scholarly journals Lost to Follow-Up in Asthmatics Does Not Mean Treatment Failure: Causes and Clinical Outcomes of Non-Adherence To Outpatient Treatment In Adult Asthma

2013 ◽  
Vol 5 (6) ◽  
pp. 357 ◽  
Author(s):  
Min-Gyu Kang ◽  
Joo-Young Kim ◽  
Jae-Woo Jung ◽  
Woo-Jung Song ◽  
Sang-Heon Cho ◽  
...  
PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0200505 ◽  
Author(s):  
Nigus Fikrie Telele ◽  
Amare Worku Kalu ◽  
Gaetano Marrone ◽  
Solomon Gebre-Selassie ◽  
Daniel Fekade ◽  
...  

2020 ◽  
Author(s):  
Biao Chen ◽  
Hankun Liu ◽  
Haitao Chen ◽  
Liaobin Chen ◽  
Hua Wang

Abstract Background: Popliteus tendinitis is an unusual factor to cause pain of the knee joint in its posterolateral compartment. There are few reports that the arthroscopy used for the treatment of refractory and symptomatic popliteus tendinitis. This study aimed to evaluate the effect of arthroscopic treatment of popliteus tendinitis via an auxiliary extreme lateral approach and to investigate the pathogenesis and treatment of popliteus tendinitis.Methods: From 2014 to 2018, arthroscopic popliteus tendon ablation was performed in 15 patients (15 knees) with popliteus tendinitis via an auxiliary extreme lateral approach. Clinical outcomes were assessed using the Lysholm knee scoring scale, the Tegner score, the International Knee Documentation Committee (IKDC) score and the visual analogue scale (VAS) pain score at the 24-month follow-up after surgery.Results: A total of 15 patients (mean age, 51.1 ± 7.1 years) were included; they had a mean body mass index of 23.8 ± 2.1. The minimum follow-up period was 24 months. Comparing the postoperative state to the preoperative state, the mean postoperative Lysholm score, Tegner score, and IKDC score improved significantly from 70.0 ± 5.0, 3.0 ± 0.9, and 62.3 ± 5.5 to 89.3 ± 4.2, 4.6 ± 0.61, and 80.5 ± 4.4, respectively (p < 0.01). The preoperative VAS score for pain improved from 4.3 ± 0.7 to 0.9 ± 0.6 (p < 0.01). No patients were lost to follow-up.Conclusion: Following arthroscopic-assisted treatment, all the patients with popliteus tendinitis achieved satisfactory clinical outcomes in terms of pain relief and improved function.


Author(s):  
Johannes Ndambuki ◽  
Joseph Nzomo ◽  
Lucy Muregi ◽  
Chris Mutuku ◽  
Francis Makokha ◽  
...  

Abstract Background Since 2016, patients with rifampicin-susceptible tuberculosis (TB) have been treated with the 6-month first-line regimen, regardless of treatment history. We assessed treatment outcomes of previously treated and new patients in Machakos subcounty, Kenya. Methods We performed a retrospective cohort study in patients started on first-line treatment between 2016 and 2017. Firth's logistic regression was used to estimate the effect of previous treatment on having a programmatic adverse outcome (either lost to follow-up, death, failure) and treatment failure vs treatment success (either cure or completion). Results Of 1024 new and 79 previously treated patients, 88.1% and 74.7% were treated successfully, 6.5% and 7.6% died, 4.2% and 10.1% were lost to follow-up and 1.2% and 7.6% had treatment failure, respectively. Previous treatment predicted having a programmatic adverse outcome (adjusted odds ratio [aOR] 2.4 [95% confidence interval {CI} 1.4 to 4.2]) and treatment failure (aOR 7.3 [95% CI 2.6 to 20.4]) but not mortality. Similar correlations were found in 334 new and previously treated patients with confirmed baseline rifampicin susceptibility. Conclusion Previously treated patients were more at risk of experiencing a poor treatment outcome, mainly lost to follow-up and treatment failure. Adherence support may reduce lost to follow-up. Rifampicin drug susceptibility testing coverage should increase. More robust retreatment regimens may reduce treatment failure.


