scholarly journals AN AYURVEDIC MANAGEMENT OF ALCOHOLIC LIVER DISEASE W.S.R TO SHAKHASHRITA KAMALA - A CASE STUDY

2021 ◽  
Vol 9 (11) ◽  
pp. 2870-2876
Author(s):  
Samata Samata ◽  
Shaila Borannavar ◽  
Ananta S Desai
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Pathological Condition ◽  
The Body ◽  
Lower Limbs ◽  
Medical College ◽  
Chief Complaints ◽  
Excessive Consumption ◽  
Bilateral Lower Limb ◽  
Deep Yellow

Alcoholic liver disease is a pathological condition of the liver parenchymal tissue due to excessive consumption of alcohol over a long period of 6-10 years or even earlier. Here in we present a case of a married male of 35 yr. old reported in the Panchakarma OPD of SJIIM Government Ayurveda Medical College Bengaluru on 30th -Jan- 2021, with chief complaints of swelling in the bilateral lower limbs, deep yellowish and burning micturition, yel- lowish discoloration of sclera, reduced appetite, nausea and generalized weakness in the body since 3 months, with the increased level of LFT and USG-abdomen report suggesting hepatomegaly with fatty changes, was ex- amined and diagnosed as alcoholic liver disease and treated with Amapachana with Trikatu Churna, Nitya Virechana with Chitraka Haritaki Leha fallowed by Mustadi Yapana Basti had shown a very good improvement in normalizing appetite, bilateral lower limb swelling and deep yellow micturition. Total bilirubin, SGOT and ALP values were reduced. Keywords: Alcoholic Liver disease, Shakhashrita Kamala, Nitya Virechana

scholarly journals Trichotillomania and Dermatitis Artefacta: A Rare Coexistence

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Neeraj Varyani ◽  
Sunny Garg ◽  
Garima Gupta ◽  
Shivendra Singh ◽  
Kamlakar Tripathi
Keyword(s):  
Blood Pressure ◽  
Conservative Management ◽  
Lower Limb ◽  
Skin Lesions ◽  
The Body ◽  
Lower Limbs ◽  
Dermatitis Artefacta ◽  
Bilateral Lower Limb ◽  
Pedal Edema

A 24-year-old pregnant female patient presented with complains of bilateral lower limb swelling and fever for 1 month. On examination, blood pressure was 144/94 mmHg along with pitting pedal edema. She had bizarre skin lesions, aligned longitudinally and distributed over the approachable site of the body with tapering ends and in various stages of healing. Lower limbs examination also revealed similar lesions with signs of cellulitis. Her scalp had short and distorted hair suggesting pulling and plucking. These skin lesions and the denial of self-infliction by the patient made us reach the diagnosis of dermatitis artefacta with trichotillomania. Psychotherapy was advocated along with conservative management of skin lesions. The patient improved and is under our follow up.

Demographic Profile and Clinical Spectrum of Alcoholic Liver Disease among Males in Pakistan

2021 ◽  
Vol 15 (12) ◽  
pp. 3470-3472
Author(s):  
Aifa Arshad ◽  
Muhammad Aslam Shaikh ◽  
Ahmad Bin Zaheer ◽  
Imran Joher ◽  
Aamir Hussain
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Clinical Symptoms ◽  
Young Patients ◽  
Abdominal Distension ◽  
Meld Score ◽  
Lower Limbs ◽  
Western World ◽  
Demographic Profile ◽  
End Stage

Introduction: Alcohol is the most common substance abused in western world. Males tend to have more severe liver disease because of heavy and regular drinking. Methods: Adult patients, 16 years of age and older, diagnosed with ALD within 1 year, were included in the study. Liver disease from other causes was excluded. Demographic profiles, clinical features, laboratory and endoscopic findings of the patients, Child-Turcotte-Pugh (CTP), Model End Stage Liver Disease (MELD) were recorded. Results: A total of 104 patients with ALD who met the inclusion criteria were enrolled in the study. The mean age of the patients enrolled in the study was 49.2 years (SD = 13.1). Most of the patients were in the 30-65 age group. The four most common clinical symptoms in patients were abdominal distension (n = 89, 85.6%), bilateral lower limb edema (n = 78, 75%), jaundice (n = 39, 37.5%) and anorexia (n = 41, 39.4%). Of 104 patients, 96 (92.3%) had cirrhosis, 9 (8.7%) had fatty liver and alcoholic hepatitis. Of 94 patients with ALD, 49(52.1%) had CTP grade C and 83 (88.3%) had MELD score ≥ 16. Conclusions: ALD was mainly observed in young patients. The most common clinical symptoms were abdominal distension, bilateral oedema of the lower limbs, jaundice and anorexia. Among patients with cirrhosis of the liver, the majority of patients were CTP class C and obtained a MELD score ≥16. Keywords: Alcoholic liver disease, clinical profile, demographic profile

