scholarly journals Bioactive Compounds in Edible Oils and Their Role in Oxidative Stress and Inflammation

2021 ◽  
Vol 12 ◽  
Author(s):  
Alessandra Mazzocchi ◽  
Valentina De Cosmi ◽  
Patrizia Risé ◽  
Gregorio Paolo Milani ◽  
Stefano Turolo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Chronic Diseases ◽  
Bioactive Compounds ◽  
Unsaturated Fatty Acids ◽  
Edible Oils ◽  
Fats And Oils ◽  
Bioactive Lipids ◽  
Edible Fats ◽  
Anti Inflammatory

Diet and inflammatory response are recognized as strictly related, and interest in exploring the potential of edible fats and oils for health and chronic diseases is emerging worldwide. Polyunsaturated fatty acids (PUFAs) present in fish oil (FO), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may be partly converted into oxygenated bioactive lipids with anti-inflammatory and/or pro-resolving activities. Moreover, the co-presence of phenolic compounds and vitamins in edible oils may prevent the development of chronic diseases by their anti-inflammatory, antioxidant, neuroprotective, and immunomodulatory activities. Finally, a high content in mono-unsaturated fatty acids may improve the serum lipid profile and decrease the alterations caused by the oxidized low-density lipoproteins and free radicals. The present review aims to highlight the role of lipids and other bioactive compounds contained in edible oils on oxidative stress and inflammation, focusing on critical and controversial issues that recently emerged, and pointing to the opposing role often played by edible oils components and their oxidized metabolites.

scholarly journals Health-promoting effects of bioactive compounds in blackcurrant (Ribes nigrum L.) Berries

2021 ◽  
pp. 229-238
Author(s):  
Michał Oczkowski
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Chronic Diseases ◽  
Bioactive Compounds ◽  
Unsaturated Fatty Acids ◽  
Nutrition Therapy ◽  
Alcoholic Beverages ◽  
Freeze Dried ◽  
Health Promoting ◽  
Potential Use

Blackcurrant (BC) is a well-known and appreciated berry fruit in our country and Poland is the largest BC producer among European Union countries and the second, after Russia, producer in the world. Due to the short shelf life of BC, its consumption in fresh form is relatively low , therefore the berries are processed into juices, jams, jellies, and freeze-dried products or alcoholic beverages. The high nutritional value of BC berries result from high content of bioactive compounds (among others, vitamin C, anthocyanins, pectins, organic acids, as well as polyunsaturated fatty acids contained in seeds of the fruit). Anthocyanins (ANTs) create the largest group among all polyphenolic compounds contained in BC. The results from different studies confirm that ANTs are important in attenuation oxidative stress parameters in the organism, and therefore can reduce the risk of certain non-communicable chronic diseases. Consumption of unprocessed and processed blackcurrants (i.e. juices and products containing fruit extracts) may support the nutrition therapy of cardiovascular diseases, certain eye diseases and may normalize the lipid profile of the blood plasma. Additionally, the beneficial profile of unsaturated fatty acids from BC seeds supports the therapy of autoimmune diseases. This article is attempts to summarize the results of the studies on the anti-inflammatory, immunomodulatory, anti-tumor and antimicrobial effects of BC bioactive compounds including the mechanisms of their action depending on the form of the fruit (e.g. juice, whole fruit extract, dried pomace, or seed oil). The article also highlights the potential use of BC in production of functional food, important in the dietary prevention of non-communicable chronic diseases resulting from increased oxidative stress in the organism.

scholarly journals POSSIBILITIES OF NONTRADITIONAL MEDICINE IN ADDITIONAL TREATMENT FOR INFLAMMATORY DISEASES OF THE RESPIRATORY TRACT

2021 ◽  
Vol 29 (4) ◽  
pp. 64-68
Author(s):  
O. О. Rechkina ◽  
◽  
O. V. Strafun ◽  
М. О. Polianska ◽  
М. Р. Budyonna
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Respiratory Tract ◽  
Dietary Supplement ◽  
Unsaturated Fatty Acids ◽  
Inflammatory Diseases ◽  
Additional Treatment ◽  
Complex Treatment ◽  
Adults And Children ◽  
Anti Inflammatory

POSSIBILITIES OF NONTRADITIONAL MEDICINE IN ADDITIONAL TREATMENT FOR INFLAMMATORY DISEASES OF THE RESPIRATORY TRACT O. О. Rechkina, O. V. Strafun, М. О. Polianska, М. Р. Budyonna Abstract Oxidative stress plays an important role іn the pathogenesis of airway inflammatory diseases. Multivitamin preparations containing antioxidants, nutritional supplements are significant support in the fight against oxidative stress. The healing properties of one such supplement, badger fat, have been known for centuries. It is used in folk medicine as a natural and effective agent with bactericidal, anti-inflammatory, immunostimulating and general strengthening effects. The main active components of badger fat include unsaturated fatty acids and vitamins, especially A, E and D. Vitamins of these groups enhance the anti-inflammatory effect of unsaturated fatty acids, and also exhibit high antioxidant activity, while unsaturated fatty acids (including omega-3, omega-6), help to improve metabolic processes and tissue trophism, exhibiting anti-inflammatory and antioxidant effects. The article presents the characteristics of the dietary supplement “Borsukovy zhyr”, the results of studies of its effectiveness and tolerability in the complex treatment of chronic bronchitis and AE COPD, as a component of therapy of adults and children with bronchopulmonary diseases, showing its effectiveness, safety and good tolerability. The supplement can be used in the complex treatment of bronchopulmonary pathology in both adults and children as a safe source of fat-soluble vitamins and polyunsaturated fatty acids. Key words: oxidative stress, antioxidants, dietary supplement, badger fat.

