Effects of soybean supplementation on blood glucose, plasma lipid levels, and erythrocyte antioxidant enzyme activity in type 2 diabetes mellitus patients

Aims: â€˜Triphalaâ€™ constituting equal parts of three medicinal dried plant fruits Emblica Officinalis Gaertn., Terminalia chebula Retz. and Terminalia bellerica Gaertn. is an antioxidant rich Ayurvedic formulation. The present study assessed therapeutic as well as protective effects of Triphala on human subjects with Type 2 diabetes mellitus (T2DM) and Impaired glucose tolerance (IGT).Â Materials and methods: Triphala at a dose of 5 gms BD was administered to two cohorts viz., IGT, N= 20 and T2DM, N=30 consecutively for a period of 12 months. The therapeutic efficacy was assessed quarterly by monitoring blood glucose and lipid levels; the protective effect by monitoring antioxidants level quarterly and DNA damage annually. Toxicity if any, to liver and kidney due to long term administration was assessed quarterly in both cohorts.Results: Continuous â€˜Triphalaâ€™ therapy for 12 months significantly reduced blood glucose (pâ‰¤0.001) and lipid levels (pâ‰¤0.05) in both the cohorts. Triphala resisted oxidative stress generated during the course of hyperglycemia by significantly increasing the activity of super oxide dismutase and Catalase (pâ‰¤0.001) and the level of reduced glutathione (pâ‰¤0.001). Protective effect on DNA was accessed through significant reduction in the comet tail length (pâ‰¤0.001).Conclusions: â€˜Triphalaâ€™ ameliorated not only the oxidative stress but also normalized glucose and lipid homeostasis in subjects with impaired glucose and T2DM.Â

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The Role of Peer Support Education Model in Management of Glucose and Lipid Levels in Patients with Type 2 Diabetes Mellitus in Chinese Adults

Journal of Diabetes Research ◽

10.1155/2019/5634030 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8

Author(s):

Xin Zhao ◽

Xiaofeng Yu ◽

Xiaomei Zhang

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Blood Glucose ◽

Peer Support ◽

Medical Staff ◽

Lipid Levels ◽

Significant Difference ◽

Education Model

Aims. To investigate the effect of peer support education model on the levels of glucose and lipids in patients with type 2 diabetes mellitus in China. Methods. 120 type 2 diabetes mellitus patients (T2DM) were assigned to two groups randomly from December 2016 to October 2017. Group 1 was trained on basic diabetic medical knowledge by a professional medical staff. After 8 weeks of studying, these specially trained patients then trained the patients of Group 2. Results. It was found that after 3 months of intervention, the levels of fasting blood glucose, triglycerides, glycosylated hemoglobin, total cholesterol, and low-density lipoprotein cholesterol were significantly decreased for the two groups (p<0.05). However, with the prolongation of time, there were no significant changes in the two groups in the above indices (p>0.05) after 6 months, and the result was the same after strafing sex, age, and education level. Meanwhile, there was no significant difference in decreasing glucose and lipid level between the two groups’ participants (p>0.05). Conclusion. It was found that both the peer support education model and medical staff education model have a better short-term effect on blood glucose and lipid levels in patients with type 2 diabetes. As there is no difference of effect between the two methods of training, the peer support education model can be widely used in diabetes education.

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Epigenetic modulation of autophagy genes linked to diabetic nephropathy by administration of isorhamnetin in Type 2 diabetes mellitus rats

Epigenomics ◽

10.2217/epi-2020-0353 ◽

2021 ◽

Author(s):

Marwa Matboli ◽

Doaa Ibrahim ◽

Amany H Hasanin ◽

Mohamed Kamel Hassan ◽

Eman K Habib ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

Light And Electron Microscopy ◽

Lipid Profiles ◽

Mirna Regulation ◽

Protein Levels

Aim: To assess isorhamnetin efficacy for diabetic kidney disease in a Type 2 diabetes mellitus rat model, through investigating its effect at the epigenetic, mRNA and protein levels. Materials & methods: Type 2 diabetes mellitus was induced in rats by streptozotocin and high-fat diet. Rats were treated with isorhamnetin (50 mg/kg/d) for 4 or 8 weeks. Fasting blood glucose, renal and lipid profiles were evaluated. Renal tissues were examined by light and electron microscopy. Autophagy genes ( FYCO1, ULK, TECPR1 and WIPI2) and miR-15b, miR-34a and miR-633 were assessed by qRT-PCR, and LC3A/B by immunoblotting. Results: Isorhamnetin improved fasting blood glucose, renal and lipid profiles with increased autophagosomes in renal tissues. It suppressed miRNA regulation of autophagy genes Conclusion: We propose a molecular mechanism for the isorhamnetin renoprotective effect by modulation of autophagy epigenetic regulators.

