scholarly journals A COMPARATIVE CLINICAL EVALUATION OF KATPHALADI CHURNA AND PIPPALYADI CHURNA IN MANAGEMENT OF TAMAKA SWASA

2021 ◽  
Vol p6 (1) ◽  
pp. 3163-3170
Author(s):  
Ashutosh Kr. Bhardwaj ◽  
Prashanth Bhat
Keyword(s):  
Bronchial Asthma ◽  
Clinical Evaluation ◽  
Oral Formulation ◽  
Comparative Efficacy ◽  
Human Race ◽  
Life Threatening ◽  
Group A ◽  
Group B

Since time immemorial man has been in a constant endeavor to find the solutions for the life-threatening and ago- nizing disorders, which afflicts the human race. One such condition is ‘Tamaka swasa’1 which is known by the name Bronchial Asthma in modern parlance, wherein remissions and exacerbations are the typical features, leav- ing the patient in a pathetic situation. The Objective of the study is to evaluate the comparative efficacy of Kat- phaladi Churna7 and Pippalyadi Churna8 in the management of Tamaka Swasa through subjective and objective parameters. The present study registers 40 out of 64 patients. Out of these 24 patients were discontinued. The re- maining 40 patients of Tamaka Swasa fulfilling the criteria of diagnosis and inclusive criteria were included in the study, fewer than two groups as distributed patients in Group–A are 20 patients and Group–B is 20 patients. While comparing between the group result shows that Pippalyadi Churna is statistically more effective in Swasa Krichrata (Dyspnoea), Pratishaya (Rhinorrhea), Kanthodavamsa (Hoarseness of voice) and AEC than the Kat- phaladi Churna. In the overall result, Pippalyadi Churna is more effective than the Katphaladi Churna in the management of Tamaka Swasa. Both of the trial drugs proved to be a safe and effective oral formulation, which helps in the management of Tamaka swasa, when the disease is not too advanced and not associated with compli- cations also when correctly used by the patient as per instructions. Keywords: Tamaka Swasa, Swasa Krichrata, Pratishaya, Kanthodavamsa, AEC, Katphaladi Churna and Pip- palyadi Churna.

scholarly journals Effectiveness of Buteyko Breathing Technique versus Nadi Shuddhi Pranayama to Improve Pulmonary Function in Subjects with Bronchial Asthma

2021 ◽  
Vol 6 (4) ◽  
pp. 124-135
Author(s):  
G Swathi ◽  
T Sunil Kumar ◽  
N Raghunadh
Keyword(s):  
Pulmonary Function ◽  
Bronchial Asthma ◽  
Statistical Significance ◽  
T Test ◽  
Age Group ◽  
Consent Document ◽  
Post Test ◽  
Life Threatening ◽  
Group A ◽  
Group B

Background: Asthma is a chronic life-threatening disease as the airways in the lungs often swollen or inflamed, which makes the airways very sensitive. So, the exposure to the environment in day-to-day life triggers asthma. Asthma can affect at any age group. This study mainly focuses on comparing the effects of Buteyko breathing technique and Pranayama on improving Pulmonary Function in subjects with Bronchial Asthma. Method: Total of 79subjects selected, out of those 66 subjects were included after obtaining the consent document. Subjects are divided into two groups by lottery method, in which 6 subjects dropped. So, the study was completed with 60 subjects. Both groups performed intervention for 1 hour a day 5 days week for 4 weeks. The outcomes of the study were FEV1, FVC & FEV1/FVC ratio. Results: Paired t test was used to assess statically significance between pre and post test scores with in the groups, independent t test was used to access statistical significance of post-test mean score between the groups, statistical analysis of the data revealed that Buteyko Breathing technique group has more difference when compare to Pranayama group. Conclusion: The results had shown that both Group-A (Buteyko Breathing Group) and Group-B (Pranayama Group) has improved significantly on pre and post-test values within the groups but when compared between the groups statistical significance is noted in Group-A. So, this study concludes that Group-A showed significant improvement on Pulmonary Function in subjects with Bronchial Asthma. Keywords: Buteyko Breathing technique, Nadishuddhi Pranayama, FEV1/FVC, Bronchial Asthma.

