A Comprehensive Evaluation of the Relationship Between Fall Risk and Other Geriatric Syndromes

Abstract This four-part series of papers addresses the problem of systematic determination of the influence of several tire factors on tire treadwear. Both the main effect of each factor and some of their interactive effects are included. The program was also structured to evaluate the influence of some external-to-tire conditions on the relationship of tire factors to treadwear. Part I describes the experimental design used to evaluate the effects on treadwear of generic tire type, aspect ratio, tread pattern (groove or void level), type of pattern (straight rib or block), and tread compound. Construction procedures and precautions used to obtain a valid and functional test method are included. Two guiding principles to be used in the data analyses of Parts II and III are discussed. These are the fractional groove and void concept, to characterize tread pattern geometry, and a demonstration of the equivalence of wear rate for identical compounds on whole tread or multi-section tread tires.

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POS0009 THE RELATIONSHIP BETWEEN DIFFERENT IGG AND IGA ANTI-MODIFIED PROTEIN AUTOANTIBODIES IN RHEUMATOID ARTHRITIS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.3003 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 206.1-207

Author(s):

C. Grönwall ◽

L. Liljefors ◽

H. Bang ◽

A. Hensvold ◽

M. Hansson ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Disease Activity ◽

Comprehensive Evaluation ◽

Patient Characteristics ◽

Post Translational Modifications ◽

Cell Clones ◽

Thermo Fisher Scientific ◽

History Of ◽

The Relationship ◽

Fisher Scientific

Background:Seropositive rheumatoid arthritis (RA) is characterized by the presence of rheumatoid factor (RF) and anti-citrullinated protein autoantibodies (ACPA) with different fine-specificities. Yet, other serum anti-modified protein autoantibodies (AMPA), e.g. anti-carbamylated (Carb), anti-acetylated (KAc), and anti-malondialdehyde acetaldehyde (MAA) modified protein antibodies, have been described. By using RA patient single-cell derived monoclonal antibodies we have previously shown that individual ACPA clones recognize small distinct citrulline-containing epitopes giving them extensive multireactivity when these epitopes are found in many peptides and proteins. Moreover, certain CCP2+ multireactive ACPA clones bind also to cabamylated and acetylated autoantigens [1].Objectives:To provide a comprehensive evaluation of serum IgG and IgA autoreactivity to different post-translational modifications in RA.Methods:We analyzed 30 different IgG and IgA AMPA reactivities to modified antigens by ELISA and autoantigen arrays, in N=1985 newly diagnosed RA patients and population controls. The study utilized both previously established (i.e IgG and IgA CCP2; IgG ACPA fine-specificities; IgG anti-Carb fibrinogen and Carb FCS; IgG and IgA Cit/Carb/KAc/Orn(Ac)-vimentin), and novel assays (e.g. IgG anti-MAA and IgG anti-acetylated histones). Association with patient characteristics such as smoking and disease activity were explored. The newly developed assays were also evaluated in SLE disease controls and CCP2+ RA-risk individuals without arthritis.Results:Carb and KAc reactivities by different assays were primarily seen in patients also positive for citrulline-reactivity. Modified vimentin (mod-Vim) peptides were used for direct comparison of different AMPA reactivities, revealing that IgA AMPA recognizing mod-Vim was mainly detected in subsets of patients with high IgG anti-Cit-Vim levels and a history of smoking. IgG acetylation reactivity was mainly detected in a subset of patients with Cit and Carb reactivity. Anti-acetylated histone 2B reactivity was RA-specific and associated with high anti-CCP2 IgG levels, multiple ACPA fine-specificities, and smoking. This reactivity was also found to be present in CCP2+ RA-risk individuals without arthritis. Our data further demonstrate that IgG autoreactivity to MAA was increased in RA compared to controls with highest levels in CCP2+ RA, but was not RA-specific, and showed low correlation with other AMPA. Anti-MAA was instead associated with disease activity and was not significantly increased in CCP2+ individuals at risk of RA. Notably, RA patients could be subdivided into four different subsets based on their AMPA IgG and IgA reactivity profiles.Conclusion:We conclude that autoantibodies exhibiting different patterns of ACPA fine-specificities as well as Carb and KAc reactivity are present in RA and may be derived from multireactive B-cell clones. Anti-Carb and anti-KAc could be considered reactivities within the “Cit-umbrella” similar to ACPA fine-specificities, while MAA is distinctly different.References:[1]Sahlström P, Hansson M, Steen J, Amara K, Titcombe PJ, Forsström B, Stålesen R, Israelsson L, Piccoli L, Lundberg K, Klareskog L, Mueller DL, Catrina AI, Skriner K, Malmström V, Grönwall C. Different Hierarchies of Anti-Modified Protein Autoantibody Reactivities in Rheumatoid Arthritis. Arthritis Rheumatol. 2020 Oct;72(10):1643-1657. PMID: 32501655Caroline Grönwall: None declared, Lisa Liljefors: None declared, Holger Bang Employee of: Employee at ORGENTEC Diagnostika GmbH, Aase Hensvold: None declared, Monika Hansson: None declared, Linda Mathsson-Alm Employee of: Employee at Thermo Fisher Scientific, Lena Israelsson: None declared, Anna Svärd: None declared, Cyril CLAVEL: None declared, Elisabet Svenungsson: None declared, Iva Gunnarsson: None declared, Guy Serre: None declared, Saedis Saevarsdottir: None declared, Alf Kastbom: None declared, Lars Alfredsson: None declared, Vivianne Malmström: None declared, Johan Rönnelid: None declared, Anca Catrina: None declared, Karin Lundberg: None declared, Lars Klareskog: None declared

