Exposure assessment of metal intakes from drinking water relative to those from total diet in Japan

2010 ◽  
Vol 62 (11) ◽  
pp. 2694-2701 ◽  
Author(s):  
Koichi Ohno ◽  
Kohei Ishikawa ◽  
Yuki Kurosawa ◽  
Yoshihiko Matsui ◽  
Taku Matsushita ◽  
...  
Keyword(s):  
Drinking Water ◽  
Toxic Metals ◽  
Food Additives ◽  
Daily Intake ◽  
Essential Elements ◽  
Expert Committee ◽  
Dietary Intakes ◽  
Nickel Copper ◽  
Total Diet ◽  
Daily Intakes

Daily intakes of 17 metals (boron, aluminium, chromium, manganese, nickel, copper, zinc, arsenic, selenium, molybdenum, cadmium, antimony, lead, uranium, magnesium, calcium, and iron) via drinking water and total diet were investigated in six cities in Japan. The daily metal intakes were estimated and compared with tolerable daily intake (TDI) values proposed by the WHO or Joint FAO/WHO Expert Committee on Food Additives for toxic metals and with recommended dietary allowances (RDAs) or adequate intake (AI) values proposed for essential metals by the Japanese Ministry of Health, Labour and Welfare. Among the 13 toxic metals, mean dietary intakes of 10 (except arsenic, selenium, and molybdenum) were less than 50% of TDI, suggesting that for these 10 metals the allocation of intake to drinking water in establishing guidelines or standards could possibly be increased from the normal allocation of 10–20% of TDI. For the 13 toxic metals, the contribution of drinking water to TDI was 2% or less in all six cities. Mean dietary intakes of the essential elements magnesium, calcium, and iron were less than the RDA or AI values. Drinking water did not contribute much to essential metal intake, accounting for less than 10% of RDA or AI.

scholarly journals Investigation of Some Metals in Leaves and Leaf Extracts of Lippia javanica: Its Daily Intake

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Kanda Artwell ◽  
Ncube France ◽  
Kunsamala Florence
Keyword(s):  
Daily Intake ◽  
Absorption Spectrometry ◽  
Essential Elements ◽  
Potential Hazard ◽  
Dietary Intakes ◽  
Leaf Extracts ◽  
Metal Concentrations ◽  
Recommended Dietary Allowances ◽  
Daily Intakes ◽  
Mn Concentrations

Consumption of plant extracts can be a source of essential elements or a route of human exposure to toxicants. Metal concentrations in leaves, leaf brew, and infusion of L. javanica collected from five sites were determined by atomic absorption spectrometry after acid and aqueous extraction. Estimated daily intakes of metals in extracts were compared with recommended dietary allowances. Total metal concentrations in leaves varied with sampling sites (p<0.05): Mn > Fe > Cu > Cr > Pb for sites SS2–SS5. The highest metal concentrations in leaves were recorded for SS3 (Cu: 15.32±4.53 and Mn: 734.99±105.49), SS5 (Fe: 210.27±17.17), SS2 (Pb: 3.11±0.21), and SS4 (Cr: 4.40±0.75 mg/kg). Leaf infusion appeared to release higher Cu and Mn concentrations in leaves across sites (Cu: 21.65; Mn: 28.01%) than leaf brew (Cu: 11.95; Mn: 19.74%). Lead was not detected in leaf extracts. Estimated dietary intakes of Cr, Cu, Fe, and Mn were below recommended dietary allowances. A 250 ml cup of leaf infusion contributed 0.30–1.18% Cu and 4.46–13.83% Mn to the recommended dietary allowances of these elements per day. Lead did not pose any potential hazard when consumed in tea beverage made from brew and infusion of leaves of L. javanica.

scholarly journals Total-diet study: dietary intakes of macro elements and trace elements in Italy