Evaluation of comparative efficacy of Guda Sunthi and Manjistha Guggulu Avapeedana Nasya in Manyastambha (Cervical Spondylitis)

2019 ◽  
Vol 4 (02) ◽  
Author(s):  
Manjunath Akki ◽  
Suresh Hakkandi ◽  
Arti Panwar
Keyword(s):  
Complete Remission ◽  
Routine Activities ◽  
Household Work ◽  
Comparative Efficacy ◽  
Exclusion Criteria ◽  
Patient Complaints ◽  
The People ◽  
Comparative Clinical Study ◽  
Group A ◽  
Group B

Manyastambha is described under Nanatmaja Vatavyadhi. It is a condition where, the aggravated Vata get localized in the Manya Pradesha causing symptoms like Stambha and Shoola. Manyastambha can be compared with earliest symptoms of cervical spondylitis. In this condition, patient complaints of neck pain. The neck is held rigidly and neck movements may exacerbate pain. Now a day, Cervical spondylitis is very common in the people who do routine activities like travelling, household work, desk job etc. It can be seen in people as early as 25 years of age. In Manyastambha, Nasya is the main line of treatment. (i.e. Vatakaphahara Nasya). Objectives: To evaluate the comparative efficacy of Guda Sunthi Avapeedana Nasya and Manjistha Guggulu Avpeedana Nasya in Manyastambha (Cervical Spondylitis). Materials and Methods: This is a comparative clinical study conducted to assess the efficacy in Manyastambha. As per the inclusion and exclusion criteria, the patients who fulfill the criteria were randomly selected and equally divided into two groups. Group A - 15 Patients received Guda-Sunthi Avapeedana Nasya. Group B - 15 Patients received Manjistha-Guggulu Avapeedana Nasya. Results and Conclusion: In Group A, 9 patients (60%) showed complete remission and 6 patients (30%) showed marked response. In Group B, 3 patients (20%) showed complete remission, 1 patient (7%) showed marked response. 6 patients (30%) showed moderate response, 4 patients (26%) showed mild response and 1 patient (7%) showed unchanged response.

Comparing the Effectiveness of Oral Formulation of Tranexamic Acid in Treating Melasma versus Topical Treatmentlike Kojic Acid

2021 ◽  
Vol 15 (6) ◽  
pp. 1372-1375
Author(s):  
M. Sheikh ◽  
R. Majeed ◽  
W. Iqbal
Keyword(s):  
Tranexamic Acid ◽  
Topical Treatment ◽  
Kojic Acid ◽  
Severity Index ◽  
Oral Formulation ◽  
Effective Treatment Modality ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Index Comparison

Aim: To compare the efficacy and safety of oral tranexamic acid with topical kojic acid in treatment of melasma. Method: This study was an interventional, randomized control trial done in Department of Dermatology Akhtar Saeed Trust Hospital Lahore from January 2020 till June 2020. 40 patients with moderate to severe melasma were enrolled for this study. These were divided into two groups A and B. In group A 20 patients were given oral tranexamic acid along with topical treatment and in group B, 20 patients were treated only with topical treatment. Oral tranexamic acid was given in dosage of 250 mg twice a day for 3 months and then follow-up was done at 8th and 12th wks. The evaluation of effectiveness of treatment was done with MASI(Melasma Area Severity Index). Comparison was done in the mean of the MASI scores obtained in both groups. Result: In both groups female patients were more in number. The mean age of patients in group A was 29.75 years & in group B it was 32.55 years. MASI scoring was done in both groups at baseline and at 8th& 12th wks. There was a significant decrease in this score in group A patients with oral tranexamic acid (12.08±2.8 vs 9.1±2.2 at 8th wk. andvs 8.2±2.0 at 12thwk.; P <0.05for both). Whereas in group B patients the decrease in mean MASI score was significant at 8thwk.& insignificant at 12th wk. (12.6±2.9 vs 10.9±2.4at 8th wk. and vs 10.3±2.4at 12th wk.; p<0.05 for former but p>0.05 for later). Conclusion: Oral tranexamic acid is a safe and effective treatment modality for treating moderate to severe melasma. Keywords: Melasma, oral tranexamic acid