scholarly journals MORTALITY ANALYSIS OF THE PATIENTS WITH ALCOHOLIC LIVER CIRRHOSIS

2019 ◽  
Vol 5 (1) ◽  
pp. 40-46
Author(s):  
N. R. Matkovska
Keyword(s):  
Liver Cirrhosis ◽  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Pancreatic Necrosis ◽  
Vascular Lesions ◽  
Pulmonary Insufficiency ◽  
The People ◽  
Excessive Consumption ◽  
The Brain ◽  
Adverse Factor

Background. Alcohol is considered to be the main risk factor for adverse event deaths around the world. In Ukraine, mortality due to alcoholic liver disease (ALD) has taken the second place in the structure of death causes from diseases of the digestive system. Objective. The aim of the research was to study the peculiarities of the causes of death in the patients with alcoholic liver disease at the stage of liver cirrhosis (LC) based on the analysis of protocols of pathoanatomical research. Methods. The analysis of 149 protocols of the pathoanatomical study of the patients, who died from alcoholic LC, has been carried out at the premises of the Pathoanatomical Department of the Ivano-Frankivsk Regional Clinical Hospital in 2006-2018. Results. Most people were young and middle aged. Fatal cases were caused by decompensation of the LC with the development of hepatic, hepatic-renal, cardio-pulmonary insufficiency, pancreatic necrosis, gastrointestinal bleeding (GIB), sepsis, hepatocellular carcinoma (HCC). In 37.6 % of the patients the concomitant illness was coronary heart disease (CHD), 10.7 % of the people had hypertension. In 6 % of the patients, ischemic stroke of the brain was diagnosed. In most people atherosclerotic vascular changes were revealed. Conclusions. Excessive consumption of alcohol and, consequently, the development of LC, can be considered as an adverse factor in the reducing social standard of living. In the majority of people, who died from the decompensation of alcoholic LC, atherosclerotic vascular lesions have been detected. This indicates a significant prevalence of lipid metabolism disturbance in the people with alcoholic LC.

scholarly journals Rhoifolin Alleviate Alcoholic Liver Disease by Inhibiting the TLR4 / NF-kB Signaling Pathway and Attenuating Oxidative Stress

2021 ◽  
Author(s):  
Baoyu Mai ◽  
Ling Han ◽  
Jiarui Zhong ◽  
Zelin Cao ◽  
Jiaqi Fang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Hepatic Function ◽  
Flavonoid Compound ◽  
Hepatic Tissue ◽  
Stress Effects ◽  
Excessive Consumption ◽  
Anti Inflammation

Abstract Alcoholic liver disease (ALD) is caused by long-term excessive consumption of alcohol, which is affected by TLR4 / NF-kB mediated inflammatory response and CYP2E1-mediated oxidative stress effects. Rhoifolin (ROF) is a flavonoid compound in Citrus grandis ‘Tomentosa’, with antioxidant and anti-inflammation effect. However, the action of its effect on ALD has been elucidated yet. In the present study, we investigated ROF’s anti-inflammatory, antioxidant and antiapoptotic action in the treatment of ALD. In established ALD mice, ROF promoted hepatic function through downgrading the amount of aminotransferase, attenuating oxidative stress, and restoring antioxidant balance in hepatic tissue. Additionally, ROF significantly reduced the expression of inflammatory cytokines, such as NF-kB, TNF-a, IL-6, and IL-1b in the mice. In vitro experiments indicated that ROF increased the LO2 cells viability and inhibited cells apoptosis. ROF reversed the expression of CYP2E1, NLRP3, p-p65, p-IkB and TLR4, which were consistent with animal experiment. Overall, ROF can alleviate ethanol-induced liver injury through inhibiting oxidative stress and inflammation, and is a promising compound for ALD treatment.