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The relationship between the Fall Risk Index-21(FRI-21) and occlusal force in the frail elderly

Japanese Journal of Health Promotion and Physical Therapy ◽

10.9759/hppt.5.9 ◽

2015 ◽

Vol 5 (1) ◽

pp. 9-14 ◽

Cited By ~ 1

Author(s):

YUH YAMASHITA ◽

HARUKI KOGO ◽

HIROSHI OTAO ◽

AYA HIRAO ◽

KATSUHIKO MIZOTA

Keyword(s):

Frail Elderly ◽

Fall Risk ◽

Risk Index ◽

Occlusal Force ◽

The Relationship

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Visual-Somatosensory Integration and Balance: Evidence for Psychophysical Integrative Differences in Aging

Multisensory Research ◽

10.1163/22134808-00002444 ◽

2014 ◽

Vol 27 (1) ◽

pp. 17-42 ◽

Cited By ~ 31

Author(s):

Jeannette R. Mahoney ◽

Roee Holtzer ◽

Joe Verghese

Keyword(s):

Older Adults ◽

Fall Risk ◽

Multisensory Processing ◽

Reaction Times ◽

The Elderly ◽

Static Balance ◽

Healthy Older Adults ◽

Stance Time ◽

Study Participants ◽

The Relationship

Research detailing multisensory integration (MSI) processes in aging and their association with clinically relevant outcomes is virtually non-existent. To our knowledge, the relationship between MSI and balance has not been well-established in aging. Given known alterations in unisensory processing with increasing age, the aims of the current study were to determine differential behavioral patterns of MSI in aging and investigate whether MSI was significantly associated with balance and fall-risk. Seventy healthy older adults ( years; 58% female) participated in the current study. Participants were instructed to make speeded responses to visual, somatosensory, and visual-somatosensory (VS) stimuli. Based on reaction times (RTs) to all stimuli, participants were classified into one of two groups (MSI or NO MSI), depending on their MSI RT benefit. Static balance was assessed using mean unipedal stance time. Overall, results revealed that RTs to VS stimuli were significantly shorter than those elicited to constituent unisensory conditions. Further, the current experimental design afforded differential patterns of multisensory processing, with 75% of the elderly sample demonstrating multisensory enhancements. Interestingly, 25% of older adults did not demonstrate multisensory RT facilitation; a finding that was attributed to extremely fast RTs overall and specifically in response to somatosensory inputs. Individuals in the NO MSI group maintained significantly better unipedal stance times and reported less falls, compared to elders in the MSI group. This study reveals the existence of differential patterns of multisensory processing in aging, while describing the clinical translational value of MSI enhancements in predicting balance and falls risk.

