scholarly journals New laboratory biomarkers of rheumatoid arthritis

2021 ◽  
Vol 59 (2) ◽  
pp. 201-207
Author(s):  
D. A. Dibrov
Keyword(s):  
Rheumatoid Arthritis ◽  
Scavenger Receptor ◽  
Rational Selection ◽  
Diagnostic Parameters ◽  
Early Stages ◽  
Scavenger Receptor A ◽  
Laboratory Biomarkers ◽  
New Biomarkers ◽  
Selection Of

The review presents data on new biomarkers for the diagnosis of rheumatoid arthritis, considers the diagnostic parameters of antibodies to carbamylated proteins, antibodies to peptidyl arginine deaminase, antibodies to homocysteinylated α1-antitrypsin, 14-3-3η, macrophage soluble scavenger receptor A. The use of new biomarkers can improve the diagnosis of RA in the early stages, as well as stratify patients based on the prognosis of the disease and provide a rational selection of therapy.

scholarly journals Potential clinical biomarkers in rheumatoid arthritis with an omic approach

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yolima Puentes-Osorio ◽  
Pedro Amariles ◽  
Miguel Ángel Calleja ◽  
Vicente Merino ◽  
Juan Camilo Díaz-Coronado ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Biological Markers ◽  
Therapeutic Option ◽  
Treatment Options ◽  
Cellular Level ◽  
Potential Influence ◽  
Clinical Biomarkers ◽  
New Biomarkers ◽  
Selection Of

Abstract Objective To aid in the selection of the most suitable therapeutic option in patients with diagnosis of rheumatoid arthritis according to the phase of disease, through the review of articles that identify omics biological markers. Methods A systematic review in PubMed/Medline databases was performed. We searched articles from August 2014 to September 2019, in English and Spanish, filtered by title and full text; and using the terms "Biomarkers" AND “Rheumatoid arthritis". Results This article supplies an exhaustive review from research of objective measurement, omics biomarkers and how disease activity appraise decrease unpredictability in treatment determinations, and finally, economic, and clinical outcomes of treatment options by biomarkers’ potential influence. A total of 122 articles were included. Only 92 met the established criteria for review purposes and 17 relevant references about the topic were included as well. Therefore, it was possible to identify 196 potential clinical biomarkers: 22 non-omics, 20 epigenomics, 33 genomics, 21 transcriptomics, 78 proteomics, 4 glycomics, 1 lipidomics and 17 metabolomics. Conclusion A biomarker is a measurable indicator of some, biochemical, physiological, or morphological condition; evaluable at a molecular, biochemical, or cellular level. Biomarkers work as indicators of physiological or pathological processes, or as a result of a therapeutic management. In the last five years, new biomarkers have been identified, especially the omics, which are those that proceed from the investigation of genes (genomics), metabolites (metabolomics), and proteins (proteomics). These biomarkers contribute to the physician choosing the best therapeutic option in patients with rheumatoid arthritis.

scholarly journals Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Fanlei Hu ◽  
Xiang Jiang ◽  
Chunqing Guo ◽  
Yingni Li ◽  
Shixian Chen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Multicenter Study ◽  
Large Scale ◽  
Scavenger Receptor ◽  
Scavenger Receptor A

Vibro-acoustic diagnostics of low-energy stage of failures evolution

2009 ◽  
Vol 223 (5) ◽  
pp. 589-597
Author(s):  
S Radkowski
Keyword(s):  
Low Energy ◽  
Dissipated Energy ◽  
Significant Growth ◽  
Diagnostic Parameters ◽  
Early Stages ◽  
Vibroacoustic Signal ◽  
Acoustic Diagnostics ◽  
Related Defect ◽  
Selection Of

The work concerns diagnosis of the origins and development of early stages of defects based on information found in vibroacoustic signal. At the beginning the necessity of selection of diagnostic parameters dependent upon the amount of dissipated energy and related defect development is proven. Emphasizing the fact that defect development does not always lead to a significant growth of the vibroacoustic signal's power, the author has shown importance of analysis and modelling of low-energy defects.

THE LEVEL OF CYTOKINES IN THE SALIVA OF PATIENTS WITH BREAST CANCER

2019 ◽  
Vol 65 (6) ◽  
pp. 825-831
Author(s):  
Lyudmila Belskaya ◽  
Viktor Kosenok
Keyword(s):  
Breast Cancer ◽  
Control Group ◽  
Early Stages ◽  
Promising Tool ◽  
Urgent Task ◽  
Advanced Stages ◽  
New Biomarkers ◽  
Histological Verification ◽  
Control Study ◽  
Biochemical Examination

Currently, the urgent task is to search for new biomarkers as a promising tool for early detection and monitoring of breast cancer. The aim of the study was to study the level of cytokines in the saliva of patients with breast cancer. In the case-control study volunteers participated, which were divided into 3 groups: the main (breast cancer, n = 43), the comparison group (fibroadenoma, n = 32) and the control group (conditionally healthy, n = 39). All participants were questioned; biochemical examination of saliva, histological verification of the diagnosis was carried out. Intergroup differences are estimated by a nonparametric criterion. It is shown that in the context of breast cancer, the level of cytokines (IL-2, IL-4, IL-6, IL-10 and IL-18) is increasing, except for IL-8, the content of which decreases compared to the control group. When the disease progresses by the nature of the dynamics, the parameters are divided into two groups: IL-2, IL-4, IL-18 and IL-6, IL-8, IL-10. For the first group of cytokines, there was a decrease in content during the transition from the early stages to the more common ones. For the second group, when passing from stages T1-2N0M0 to T1-2NjM0, the level of cytokines remains practically constant. In the future, the level of cytokines is observed for stage T3_4N0_2M0, and for IL-2, IL-4 and IL-10, the level of cytokines reaches values corresponding to early stages, whereas for IL-6, IL-8 and IL-18 in the same direction, a significant increase in indicators was noted. Additionally, the IL-6/IL-8 ratio was calculated depending on the tumor size, as well as the presence / absence of metastasis. It is shown that this ratio is statistically significantly increased in the advanced stages of the disease. Particularly interesting is the increase in this ratio in saliva at the initial stages of the disease.

