Differential Anti-Inflammatory Effects of Three Purified Omega Unsaturated Fatty Acids on Collagen-Induced Arthritis in Mouse

Acai (Euterpe oleracea Mart. Palmae, Arecaceae) is a palm plant native to the Brazilian Amazon. It contains many nutrients, such as polyphenols, iron, vitamin E, and unsaturated fatty acids, so in recent years, many of the antioxidant and anti-inflammatory effects of acai have been reported. However, the effects of acai on hematopoiesis have not been investigated yet. In the present study, we administered acai extract to mice and evaluated its hematopoietic effects. Acai treatment significantly increased the erythrocytes, hemoglobin, and hematocrit contents compared to controls for four days. Then, we examined the hematopoietic-related markers following a single injection. Acai administration significantly increased the levels of the hematopoietic-related hormone erythropoietin in blood compared to controls and also transiently upregulated the gene expression of Epo in the kidney. Furthermore, in the mice treated with acai extract, the kidneys were positively stained with the hypoxic probe pimonidazole in comparison to the controls. These results demonstrated that acai increases the erythropoietin expression via hypoxic action in the kidney. Acai can be expected to improve motility through hematopoiesis.

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Magnetoliposomes Loaded with Poly-Unsaturated Fatty Acids as Novel Theranostic Anti-Inflammatory Formulations

Theranostics ◽

10.7150/thno.10069 ◽

2015 ◽

Vol 5 (5) ◽

pp. 489-503 ◽

Cited By ~ 14

Author(s):

Daniel Calle ◽

Viviana Negri ◽

Paloma Ballesteros ◽

Sebastián Cerdán

Keyword(s):

Fatty Acids ◽

Unsaturated Fatty Acids ◽

Anti Inflammatory

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Diet Content of Non-Saturated Fatty Acids is Related to Lower Plasma Adiponectin in Patients with Metabolic Syndrome

10.21203/rs.3.rs-713993/v1 ◽

2021 ◽

Author(s):

Juan Antonio Suárez-Cuenca ◽

Diana Elisa Díaz-Jiménez ◽

Juan Antonio Pineda-Juárez ◽

Alondra Gissel Mendoza-Mota ◽

Ofelia Dinora Valencia-Aldana ◽

...

Keyword(s):

Metabolic Syndrome ◽

Fatty Acids ◽

Inflammatory Cytokines ◽

Unsaturated Fatty Acids ◽

Saturated Fatty Acids ◽

Cross Sectional ◽

Plasma Adiponectin ◽

The Metabolic Syndrome ◽

Metabolic Role ◽

Anti Inflammatory

Abstract Introduction. The metabolic syndrome (MS) has been related to the unbalance between pro- and anti-inflammatory cytokines; where adiponectin, an anti-inflammatory adipokine, is considered to play a key metabolic role. The consumption of certain micronutrients has been claimed to modify pro- and anti-inflammatory cytokines. Aim. To explore whether dietary micronutrients are related with plasma adiponectin in patients with MS. Methods. Cross-sectional analysis. Quartiles of dietary bioactive compounds were compared according to values of plasma adiponectin. Interquartile variation (IQV) and correlation analyses were performed. Results. There was a significant IQV of dietary unsaturated fatty acids (between -50% to -66% of change, p25 vs p75, p<0.05), particularly for trans-fatty acids, poly-unsaturated fatty acids, mono-unsaturated fatty acids and w-6 fatty acids, in relation to plasma adiponectin; as well as a negative correlation (rho= -0.53, -0.37, -0.29 and -0.34, respectively; p<0.05). Conclusion. Dietary amounts of unsaturated fatty acids inversely related to plasma adiponectin in patients with MS.

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Bioactive Compounds in Edible Oils and Their Role in Oxidative Stress and Inflammation

Frontiers in Physiology ◽

10.3389/fphys.2021.659551 ◽

2021 ◽

Vol 12 ◽

Author(s):

Alessandra Mazzocchi ◽

Valentina De Cosmi ◽

Patrizia Risé ◽

Gregorio Paolo Milani ◽

Stefano Turolo ◽

...