Children ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 275
Author(s):  
Hamidu Adinani ◽  
Liane Campbell ◽  
Nader Kim El-Mallawany ◽  
Jeremy Slone ◽  
Parth Mehta ◽  
...  

Treating Kaposi sarcoma (KS) in children, adolescents, and young adults (AYA) remains a challenge in low- and middle-income countries (LMIC) where chemotherapy options and availability are limited. We describe a retrospective cohort review of pediatric patients with KS treated with paclitaxel in Mbeya, Tanzania, between 1 March 2011 and 31 December 2019. Paclitaxel was given to patients who had KS relapse, a contraindication to bleomycin, vincristine, and doxorubicin (ABV), special circumstances in which a clinician determined that paclitaxel was preferable to ABV, or experienced treatment failure, defined as persistent KS symptoms at the completion of treatment. All patients also received multidisciplinary palliative care. Seventeen patients aged 5.1–21.3 years received paclitaxel, of whom 47.1% (8/17) had treatment failure, 29.4% (5/17) received paclitaxel as initial treatment, and 23.5% (4/17) had relapsed. All HIV positive patients (16/17) were given anti-retroviral therapy (ART) and 87.5% (14/16) achieved viral load <1000 cp/mL. At censure, 82.3% (14/17) of patients were alive—71.4% (10/14) achieved complete clinical remission and 28.6% (4/14) achieved a partial response. The median follow up was 37.3 months (range 8.0–83.5, IQR 19.7–41.6), and no patients were lost to follow up. In this cohort, high rates of long-term survival and favorable outcomes were possible with paclitaxel treatment.


2021 ◽  
Author(s):  
Jung-Ro Yoon ◽  
Phil Sun Park ◽  
Tae Hyuck Yoon ◽  
Seung Hoon Lee

Abstract Background The hypotheses were as follows: 1) the clinical outcome of patients lost to follow-up after total knee arthroplasty (TKA) will be different compared to patients with follow-up; 2) follow-up rate will be affected by various social economic factors. Methods Patients who underwent TKA between March 2019 and February 2020 were retrospectively included. Patients lost to follow-up were defined as patients who did not undergo follow-up 6 months after TKA; all patients were divided into follow-up and follow-up loss groups. Western Ontario and McMaster Universities Osteoarthritis (WOMAC) and Knee Society Score (KSS) were measured before surgery. After surgery, WOMAC, KSS function, and satisfaction were measured via telephone. Age, sex, unilateral or bilateral TKA, distance from hospital, presence of a family, and insurance were investigated. Results A total of 137 patients were included in the study. There were 92 (67.2%) patients that followed up 6 months after TKA, on the other hand, 45 patients (32.8%) were lost to follow-up. There was no difference in clinical outcomes (WOMAC, p = 0.932; KSS clinical, p = 0.450) and satisfaction (pain: p = 0.230, function: p = 0.300) between two groups. Age, sex, unilateral or bilateral TKA, distance from hospital, presence of a family, and insurance had no effect on follow-up rates. Conclusion The clinical outcomes of patients lost to follow-up after TKA did not show a difference from those who were followed up. Age, sex, unilateral or bilateral TKA, distance from hospital, presence of a family, insurance status, and postoperative clinical symptoms did not affect the follow-up rate.


2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S424-S425
Author(s):  
David Pavkovich ◽  
Deborah Richmond ◽  
Jennifer Veltman