2003 ◽  
Vol 90 (6) ◽  
pp. 1117-1121 ◽  
Author(s):  
Ginevra Lombardi-Boccia ◽  
Altero Aguzzi ◽  
Marsilio Cappelloni ◽  
Giuseppe Di Lullo ◽  
Massimo Lucarini
Keyword(s):  
Trace Elements ◽  
Daily Intake ◽  
Food Group ◽  
Italian Population ◽  
Dietary Intakes ◽  
Food Groups ◽  
Fish Food ◽  
Macro Elements ◽  
Total Diet ◽  
Daily Intakes

The present study provides the dietary intakes of macro elements (Ca, Mg, Na, K, P) and trace elements (Fe, Zn, Cu, Se) from the Italian total diet. The contribution of the most representative food groups of the total diet (cereals and cereal products, vegetables, fruit, milk and dairy products, meat and meat products, fish) to the daily intakes of these nutrients was also evaluated. The Italian total diet was formulated following the ‘market-basket’ approach. Cereals represented the primary sources of Cu (35 %), Fe (30 %) and Mg (27 %). About 89 % of the total daily intake of Fe was derived from plant foods. The vegetables food group was the main source of dietary K (27 %). Most of the Ca (59 %) and P (27 %) was derived from the milk-and-dairy food group. Of the dietary Zn, 41 % was provided by meat, which, together with the fish food group, was the primary source of Se (20 %). The adequacy of the Italian total diet with respect to nutritional elements was assessed by comparing the daily intakes with the average requirement values of the Italian recommended dietary allowances. The present findings indicated that the dietary patterns of the Italian total diet were generally consistent with current Italian dietary recommendations for both macro and trace elements. The major concern was for Ca, for which daily intake was 76 % of the average recommendation for the Italian population. It should not be ruled out that there could be a potential risk of inadequate Fe intake in some segments of the population.

scholarly journals Occurrence and Risk Assessment of Dietary Exposure to Deoxynivalenol in Wheat-Based Products Based Different Wheat-Producing Area for the Inhabitants in Shanghai, China

2021 ◽  
Vol 7 (12) ◽  
pp. 1015
Author(s):  
Xianli Yang ◽  
Zhiyong Zhao ◽  
Jianhua Wang ◽  
Junhua Yang ◽  
Hengchao E ◽  
...  
Keyword(s):  
Health Risks ◽  
Food Additives ◽  
Daily Intake ◽  
Dietary Exposure ◽  
Expert Committee ◽  
Potential Health ◽  
Adverse Health Effects ◽  
Main Production ◽  
Daily Intakes ◽  
Production Areas

Deoxynivalenol (DON) is one of the major mycotoxins that contaminate cereals. In this study, we determined the DON level in wheat-based products from Chinese five main production areas collected in Shanghai and calculated the daily intake of DON for inhabitants using the point evaluation and the probabilistic evaluation based on Monte Carlo simulation. The results showed the positive rates of DON in the products were higher than 80.0%, with the concentrations ranging from 41.8 to 1110 µg/kg. The estimated mean daily intakes of DON for 7- to 10-year-old children and adults groups were below 1 µg/kg bw/day, the provisional maximum tolerable daily intake (PMTDI) set by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), suggesting no health risks for the consumers. However, the 99th percentiles of dietary DON exposures for children and adults exceeded the PMTDI, indicating adverse health effects might occur if the two groups intake highly contaminated wheat-based products. The potential health risks for the two groups exposed to DON in the wheat-based products from the Middle and Lower Yangtze Valley (MLYV) were higher than those from the other areas in China.

scholarly journals An analysis of heavy metals contamination and estimating the daily intakes of vegetables from Uganda

2021 ◽  
Vol 5 ◽  
pp. 239784732098525
Author(s):  
Keneth Iceland Kasozi ◽  
Eric Oloya Otim ◽  
Herbert Izo Ninsiima ◽  
Gerald Zirintunda ◽  
Andrew Tamale ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Daily Intake ◽  
Principal Component ◽  
Absorption Spectrometry ◽  
Cross Sectional Study ◽  
Essential Elements ◽  
World Health ◽  
Cross Sectional ◽  
Health Organization ◽  
Daily Intakes