Laboratory Biomarkers for Guiding Therapy with Methotrexate in Rheumatoid Arthritis

2014 ◽  
Vol 21 (2) ◽  
pp. 202-211 ◽  
Author(s):  
Carlos Abud-Mendoza ◽  
Marco Martínez-Martínez ◽  
Adriana Monsivais-Urenda ◽  
Roberto Gonzalez- Amaro
Keyword(s):  
Rheumatoid Arthritis ◽  
Laboratory Biomarkers

scholarly journals The use of cement concrete pavements for roads, depending on climatic conditions

2019 ◽  
Vol 13 (3) ◽  
pp. 235-240
Author(s):  
Iryna Solonenko
Keyword(s):  
European Union ◽  
Statistical Models ◽  
Road Network ◽  
The European Union ◽  
Rational Selection ◽  
Cement Concrete ◽  
The Road ◽  
Road Pavement ◽  
Operational Characteristics ◽  
Selection Of

The development of road network infrastructure is an important component of the economic development of the European Union. Updating of the road network contributes to the integration of the economies of countries into a coherent whole. The road network provides the free movement of citizens, the movement of goods and the effective implementation of various services. The increase in the length of the road network leads to an increase in the financial and material costs necessary to ensure its maintenance and repair. One of the ways to reduce costs is by strengthening the physic-mechanical and operational characteristics of the pavement due to the widespread use of cement concrete. The quality of the pavement of cement concrete depends largely on the rational selection of its composition. This allows a significant increase in the durability of road pavement. The purpose of the research was: the development of recommendations for the rational selection of the composition of the road pavement material of cement concrete, aimed at upgrading longevity, and taking into account its frost resistance grade. According to the goal, the following tasks were developed: the analyses of the climatic zones in which the road network of the European Union is located; the development of a research plan, a selection of the response function and influence factors; the study of physico-mechanical and operational characteristics of the researched material of road pavement; on the basis of the obtained data, the calculation of the complex of experimental-statistical models, which describe the physico-mechanical and operational characteristics of the road pavement material; on the basis of experimental statistical models, a method was proposed for selecting the rational compositions of the cement concrete pavement road material depending on the conditions of its application. The results presented in the article can be used in engineering and scientific practice for the selection of road pavement from cement concrete for highways.

scholarly journals Distinct Roles of Vav Family Members in Adaptive and Innate Immune Models of Arthritis

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 695
Author(s):  
Javier Conde ◽  
Isabel Fernández-Pisonero ◽  
Myriam Cuadrado ◽  
Antonio Abad ◽  
Javier Robles-Valero ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Family Members ◽  
Experimental Models ◽  
Innate Immune ◽  
Main Role ◽  
Zymosan A ◽  
Proliferation And Differentiation ◽  
Signal Transduction Proteins ◽  
Selection Of

Genetic evidence suggests that three members of the VAV family (VAV1, VAV2 and VAV3) of signal transduction proteins could play important roles in rheumatoid arthritis. However, it is not known currently whether the inhibition of these proteins protects against this disease and, if so, the number of family members that must be eliminated to get a therapeutic impact. To address this issue, we have used a collection of single and compound Vav family knockout mice in experimental models for antigen-dependent (methylated bovine serum albumin injections) and neutrophil-dependent (Zymosan A injections) rheumatoid arthritis in mice. We show here that the specific elimination of Vav1 is sufficient to block the development of antigen-induced arthritis. This protection is likely associated with the roles of this Vav family member in the development and selection of immature T cells within the thymus as well as in the subsequent proliferation and differentiation of effector T cells. By contrast, we have found that depletion of Vav2 reduces the number of neutrophils present in the joints of Zymosan A-treated mice. Despite this, the elimination of Vav2 does not protect against the joint degeneration triggered by this experimental model. These findings indicate that Vav1 is the most important pharmacological target within this family, although its main role is limited to the protection against antigen-induced rheumatoid arthritis. They also indicate that the three Vav family proteins do not play redundant roles in these pathobiological processes.

L-theanine inhibits foam cell formation via promoting the scavenger receptor A degradation

2021 ◽  
pp. 174181
Author(s):  
Jianzhen Lei ◽  
Jingheng Ye ◽  
Rong She ◽  
Ruyi Zhang ◽  
Yanan Wang ◽  
...  
Keyword(s):  
Foam Cell ◽  
Scavenger Receptor ◽  
Cell Formation ◽  
Foam Cell Formation ◽  
Scavenger Receptor A

scholarly journals Correction to: In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Johannes Notni ◽  
Florian T. Gassert ◽  
Katja Steiger ◽  
Peter Sommer ◽  
Wilko Weichert ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Positron Emission Tomography ◽  
In Vivo Imaging ◽  
Emission Tomography ◽  
Early Stages ◽  
Positron Emission ◽  
Α5β1 Integrin

Following publication of the original article [1], the authors have reported an error in the ‘Histopathology’ (under ‘Materials and methods’) section of the article that compromises the reproducibility of the paper.

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