scholarly journals A CLINICAL EVALUATION OF MATRA BASTI AND KATI BASTI WITH DHANWANTARAM TAILA IN THE MANAGEMENT OF GRIDHRASI

2021 ◽  
pp. 17-31
Author(s):  
N. Haritha ◽  
Rashmi. R ◽  
Nighil Gigi ◽  
Binu.M.B
Keyword(s):  
Clinical Evaluation ◽  
Combined Treatment ◽  
Signs And Symptoms ◽  
Age Group ◽  
Group A ◽  
Group B

Gridhrasi comes under 80 types of Nanatmaja Vatavyadhi. The cardinal signs and symptoms of Gridhrasi are Ruk (pain), Toda (pricking sensation), Spandana (twitching) in the Sphik, Kati, Uru, Janu, Jangha and Pada in order and Sakthikshepa Nigraha i.e., restricted lifting of the leg associated with Gourava, Aruchi. Kati Basti is widely being practiced throughout country as Bahyaupakrama which has both Snehana and Swedana effects. Matra Basti is Snehana procedure which does Vataanulomana, Vatashamana. Objectives: To evaluate the efficacy of Matrabasti and Katibasti with Dhanvantaram Taila in the management of Gridhrasi. Materials and Methods: Patients presenting with the classical features of Gridhrasi and between the age group of 16 to 50 years irrespective of sex were selected and allotted in Group A, B and C with 15 patients in each group. Group A was administered with Matra basti with Dhanwantram Taila and Group B with Kati basti with Dhanwantram Taila and Group C with both Matra basti and Kati basti with Dhanwantram Taila for 9 days. Results: In combined treatment of Kati Basti and Matra Basti in Group C there was tremendous response in relieving Ruk (73%), Toda (46%), Spandana (60%), Supti (80%), Gourava (73%), Aruchi (66%), Sparshasahyata (73.3%) SLR (60%). In Group A, patients subjected to Matra Basti was effective in relieving Ruk (26.7%), Toda (13.3%), Spandana (26.7%), Supti (66.7%), Gourava (46.7%), Aruchi (53.3%), Sparshasahyata (13.3%) SLR (6.7%). In Group B patients subjected to Kati Basti was effective in relieving Ruk (6.7%), Toda (0%), Spandana (0%), Supti (40%), Gourava (20%), Aruchi (0%), Sparshasahyata (20%) SLR (0%). Conclusion: On the basis of the results of this study, it can be clearly concluded that combined treatment of Matrabasti and Kati basti with Dhanwantaram taila provided significant relief in the signs and symptoms of Gridhrasi than individually performed Matra basti and Kati basti with Dhanwantaram taila.

scholarly journals Palmoplantar psoriasis: a comparative therapeutic study

2019 ◽  
Vol 5 (4) ◽  
pp. 779
Author(s):  
Sathya Narayanan Rajendran ◽  
Sukanya Mathupal Gurusamy
Keyword(s):  
Treatment Options ◽  
Clinical Manifestations ◽  
Simple Random Sampling ◽  
Inflammatory Dermatosis ◽  
Duration Of Illness ◽  
Erythrodermic Psoriasis ◽  
Life Threatening ◽  
Group A ◽  
Group B ◽  
Therapeutic Study

