The Essential Role of Pandemics: A Fresh Insight into the Oil Market

Macromolecular markers for glial cells have been sought for a variety of reasons. One of the earliest was the need for a means of assessing the purity of cell and subcellular fractions prepared from nervous tissue. While there is still a requirement for this kind of tool, emphasis has shifted towards seeking information on biochemical differentiation among cells and their functional interactions. A brief general review will be made of glial markers and two of these, 2′,3′-cyclic nucleotide 3′-phosphohydrolase (CNP) and glutamine synthetase (GS), will be considered in detail. Until recently studies of markers have been concentrated on the higher vertebrates and those on lower vertebrates and invertebrates have hardly begun. However, such comparative studies may lead to fresh insight into old problems. For example, CNP has long been regarded as a marker for myelin and oligodendrocytes but it has not been possible to attribute a functional role to it and its relation to myelination has remained obscure. The finding that it is present in the glia of a moth Manduca sexta which lacks myelin provides a stimulus for a fresh approach to the problem. Another example is provided by studies on GS. This enzyme is found in astrocyte feet and preliminary results indicate that it is localized also in the perineurial glia of Aplysia ganglia. These results lead to a reconsideration of the perennial question of the possible role of astrocyte feet in barrier mechanisms. Extension of comparative studies may not only raise new questions but also provide some answers.

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Insight into the essential role of the Helicobacter pylori HP1043 orphan response regulator: genome-wide identification and characterization of the DNA-binding sites

Scientific Reports ◽

10.1038/srep41063 ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 14

Author(s):

Simone Pelliciari ◽

Eva Pinatel ◽

Andrea Vannini ◽

Clelia Peano ◽

Simone Puccio ◽

...

Keyword(s):

Helicobacter Pylori ◽

Binding Sites ◽

Essential Role ◽

Response Regulator ◽

Dna Binding Sites ◽

Genome Wide ◽

Identification And Characterization ◽

Insight Into

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Stravinsky's Les Noces and Russian Village Wedding Ritual

Journal of the American Musicological Society ◽

10.2307/831407 ◽

1990 ◽

Vol 43 (1) ◽

pp. 99-142 ◽

Cited By ~ 4

Author(s):

Margarita Mazo

Keyword(s):

Folk Music ◽

Voice Quality ◽

Emotional Intensity ◽

Folk Ritual ◽

The Village ◽

Fresh Insight ◽

Insight Into ◽

The Way

This study presents Stravinsky's well-known ballet Les Noces as seen by an ethnomusicologist familiar with wedding rituals and, particularly, laments of Russian villages. The music of Les Noces, statements made by the composer himself, and the data gleaned from published sources of folk music (those Stravinsky is known to have come in contact with or those accessible to him) are juxtaposed with observations obtained in field interviews with Russian villagers who themselves were participants in wedding rituals and performers of wedding laments. The conceptual and structural ideas of Les Noces are compared to those of the village ritual. The examination of the role of laments and songs in the unfolding of the ritual, the use of ostinato, the analysis of the manner of singing and voice quality in laments, and an inquiry into the polyphonic forms based on polymorphic texture enable a fresh insight into Les Noces and the way Stravinsky handled materials derived from folk practice. The general conceptualization of the composition with its coalescence of high emotional intensity and, at the same time, personal detachment is traced to folk ritual where the episodes, being part of the ritual, embody primarily impersonal responses to the requirements of a ritualized situation, even though they are presented as highly tense and emotionally charged.

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Comparison of lncRNA and mRNA expression in mouse brains infected by a wild-type and a lab-attenuated Rabies lyssavirus

Journal of General Virology ◽

10.1099/jgv.0.001538 ◽

2020 ◽

Author(s):

Baokun Sui ◽

Dong Chen ◽

Wei Liu ◽

Bin Tian ◽

Lei Lv ◽

...

Keyword(s):

Mrna Expression ◽

Clinical Symptoms ◽

Expression Profiles ◽

Differentially Expressed ◽

Wild Type ◽

Fresh Insight ◽

Neuron Injury ◽

Insight Into ◽

Generation Sequencing

Rabies is a lethal disease caused by Rabies lyssavirus, commonly known as rabies virus (RABV), and results in nearly 100 % death once clinical symptoms occur in human and animals. Long non-coding RNAs (lncRNAs) have been reported to be associated with viral infection. But the role of lncRNAs involved in RABV infection is still elusive. In this study, we performed global transcriptome analysis of both of lncRNA and mRNA expression profiles in wild-type (WT) and lab-attenuated RABV-infected mouse brains by using next-generation sequencing. The differentially expressed lncRNAs and mRNAs were analysed by using the edgeR package. We identified 1422 differentially expressed lncRNAs and 4475 differentially expressed mRNAs by comparing WT and lab-attenuated RABV-infected brains. Then we predicted the enriched biological pathways by the Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) database based on the differentially expressed lncRNAs and mRNAs. Our analysis revealed the relationships between lncRNAs and RABV-infection-associated immune response and ion transport-related pathways, which provide a fresh insight into the potential role of lncRNA in immune evasion and neuron injury induced by WT RABV.

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The experience of facilitating debriefing after simulation: A qualitative study

Nursing Praxis Aotearoa New Zealand ◽

10.36951/27034542.2020.015 ◽

2020 ◽

Vol 36 (3) ◽

pp. 51-60

Author(s):

Rachel Macdiarmid ◽

◽

Stephen Neville ◽

Shelaine Zambas ◽

◽

...