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Logistics Infrastructure Network Evaluation Method Research Based on Logistics Resource Integration in Railway Logistics Enterprises

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.933.941 ◽

2014 ◽

Vol 933 ◽

pp. 941-946

Author(s):

Xi Chen ◽

Xiao Ning Zhu

Keyword(s):

Evaluation Method ◽

Comprehensive Evaluation ◽

Evaluation Model ◽

Evaluation Criteria ◽

Theory And Practice ◽

Logistics Network ◽

Proposed Model ◽

Infrastructure Network ◽

Logistics Enterprises ◽

The Relationship

In view of logistics resources integration, this paper introduces an evaluation method of logistics network infrastructure in railway logistics enterprises. The comprehensive evaluation model is established according to the aspects which demonstrate several key indexes and the relationship between them. To illustrate the effectiveness of the above method and the application of the proposed model, a case is studied that verifies the importance of the research in the logistics theory and practice. It presents an evaluation criteria and evaluation model of logistics infrastructure network. The computational results indicate that the evaluation method in selected case is in decent rank.

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The Relationship between Tissue Hardness and the Fall Risk of the Community-dwelling Elderly after Lower Limb Surgery

Rigakuryoho Kagaku ◽

10.1589/rika.31.419 ◽

2016 ◽

Vol 31 (3) ◽

pp. 419-422

Author(s):

Makoto GOTO ◽

Kenji YAMAMOTO ◽

Wataru SAKURAGI ◽

Hideki KOEDA ◽

Susumu NARUSE ◽

...

Keyword(s):

Lower Limb ◽

Fall Risk ◽

Community Dwelling ◽

Tissue Hardness ◽

Lower Limb Surgery ◽

The Relationship

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Spatial Identification and Redevelopment Evaluation of Brownfields in the Perspective of Urban Complex Ecosystems: A Case of Wuhu City, China

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph19010478 ◽

2022 ◽

Vol 19 (1) ◽

pp. 478

Author(s):

Zihao Wang ◽

Xiaoqiang Chen ◽

Na Huang ◽

Yinan Yang ◽

Li Wang ◽

...

Keyword(s):

Evaluation Method ◽

Comprehensive Evaluation ◽

Remote Sensing Data ◽

Evaluation Index System ◽

Brownfield Redevelopment ◽

Land Use Types ◽

Urbanization In China ◽

Urban Complex ◽

The Relationship ◽

The City

Rapid industrialization and urbanization in China have led to a rapid increase in the number of brownfields, however there is a lack of identification of the spatial extent of brownfields in cities and accurate assessment of brownfield redevelopment. Based on the relationship between brownfields and urban complex ecosystems, this paper defines brownfields in China and constructs a comprehensive evaluation index system including socio-economic and ecological subsystems. Using Wuhu City as empirical evidence, 19 brownfields were identified using remote sensing data and field surveys. Based on the detection of soil contaminants in brownfields, a fuzzy integrated evaluation method was used to suggest their redevelopment direction. It is found that the government’s planned land use types and the brownfield redevelopment evaluation results match to a large extent, but social, economic and ecological environmental factors should be more fully considered. At the same time, the identification and redevelopment of brownfield sites in the city as a whole need to be carried out by the government’s professional forces in order to obtain more effective and scientific conclusions.

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Investigating the Relationship Between Lower Limb Flexibility With Motor Function and Risk of Falling in Visually Impaired Individuals

Physical Treatments - Specific Physical Therapy ◽

10.32598/ptj.11.2.429.2 ◽

2021 ◽

pp. 93-102

Author(s):

Kamal Mohammad Khani ◽

◽

Mohammad Karimizadeh Ardakani ◽

Mohammad Hani Mansori ◽

◽

...

Keyword(s):

Range Of Motion ◽

Motor Function ◽

Significant Relationship ◽

Fall Risk ◽

Visually Impaired ◽

Pearson Correlation ◽

Influential Factor ◽

Lower Limbs ◽

Risk Of Falling ◽

The Relationship

Objective: The present study aimed to investigate the flexibility of the ankle and knee joints and to determine its relationship with balance, motor function, and risk of falling in visually impaired individuals. Methods: The sample consisted of 32 blind males, 20-30 years old. They were selected by the purposeful sampling method. We used modified stork tests, tendon gait, and Berg balance scale to evaluate their balance. The Tinetti test was used to evaluate motor performance and the Timed Up and Go (TUG) test to assess the risk of falling. The SLR test and Lunge test were used to assess the range of motion of the knee and ankle joint, respectively. This study was conducted in the men’s dormitories of Tehran University in the fall of 2019. The obtained data were normalized using the Shapiro-Wilk test and Pearson correlation coefficient at the significant level of 0.05 to investigate the relationship between the variables. Results: The results of the Pearson correlation test showed a significant relationship between balance (P=0.001), motor function (P=0.002), and TUG fall risk test (P=0.010) (ankle motor restriction). On the other hand, there was a significant relationship between balance (P=0.002), motor function (P=0.001), and TUG fall risk test (P=0.003) with hamstring flexibility test (knee motor restriction). Conclusion: Given the significant relationship between the range of motion of the lower limbs with balance and motor function, the use of stretching exercises can be an influential factor in increasing the range of motion of the ankle and knee in blind people, which improves balance, motor function, and reduced risk of falling in blindness.