Advances in the Chromatographic Separation and Determination of Bioactive Compounds for Assessing the Nutrient Profile of Nuts

2020 ◽  
Vol 16 ◽  
Author(s):  
Natasa P. Kalogiouri ◽  
Natalia Manousi ◽  
Erwin Rosenberg ◽  
George A. Zachariadis ◽  
Victoria F. Samanidou
Keyword(s):  
Fatty Acids ◽  
Phenolic Compounds ◽  
Bioactive Compounds ◽  
High Performance ◽  
Unsaturated Fatty Acids ◽  
Nutritional Deficiencies ◽  
Analytical Technique ◽  
High Volatility ◽  
Analytical Approaches

Background:: Nuts have been incorporated into guidelines for healthy eating since they contain considerable amounts of antioxidants and their effects are related to health benefits since they contribute to the prevention of nutritional deficiencies. The micronutrient characterization is based mainly on the determination of phenolics which is the most abundant class of bioactive compounds in nuts. Terpenes constitute another class of bioactive compounds that are present in nuts and show high volatility. The analysis of phenolic compounds and terpenes are very demanding tasks that require optimization of the chromatographic conditions to improve the separation of the components. Moreover, nuts are rich in unsaturated fatty acids and they are therefore considered as cardioprotective. Gas chromatography is the predominant instrumental analytical technique for the determination of derivatized fatty acids and terpenes in food matrices, while high performance liquid chromatography is currently the most popular technique for the determination of phenolic compounds Objective:: This review summarizes all the recent advances in the optimization of the chromatographic conditions for the determination of phenolic compounds, fatty acids and terpenes in nuts Conclusion:: The state-of-the art in the technology available is critically discussed, exploring new analytical approaches to reduce the time of analysis and improve the performance of the chromatographic systems in terms of precision, reproducibility, limits of detection and quantification and overall quality of the results

Bee collected pollen as a value-added product rich in bioactive compounds and unsaturated fatty acids: A comparative study from Turkey and Romania

LWT ◽  
2021 ◽  
pp. 111925
Author(s):  
Rodica Mărgăoan ◽  
Aslı Özkök ◽  
Şaban Keskin ◽  
Nazlı Mayda ◽  
Adriana Cristina Urcan ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Comparative Study ◽  
Bioactive Compounds ◽  
Unsaturated Fatty Acids ◽  
Value Added ◽  
A Value

scholarly journals “Cell Membrane Theory of Senescence” and the Role of Bioactive Lipids in Aging, and Aging Associated Diseases and Their Therapeutic Implications

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 241
Author(s):  
Undurti N. Das
Keyword(s):  
Fatty Acids ◽  
Cell Membrane ◽  
Linolenic Acid ◽  
Genomic Stability ◽  
Bioactive Lipids ◽  
Camp Content ◽  
Associated Diseases ◽  
Epa And Dha ◽  
Oncogene Activation ◽  
Anti Inflammatory

Lipids are an essential constituent of the cell membrane of which polyunsaturated fatty acids (PUFAs) are the most important component. Activation of phospholipase A2 (PLA2) induces the release of PUFAs from the cell membrane that form precursors to both pro- and ant-inflammatory bioactive lipids that participate in several cellular processes. PUFAs GLA (gamma-linolenic acid), DGLA (dihomo-GLA), AA (arachidonic acid), EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are derived from dietary linoleic acid (LA) and alpha-linolenic acid (ALA) by the action of desaturases whose activity declines with age. Consequently, aged cells are deficient in GLA, DGLA, AA, AA, EPA and DHA and their metabolites. LA, ALA, AA, EPA and DHA can also be obtained direct from diet and their deficiency (fatty acids) may indicate malnutrition and deficiency of several minerals, trace elements and vitamins some of which are also much needed co-factors for the normal activity of desaturases. In many instances (patients) the plasma and tissue levels of GLA, DGLA, AA, EPA and DHA are low (as seen in patients with hypertension, type 2 diabetes mellitus) but they do not have deficiency of other nutrients. Hence, it is reasonable to consider that the deficiency of GLA, DGLA, AA, EPA and DHA noted in these conditions are due to the decreased activity of desaturases and elongases. PUFAs stimulate SIRT1 through protein kinase A-dependent activation of SIRT1-PGC1α complex and thus, increase rates of fatty acid oxidation and prevent lipid dysregulation associated with aging. SIRT1 activation prevents aging. Of all the SIRTs, SIRT6 is critical for intermediary metabolism and genomic stability. SIRT6-deficient mice show shortened lifespan, defects in DNA repair and have a high incidence of cancer due to oncogene activation. SIRT6 overexpression lowers LDL and triglyceride level, improves glucose tolerance, and increases lifespan of mice in addition to its anti-inflammatory effects at the transcriptional level. PUFAs and their anti-inflammatory metabolites influence the activity of SIRT6 and other SIRTs and thus, bring about their actions on metabolism, inflammation, and genome maintenance. GLA, DGLA, AA, EPA and DHA and prostaglandin E2 (PGE2), lipoxin A4 (LXA4) (pro- and anti-inflammatory metabolites of AA respectively) activate/suppress various SIRTs (SIRt1 SIRT2, SIRT3, SIRT4, SIRT5, SIRT6), PPAR-γ, PARP, p53, SREBP1, intracellular cAMP content, PKA activity and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC1-α). This implies that changes in the metabolism of bioactive lipids as a result of altered activities of desaturases, COX-2 and 5-, 12-, 15-LOX (cyclo-oxygenase and lipoxygenases respectively) may have a critical role in determining cell age and development of several aging associated diseases and genomic stability and gene and oncogene activation. Thus, methods designed to maintain homeostasis of bioactive lipids (GLA, DGLA, AA, EPA, DHA, PGE2, LXA4) may arrest aging process and associated metabolic abnormalities.

