scholarly journals Ayurvedic Literature Review of Pratishyaya w.s.r. Rhinitis

2020 ◽  
Keyword(s):  
Global Warming ◽  
Side Effects ◽  
Literature Review ◽  
Life Style ◽  
Clinical Condition ◽  
Treatment Modalities ◽  
Common Disease ◽  
Nasal Discharge ◽  
Modern System ◽  
Prevention And Cure

Ayurveda is the ancient most medicine science with equal emphasis upon prevention and cure. Due to environmental pollution, global warming, and life style disorders, a very common disease, Pratishyaya/Rhinitis occurs much more frequently than before. Pratishyaya has been considered as a separate clinical condition in Uttar Tantra of Sushruta Samhita. Improper management or negligence can lead to lots of complications like Badhirya, Andhata, Gandhanasha, Kasa etc. Rhinitis is an inflammation of the nasal membranes, characterized by watery nasal discharge, nasal obstruction, sneezing and nasal itching. This may also be associated with symptoms of itching in the eyes, palate and pharynx. Many treatment modalities are explained in modern system of medicine like corticosteroids, antiallergics, inhalers, antihistamines etc., but none of them are totally effective in curing the disease as well as preventing its recurrence, more over they have their own side effects.

scholarly journals Review on Evidence Based Ayurvedic Treatment Practices for Psoriasis

2018 ◽  
Vol 9 (2) ◽  
pp. 39-41
Author(s):  
Venkateshwarlu B ◽  
Anumol K ◽  
Mithuna Mohan ◽  
Priyanka Bai ◽  
Murali Krishna C ◽  
...  
Keyword(s):  
Side Effects ◽  
Time Use ◽  
Treatment Modalities ◽  
Evidence Based ◽  
Therapeutic Approaches ◽  
Treatment Practices ◽  
Therapeutic Regime ◽  
Modern System ◽  
Long Time ◽  
Ayurvedic Treatment

Psoriasis is characterized by sharply defined erythematous squamous lesions. It is one of the commonest chronic, non-infectuous papulo-squamous disorder of the skin. Several treatment modalities are in existence in modern system of medicine; however they have limitations due to their side effects due to long time use. Considering this, search for new safe therapeutic regime in psoriasis is going on. The present paper presents some of the promising evidence based Ayurvedic therapeutic approaches in the management of psoriasis.  

scholarly journals Comparison of metformin and N-acetylcysteine on metabolic parameters in women with polycystic ovarian syndrome

2017 ◽  
Vol 6 (7) ◽  
pp. 3076 ◽  
Author(s):  
Hina Ali ◽  
Gita Radhakrishnan ◽  
Alpana Singh
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Side Effects ◽  
Reproductive Age ◽  
Treatment Modalities ◽  
Term Therapy ◽  
Controlled Clinical Trial ◽  
P Value ◽  
Common Disease ◽  
Study Results

Background: Polycystic ovary syndrome (PCOS) is a common disease that affects up to 10% of women of reproductive age, in which hyperandrogenism (HA), enlarged cystic ovaries, and chronic anovulation often co-exist with obesity, dyslipidemia and insulin resistance (IR). There is a need for an alternative to metformin with minimal side effects to improve insulin sensitivity and correct dyslipidemia in PCOS patients.Methods: It was a prospective, Randomized controlled clinical trial. 116 PCOS patients, 58 each in two groups received either Metformin 500 mg TDS or N-acetylcysteine (NAC) 600 mg TDS for 3 months. Clinical and biochemical parameters contributing to metabolic syndrome (MS) and insulin resistance (fasting blood sugar (FBS), fasting insulin (FI), FBS:FI, HOMA-IR and QUICKI) were assessed at the start and end of the study. Results were compared between the two groups.Results: Both treatment modalities resulted in a significant reduction in number of cases with IR (p=0.001) and MS. Fasting hyperinsulinemia improved in 15 % (p=0.12) and 30% (p=0.001) of patients while 12% (p=0.23) and 18% (p=0.049) improvement was seen in FBS:FI in MET and NAC group respectively. Similarly, improvement in HOMA-IR was 12% (p=0.30) and 32% (p=0.001) in MET and NAC group which is significant with NAC. QUICKI and impaired glucose tolerance showed significant improvement in both the groups with a p-value of 0.04 and 0.006, 0.035 and 0.046 respectively. Significant reduction was seen in triglycerides (p=0.048) in NAC group.Conclusions: NAC is equally efficacious as metformin in improving parameters of insulin resistance and metabolic syndrome with minimal occasional side effects ensuring better compliance for a long-term therapy.