Abstract Background Integrase Strand Transfer Inhibitor (INSTIs) transmitted resistance has remained uncommon, estimated at 0.04%, with E157Q being the mutation most commonly identified. E157Q is thought to cause low-level resistance to raltegravir and elvitegravir but has also been the only mutation implicated in a recent case of dolutegravir treatment failure. INSTI resistance testing is not currently recommended and little data is available on clinical outcomes on INSTI therapy in the presence of E157Q, therefore we reviewed all the patients in an urban clinic in Detroit with E157Q seen on genotype to determine its clinical impact. Methods We reviewed the records of all Wayne State University Adult HIV clinic attendees in Detroit, Michigan who had an INSTI genotype performed between February 2014 and February 2016 to identify those with an E157Q mutation. We reviewed demographics, HIV risk factors, treatment and clinical outcomes. Results 292 patients had INSTI resistance testing during our study period. 24 patients (8.2%) had an E157Q mutation. These patients had a median age of 27.5 years. They were predominately male (87.5%), black (87.5%), and MSM (70.8%). Four patients had an additional mutation (N155H, T97S, L74V, and V151I). Eleven patients were treatment-naïve, consistent with transmitted E157Q drug resistance. One treatment-naïve patient had both the E157Q mutation and the T97S mutations. Of the 24 patients with E157Q, 15 were placed on an INSTI-based regimen and 6 (40%) achieved viral suppression at 12 months. 7 patients were lost to follow up at and 2 had stopped treatment at 12 months. Amongst patients adherent to INSTI based ART, there were no cases of treatment failure. Conclusion While our sample size was relatively small, our data suggests that E157Q is not an infrequent mutation and patients with E157Q who were started on INSTI based regimens and were adherent achieved viral suppression. This is reassuring for rapid ART start at time of HIV diagnosis with INSTI based ART without genotype data. Loss to follow up and poor adherence were seen frequently, limiting our ability to determine clinical outcomes on ART. In short, patients with E157Q mutation have good clinical outcomes on INSTI based ART. Disclosures All authors: No reported disclosures.


2018 ◽  
Vol 90 (3) ◽  
pp. 166-168
Author(s):  
Grazia Bianchi ◽  
Diego Marega ◽  
Roberto Knez ◽  
Stefano Bucci ◽  
Carlo Trombetta

Introduction. After extracorporeal lithotripsy (SWL), a spontaneous expulsion of fragments is often reported. The aim of this study is to demonstrate the presence of a stone free status or the presence of clinically insignificant residual fragments (CIRFs, defined as “asymptomatic, noninfectious, ≤ 3 mm fragments”) in people with undetected spontaneous expulsion. Materials and methods. Between May and September 2017, we performed a total of 87 treatments. The device used was a Storz Medical Modulith® SLK. All the patients were treated in prone position to reduce respiratory movements and underwent sonography before and four to eight weeks after the treatment. An in line ultrasound targeting was possible with all the stones. People lost to follow up or with ureteral stones were excluded. Patients were divided in groups according to gender, previous treatments, stone diameter and position. Results. We enrolled 73 patients. 57 patients had a single stone and 16 multiple stones. A mean number of 3044 shock waves was administered with a maximum average energy of 0.68mj/mmq. At follow up, 41 patients (56.2%) were found stone free or with CIRFs. The association between undetected expulsion and the presence of CIRFs is considered to be not statistically significant (p = 0.89). Among patients with CIRFs, 25/41 didn’t report expulsion. Taking in account the groups our population was divided in, according to gender (p = 0.36), previous treatments (p = 0.44), stone diameter (p = 0.28) and stone position (p = 0.35), the association between undetected spontaneous expulsion and presence of CIRFs was never statistically significant. Conclusions. An undetected spontaneous expulsion of stone fragments could not be considered a sign of SWL treatment failure. The association between undetected expulsion and presence of CIRFs is never statistically significant if gender of the patients, previous treatments, stone diameter and stone position are considered.


2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Diriba Mulisa ◽  
Mulugeta Tesfa ◽  
Getachew Mullu Kassa ◽  
Tadesse Tolossa

