scholarly journals Prunus africanus Herbal Extracts Reverse and Ameliorate the Histological and Histomorphometric Changes in Testosterone-induced Benign Prostate Hyperplasia Rat Models

2021 ◽  
Vol 47 (3) ◽  
pp. 1184-1194
Author(s):  
Felix P. William ◽  
Denis A. Russa
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Positive Control ◽  
Negative Control ◽  
Herbal Extract ◽  
Herbal Extracts ◽  
Prostate Hyperplasia ◽  
Male Wistar Rats ◽  
Group 2 ◽  
Negative Controls ◽  
Benign Prostate

Benign prostatic hyperplasia (BPH) is the most common benign proliferative disease among men during aging. The herbal extract of P. africanus has been used for the treatment of BPH since time immemorial. However microstructural changes of this extract to the prostate of animal or human models are still elusive. Therefore, histological and histomorphometric changes in rats with testosterone-induced BPH due to P. africanus herbal extracts were investigated. Twenty-eight male Wistar rats (200 ± 50 g) were divided into four groups each with 7 rats. Group 1 (Negative control) was given 2 ml/day of olive oil subcutaneously and 2 ml/day of normal saline intragastrically for 28 days. Three groups were induced with BPH by subcutaneous injection of testosterone propionate 3 mg/kg body weight/day for 28 days. Thereafter Group 2 (BPH) was sacrificed, while Group 3 (Positive control) and Group 4 (Treatment group) were administered with finasteride 5 mg/kg/day and P. africanus extract 400 mg/kg/day intragastrically for 28 days, respectively. BPH group revealed thickening and hyperplasia of tubular epithelium with involutions with the stroma showing large spaces and dilated blood vessels. These features were restored with P. africanus extract administration. High epithelial height, large stromal area and lower luminal area observed in the BPH were greatly reversed with P. africanus extract comparable to negative controls. Generally, P. africanus extract restored and ameliorated histological and histomorphometrical changes of the BPH-induced rat’s prostates. Keywords: Benign prostate hyperplasia; Prunus africanus; finasteride; testosterone

scholarly journals Effect of Sodium Carboxymethylcellulose and Sorbitol on Anti-Peptic Ulcer Activity of Anredera cordifolia Leaves Extract

2019 ◽  
Vol 4 (1) ◽  
pp. 16
Author(s):  
Maria Ulfah ◽  
Revika Rachmaniar ◽  
Egi MR. Sudrajat ◽  
Rida W. Fadla ◽  
Hary S. Pinuji
Keyword(s):  
Body Weight ◽  
Peptic Ulcer ◽  
Normal Control ◽  
Wistar Rat ◽  
Positive Control ◽  
Negative Control ◽  
Sodium Carboxymethylcellulose ◽  
Freeze Dried ◽  
Male Wistar Rats ◽  
Negative Controls

Anredera cordifolia or binahong is one of the Indonesian medicinal plants that is used to treat peptic ulcer. The purpose of this study was to evaluate the effect of the addition of sodium carboxymethylcellulose (CMC) and sorbitol on anti-peptic ulcer activity of A. cordifolia leaves extracts in male Wistar rats. The plants were extracted using decoction method and freeze dried. Three liquid formulas were used i.e., i) a combination of sodium CMC and sorbitol; ii) only sorbitol; iii) extract only. The rats were divided into 6 groups, i.e., positive control (sucralfate 35 mg/kg body weight); negative control (80% ethanol); normal control; and 3 formulas. After the administration of the liquid formula, all groups, except normal control, were given 80% ethanol (l5 ml/kg body weight) to induce peptic ulcer. Antipeptic ulcer activity was evaluated using direct observation on rats gastric mucosa, and histopathology assessment. The result showed that the strongest anti-peptic ulcer  was shown by sorbitol only (96.95% inhibition),  followed by the combination of sodium CMC and sorbitol (92.68% inhibition). The formula which only contained extract showed only  31.70% inhibition.  Statistical analysis showed significant differences between formula 1 and 2 with negative controls. In conclusion, A. cordifolia leaves extract with the addition of sorbitol showed the strongest anti-peptic ulcer activity. Keyword: Anredera cordifolia, peptic ulcer, suspense, Wistar rat.