Keyword(s):

Health Care ◽

Qualitative Study ◽

Health Professionals ◽

Essential Role ◽

Care Setting ◽

Knowing How ◽

Know How ◽

Individual Interviews ◽

Insight Into

Research suggests that debriefing is the most important component of simulation. Debriefing is the time when participants think over and reflect on what happened during the simulated experience. The aim of this research is to gain insight into the experience of facilitating debriefing following a simulated experience in a tertiary health care setting. This qualitative study was guided by phenomenology, as developed by Heidegger and Gadamer, and included 10 health professionals (nurses, doctors, and a midwife) debriefing simulation experiences. Data were collected through individual interviews and analysed through iterative re-writing and the generation of three stories as getting started; supporting the debrief to unfold, and knowing how to end. This study affirmed the role of the facilitator in debriefing following simulated experiences. The facilitator’s role includes leading the dialogue beyond “talk” and into “learning”. The art of asking a question, working with silence, and enabling learning all require skill. Through experience, facilitators learn to respond to whatever unfolds in the session. This study contributed detail of what facilitators do to draw out thinking, which confirmed their essential role. Facilitators cannot prepare a script for debriefing beforehand but must rely on their debriefing know-how to respond in each debrief. The facilitator’s know-how is therefore central to debriefing following simulated experiences.

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‘Have we any motherJuliana’samong us?’: The multiple identities of Julian of Norwich in Restoration England

British Catholic History ◽

10.1017/bch.2017.3 ◽

2017 ◽

Vol 33 (3) ◽

pp. 383-400 ◽

Cited By ~ 1

Author(s):

Liam Temple

Keyword(s):

Seventeenth Century ◽

Fourteenth Century ◽

Julian Of Norwich ◽

Multiple Identities ◽

Political Issues ◽

Restoration England ◽

New Perspective ◽

Fresh Insight ◽

Insight Into

The true identity of the fourteenth-century anchoress Julian of Norwich has been lost to history. Yet in the seventeenth century Catholic and Protestant polemicists created different ‘Julians’ to construct and contrast their own confessional positions. This article traces the different identities prescribed to Julian and argues that they allow us fresh insight into some of the most prevalent religious and political issues of Restoration England. It begins by tracing the positive reception of Julian’s theology among the Benedictine nuns of Paris and Cambrai, including the role of Augustine Baker in editing Julian’s text. It then explores how the Benedictine Serenus Cressy and the Anglican Edward Stillingfleet created different identities for Julian in their ongoing polemical battles in the Restoration period. For Cressy, Julian was proof of the strength of Catholic devotional and spiritual traditions, while Stillingfleet believed she was evidence of the religious melancholy encouraged by monasticism. By exploring these identities, this article offers new perspective on issues of Catholic loyalty, enthusiasm, sectarianism and doctrinal authority.

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Topoisomerase VI participates in an insulator-like function that prevents H3K9me2 spreading into euchromatic islands

10.1101/829416 ◽

2019 ◽

Author(s):

Louis-Valentin Méteignier ◽

Cécile Lecampion ◽

Florent Velay ◽

Cécile Vriet ◽

Laura Dimnet ◽

...

Keyword(s):

Essential Role ◽

Boundary Function ◽

Dna Topoisomerase ◽

Chromatin Domains ◽

Mechanistic Insight ◽

Expression Of Genes ◽

Chromatin Boundary ◽

Insight Into ◽

Inactive Chromatin

AbstractThe organization of the genome into transcriptionally active and inactive chromatin domains requires well-delineated chromatin boundaries and insulator functions in order to maintain the identity of adjacent genomic loci with antagonistic chromatin marks and functionality. In plants that lack known chromatin insulators, the mechanisms that prevent heterochromatin spreading into euchromatin remain to be identified. Here, we show that DNA Topoisomerase VI participates in a chromatin boundary function that safeguards the expression of genes in euchromatin islands within silenced heterochromatin regions. While some transposable elements are reactivated in mutants of the Topoisomerase VI complex, genes insulated in euchromatin islands within heterochromatic regions of the Arabidopsis thaliana genome are specifically downregulated. H3K9me2 levels consistently increase at euchromatin island loci and decrease at some TE loci. We further show that Topoisomerase VI physically interacts with S-adenosylmethionine (SAM) synthase MAT3, which is required for H3K9me2 deposition. Topoisomerase VI promotes MAT3 occupancy on heterochromatic elements and its exclusion from euchromatic islands, thereby providing a mechanistic insight into the essential role of Topoisomerase VI in the delimitation of chromatin domains.

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Global Justice and Climate Governance

10.3366/edinburgh/9781474437912.001.0001 ◽

2019 ◽

Author(s):

Alix Dietzel

Keyword(s):

Climate Change ◽

Global Justice ◽

Theory And Practice ◽

Climate Justice ◽

Global Response ◽

Climate Governance ◽

Big Picture ◽

Fresh Insight ◽

Insight Into

This book evaluates the global response to climate change from a cosmopolitan justice perspective. Going above and beyond existing studies, Alix Dietzel neatly illustrates that climate justice theory can be used to normatively assess and compare both state (multilateral) and non-state (transnational) climate change governance – in other words, that theory and practice can be bridged. Investigating the role of states, cities, corporations, and non-governmental organisations in the post-Paris Agreement era, Dietzel provides fresh insight into the ‘big picture’ of climate change (mis)management and the injustices that come along with it. These insights allow her to make recommendations for change that should be of keen interest to climate justice scholars and climate governance practitioners alike.

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