scholarly journals ISOTRETINOIN FOR TREATING ACNE VULGARIS

2021 ◽  
pp. 20-25
Author(s):  
IRMA BERNADETTE S. SITOHANG
Keyword(s):  
Side Effects ◽  
Literature Review ◽  
Cellular Proliferation ◽  
Acne Vulgaris ◽  
Treatment Modalities ◽  
Extensive Literature ◽  
Essential Information ◽  
Therapeutic Modalities ◽  
Oral Isotretinoin ◽  
Systemic Antibiotics

Acne vulgaris (AV) occurs in more than 80% of dermatological cases in adolescents and young adults and affects the quality of life. Oral isotretinoin, a metabolite product of vitamin A, is well-known to be the most effective treatment for severe nodulocystic AV and moderate AV that does not respond to other therapeutic modalities. Thus, this literature review was conducted to explain the mechanism of action, effectiveness, contraindications, side effects, and safety of oral isotretinoin in AV, which provided essential information for dermatologists. Furthermore, isotretinoin is the only treatment modality that has implications for the entire pathogenesis of acne. It contributes to decreasing corneocytes’ adhesion, supporting cellular proliferation and follicular renewal, induction of cell apoptosis, and immune regulation. The effectiveness of AV therapy with isotretinoin has expanded as it is also indicated for moderate to severe AV that does not respond well to topical combination therapy or systemic antibiotics. However, isotretinoin is included in Category X drugs and may induce many side effects from mucocutaneous effects to teratogenicity. From this extensive literature review, it can be concluded that isotretinoin is one of the treatment modalities for acne with good effectivity due to its mechanism of actions that affect the entire acne pathogenesis. Considering the various side effects of isotretinoin, its use requires adequate clinical assessment and monitoring by a dermatologist.

Peptide Receptor Radionuclide Therapy for Pancreatic Neuroendocrine Tumours

2019 ◽  
Vol 12 (2) ◽  
pp. 126-134 ◽  
Author(s):  
Shahad Alsadik ◽  
Siraj Yusuf ◽  
Adil AL-Nahhas
Keyword(s):  
Side Effects ◽  
Effective Treatment ◽  
Radionuclide Therapy ◽  
Neuroendocrine Tumours ◽  
Peptide Receptor Radionuclide Therapy ◽  
Progression Free Survival ◽  
Treatment Modalities ◽  
Effective Treatment Option ◽  
Peptide Receptor ◽  
Pancreatic Neuroendocrine Tumours