<p class="abstract"><strong>Background:</strong> Psoriasis is an immunologically mediated inflammatory dermatosis presenting with extremely variable clinical manifestations ranging from indolent lesions to life threatening forms of pustular and erythrodermic psoriasis. Palmoplantar psoriasis present as hyperkeratotic scaly plaques with fissures and can be managed with different treatment forms. This study was done to compare the efficacy between topical and systemic treatment options.</p><p class="abstract"><strong>Methods:</strong> The study was conducted in a tertiary level teaching hospital after ethical committee clearance. Fifty patients with palmoplantar psoriasis were allocated into the two groups using simple random sampling. PPPASI scoring was calculated to assess the extent of involvement. Patients in Group A were prescribed calcipotriol with clobetasol propionate ointment. Group B patients were given tablet methotrexate.<strong></strong></p><p class="abstract"><strong>Results:</strong> Twenty eight patients were males M: F of 1.27: 1. Mean age was 36. Mean duration of illness was eleven months. Most of these patients were manual laborers. 32 patients had lesions over both palms and soles, 9 over palms alone and 9 involving soles alone. Mean PASI reduction at 16 weeks was seen maximum with methotrexate. Compliance was comparatively good with methotrexate than topical. Though mean PASI reduction and compliance was good, relapse rates were higher with methotrexate in our study.</p><p class="abstract"><strong>Conclusions:</strong> There was no significant change in clinico-epidemiology and presentation of palmoplantar psoriasis. Methotrexate was observed to be the more efficacious modality in treating palmoplantar psoriasis.</p>

scholarly journals Role of SatO2, PaO2/FiO2 Ratio and PaO2 to Predict Adverse Outcome in COVID-19: A Retrospective, Cohort Study

2021 ◽  
Vol 18 (21) ◽  
pp. 11534
Author(s):  
Stefano Sartini ◽  
Laura Massobrio ◽  
Ombretta Cutuli ◽  
Paola Campodonico ◽  
Cristina Bernini ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Adverse Outcome ◽  
University Hospital ◽  
Rt Pcr ◽  
Threatening Condition ◽  
Life Threatening ◽  
Group A ◽  
Group B ◽  
The University

COVID-19 respiratory failure is a life-threatening condition. Oxygenation targets were evaluated in a non-ICU setting. In this retrospective, observational study, we enrolled all patients admitted to the University Hospital of Genoa, Italy, between 1 February and 31 May 2020 with an RT-PCR positive for SARS-CoV-2. PaO2, PaO2/FiO2 and SatO2% were collected and analyzed at time 0 and in case of admission, patients who required or not C-PAP (groups A and B) were categorized. Each measurement was correlated to adverse outcome. A total of 483 patients were enrolled, and 369 were admitted to hospital. Of these, 153 required C-PAP and 266 had an adverse outcome. Patients with PaO2 <60 and >100 had a higher rate of adverse outcome at time 0, in groups A and B (OR 2.52, 3.45, 2.01, respectively). About the PaO2/FiO2 ratio, the OR for < 300 was 3.10 at time 0, 4.01 in group A and 4.79 in group B. Similar odds were found for < 200 in any groups and < 100 except for group B (OR 11.57). SatO2 < 94% showed OR 1.34, 3.52 and 19.12 at time 0, in groups A and B, respectively. PaO2 < 60 and >100, SatO2 < 94% and PaO2/FiO2 ratio < 300 showed at least two- to three-fold correlation to adverse outcome. This may provide simple but clear targets for clinicians facing COVID-19 respiratory failure in a non ICU-setting.

scholarly journals Abdominal Wound Closure in Gynaecological or Obstetrical Surgery with Vicryl® (Polyglactin910) Versus Vicryl Plus® (Polyglactin910 with Triclosan Added): A Comparative Study

2019 ◽  
Vol 17 (1) ◽  
pp. 10-12
Author(s):  
Binod Kumar Mahaseth
Keyword(s):  
Surgical Site Infection ◽  
Surgical Complication ◽  
College Teaching ◽  
Controlled Study ◽  
Skin Closure ◽  
Site Infection ◽  
Comparative Efficacy ◽  
Group A ◽  
Group B ◽  
Johnson Company

