EDE of other metals in each class of marine invertebrate was less than 2% of the PTDI. The hazard index is a reasonable parameter for assessing the risk of heavy metal consumption associated with contaminated food. In the present study, the hazard index for all of the species was less than 1.0, which indicates that the intake of heavy metals from consumption of these marine invertebrates does not represent an appreciable hazard to humans.

Occurrence of Multiple Mycotoxins in Various Types of Rice and Barley Samples in Thailand

2019 ◽  
Vol 82 (6) ◽  
pp. 1007-1015 ◽  
Author(s):  
PIYALUK SINPHITHAKKUL ◽  
AMNART POAPOLATHEP ◽  
NARUMOL KLANGKAEW ◽  
KANJANA IMSILP ◽  
ANTONIO F. LOGRIECO ◽  
...  
Keyword(s):  
Health Risk ◽  
Food Additives ◽  
Daily Intake ◽  
Climatic Conditions ◽  
Expert Committee ◽  
Safe Procedure ◽  
Triple Quadrupole Mass Spectrometer ◽  
Ionization Source ◽  
Tropical Regions ◽  
Mycotoxin Contamination

ABSTRACT The prevalence of mycotoxins is often increased by climatic conditions prevailing in tropical regions. Therefore, consumers in tropical countries such as Thailand have a higher risk of mycotoxin exposure. Existing reports have revealed mycotoxin contamination in rice. This study was conducted to determine the occurrence of multiple mycotoxins in barley and nine types of rice sold in Thailand and to assess consumer health risk. A total of 300 samples collected from various markets in Thailand were analyzed for the presence of 16 mycotoxins using a QuEChERS (quick, easy, cheap, effective, rugged, and safe) procedure and a triple quadrupole mass spectrometer equipped with an electrospray ionization source. Of the 300 samples, 124 (41.33%) were contaminated with at least one mycotoxin, and 38.71% of the mycotoxin-positive samples were simultaneously contaminated with more than one toxin. The incidence of mycotoxin contamination differed among the rice and barley samples. Beauvericin, diacetoxyscirpenol, zearalenone, and aflatoxins were the most frequently found mycotoxins. However, the concentrations of regulated mycotoxins were below the regulatory limits. The assessed mycotoxin exposure does not represent a health risk for Thai consumers because the estimated exposure concentrations were lower than the tolerable daily intake values established by the Joint FAO/WHO Expert Committee on Food Additives. However, our findings suggest that continued monitoring of mycotoxin contamination in rice and barley and concomitant risk assessments are warranted. HIGHLIGHTS

Exposure assessment of metal intakes from drinking water relative to those from total diet in Japan

2010 ◽  
Vol 62 (11) ◽  
pp. 2694-2701 ◽  
Author(s):  
Koichi Ohno ◽  
Kohei Ishikawa ◽  
Yuki Kurosawa ◽  
Yoshihiko Matsui ◽  
Taku Matsushita ◽  
...  
Keyword(s):  
Drinking Water ◽  
Toxic Metals ◽  
Food Additives ◽  
Daily Intake ◽  
Essential Elements ◽  
Expert Committee ◽  
Dietary Intakes ◽  
Nickel Copper ◽  
Total Diet ◽  
Daily Intakes

Daily intakes of 17 metals (boron, aluminium, chromium, manganese, nickel, copper, zinc, arsenic, selenium, molybdenum, cadmium, antimony, lead, uranium, magnesium, calcium, and iron) via drinking water and total diet were investigated in six cities in Japan. The daily metal intakes were estimated and compared with tolerable daily intake (TDI) values proposed by the WHO or Joint FAO/WHO Expert Committee on Food Additives for toxic metals and with recommended dietary allowances (RDAs) or adequate intake (AI) values proposed for essential metals by the Japanese Ministry of Health, Labour and Welfare. Among the 13 toxic metals, mean dietary intakes of 10 (except arsenic, selenium, and molybdenum) were less than 50% of TDI, suggesting that for these 10 metals the allocation of intake to drinking water in establishing guidelines or standards could possibly be increased from the normal allocation of 10–20% of TDI. For the 13 toxic metals, the contribution of drinking water to TDI was 2% or less in all six cities. Mean dietary intakes of the essential elements magnesium, calcium, and iron were less than the RDA or AI values. Drinking water did not contribute much to essential metal intake, accounting for less than 10% of RDA or AI.

Aflatoxin M1 in Milk Products in China and Dietary Risk Assessment

2013 ◽  
Vol 76 (5) ◽  
pp. 849-853 ◽  
Author(s):  
YAODONG GUO ◽  
YAHONG YUAN ◽  
TIANLI YUE
Keyword(s):  
Body Weight ◽  
Cancer Risk ◽  
Probabilistic Approach ◽  
Food Additives ◽  
World Health ◽  
Assay Method ◽  
Aflatoxin M1 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Expert Committee ◽  
Milk Products

This study was conducted to investigate the occurrence of aflatoxin M1 (AFM1) in milk products in China using the competitive enzyme-linked immunosorbent assay method and to estimate the dietary exposure to this toxin through a probabilistic approach. Based on the exposure assessment results, a quantitative cancer potency formula developed by the Joint Food and Agriculture Organization and World Health Organization Expert Committee on Food Additives was applied to assess the cancer risk. AFM1 was detected in 48.07% of the milk samples and 4.49% of the yoghurt samples. No samples contained AFM1 above the current regulatory limit in China. The simulated AFM1 intake (90% confidence interval) in various sex-age groups ranged from 0.023 (0.021 to 0.023) ng/kg of body weight per day for 30- to 45-year-old men to 0.382 (0.354 to 0.386) ng/kg of body weight per day for 2- to 4-year-old girls at the 99th percentile. The cancer risk of AFM1 to the general population of China was assessed to be 0.129 cancer cases per year per 108 persons at the 99th percentile. These results indicate that the health risk associated with AFM1 in milk in China is relatively low.

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