Background: Environmental contamination with elevated levels of copper (Cu), cobalt (Co), iron (Fe), zinc (Zn), lead (Pb), chromium (Cr6+), cadmium (Cd), and nickel (Ni)—all states of which are found in Uganda—raises health risk to the public. Pb, Cr6+, Cd, and Ni for instance are generally considered nonessential to cellular functions, notwithstanding the importance of the oxidative state of the metals in bioavailability. As such, we aimed in this study (i) to evaluate heavy metal concentrations in four vegetables from a typical open-air market in Uganda, (ii) to assess the safety of consuming these vegetables against the World Health Organization (WHO) recommended limits of heavy metals consumption, and (iii) to formulate a model of estimated daily intake (EDI) among consumers in the country. Methods: This was a cross-sectional study conducted in five georeferenced markets of Bushenyi district in January 2020. Amaranthus, cabbages, scarlet eggplants, and tomatoes were collected from open markets, processed, and analyzed by atomic absorption spectrometry. Modeled EDI, principal component (PCA) and cluster analysis (CA) were conducted to identify relationships in the samples. Results: The levels of essential elements in the four vegetables were found to fall from Co > Cu > Fe > Zn. Those of non-essential metals were significantly higher and followed the pattern Cd > Cr > Pb > Ni. The highest EDI values were those of Cu in scarlet eggplants, Zn in amaranthus, Fe in amaranthus, Co in amaranthus, Pb in cabbages, total Cr in scarlet eggplant, Cd in cabbages and tomatoes, and Ni in cabbages. In comparison to international limits, EDIs for Zn, Cu, Co and Fe were low while Ni in cabbages were high. PCA showed high variations in scarlet eggplant and amaranthus. The study vegetables were found to be related with each other, not according to the location of the markets from where they were obtained, but according to their species by CA. Conclusion: The presence of non-essential elements above WHO limits raises policy challenges for the consumption and marketing of vegetables in the study area. Furthermore, low EDIs of essential elements in the vegetables create demand for nutritious foods to promote healthy communities.

scholarly journals Considerations for determining ‘optimal nutrition’ for copper, zinc, manganese and molybdenum

1999 ◽  
Vol 58 (2) ◽  
pp. 497-505 ◽  
Author(s):  
Mark L. Failla
Keyword(s):  
Trace Metals ◽  
Daily Intake ◽  
Functional Markers ◽  
Dietary Intakes ◽  
Normal Range ◽  
Copper Zinc ◽  
Daily Intakes ◽  
Zn Status ◽  
The Impact ◽  
Cu And Zn

Defining optimal dietary intakes of Cu and Zn throughout the life cycle continues to present a considerable challenge for nutrition scientists. Although the daily intake of these micronutrients is below that currently recommended for many groups, traditional biochemical indicators of nutritional status for these trace metals largely remain within the normal range. Thus, it is unclear whether the recommended daily intakes may be unnecessarily high, or if the commonly-used markers simply lack the necessary sensitivity and specificity that are required for accurately assessing Cu and Zn status. The increasing number of reports that daily supplements with these trace metals enhance the activities of selective metalloenzymes and specific cellular and organ processes further points out the need to differentiate between meeting the requirement and providing optimal nutriture. Results from recent studies suggesting that alternative molecular and functional markers possess sufficient sensitivity to better assess Cu and Zn status are discussed. Likewise, recent studies evaluating the impact of very low and excessive levels of dietary Mn and Mo on selective biochemical and metabolic indicators are reviewed.