Background: Surgical site infection is the most common post-surgical complication in surgical patients. The incidence of surgical site infection varies from 3-20% (or even more) in different part of the world. To date, the best method and material for skin closure has not been recommended by anybody. Triclosan is an antiseptic agent used for coating a suture material to prevent the infections. This case-controlled study was carried out to determine the comparative efficacy of sutures; Objective: This case-controlled study was carried out to determine the comparative efficacy of sutures: vicryl® and vicryl plus® (triclosan, an antiseptic incorporated with suture), in reducing surgical site infection in laparotomy for clean Gyn/Obs operations. Material and method: This case-controlled study was carried out in Dept. Of Gynae/Obs at Nepalgunj Medical College Teaching Hospital, Kohalpur. The period of the study was from Jan 2018 to January 2019. A total of 50 participants were enrolled in the study, who met the inclusion criteria. The patients were divided into two groups A and B, each consisting of 25 patients. The patients were allocated in the groups alternately to remove bias. The Group A consisted of patients where Vicrylplus® (Ethicon, Johnson & Johnson Company, Ahmadabad, India) polyglactin910 with triclosan) was used and Group B consisted of patients where vicryl ® (Ethicon, Johnson & Johnson Company, Ahmadabad, India) polyglactin910 alone) was used. Patients whose abdominal wounds were found infected, pus swab for culture were taken and sent for aerobic culture and sensitivity. All patients received ceftriaxone and metronidazole single dose before operations prophylactically. Result: Surgical site infection ingroup A was 3 cases out of 25 (12%) and in group B it was 6 cases out of 25(24%). Triclosan added polyglactin910 suture found to be statistically non significant concerning prevention of SSI as compared to polyglactin910 (p=0.472). The mean age of the study population was in group A was (29.76±7.47) and in group B was (27.12±7.42).

Use of Perioperative Steroids with Microvascular Decompression Operations

Neurosurgery ◽  
1988 ◽  
Vol 22 (2) ◽  
pp. 353-357 ◽  
Author(s):  
Donald W. Marion ◽  
Peter J. Jannetta
Keyword(s):  
Postoperative Complications ◽  
Microvascular Decompression ◽  
Cranial Nerves ◽  
Wound Infections ◽  
Related Complication ◽  
Deep Wound ◽  
Life Threatening ◽  
Group A ◽  
Group B ◽  
Single Blind

Abstract Complications associated with the use of perioperative steroids in elective craniotomies were evaluated in a single-blind prospective study of 222 consecutive microvascular decompression operations. Patients were randomized into one of three groups: Group A received steroids preoperatively and for 4 days postoperatively, Group B received steroids preand postoperatively for 1 day, and Group C received no steroids. There were 17 complications in Group A; 12 of these were wound-related. There were significantly fewer complications in Groups B and C (P &lt; 0.01). Group B had 3 complications, Group C had 4, and there was only 1 wound-related complication in Group C. There were no deaths, deep wound infections, or life-threatening complications. Severe postoperative headaches, a symptom that steroids were intended to minimize, occurred in 38% of patients in Group A, 42% of patients in Group B, and 25% of patients in Group C. The use of perioperative steroids did not reduce the length of postoperative hospitalization. Duration of the operation had no significant effect on the incidence of postoperative complications or the length of postoperative hospitalization. We conclude that there is no indication for the routine perioperative use of steroids with microvascular decompression operations of the posterior fossa cranial nerves and that such use leads to a higher incidence of postoperative complications. (Neurosurgery 22:353-357, 1988)

scholarly journals Evaluation of Hyperosmotic Sodium Bicarbonate as Adjunct to Ciprofloxacin in the Amelioration of Septicaemia in Salmonella-Induced Bubaline Neonatal Diarrhoea

2021 ◽  
Vol 25 (05) ◽  
pp. 921-928
Author(s):  
Ayesha Humayun
Keyword(s):  
Sodium Bicarbonate ◽  
Partial Pressure ◽  
Blood Gases ◽  
Comparative Efficacy ◽  
Treatment Regimens ◽  
Flunixin Meglumine ◽  
Neonatal Diarrhoea ◽  
Group A ◽  
Neonatal Calves ◽  
Group B