scholarly journals Evaluation of Mutagenic and Antimutagenic Activity of Methanol Extract of Cousinia thomsonii against Cyclophosphamide

2020 ◽  
pp. 53-57
Author(s):  
Ishfaq Shafi Khan ◽  
Khalid Bashir ◽  
Naveed Gulzar ◽  
Yaseen Maqbool Bhat
Keyword(s):  
Bone Marrow Cells ◽  
Positive Control ◽  
Negative Control ◽  
Male Rats ◽  
Free Access ◽  
Antimutagenic Activity ◽  
Male Wistar Rats ◽  
Group 5 ◽  
Group 2 ◽  
Group 1

The present study was conducted to evaluate the mutagenic and antimutagenic potential of Cousinia thomsonii (CT) extract in bone marrow cells of male wistar rats using some important parameters like micronucleated polychromatic erythrocyte (MnPCE), mitotic index (MI), chromosomal aberrations (CA) and polychromatic erythrocyte to normochromatic erythrocyte ratio (PCE/NCE). 30 male rats of wistar strain were divided into 6 groups with 5 rats each group. Group 1 rats were taken as negative control having free access to distilled water and rat feed. Group 2 rats were taken as positive control treated with mutagen cyclophosphamide (CP) at dose of 60 mg/kg b wt. for 2 days. Group 3 and 4 were treated with CT extract at dose of 100 and 200 mg/kg b wt. for 20 days. Group 5 and 6 were treated with 100 and 200 mg/kg b wt of CT extract for first 18 days and for last 2 days with CP at dose concentration of 60 mg/kg. It was found that rats treated with CT extract alone did not produce any significant changes in MnPCE, PCE/NCE ratio, CA and MI when compared with control treated rats (group 1). However in group 5 and 6 rats treated with CT extract in combination with CP a protective effect was observed against the cyclophosphamide induced cellular mutagenicity. In concluding remark Cousinia thomsonii was found to show antigenotoxic potential and also produce protective antimutagenic effects against CP induced chromosomal damage.

scholarly journals Ameliorative effects of the ethanolic extract of Allium saralicum R.M. Fritsch on CCl4-induced nephrotoxicity in mice: A stereological examination

2017 ◽  
Vol 69 (3) ◽  
pp. 535-543 ◽  
Author(s):  
Hamidreza Sherkatolabbasieh ◽  
Lida Hagh-Nazari ◽  
Shiva Shafiezadeh ◽  
Nader Goodarzi ◽  
Mohammad Zangeneh ◽  
...  
Keyword(s):  
Olive Oil ◽  
Ethanolic Extract ◽  
Positive Control ◽  
Negative Control ◽  
Interstitial Tissue ◽  
Ccl4 Administration ◽  
Group 2 ◽  
Negative Controls ◽  
Convoluted Tubules ◽  
Different Doses

The present study was carried out to investigate the nephroprotective effect of the ethanolic extract of Allium saralicum R.M. Fritsch (ASRMF) in mice. Thirty-five male mice were divided into five groups (n=7). Group 1 (positive control) received 1 mL/kg olive oil intraperitoneally (i.p.) and 0.5 mL distilled water orally; Group 2 (negative control) received CCl4 (50% in olive oil, 1 mg/kg; i.p.); Groups 3, 4 and 5 received CCl4 and 200, 800 and 1600 ?g/kg of ASRMF extract, respectively. The renal volume and cortex in Groups 1 and 2 were increased by 55% and 62% (p?0.001) following CCl4 administration, respectively, and were improved after ASRMF administration. The volume of proximal convoluted tubules (PCTs), glomeruli, vessels and interstitial tissue increased 80%, 150%, 83% and 64% (p?0.05), respectively, in CCl4-treated mice, and decreased significantly with 800 and 1600 ?g/kg of ASRMF. The length of PCTs and vessels increased 51% and 45% and decreased (p?0.05) with 200, 800 and 1600 ?g/kg of ASRMF, respectively. CCl4-treated mice lost 22.5% of glomeruli; the loss was inhibited significantly (p?0.05) by ASRMF. Urea and creatinine concentrations were increased (p?0.05) in CCl4-induced nephrotoxicity as compared to the controls, whereas different doses of ASRMF restored the levels of these biomarkers compared to the negative controls. In conclusion, ASRMF has a potent nephroprotective property and can improve renal structural and serum biomarkers in CCl4-induced nephrotoxicity in mice.