scholarly journals The Chronic Liver Diseases from Autoimmune cause, Autoimmune Hepatitis (AIH): Updating Review

2020 ◽  
Vol 7 (2) ◽  
pp. 12-17
Author(s):  
Baydaa H. Abdullah ◽  
Huda J. Waheed ◽  
Zahraa A.E Alnaqqash
Keyword(s):  
Immune Response ◽  
Liver Disease ◽  
Autoimmune Hepatitis ◽  
Liver Diseases ◽  
Pathological Condition ◽  
Acute Infection ◽  
Liver Cells ◽  
The Body ◽  
Chronic Liver ◽  
Biliary Cirrhosis

The classic autoimmune liver diseases (AILDs) are one of the main causes of chronic liver disease; which include primary biliary cirrhosis (PBC), autoimmune hepatitis (AIH) constitute and primary sclerosing cholangitis (PSC).This pathological condition represents an immune attack on the bile epithelial liver cells, which leads to chronic inflammation in the liver, due to the proliferation of cells and the deposition of the matrix proteins between the hepatocytes and their types. Then the liver cells gradually lose their functions until the liver reaches the stage of myofibroblasts.The liver lost its functions inevitably and gradually gets until the liver loses its normal size leads to high blood pressure in the hepatic portal vein and from here begins the rapid deterioration of the liver condition so this requires follow-up and monitoring of liver cirrhosis and at this stage requires a liver biopsy examination In this case, liver transplantation is the effective and golden treatment option for liver disease at this stage. The abundance of MHC receptors class II in the surface liver cells, genetic predisposition or due to acute infection of the liver, leads to an immune response in the body, which leads to autoimmune hepatitis. This abnormal immune response leads to persistent hepatitis, which may lead to more symptoms and complications such as fatigue and cirrhosis. The disease may be related to race or age, diagnosis is often after the age of 40 years.

scholarly journals ANI scoring system – In differentiating alcoholic and non-alcoholic liver disease

2021 ◽  
Vol 12 (11) ◽  
pp. 104-107
Author(s):  
Anitha G ◽  
Sivakumar J ◽  
Kalavathy Ponniraivan
Keyword(s):  
Liver Disease ◽  
Liver Biopsy ◽  
Alcoholic Liver Disease ◽  
Scoring System ◽  
Research Centre ◽  
College Hospital ◽  
Alcoholic Fatty Liver ◽  
Medical College ◽  
Non Invasive ◽  
Invasive Method

Background: Alcoholic liver disease/non-alcoholic liver disease Index – ANI scoring system was constructed for clinically diagnosing the etiology of liver diseases, avoiding the risks of liver biopsy. Aims and Objectives: This study aims to test the reliability of ANI scoring system as a non-invasive method to distinguish alcoholic liver disease (ALD) from non-alcoholic fatty liver disease (NAFLD). Materials and Methods: This retrospective study was conducted on 177 (114 men and 58 women) treated as inpatients in Trichy SRM Medical College Hospital and Research Centre, Trichy, in the period of December 1, 2015–August 1, 2016. About 40 patients with etiology of viral, autoimmune, and biliary lithiasis were excluded. A total of 137 patients (98 men and 39 women) were classified into two groups, ALD (70) and NAFLD (67) based on diagnosis. Parameters of ANI – AST, ALT, MCV, BMI, and sex were recorded. ANI was calculated by online calculator. Results: ANI was significantly higher in patients with ALD than NAFLD (P<0.01). The cutoff value of ANI is –0.11. Conclusion: On the basis of the results, ANI scoring system may be used in clinically distinguishing ALD from NAFLD, avoiding the risks of liver biopsy.

scholarly journals ASSESSMENT OF CLINICAL PROFILE OF PATIENTS WITH ALCOHOLIC LIVER DISEASE

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Dr. Chetan Nayak
Keyword(s):  
Liver Disease ◽  
Alcohol Consumption ◽  
Alcoholic Liver Disease ◽  
Tertiary Care ◽  
The Body ◽  
World Health ◽  
Clinical Feature ◽  
High Morbidity ◽  
Care Hospital ◽  
Study Participants