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Reduced strength, poor balance and concern about falls mediate the relationship between knee pain and fall risk in older people

10.21203/rs.2.12970/v2 ◽

2019 ◽

Author(s):

Cameron J Hicks ◽

Pazit Levinger ◽

Jasmine C Menant ◽

Stephen R Lord ◽

Perminder S Sachdev ◽

...

Keyword(s):

Older People ◽

Knee Pain ◽

Fall Risk ◽

Postural Sway ◽

Knee Extension ◽

Community Dwelling ◽

Pain Group ◽

Eyes Closed ◽

The Relationship

Abstract Aims Pain is an independent risk factor for falling. One in two older community-dwelling people with musculoskeletal pain fall each year. This study examined physical, psychological and medical factors as potential mediators to explain the relationship between knee pain and falls.Methods Three hundred and thirty-three community-dwelling people aged 70+ years (52% women) participated in this cohort study with a 1-year follow-up for falls. Participants completed questionnaires (medical history, general health and concern about falls) and underwent physical performance tests. Participants were classified into ‘pain’ and ‘no pain’ groups based on self-reported knee pain. Poisson Regression models were computed to determine the Relative Risk (RR) of having multiple falls and potential mediators for increased fall risk.Results One hundred and eighteen (35.5%) participants were categorised as having knee pain. This group took more medications and had more medical conditions (P <0.01) compared to the no pain group. The pain group had poorer balance, physical function and strength and reported increased concern about falls. Sixty one participants (19.5%) reported ≥ 2 falls, with the pain group twice as likely to experience multiple falls over the 12 month follow up (RR = 2.0, 95% confidence interval (CI) = 1.27 – 3.13). Concern about falls, knee extension torque and postural sway with eyes closed were identified as significant and independent mediators of fall risk, and when combined explained 23% of the relationship between knee pain and falls.Conclusion This study has identified several medical, medication, psychological, sensorimotor, balance and mobility factors to be associated with knee pain, and found the presence of knee pain doubles the risk of multiple falls in older community living people. Alleviating knee pain, as well as addressing associated risk factors may assist in preventing falls in older people with knee pain.

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LETTER TO THE EDITOR: COVID-19 AND THE CHALLENGES OF FRAILTY SCREENING IN OLDER ADULTS

Journal of Frailty & Aging ◽

10.14283/jfa.2020.30 ◽

2020 ◽

pp. 1-2 ◽

Cited By ~ 1

Author(s):

R. O’Caoimh ◽

S. Kennelly ◽

E. Ahern ◽

S. O’Keeffe ◽

R.R. Ortuño

Keyword(s):

Older Adults ◽

Severe Acute Respiratory Syndrome ◽

Healthcare Professionals ◽

Management Strategies ◽

Careful Examination ◽

Geriatric Syndromes ◽

Clinical Frailty Scale ◽

The Impact ◽

Recent Editorial ◽

The Relationship

We read with interest the recent editorial examining the relationship between geriatric syndromes and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of Covid-19 (1), particularly the authors recognition of the need to identify frailty among older adults presenting with suspected symptoms and the importance of mobilising a range of healthcare professionals to tackle this disease (1). However, the identification of frailty and the utilisation of screening instruments by those without geriatric training and especially in acute care is challenging. Frailty is a complex condition. While age-associated, it is multi-dimensional and remains difficult to define (2). Although the Covid-19 pandemic has disproportionately affected older adults (1), data are lacking and pathophysiological mechanisms and the impact of differential management strategies on the course of the disease among older adults is uncertain (1). Further, the prevalence of frailty among those diagnosed, admitted or dying is not clearly reported at present. Nevertheless, the rationale for using frailty to identify those at risk and to allocate care has been correctly highlighted (1). We suggest however, that the use of instruments such as the Clinical Frailty Scale (CFS) (3) and particularly by non-specialised staff in this setting warrants more careful examination.

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