scholarly journals Alpha-1 blockers and susceptibility to COVID-19 in benign prostate hyperplasia patients : an international cohort study

2021 ◽  
Author(s):  
Akihiko Nishimura ◽  
Junqing Xie ◽  
Kristin Kostka ◽  
Talita Duarte-Salles ◽  
Sergio Fernández Bertolín ◽  
...  
Keyword(s):  
Cohort Study ◽  
Large Scale ◽  
Benign Prostate Hyperplasia ◽  
Medical Center ◽  
The United States ◽  
Negative Control ◽  
United States Department ◽  
Columbia University ◽  
Prostate Hyperplasia ◽  
Benign Prostate

AbstractAlpha-1 blockers, often used to treat benign prostate hyperplasia (BPH), have been hypothesized to prevent COVID-19 complications by minimising cytokine storms release. We conducted a prevalent-user active-comparator cohort study to assess association between alpha-1 blocker use and risks of three COVID-19 outcomes: diagnosis, hospitalization, and hospitalization requiring intensive services. Our study included 2.6 and 0.46 million users of alpha-1 blockers and of alternative BPH therapy during the period between November 2019 and January 2020, found in electronic health records from Spain (SIDIAP) and the United States (Department of Veterans Affairs, Columbia University Irving Medical Center, IQVIA OpenClaims, Optum DOD, Optum EHR). We estimated hazard ratios using state-of-the-art techniques to minimize potential confounding, including large-scale propensity score matching/stratification and negative control calibration. We found no differential risk for any of COVID-19 outcome, pointing to the need for further research on potential COVID-19 therapies.

scholarly journals TREATMENT OF ACUTE URINARY RETENTION CAUSED BY BENIGN PROSTATE HYPERPLASIA IN THE UROLOGY DEPARTMENT OF HOSPITAL

2019 ◽  
Vol 20 (3) ◽  
pp. 46-51
Author(s):  
S. N. Kalinina ◽  
O. O. Burlaka ◽  
M. S. Alexandrov ◽  
P. S. Vydrin
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Prostate Tissue ◽  
Prostate Hyperplasia ◽  
Heart Attacks ◽  
Conservative And Operative Treatment ◽  
Pathogenetic Factor ◽  
Group 2 ◽  
First Time ◽  
Benign Prostate ◽  
Positive Effect

In the article the results of conservative and operative treatment of 122 patients ranging in age from 42 to 80 years of age with acute delay of urine caused by benign prostate hyperplasia in the urology Department Alexander Hospital 2016 to 2018 years. n men, the most common cause of SSM is safe giperplazia (adenoma) prostate (BPH), found in the 45–53% of observations, tending to cause heart attacks in prostate tissue and in­creased Alpha-adrenergic activity. The main pathogenetic factor SSM in men is BPH, where heart attacks occur in the prostate tissue and increased Alpha-adrenergicheskaja activity. In 1 group comprised 42 patients diag­nosed for the first time, SSM, caused by BPH, in Group 2–80 patients with multiple SSM caused by BPH. All patients of Group 1 after combination therapy of Alpha alfuprost MICRORAION adrenoblokatorom in com­bination with jelefloksom noted restore self-sustaining urination. In Group 2 at 72 patients recovered partially and urinating they have plus sizes BPH, they performed Transurethral enucleation of BPH with positive effect.  

scholarly journals Can We Use the Silodosin as Second Line Treatment of Benign Prostate Hyperplasia?