scholarly journals Quantitative Analysis of Nutrients and Biochemical Evaluation in Pomfret Fish (Pampus argenteus) During Frozen Storage

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Utkalendu suvendusekhar Samantaray ◽  
Swagatika Tripathy
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
Frozen Storage ◽  
Storage Condition ◽  
Essential Amino Acids ◽  
Omega 3 ◽  
High Concentration ◽  
Balanced Diet ◽  
Pampus Argenteus

Marine fish are well-known for being a high-quality protein source having high concentration of essential amino acids. It has high concentration of mono unsaturated and poly unsaturated fatty acids, which may aid in the optimization of lipid profiles and the reduction of the risk of coronary heart disease (CHD). The goal of this study was to estimate the nutritional and biochemical status of raw sea fish Pampus argenteus after 30 days of frozen storage at -200C with 15-day intervals. Nutrient study showed a decrease in protein and lipid content. The changes of hydrogen peroxide and oxidized lipid products were estimated in the muscle tissue during fresh and storage condition. Results indicate that during storage the oxidative stress increased. An antioxidant enzyme (superoxide dismutase, smutase, catalase, glutathione peroxidase) measurement was determined. The increased amount of oxidative stress during fish storage is shown by the differential activity of antioxidant enzymes. The amount of protein in fish varies slightly between species and even within species. Fish is high in protein, vitamins, minerals, and omega-3 fatty acids, which are essential for brain development (Spencer et al., 1971; Jacylin et al., 2010). A well-balanced diet consists variety of fish that can help in children's growth and development as well as their heart health (Jinadasa, 2014).

scholarly journals Anti‐inflammatory effect of omega unsaturated fatty acids and dialysable leucocyte extracts on collagen‐induced arthritis in DBA/1 mice

2020 ◽  
Vol 101 (1-2) ◽  
pp. 55-64
Author(s):  
Pamela I. Pérez‐Martínez ◽  
Oscar Rojas‐Espinosa ◽  
Víctor G. Hernández‐Chávez ◽  
Patricia Arce‐Paredes ◽  
Sergio Estrada‐Parra
Keyword(s):  
Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
Collagen Induced Arthritis ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Acai Extract Transiently Upregulates Erythropoietin by Inducing a Renal Hypoxic Condition in Mice

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 533 ◽  
Author(s):  
Shuichi Shibuya ◽  
Toshihiko Toda ◽  
Yusuke Ozawa ◽  
Mario Jose Villegas Yata ◽  
Takahiko Shimizu
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Vitamin E ◽  
Unsaturated Fatty Acids ◽  
Single Injection ◽  
Hypoxic Condition ◽  
Brazilian Amazon ◽  
Euterpe Oleracea ◽  
Anti Inflammatory ◽  
Euterpe Oleracea Mart

Acai (Euterpe oleracea Mart. Palmae, Arecaceae) is a palm plant native to the Brazilian Amazon. It contains many nutrients, such as polyphenols, iron, vitamin E, and unsaturated fatty acids, so in recent years, many of the antioxidant and anti-inflammatory effects of acai have been reported. However, the effects of acai on hematopoiesis have not been investigated yet. In the present study, we administered acai extract to mice and evaluated its hematopoietic effects. Acai treatment significantly increased the erythrocytes, hemoglobin, and hematocrit contents compared to controls for four days. Then, we examined the hematopoietic-related markers following a single injection. Acai administration significantly increased the levels of the hematopoietic-related hormone erythropoietin in blood compared to controls and also transiently upregulated the gene expression of Epo in the kidney. Furthermore, in the mice treated with acai extract, the kidneys were positively stained with the hypoxic probe pimonidazole in comparison to the controls. These results demonstrated that acai increases the erythropoietin expression via hypoxic action in the kidney. Acai can be expected to improve motility through hematopoiesis.

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