Keyword(s):

Oxidative Stress ◽

Fatty Acids ◽

Chronic Diseases ◽

Bioactive Compounds ◽

Unsaturated Fatty Acids ◽

Edible Oils ◽

Fats And Oils ◽

Bioactive Lipids ◽

Edible Fats ◽

Anti Inflammatory

Diet and inflammatory response are recognized as strictly related, and interest in exploring the potential of edible fats and oils for health and chronic diseases is emerging worldwide. Polyunsaturated fatty acids (PUFAs) present in fish oil (FO), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may be partly converted into oxygenated bioactive lipids with anti-inflammatory and/or pro-resolving activities. Moreover, the co-presence of phenolic compounds and vitamins in edible oils may prevent the development of chronic diseases by their anti-inflammatory, antioxidant, neuroprotective, and immunomodulatory activities. Finally, a high content in mono-unsaturated fatty acids may improve the serum lipid profile and decrease the alterations caused by the oxidized low-density lipoproteins and free radicals. The present review aims to highlight the role of lipids and other bioactive compounds contained in edible oils on oxidative stress and inflammation, focusing on critical and controversial issues that recently emerged, and pointing to the opposing role often played by edible oils components and their oxidized metabolites.

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The increase in unsaturated fatty acids is related with an anti-inflammatory profile in the hypothalamus of non-diabetic IRS2-deficient mice

Endocrine Abstracts ◽

10.1530/endoabs.49.ep435 ◽

2017 ◽

Author(s):

Vicente Barrios ◽

Maria Vinaixa ◽

Laura M. Frago ◽

Sandra Canelles ◽

Angela M. Valverde ◽

...

Keyword(s):

Fatty Acids ◽

Unsaturated Fatty Acids ◽

Anti Inflammatory ◽

Inflammatory Profile ◽

Deficient Mice

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POSSIBILITIES OF NONTRADITIONAL MEDICINE IN ADDITIONAL TREATMENT FOR INFLAMMATORY DISEASES OF THE RESPIRATORY TRACT

Ukrainian Pulmonology Journal ◽

10.31215/2306-4927-2021-29-4-64-68 ◽

2021 ◽

Vol 29 (4) ◽

pp. 64-68

Author(s):

O. О. Rechkina ◽

◽

O. V. Strafun ◽

М. О. Polianska ◽

М. Р. Budyonna

Keyword(s):

Oxidative Stress ◽

Fatty Acids ◽

Respiratory Tract ◽

Dietary Supplement ◽

Unsaturated Fatty Acids ◽

Inflammatory Diseases ◽

Additional Treatment ◽

Complex Treatment ◽

Adults And Children ◽

Anti Inflammatory

POSSIBILITIES OF NONTRADITIONAL MEDICINE IN ADDITIONAL TREATMENT FOR INFLAMMATORY DISEASES OF THE RESPIRATORY TRACT O. О. Rechkina, O. V. Strafun, М. О. Polianska, М. Р. Budyonna Abstract Oxidative stress plays an important role іn the pathogenesis of airway inflammatory diseases. Multivitamin preparations containing antioxidants, nutritional supplements are significant support in the fight against oxidative stress. The healing properties of one such supplement, badger fat, have been known for centuries. It is used in folk medicine as a natural and effective agent with bactericidal, anti-inflammatory, immunostimulating and general strengthening effects. The main active components of badger fat include unsaturated fatty acids and vitamins, especially A, E and D. Vitamins of these groups enhance the anti-inflammatory effect of unsaturated fatty acids, and also exhibit high antioxidant activity, while unsaturated fatty acids (including omega-3, omega-6), help to improve metabolic processes and tissue trophism, exhibiting anti-inflammatory and antioxidant effects. The article presents the characteristics of the dietary supplement “Borsukovy zhyr”, the results of studies of its effectiveness and tolerability in the complex treatment of chronic bronchitis and AE COPD, as a component of therapy of adults and children with bronchopulmonary diseases, showing its effectiveness, safety and good tolerability. The supplement can be used in the complex treatment of bronchopulmonary pathology in both adults and children as a safe source of fat-soluble vitamins and polyunsaturated fatty acids. Key words: oxidative stress, antioxidants, dietary supplement, badger fat.

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Unsaturated fatty acids from flaxseed oil and exercise modulate GPR120 but not GPR40 in the liver of obese mice: a new anti-inflammatory approach

The Journal of Nutritional Biochemistry ◽

10.1016/j.jnutbio.2018.12.003 ◽

2019 ◽

Vol 66 ◽

pp. 52-62 ◽

Cited By ~ 10

Author(s):

Rafael Calais Gaspar ◽

Camilla Bertuzzo Veiga ◽

Mariana Pereira Bessi ◽

Marcella Neves Dátilo ◽

Marcella Ramos Sant'Ana ◽

...