FDA Total Diet Study, July 1986-April 1991, Dietary Intakes of Pesticides, Selected Elements, and Other Chemicals

1995 ◽  
Vol 78 (6) ◽  
pp. 1353-1362 ◽  
Author(s):  
Gunderson Ellis L.
Keyword(s):  
Metropolitan Areas ◽  
Sampling Period ◽  
Dietary Intakes ◽  
Industrial Chemicals ◽  
Population Groups ◽  
Total Diet Study ◽  
Total Diet ◽  
Diet Study ◽  
Daily Intakes ◽  
The U.S

Abstract The U.S. Food and Drug Administration conducts the Total Diet Study to determine dietary intakes of selected pesticides, industrial chemicals, and elements (including radionuclides). This paper reports results for the sampling period July 1986 to April 1991. The study involves retail purchase of foods representative of the "total diet" of the U.S. population, preparation for "table-ready" consumption, and individual analyses of 234 items making up the diets of 8 population groups. The diets were based on 2 nationwide food consumption surveys. The data presented represent 21 food collections (also termed "market baskets") in regional metropolitan areas during the 5-year period. Dietary intakes of nearly 120 analytes are presented for 8 population groups, which range from infants to elderly adults. Intakes of selected population groups are compared with representative findings from earlier Total Diet Study sampling periods. As reported previously, average daily intakes are well below acceptable limits.

Pesticides, Selected Elements, and Other Chemicals in Adult Total Diet Samples, October 1978-September 1979

1985 ◽  
Vol 68 (5) ◽  
pp. 862-875 ◽  
Author(s):  
Marcia J Gartrell ◽  
John C Craun ◽  
David S Podrebarac ◽  
Ellis L Gunderson
Keyword(s):  
Daily Intake ◽  
Food Group ◽  
Average Concentration ◽  
Food Groups ◽  
Industrial Chemicals ◽  
Food Items ◽  
Total Diet ◽  
The Individual ◽  
Daily Intakes ◽  
Calculated Average

Abstract The U.S. Food and Drug Administration (FDA) conducts Total Diet Studies to determine the dietary intake of selected pesticides, industrial chemicals, and elements (including radionuclides). These studies involve the retail purchase and analysis of foods representative of the diets of infants, toddlers, and adults. The individual food items are separated into a number of food groups, each of which is analyzed as a composite. This report summarizes the results for adult Total Diet samples collected in 20 cities between October 1978 and September 1979. The average concentration, range of concentrations, and calculated average daily intake of each chemical found are presented by food group. The average daily intakes of the chemicals are similar to those found in the several preceding years and are within acceptable limits. The results for samples collected during the same period that represent the diets of infants and toddlers are reported separately.

scholarly journals Fusarium mycotoxins and human health

2011 ◽  
Vol 64 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Gordon Shephard
Keyword(s):  
Human Health ◽  
Food Additives ◽  
Expert Committee ◽  
Diverse Range ◽  
Endocrine Disrupting Chemical ◽  
Toxicological Effects ◽  
Naturally Occurring ◽  
Carcinogenic Potential ◽  
Endocrine Disrupting ◽  
Daily Intakes

Fusariummycotoxins and human healthSpecies within the genusFusariumproduce a diverse range of mycotoxins, many of which have significant impacts on human health. Of the five generally recognised major mycotoxins, three (fumonisins, deoxynivalenol (DON) and zearalenone (ZON)) are produced by Fusaria. Apart from DON, other trichothecenes such as T-2 toxin, have received considerable international attention due to their impact on human health. The fumonisins, which occur ubiquitously in maize and its products, have been linked to oesophageal cancer, liver cancer and neural tube defects. DON, a frequent contaminant of maize, wheat and their products, although showing no carcinogenic potential, is immunomodulatory and produces emesis and growth retardation in animals. ZON is a naturally occurring endocrine disrupting chemical. Acute exposure to these mycotoxins has in each case been linked to outbreaks of human disease - gastro-intestinal effects in the case of fumonisins and DON, and precocious pubertal changes in the case of ZON. Concern over their toxicological effects has led to risk assessments by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which has set maximum tolerable daily intakes (TDI) of 2 μg/ kg body weight (bw) for fumonisins and 0.5 μg/kg bw for ZON. The initial TDI set for DON, namely 1 μg/kg bw has recently been updated by JECFA to include both 3 - and 15-acetylDON. Apart from the above mycotoxins, a number of other secondary metabolites (moniliformin, beauvericin and fusaproliferin) are produced by different Fusaria and their effects on human health, either alone or in combination with other mycotoxins, is largely unexplored.