Background: Alcohol consumption affects both mental and physical function of the body and hence called as “dual disease” because it has mentioned in etiology of morbidity in both the components of the body. According to the reports of World Health Organization there were more than 150 million people worldwide has indulged with alcoholism. Material & Methods: The present prospective study was conducted at department of general medicine of our tertiary care hospital. 100 Patients who were diagnosed as acute onset alcoholic liver disease were enrolled from outdoor and from ward by simple random sampling. Results: The most common clinical feature recorded among study participants was of nausea and vomiting seen in 46 (92%) of patients, which was followed by jaundice reported among 43 (86%) of patients. Hepatomegaly was reported among 37 (74%) of patients, which was followed by signs of liver failure reported among 30 (60%) patients, followed by anorexia reported among 29 (58%) of patients. Splenomegaly was reported among 17 (34%) of patients, fever was reported among 13 (26%) of patients, abdominal pain was reported among 12 (24%) of cases and ascites was reported among 8 (16%) study participants. Conclusion:  We concluded from the present study that larger quantities of alcohol consumption for a longer duration of time result in high morbidity and mortalities. Alcoholic liver disease is not only a medical burden but also a social burden which leads to frequent hospitalization and unwanted out of pocket expenditure. Key words: alcoholic liver disease, liver cirrhosis, hepatomegaly.

scholarly journals Tragedy in Savar: Management of Victims in Enam Medical College Hospital

2014 ◽  
Vol 4 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Mithun Alamgir ◽  
Rukhsana Parvin ◽  
Md Aminul Haque Khan
Keyword(s):  
Research Work ◽  
Sampling Technique ◽  
Mass Casualty ◽  
The Body ◽  
Medical College Hospital ◽  
Lower Limbs ◽  
College Hospital ◽  
Disaster Victims ◽  
Medical College ◽  
Mass Casualty Event

Background: Rana Plaza collapse is the worst and deadliest man-made industrial disaster in the history of garment sector in the world. Around 1200 people died and thousands more were injured. Most of the victims of the disaster were treated in Enam Medical College Hospital (EMCH). We conducted this study to give an overview on the disaster victims and services provided by EMCH. Objective: The study was done to observe the length of time between accident and admission in EMCH, length of time between admission and discharge, to observe the numbers, types and sites of injuries to the victims, medical measures given to the victims and finally to observe the status of the victims at the time of discharge. Materials and Methods: This descriptive type of observational study was carried out among the victims of Rana Plaza tragedy during the period of May to October 2013. All admitted patients in EMCH were included in the study. Purposive nonprobability sampling technique was applied in this research work. Data were collected from the hospital record. After collection, data were manually compiled, edited and analyzed. Results: Among 621 victims treated in different wards, 276 (44.45%) were admitted to the hospital on the day of accident. Among the admitted patients, 255 (41.06%) stayed in the hospital for 1--3 days,133 (21.42%) for 4--7 days and 88 (14.17%) for more than 10 days. Fracture and dislocation were present in 32.70% patients, lacerated injury in 18.20%, abrasion in 15.78%, bruise in 13.53%, incised wound in 15.45% and punctured wound in 4.34% patients. Single injury was present in 56.68% and rest had multiple injuries. Lower limbs were the most (33.01%) affected part of the body followed by head and neck (22.06%), upper limbs (18.52%), thorax (17.55%) and abdomen (8.86%). Two hundred seventy two patients (43.80%) were improved after treatment and 56 (9.02%) were fully cured; 23.83% of the victims were referred to higher medical centers for special measures. Conclusion: The collapse of Rana Plaza has fueled a greater call for reform and safety in garment industry. At the same time, all health care centers should adopt a broad-based approach to disaster-preparedness by providing a framework to ensure a well-coordinated response to mass casualty event. DOI: http://dx.doi.org/10.3329/jemc.v4i1.18066 J Enam Med Col 2014; 4(1): 31-35

scholarly journals Ataxia Telangiectasia: A Case Report

1970 ◽  
Vol 19 (1) ◽  
pp. 69-71 ◽  
Author(s):  
MI Islam ◽  
SKA Hoque ◽  
MT Islam ◽  
ASM Saleh ◽  
NC Saha ◽  
...  
Keyword(s):  
Case Report ◽  
Neurodegenerative Disease ◽  
Ataxia Telangiectasia ◽  
Cranial Nerves ◽  
The Body ◽  
Lower Limbs ◽  
College Hospital ◽  
Medical College ◽  
Progressive Cerebellar Ataxia ◽  
Atm Gene