Abstract Background In 2018 in Ethiopia, magnitude of human immunodeficiency virus Acquired Immunodeficiency Syndrome treatment failure was 15.9% and currently the number of patient receiving second line antiretroviral therapy (ART) is more increasing than those taking first line ART. Little is known about the predictors of treatment failure in the study area. Therefore; more factors that can be risk for first line ART failure have to identified to make the patients stay on first line ART for long times. Consequently, the aim of this study was to identify determinants of first line ART treatment failure among patients on ART at St. Luke referral hospital and Tulubolo General Hospital, 2019. Methods A 1:2 un-matched case-control study was conducted among adult patients on active follow up. One new group variables was formed as group 1 for cases and group 0 for controls and then data was entered in to Epi data version 3 and exported to STATA SE version 14 for analysis. From binary logistic regression variables with p value ≤0.25 were a candidate for multiple logistic regression. At the end variables with a p-value ≤0.05 were considered as statistically significant. Result A total of 350 (117 cases and 233 controls) patients were participated in the study. Starting ART after 2 years of being confirmed HIV positive (AOR = 3.82 95% CI 1.37,10.6), nevirapine (NVP) based initial ART (AOR = 2.77,95%CI 1.22,6.28) having history of lost to follow up (AOR 3.66,95%CI 1.44,9.27) and base line opportunistic infection (AOR = 1.97,95%CI 1.06,3.63), staying on first line ART for greater than 5 years (AOR = 3.42,95%CI 1.63,7.19) and CD4 less than100cell/ul (AOR = 2.72,95%CI 1.46,5.07) were independent determinants of first line ART treatment failure. Conclusion Lost to follow up, staying on first line ART for greater than 5 years, presence of opportunistic infections, NVP based NNRT, late initiation of ART are determinant factors for first line ART treatment failure. The concerned bodies have to focus and act on those identified factors to maintain the patient on first line ART.


2021 ◽  
Vol 9 (7_suppl4) ◽  
pp. 2325967121S0021
Author(s):  
Joseph Lamplot ◽  
Sarav Shah ◽  
Justin Chan ◽  
Kyle Hancock ◽  
Joseph Gentile ◽  
...  

Objectives: Over the past decade, there have been advances in arthroscopic-assisted approaches for coracoclavicular (CC) reconstruction with less surgical morbidity and enhanced visualization while also allowing for the treatment of concomitant glenohumeral pathology. Previous studies reporting outcomes using both open and arthroscopic-assisted techniques are limited by short-term follow-up and small patient populations. It also remains unclear how maintenance of reduction and clinical outcomes correlate with one another. The purpose of our study was to report clinical and functional outcomes including return to pre-injury activity level following arthroscopic-assisted CC ligament reconstruction (AA-CCR) and to determine associations between return to pre-injury activity level, radiographic outcomes and patient-reported outcomes scores following AA-CCR. We hypothesized that patients undergoing AA-CCR would have a high rate of return to pre-injury activity level, clinical outcomes would not be associated with RLOR, and that the treatment of concomitant glenohumeral pathology would not adversely affect outcomes. Methods: A retrospective review of prospectively collected data from an institutional registry of all AA-CCR performed from January 2007-January 2016 was performed. Exclusion criteria included revision CCR, open CCR, and patients with less than two-year follow-up. Demographics and patient characteristics including sex, age at index surgery, grade of AC joint injury, duration between injury and index surgery, concomitant glenohumeral pathologies and procedures performed, complications, and subsequent surgeries were recorded. Grade of AC joint injury was determined using the Rockwood classification, and patients indicated for surgery had at least a Type III injury. Time elapsed between injury and index surgery was recorded and classified as acute (0–30 days) or chronic (> 30 days). The arthroscopic-assisted portion of the CC reconstruction has been prevously described and is as follows: The base of the coracoid then exposed either through a subacromial or intraarticular approach. Passing sutures were then placed around the coracoid for later shuttling of the soft tissue graft (allograft semitendinosus/posterior tibialis/anterior tibialis or autograft semitendinosus, according to surgeon preference) and heavy suture, which was used for ancillary fixation. Postoperative radiographs were obtained at approximately two weeks and six months following surgery. The CC distance was measured at final radiographic follow-up and compared to the unaffected contralateral side on an anteroposterior (AP) radiograph. Radiographic loss of reduction (RLOR), was defined as at least a 25% increase in CC distance as measured from the superior cortex of the coracoid process and the undersurface of the clavicle using a radiographic ruler compared to the contralateral side. Clinical assessment at final follow-up included SANE score, and additionally, patients were asked which sports(s) and/or recreational activity(s) they participated in prior to injury. For each sport or recreational activity, they were then specifically asked: “Were you able to return to the same or higher level of (specific sport or activity) as prior to your injury?” Failure of AA-CCR was defined as any one of the following: 1.) Patient underwent revision AC joint stabilization surgery, 2.) Patient was unable to return to the same or higher level of sport(s) and/or recreational activity(s) as prior to injury, 3.) Patient had RLOR as defined above. For comparative analysis, patients were characterized as having one primary mode of treatment failure. Post-hoc analysis was performed considering that patients may have more than one mode of treatment failure. Results: There were 88 patients (89.8% male) with a mean age of 39.6 years (range 18-65) and minimum 2-year follow-up (mean 6.1 years, range 2.1-10.3). Follow-up rate was 67.7%. Mean time from injury to surgery was 7.2±2.4 months, with 70% chronic injuries and 63.6% grade V. Concomitant arthroscopic procedures were performed in 48.9% of cases. Overall, mean SANE score was 86.3 ± 17.5. Treatment failure occurred in 17.1%, with 8.0% unable to return to activity, 5.7% with RLOR, and 3.4% undergoing revision surgery for failed AA-CCR. Each patient undergoing revision surgery had an identifable traumatic event. All patients with RLOR were able to return to pre-injury activity level. SANE score was lower among patients who were unable to return to activity compared to those with RLOR and compared to non-failures (p=0.0002) (Table 1). Post-hoc analysis considering multiple modes of treatment failure for individual patients demonstrated that SANE score was still significantly lower among those unable to return to pre-injury activity level compared to patients with RLOR and compared to patients considered non-failures (p=0.00003). Ninety three percent of patients who participated in weightlifting, 97% who participated in swimming, and 83% of those who participated in yoga were able to return to their respective activity at the same or higher level as pre-injury at final followup. For all other sporrts, all patients returned to their pre-injury activity level. There were no differences in revision surgery rates, return to activity, or SANE scores according to the specific surgical technique used, Rockwood grade, or if concomitant pathology was treated (Table 2-4). Conclusions: AA-CCR with free tendon grafts resulted in good clinical outcomes and a high rate of return to pre-injury activity level. RLOR did not correlate with return to pre-injury activity level. Concomitant pathology that required treatment did not adversely affect outcomes. Return to pre-injury activity level may be a more clinically relevant outcome measure than radiographic maintenance of AC joint reduction. [Table: see text][Table: see text][Table: see text][Table: see text]