Background: The incidence of pancreatic Neuroendocrine Tumours (pNETs) has increased considerably in the last few decades. The characteristic features of this tumour and the development of new investigative and therapeutic methods had a great impact on its management. Objective: The aim of this review is to investigate the outcome of Peptide Receptor Radionuclide Therapy (PRRT) in the treatment of pancreatic neuroendocrine tumours. Methods: A comprehensive literature search strategy was used based on two databases (SCOPUS, and PubMed). We considered all studies published in English, evaluating the use of PRRT (177Luteciuim- DOTA-conjugated peptides and 90Yetrium- DOTA- conjugated peptides) in the treatment of pancreatic neuroendocrine tumours as a standalone entity or as a subgroup within the wider category of Gastroenteropancreatic Neuroendocrine Tumours (GEP NETs). Results: PRRT was found to be an effective treatment modality as a monotherapy or in combination with other therapies in the treatment of non-operable and metastatic pNETs where other options are limited. Complete response was reported to be between 2-6% while partial response was achieved in up to 60% of cases. Survival analysis was also impressive. Progression Free Survival (PFS) reached a mean of 34 months and Overall Survival (OS) of 53 months. PRRT also proved to improve patients’ Quality of Life (QoL). Acute and sub-acute side effects like nephrotoxicity and haematotoxicity are usually mild and reversible. Conclusion: PRRT is well tolerated and effective treatment option for non-operable and/or metastatic pNETs. Side effects are usually mild and reversible. Larger randomized controlled trails need to be done to compare PRRT with other treatment modalities and to provide more detailed guidelines regarding patient selections, the choice of PRRT, follow up and response assessment to maximum potential benefit.

SARS-CoV-2 Biology Insights, Part I. Genome-wide structure and druggability: literature review (Preprint)

2020 ◽  
Author(s):  
Laura Lafon-Hughes
Keyword(s):  
Side Effects ◽  
Literature Review ◽  
Host Cell ◽  
Nucleoside Analogs ◽  
Viral Proteins ◽  
Therapeutic Strategies ◽  
Adverse Side Effects ◽  
Viral Proteases ◽  
Genome Wide ◽  
Therapeutic Alternatives

BACKGROUND COVID-19 pandemic prompts the study of coronavirus biology and search of putative therapeutic strategies. OBJECTIVE To compare SARS-CoV-2 genome-wide structure and proteins with other coronaviruses, focusing on putative coronavirus-specific or SARS-CoV-2 specific therapeutic designs. METHODS The genome-wide structure of SARS-CoV-2 was compared to that of SARS and other coronaviruses in order to gain insights, doing a literature review through Google searches. RESULTS There are promising therapeutic alternatives. Host cell targets could be modulated to hamper viral replication, but targeting viral proteins directly would be a better therapeutic design, since fewer adverse side effects would be expected. CONCLUSIONS Therapeutic strategies (Figure 1) could include the modulation of host targets (PARPs, kinases) , competition with G-quadruplexes or nucleoside analogs to hamper RDRP. The nicest anti-CoV options include inhibitors of the conserved essential viral proteases and drugs that interfere ribosome slippage at the -1 PRF site.

scholarly journals The Clinical Spectrum of Primary Cutaneous CD4+ Small/Medium-Sized Pleomorphic T-Cell Lymphoproliferative Disorder: An Updated Systematic Literature Review and Case Series

Dermatology ◽  
2020 ◽  
Vol 237 (4) ◽  
pp. 618-628
Author(s):  
Philip Surmanowicz ◽  
Sean Doherty ◽  
Arunima Sivanand ◽  
Nikoo Parvinnejad ◽  
Jean Deschenes ◽  
...  
Keyword(s):  
T Cell ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Lymphoproliferative Disorder ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Cutaneous Lymphoma ◽  
World Health ◽  
Treatment Modalities ◽  
Systemic Treatments