This study was conducted to evaluate the comparative efficacy of hyperosmotic sodium bicarbonate (HSB 8.4%), hypertonic saline (HSS 7.5%) and normal saline (NSS 0.9%) solutions associated with experimentally Salmonella-induced diarrhoea in buffalo neonatal calves. For this purpose, 14–17 days old 18 healthy buffalo calves were reared. After 8–12 h of oral administration of Salmonella broth (6.5 × 108 CFU), diarrhoea was induced successfully. Calves were then randomly divided into three equal groups viz., groups A, B and C and treatment was instituted. Group A received NSS (0.9%) @ 60 mL/kg (body weight) B.W, intravenous (IV) once, group B was administered HSS (7.5%) @ 5 mL/kg B.W, IV once and group C instituted with HSB (8.4%) @ 5 mL/kg B.W, IV once. All three groups were additionally treated with ciprofloxacin @ 7 mg/kg B.W, IV bid and flunixin meglumine @ 2 mg/kg B.W, IV tid. Comparative efficacy of all treatment regimens was assessed through haemodynamic measurements, blood gases determination and serum electrolyte analysis. All parameters were noted at baseline (prior to diarrhoea induction), during neonatal diarrhoea, t=3, t=9, t=18, t=36, t=72, t=120, t=168 h after treatment. The HSB treated calves (group C) revived from diarrhoea quickly (within 9 h) and efficiently than NSS (group A) and HSS (group B), exhibited significantly (P < 0.05) enhancement. At t=18 h, values for central venous partial pressure and systemic vascular resistance were 11.67 ± 0.7, 13.67 ± 0.61 and 13.50 ± 0.56 and 1180. 83 ± 6.94, 1180.83 ± 6.94 and 1465.00 ± 6.76 in groups A, B and C, respectively. HSB treated buffalo neonatal calves also showed significant increase in bicarbonate, blood pH, serum electrolytes and partial pressure of venous oxygen. Basis on the results of this study, it was concluded that small-volume administration of HSB profoundly ameliorated deleterious effects of septicaemia and improve haemodynamic stability in Salmonella-induced bubaline neonatal diarrhoea. It provides a practical and economical method to resuscitate dehydrated diarrhoeic calves thus make it convenient to accomplish in on-farm situation. © 2021 Friends Science Publishers

scholarly journals Comparative Efficacy of Low level Laser Therapy And Pulsed Ultrasound in the Management of Second - Degree Contusion

2007 ◽  
Author(s):  
O Ayanniyi ◽  
O B Ogunkunle ◽  
C E Mbada
Keyword(s):  
Laser Therapy ◽  
Low Level Laser Therapy ◽  
Comparative Efficacy ◽  
Pulsed Ultrasound ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Group A ◽  
Group B ◽  
Second Degree

Low level LASER therapy (LLLT) and pulsed ultrasound have been shown to relieve pain, promote healing and tissue repair in sport injuries. The objective of this study was to investigate the comparative efficacy of LLLT and pulsed ultrasound in the management of second - degree contusion in sportsmen. This is a 2 group pre-test – post-test quasi – experimental study involving 20 sportsmen, ten were in Group A (LLLT) and ten in Group B (P-US). They were aged between 19 and 30 years with the mean age 24.9 ± 3.28 years and 27.4 ± 3.75 years for the Group A and Group B respectively. Treatment consisted of six sessions, in a period of 2 weeks. Data collected on each participants included age, weight, height, site of injury, pain intensity, swelling, calf girth and range of motion. The result of the study revealed decrease in pain for both LLLT and pulsed ultrasound (p0.05). It was concluded that both therapies are equally effective in the management of pain resulting from second – degree contusion in sportsmen. KEYWORDS: Low level LASER, pulsed ultrasound, second – degree contusions.

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