2021 ◽  
Vol 25 (8) ◽  
pp. 632-639
Author(s):  
A. G. C. Smith ◽  
M. Gujabidze ◽  
T. Avaliani ◽  
H. M. Blumberg ◽  
J. M. Collins ◽  
...  

SETTING: National Center for Tuberculosis and Lung Diseases (NCTLD), Tbilisi, Georgia.OBJECTIVE: To determine clinical outcomes of patients with tuberculous meningitis (TBM) treated with an intensified regimen including a fluoroquinolone (FQ) and an injectable agent.DESIGN: Prospective cohort of patients aged ≥16 years initiating treatment for TBM at the NCTLD from January 2018 to December 2019. Treatment outcomes and neurologic disability at 1, 6 and 12 months after treatment initiation were assessed.RESULTS: Among 77 patients with median follow-up time of 363 days (IQR 269–374), 97% received a FQ, 62% an injectable agent, 44% linezolid and 39% a carbapenem. Fifty-seven patients (74%) successfully completed treatment, 2 (2.6%) had treatment failure, 6 (7.8%) died, and the remainder (12%) were lost to follow up. Among 11 patients treated for multidrug-resistant TBM, the median follow-up time was 467 days and one patient (8%) died. Regarding neurologic outcomes, 14/76 (18%) patients had Modified Rankin Scores of 0 at baseline, improving to 85% (56/66) and 94% (47/50) at 6 and 12 months, respectively.CONCLUSION: Intensified multidrug treatment regimens including a FQ and an injectable agent in all patients and newly implemented drugs in patients with multidrug-resistant TBM resulted in low mortality and favorable neurologic outcomes.


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