<b><i>Background:</i></b> Primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoproliferative disorder (SMPLPD) is a provisional entity within the 2016 World Health Organization classification of primary cutaneous lymphomas. The condition is currently classified as a lymphoproliferative disorder to emphasize its benign course and discourage aggressive, systemic treatment modalities. <b><i>Objective:</i></b> To provide a relevant synthesis for the dermatological practitioner on the prevalence, presentation, and treatment of SMPLPD. <b><i>Methods:</i></b> We conducted an updated systematic literature review and a retrospective chart review of diagnosed cases of SMPLPD from 2 Canadian academic cutaneous lymphoma centers. <b><i>Results:</i></b> A total of 23 studies with 136 cases were extracted from the systematic review and 24 patients from our retrospective chart review. SMPLPD proved relatively common accounting for 12.5% of all cutaneous T-cell lymphomas encountered in our cutaneous lymphoma clinics, second in frequency only to mycosis fungoides. The typical clinical presentation was that of an older individual (median age 59 years) with an asymptomatic solitary lesion on their upper extremity. The most common clinical differentials were cutaneous lymphoid hyperplasia, basal cell carcinoma, and lymphoma unspecified. T follicular helper markers were reliably detected. The main treatment modalities were surgical excision, local radiation therapy, and topical or intralesional steroids. Cure was achieved in the vast majority of cases. <b><i>Conclusions:</i></b> SMPLPD is an underdiagnosed T-cell lymphoma with an overtly benign clinical course. The condition has an excellent prognosis and responds well to skin-directed therapies. Practitioners should be aware of this condition to avoid aggressive systemic treatments.

Current Treatment Modalities of JIA-associated Uveitis and its Complications: Literature Review

2016 ◽  
Vol 24 (4) ◽  
pp. 431-439 ◽  
Author(s):  
Khawla Abu Samra ◽  
Armin Maghsoudlou ◽  
Ramak Roohipoor ◽  
Manuel Valdes-Navarro ◽  
Stacey Lee ◽  
...  
Keyword(s):  
Literature Review ◽  
Current Treatment ◽  
Treatment Modalities

Empirical and long-term therapy for endometriosis-associated pelvic pain

2021 ◽  
pp. 8-12
Author(s):  
I. V. Kuznetsova
Keyword(s):  
Literature Review ◽  
Medical Treatment ◽  
Pelvic Pain ◽  
Clinical Characteristics ◽  
Current Data ◽  
Diagnosis And Treatment ◽  
Term Therapy ◽  
Common Disease ◽  
Long Term Therapy

Endometriosis is a common disease, the diagnosis and treatment of which is still a matter of debate. One of the main symptoms of endometriosis -pelvic pain is a particular problem due to the difficulties in identifying the cause and the lack of sufficient effect from surgical and medical treatment. The literature review presents current data on the prevalence, clinical characteristics and methods of individualized therapy in patients with pelvic pain established or presumably associated with endometriosis.

Self-limiting benign paroxysmal positional vertigo following use of whole-body vibration training plate

2009 ◽  
Vol 124 (7) ◽  
pp. 796-798 ◽  
Author(s):  
I Amir ◽  
E Young ◽  
A Belloso
Keyword(s):  
Side Effects ◽  
Literature Review ◽  
Benign Paroxysmal Positional Vertigo ◽  
Whole Body Vibration ◽  
Whole Body ◽  
Body Vibration ◽  
Positional Vertigo ◽  
Vibration Training ◽  
Whole Body Vibration Training ◽  
Paroxysmal Positional Vertigo

AbstractObjective:We describe a case of benign paroxysmal positional vertigo which occurred after use of a whole-body vibration training plate.Method:Case report and literature review concerning the secondary causes of benign paroxysmal positional vertigo and the physiological effects of whole-body vibration training plates.Results:A 44-year-old woman was referred with classic symptoms of benign paroxysmal positional vertigo following use of a whole-body vibration training plate, a popular form of fitness equipment widely used in sports, rehabilitation and beauty treatments. The condition resolved spontaneously after several days. There have been reports of negative side effects in users of this equipment, such as dizziness, headache and a sensation of imbalance; however, there have been no reported cases involving vertigo. Based on a literature review, this equipment may cause side effects, including vertigo, by generating forces that can increase the original amplitude of internal organs, which may potentially cause labyrinthine trauma or dislocation of otoconia, leading to benign paroxysmal positional vertigo.Conclusions:We suggest that whole-body vibration training plates may potentially induce benign paroxysmal positional vertigo. Manufacturers may need to make users of this equipment aware of this risk, and remind them to use it with caution.

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