2020 ◽  
Author(s):  
Bekir Voyvoda ◽  
Ömür Memik ◽  
Murat Üstüner ◽  
Onur Karslı ◽  
Levent Özcan
Keyword(s):  
Surgical Treatment ◽  
Benign Prostate Hyperplasia ◽  
Symptom Control ◽  
Routine Clinical Practice ◽  
Prostate Hyperplasia ◽  
Blocker Therapy ◽  
The Third ◽  
Group 2 ◽  
Benign Prostate ◽  
Group 1

Objective: Our study aimed to the efficacy of silodosin in patients with LUTS associated with BPH who were not-responder to previous ARs blocker therapy. Methods: Patients who did not benefit from alpha blockers treatment, but did not want surgical treatment are included in this study. At enrollment, 75 patients and 75 patients were assigned to group 1 and group 2, respectively. Group 1 received silodosin 8 mg, group 2 received their previous α blocker. Results: Although, in group 1 mean IPSS score at baseline was 20,81±0,97, and it significantly decreased to 17,12±1,25 at third months, in group 2 no significant changes were observed. On the other hand in group 1 a decrease was also observed for both IPSS sub score was significantly reduced at third months, when it is compared with baseline. At the end of the third month, a significant improvement in this parameter was observed after switching to silodosin, as compared with first value (p< 0,05). As to the residual urine, significant improvement was observed in the silodosin group but no significant improvement was observed in group 2. Conclusion: This study was conducted to investigate the effectiveness and safety of silodosin in patients with BPH who had not achieved satisfactory symptom control with other α blockers in routine clinical practice before surgical treatment. Thus, at least patients who have different comorbidities will be protected from morbidities of surgery.

HUBUNGAN USIA, OBESITAS DAN RIWAYAT PENYAKIT DIABETES MELLITUS DENGAN KEJADIAN BENIGN PROSTATE HYPERPLASIA (BPH) DERAJAT IV DI RSUD DR. M. HAULUSSY AMBON PERIODE 2012-2014

2017 ◽  
pp. 141-151
Author(s):  
Andrew Ruspanah
Keyword(s):  
Diabetes Mellitus ◽  
Benign Prostate Hyperplasia ◽  
Chi Square ◽  
Cross Sectional ◽  
Prostate Hyperplasia ◽  
Benign Prostate

Pendahuluan. Benign Postate Hiperplasia (BPH) adalah penyakit yang umumnya terjadi pada pria lansia yang disebabkan oleh penuaan. Hiperplasia prostat adalah pertumbuhan jaringan nodul fibroadenomatosa pada prostat. Pembesaran prostat jinak merupakan penyakit yang tersering kedua setelah batu saluran kemih didapatkan secara klinis di Indonesia. Tujuan. Penelitian ini bertujuan untuk mengetahui hubungan antara usia, obesitas dan riwayat diabetes mellitus dengan kejadian Benign Prostate Hyperplasia (BPH) grade IV di Rumah Sakit Dr. M. Haulussy Ambon periode 2012-2014. Metode. Jenis penelitian ini adalah penelitian analitik desain Cross-Sectional, dengan menggunakan catatan medis data di ruang operasi di Rumah Sakit Dr. M. Haulussy Ambon Tahun 2012-2014 dan memperoleh jumlah sampel yang memenuhi kriteria inklusi sebanyak 239, yang diambil dengan teknik total sampling. Analisis dilakukan dengan analisis univariat dan bivariat menggunakan uji Chi Square. Hasil yang di temukan dalam penelitian ini bahwa kejadian BPH lebih besar pada mereka yang berusia> 65 tahun dan 56-65 tahun dibandingkan dengan usia 46-55 dan <46 tahun dengan hasil tes menunjukkan adanya hubungan antara usia dengan BPH dengan nilai (p= 0,000), ada hubungan antara obesitas dengan nilai BPH (p=0,019) dan riwayat diabetes mellitus setelah menggunakan uji Chi-Square, hubungan antara riwayat diabetes mellitus dengan BPH dengan nilai (p = 0,000). Kesimpulan. Ada hubungan antara umur, obesitas dan riwayat diabetes mellitus dengan kejadian BPH.

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