Keyword(s):

Fatty Acids ◽

Unsaturated Fatty Acids ◽

Flaxseed Oil ◽

Obese Mice ◽

Anti Inflammatory

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A novel anti-inflammatory role of GPR120 in intestinal epithelial cells

AJP Cell Physiology ◽

10.1152/ajpcell.00123.2015 ◽

2016 ◽

Vol 310 (7) ◽

pp. C612-C621 ◽

Cited By ~ 31

Author(s):

Arivarasu N. Anbazhagan ◽

Shubha Priyamvada ◽

Tarunmeet Gujral ◽

Sumit Bhattacharyya ◽

Waddah A. Alrefai ◽

...

Keyword(s):

Fatty Acids ◽

Cell Line ◽

Unsaturated Fatty Acids ◽

Inflammatory Responses ◽

Hormone Secretion ◽

Receptor Internalization ◽

Intestinal Epithelial ◽

Gut Hormone ◽

Anti Inflammatory

GPR120 (free fatty acid receptor-4) is a G protein-coupled receptor for medium- and long-chain unsaturated fatty acids, including ω-3 fatty acids. Recent studies have shown GPR120 to play cardinal roles in metabolic disorders via modulation of gut hormone secretion and insulin sensitivity and to exert anti-inflammatory effects in macrophages and adipose tissues. However, information on anti-inflammatory role of GPR120 at the level of intestinal epithelium is very limited. Current studies demonstrated differential levels of GPR120 mRNA and protein along the length of the human, mouse, and rat intestine and delineated distinct anti-inflammatory responses following GPR120 activation in model human intestinal epithelial Caco-2 cells, but not in model mouse intestinal epithelial endocrine cell line STC-1. In Caco-2 cells, GPR120 was internalized, bound to β-arrestin-2, and attenuated NF-κB activation in response to 30-min exposure to the agonists GW9508, TUG-891, or docosahexaenoic acid. These effects were abrogated in response to small interfering RNA silencing of β-arrestin-2. Treatment of STC-1 cells with these agonists did not induce receptor internalization and had no effects on NF-κB activation, although treatment with the agonists GW9508 or TUG-891 for 6 h augmented the synthesis and secretion of the gut hormone glucagon-like peptide-1 in this cell line. Our studies for the first time demonstrated a GPR120-mediated novel anti-inflammatory pathway in specific intestinal epithelial cell types that could be of therapeutic relevance to intestinal inflammatory disorders.

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Antiglycation and Fatty Acids Profiling in Response to Phyocyanin Extracted from Chlorophyta Ulva lactuca Algae Loaded on Albumin Nano-particles (ULANP) in Diabetic Rats

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2019/v26i430144 ◽

2019 ◽

pp. 1-7

Author(s):

Abdulrahman L. Al-Malki ◽

Elie K. Barbour ◽

Khadijah S. Balamash ◽

Fawzia A. Alshubaily ◽

Khalid O. Abualnaja ◽

...

Keyword(s):

Fatty Acids ◽

Unsaturated Fatty Acids ◽

Saturated Fatty Acids ◽

Diabetic Rats ◽

Ulva Lactuca ◽

Nano Particles ◽

Albino Rats ◽

Fatty Acids Profile ◽

Spectral Bands ◽

Anti Inflammatory

Aim: This study evaluated the effect of Phyocyanin extracted from Chlorophyta Ulva lactuca algae loaded on albumin nano-particles (ULANP) on diabetic rats. Materials and Methods: Fifty albino rats were divided into 5 goups. GPI: control and GPII: rats were injected with alloxan (75 mg /kg) i.p for six consecutive days for induction of diabetes. This group was subdivided into 4 subgroups: GP IIa: (Untreated diabetic): GP IIb: rats were given with ULANP (100 mg/kg).GP IIc: Rats were given ULANP (200 mg/kg) i.p. GP IId: Rats were given insulin (100 unit/ day). Serum NO, interleukin-6 glucose, AGEs and fatty acids profile was determined. Results: Analysis of ULANP by FTIR showed the characteristic band (2100 cm-1~ 3700 cm-1) that is indicated mainly from -COO, – CO and conjugated double bond. These bonds showed spectral bands peak 2985 cm-1 and 2860 cm-1, 2986 cm-1. Administration of ULANP in diabetic rats exerted an anti-inflammatory by lowering NO and IL-6 levels and hypoglycemic effects by decreased glucose and reduced AGEs levels. In addition, ULAPN lowered percent of saturated fatty acids while elevated unsaturated fatty acids percent. Conclusion: It was concluded that, ULAPN is a promising effective anti-inflammatory and hypoglycemic agent compared with other therapeutic agents with lower site effects.

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