Contents and Risk Assessment of Heavy Metals in Marine Invertebrates from Korean Coastal Fish Markets

2014 ◽  
Vol 77 (6) ◽  
pp. 1022-1030 ◽  
Author(s):  
JONG SOO MOK ◽  
JI YOUNG KWON ◽  
KWANG TAE SON ◽  
WOO SEOK CHOI ◽  
SUNG RIM KANG ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Risk Assessment ◽  
Marine Invertebrates ◽  
Marine Invertebrate ◽  
Food Additives ◽  
Daily Intake ◽  
Hazard Index ◽  
Human Consumption ◽  
Expert Committee ◽  
Consumer Safety

The concentrations of the heavy metals cadmium (Cd), mercury (Hg), lead (Pb), chromium, silver, nickel, copper, and zinc in the edible portions of 105 marine invertebrates representing 16 mollusk and crustacean species were accurately determined to evaluate their hazard for human consumption. The samples were collected in 2011 from major fish markets on the coast of Korea and analyzed for Hg using a direct Hg analyzer and for other metals using inductively coupled plasma mass spectrometry. Estimated dietary exposure (EDE) was determined, and a risk assessment was made of the heavy metals to provide information concerning consumer safety. The Cd concentrations, which were the highest for the three hazardous metals (Cd, Hg, and Pb), were significantly higher (P &lt; 0.05) in the bivalves and crabs than in the gastropods and cephalopods. However, the concentrations of these metals in all samples were within the regulatory limits set by Korea and other countries. The EDE was compared with the provisional tolerable daily intake (PTDI) adopted by the Joint FAO/WHO Expert Committee on Food Additives or the U.S. Environmental Protection Agency. The EDE of Cd, Hg, and Pb for each class of marine invertebrate were 0.07 to 2.64, 0.01 to 0.43, and 0.001 to 0.16% of the PTDI, respectively. The total EDE of Cd, Hg, and Pb for marine invertebrates accounted for 4.03, 0.96, and 0.21%, respectively, of the PTDI. The EDE of other metals in each class of marine invertebrate was less than 2% of the PTDI. The hazard index is a reasonable parameter for assessing the risk of heavy metal consumption associated with contaminated food. In the present study, the hazard index for all of the species was less than 1.0, which indicates that the intake of heavy metals from consumption of these marine invertebrates does not represent an appreciable hazard to humans.

Pesticides, Selected Elements, and Other Chemicals in Infant and Toddler Total Diet Samples, October 1979-September 1980

1985 ◽  
Vol 68 (6) ◽  
pp. 1184-1197
Author(s):  
Marcia J Gartrell ◽  
John C Craun ◽  
David S Podrebarac ◽  
Ellis L Gunderson
Keyword(s):  
Daily Intake ◽  
Food Group ◽  
Average Concentration ◽  
Food Groups ◽  
Industrial Chemicals ◽  
Total Diet ◽  
The Individual ◽  
Daily Intakes ◽  
Adult Diet ◽  
Calculated Average

Abstract The U.S. Food and Drug Administration (FDA) conducts Total Diet Studies to determine the dietary intake of selected pesticides, industrial chemicals, and elements (including radionuclides). These studies involve the retail purchase and analysis of foods representative of the diets of infants, toddlers, and adults. The individual food items are separated into a number of food groups, each of which is analyzed as a composite. This report summarizes the results for infant and toddler Total Diet samples collected in 10 cities between October 1979 and September 1980. The average concentration, range of concentrations, and calculated average daily intake of each chemical found are presented by food group. The average daily intakes of the chemicals are similar to those found in the several preceding years and generally are within acceptable limits. The results for samples collected during the same period that represent the adult diet are reported separately.

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