Ataxia Telangiectasia (AT) is a rare, neurodegenerative disease that affects many parts of the body and causes severe disability is characterized by progressive Cerebellar ataxia, oculocutaneous telangiectasia, and recurrent respiratory and sinus infections. AT is caused by a defect in the ATM gene, which is responsible for recognizing and correcting errors in duplicating DNA when cells divide, and in destroying the cells when the errors can not be corrected. A 10 years old girl who is the first issue of non consanguineous parents completely immunized according to EPI schedule was admitted to Dhaka Medical College Hospital, Dhaka, on 26.01.2010 with the complaints of generalized weakness and difficulty to walk from the 6th year. The patient has one younger sister of 7 years old who has such complaints. On examination the patient was found mildly anemic with congestions in both eyeballs that is radiating from the both corners to limbus. The patient was conscious and cooperative. Cranial nerves were intact. There were hypotonia which was more marked in lower limbs with diminished jerks and flexor plantar reflexes. Gait was wide based and ataxic. She was diagnosed as a case of AT. This case is presented as academic interest. Key words: Ataxia Telangiectasia (AT); neurodegenerative disease. DOI: 10.3329/jdmc.v19i1.6258 J Dhaka Med Coll. 2010; 19(1) : 69-71.

scholarly journals A 29-Year-Old Male with Borderline Lepromatous Leprosy

2013 ◽  
Vol 3 (2) ◽  
pp. 109-112
Author(s):  
Lubna Khondker ◽  
Md. Shirajul Islam Khan ◽  
Md. Anwar Husain
Keyword(s):  
Peripheral Nerves ◽  
Histopathological Examination ◽  
Dorsal Surface ◽  
Lepromatous Leprosy ◽  
The Body ◽  
Lower Limbs ◽  
Upper Respiratory Tract ◽  
Medical College ◽  
Great Auricular Nerve ◽  
Ulcerative Lesions

Leprosy (Hansen’s disease) is a chronic granulomatous infectious disease that primarily affects the peripheral nerves, skin, upper respiratory tract mucosa, eyes and certain other tissues. It is diagnosable and curable if recognized early and treated adequately. A twenty nine-year-old male from Jessore, Bangladesh reported in Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh with the complaints of multiple erythematous, large, raised and circumscribed lesions with loss of sensations on different parts of the body, especially distal portions of all four limbs for last eight months. Subsequently he developed ulcers on the anesthetic fingers due to smoking and few ulcerative lesions on both feet. Skin examination revealed multiple erythematous, large nodular lesions on both sides of the cheek and forehead, multiple erythematous, indurated, large plaques with raised margin and central clearing on the trunk, waist and all four limbs, few satellite lesions around the large plaques on the trunk, few hypopigmented patches and plaques on buttock and lower limbs, multiple painless ulcers on dorsal surface of fingers of both hands, both lateral malleoluses and right sole. On examination of peripheral nerves, left great auricular nerve, both ulnar nerves and both common peroneal nerves were moderately enlarged and tender. Slit skin smear for AFB (modified Z-N stain) was done and revealed that there were large number of acid and alcohol-fast bacilli arranged in straight and curved parallel bundles with globular masses (cigar-bundle appearance), morphologically resembling Mycobacterium leprae. Skin biopsy for histopathological examination revealed extensive infiltration of macrophages in the dermis, separated from epidermis by narrow grenz zone, with destruction of skin adnexa. Few foci of poorly defined granuloma in dermis were also noted. The patient was managed with rifampicin, clofazimine, dapsone, prednisolone and omeprazole. Journal of Enam Medical College; Vol 3 No 2 July 2013; Page 109-112 DOI: http://dx.doi.org/10.3329/jemc.v3i2.16134

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