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Application value of combination therapy of periodontal curettage and root planing on moderate-to-severe chronic periodontitis in patients with type 2 diabetes

Head & Face Medicine ◽

10.1186/s13005-020-00253-z ◽

2021 ◽

Vol 17 (1) ◽

Author(s):

Yonghuan Bian ◽

Changhao Liu ◽

Zhaojiang Fu

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Blood Glucose ◽

Chronic Periodontitis ◽

Root Planing ◽

Tnf Α ◽

Significant Difference ◽

Hs Crp

Abstract Background Our study attempted to observe the value of periodontal curettage combined with root planing on moderate-to-severe chronic periodontitis in patients with type 2 diabetes. Methods There involved 72 patients with type 2 diabetes mellitus complicated with moderate-to-severe chronic periodontitis who were diagnosed and treated in our hospital from January 2019 to December 2019. The patients enrolled were randomly divided into four groups using a computer-generated table: root planing and periodontal curettage combined group (n = 18), root planning group (n = 18), periodontal curettage group (n = 18) and cleansing group (n = 18). Blood glucose, plaque index (PI), gingival index (GI), probing depth (PD), attachment loss (AL), serum levels of inflammatory factors (Tumor Necrosis Factor Alpha [TNF- α] and hypersensitive C-reactive protein [hs-CRP]) were observed before and after treatment. The collecting dates were analyzed by the chi-square χ 2 test, repeated measurement analysis of variance, or t-test according to different data types and research objectives. Results Before treatment, there was no significant difference in PI, GI, PD and AL among the four groups (P> 0.05), while after 3-month treatment, the levels of PI, GI, PD and AL in the combined group were lower than those in the root planing group, periodontal curettage group and cleansing group, with both root planing group and periodontal curettage group significantly lower than cleansing group (P< 0.05). The fasting blood glucose, 2-h postprandial blood glucose and glycosylated hemoglobin in the combined group, root planing group, periodontal curettage group and cleansing group were significantly lower than those before treatment (P < 0.05). Before treatment, there was no significant difference in TNF- α and hs-CRP among the four groups (P> 0.05), but the levels of TNF- α and hs-CRP in the four groups decreased significantly after 3-month treatment (P< 0.05). The levels of TNF- α and hs-CRP in the combined group were lower than those in the root planing group, periodontal curettage group and cleansing group, and those in the root planing group and periodontal curettage group were significantly lower than those in the cleansing group (P< 0.05). Conclusion The combination therapy of periodontal curettage and root planing exerted beneficial effects on moderate-to-severe chronic periodontitis in patients with type 2 diabetes mellitus, which holds the potential to maintain the level of blood glucose and improve the quality of life of the patients.

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Pharmaceutical hit of anti type 2 Diabetes mellitus on the phenolic extract of Malaka (Phyllanthus emblica L.) flesh

Clinical Phytoscience ◽

10.1186/s40816-019-0138-7 ◽

2019 ◽

Vol 5 (1) ◽

Author(s):

Musri Musman ◽

Mauli Zakia ◽

Ratu Fazlia Inda Rahmayani ◽

Erlidawati Erlidawati ◽

Safrida Safrida

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Body Weight ◽

Blood Glucose ◽

Phyllanthus Emblica ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Phenolic Extract

Abstract Background Ethnobotany knowledge in a community has shaped local wisdom in utilizing plants to treat diseases, such as the use of Malaka (Phyllanthus emblica) flesh to treat type 2 diabetes. This study presented evidence that the phenolic extract of the Malaka flesh could reduce blood sugar levels in the diabetic induced rats. Methods The phenolic extract of the P. emblica was administrated to the glucose-induced rats of the Wistar strain Rattus norvegicus for 14 days of treatment where the Metformin was used as a positive control. The data generated were analyzed by the two-way ANOVA Software related to the blood glucose level and by SAS Software related to the histopathological studies at a significant 95% confidence. Results The phenolic extract with concentrations of 100 and 200 mg/kg body weight could reduce blood glucose levels in diabetic rats. The post hoc Dunnet test showed that the administration of the extract to the rats with a concentration of 100 mg/kg body weight demonstrated a very significant decrease in blood glucose levels and repaired damaged cells better than administering the extract at a concentration of 200 mg/kg weight body. Conclusion The evidence indicated that the phenolic extract of the Malaka flesh can be utilized as anti type 2 Diabetes mellitus without damaging other organs.

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