Journal of Pharmaceutical Research and Development
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This work deals with the problem of modeling and prediction of compressive strength of concrete structure in multiproduct batch plant design of protein production found in a chemical engineering process with uncertain demand. Modeling the strength of concrete for this process is very complex. However, it can be solved by minimizing the investment cost. Therefore, the aim of this work is to minimize the investment cost and find out the number and size of parallel equipment units in each stage. For this purpose, it is proposed to solve the problem by using extreme gradient boosting regressor with grid search support (XGBoost), could be interpreted as an optimization algorithm on a suitable cost function, which take into account, the uncertainty on the demand using gaussian process modeling. The results about number and size of equipment’s, investment cost, production time, process time and idle times in plant obtained by light gradient boosted trees regressor are the best. This methodology can help the decision makers and constitutes a very promising framework for finding a set of “good solutions”.


The antibacterial activity, phytochemical constituents and the radical scavenging ability using FRAP and DPPH of Piliostigma reticulatum were investigated in this study. Of all the solvent extracts used to assay the antibacterial effect, ethanol extract had the highest activity, followed by the aqueous extract with very weak activity against Pseudomonsa aeruginosa, Salmonella typhi and E. coli, methanol extract had no visible effect on the test organisms while ethyl acetate was active against only E. coli. The presence of phytochemicals such as alkaloids, glycosides, steroids, anthraquinones, phenol, tanin and saponin was observed. Antinutrients such as Tanin, Phenol, Phylate, Oxalate, Saponin and Flavonoids in copious amount. Ethanol extract of P. reticulatum was found to have the highest antioxidant ability, followed by the methanol extract. Ehtyl acetate extract had minimal radical scavenging ability. The antibacterial effect, phytochemical content and the radical scavenging properties of the plant makes it a good candidate in the development of antimicrobial therapeutics.


Health is the ultimate product of food and its proper digestion and metabolism. If we take proper food, then there is no need of medicine. But now a day’s food habits are changing dramatically. Good eating habits which are established in childhood often carry into adulthood. In present era, every individual prefer junk food, snacks, processed food and skipping breakfast. Their children also adopt the same pattern of diet; therefore they are more susceptible to various disorders of gastro-intestinal tract. Ayurveda is the ancient science of healing which emphasizes on restoration of health as well as the treatment of diseases. Acharya stated that health depends upon bhojana (food), bhojana depend on vidhi and vidhi depends on vikalp. Ayurveda described diet, dietary habits on dincharya (daily basis), ritucharya (seasonal basis), ashthvidh aahar visheshaayatana, dwadash pravicharna etc. According to Ayurveda homeostasis in vata, pitta and kapha doshas (humors) brings arogya (health) while their derangements cause roga (disease). Food has power of aggravating, pacifying or balancing these doshas (humors). By adopting this Ayurvedic pattern of diet and dietary regimens we can achieve a healthy and disease free life


Ayurveda is the ancient most medicine science with equal emphasis upon prevention and cure. Due to environmental pollution, global warming, and life style disorders, a very common disease, Pratishyaya/Rhinitis occurs much more frequently than before. Pratishyaya has been considered as a separate clinical condition in Uttar Tantra of Sushruta Samhita. Improper management or negligence can lead to lots of complications like Badhirya, Andhata, Gandhanasha, Kasa etc. Rhinitis is an inflammation of the nasal membranes, characterized by watery nasal discharge, nasal obstruction, sneezing and nasal itching. This may also be associated with symptoms of itching in the eyes, palate and pharynx. Many treatment modalities are explained in modern system of medicine like corticosteroids, antiallergics, inhalers, antihistamines etc., but none of them are totally effective in curing the disease as well as preventing its recurrence, more over they have their own side effects.


Impacted foreign bodies in the Upper GIT are frequently encountered in the Gastroenterology department, identification of such foreign bodies and its safe extraction without hindering the normal physiology requires a stupendous clinical skill and technique. An earliest record of such condition and its approach based on the material trapped is detailed in Sushruta’s treatise, Sushruta Samhita. And this is the earliest use of endoscopic procedure in extracting the impacted foreign bodies. Among these methods, Sushruta’s trap method is highly praiseworthy and commendable in extraction of the foreign body.


The author utilizes quantitative analysis results based on diabetes control for two periods: the pre-COVID-19 period, from 5/5/2018 to 1/18/2020, and the COVID-19 period, from 1/19/2020 to 8/25/2020, within a duration of 2.3 years. Special attention has been placed on the comparison of quantitative glucose results, including FPG, PPG, daily glucose, and HbA1C, especially the COVID-19 quarantine period from 1/19/2020 to 8/25/2020.


This study was carried out to investigate the aetiologic agents of vaginitis in sexually active women in Ikot Ekpene, Akwa Ibom State, Nigeria. The subjects were 150 randomly selected sexually active women attending antenatal, postnatal, gynaecology and family planning clinics in the Department of Obstetrics and Gynaecology of General Hospital Ikot Ekpene, Akwa Ibom State. Two high vaginal swab samples were taken from each pregnant and non-pregnant woman, which translated to 80 samples from pregnant and 70 samples from non-pregnant women. Microscopy and culture including biochemical tests were done for the isolation and identification of organisms. Questionnaires assessing socio-demographic characteristics of the patients were administered. The prevalence of various aetiologic agents was found to be higher in pregnant women than in non-pregnant women. Candida albicans was more prevalent in pregnant women. Twenty eight samples (35.0%) from the pregnant women yielded C. albicans with p < 0.05. Age range of 16-30 years and ≥ 45 years had high prevalence of C. albicans, though more (40%) in pregnant women. While non-pregnant women in the age group 16-30 years had the highest prevalence of G. vaginalis, 8 (26.7%). Among pregnant women, the widowed had a higher prevalence rate of C. albicans, infection (50%) which was not statistically significant. The divorced non-pregnant women had the highest prevalence of C. albicans with p < 0.05 which was statistically significant. This study also revealed that pregnant women in their second trimester of pregnancy had more C. albicans infection, 15 (46.9%) when compared to other trimesters of pregnancy. Women who were pregnant for the first time or primigravidae had higher prevalence of C. albicans, 13 (37.1%) when compared to others. Pregnant women who use contraceptives prior to their recent pregnancies were found to have more infections of G. vaginalis, 14 (93.3%). Non-pregnant women on antibiotics had increased prevalence of C. albicans, 44.4%. The highest prevalence of C. albicans and T. vaginalis, 5 (6.3%) coinfection was seen in pregnant women. Irrespective of the women’s status, none were coinfected with the three microbial agents.


The aim of the study was to evaluate the toxic effect of Datura innoxia seeds and leaves on experimental rats by determining the elements content of seeds and leaves, the chemical compounds in aqueous and methanolic extracts of seeds and leaves and the chemical compounds in the stomach content of rats. Seeds and leaves were collected from El-Obied, North Kordofan State, Sudan, in October, 2016. The aqueous and methanol extracts were carried out by using maceration method and soxhelt apparatus respectively. Sixty five male albino wister rats, three months old and with an average body weight ranged 110-120 g, were randomly divided into thirteen groups, consisting of five rats in each group. Group 1 served as control and fed with normal rats food and water for thirty days. Groups 2, 6 and 10 administered aqueous seeds extract, groups 4, 8 and 12 received methanol seeds extract, groups 3, 7 and 11 received aqueous leaves extracts, groups 5, 9 and 13 received methanol leaves extract, all the groups received the same type of extract were administered 40, 60 and 80 mg/kg body weight respectively. The extracts administered to the rats intra gastrically using cathodal tube daily for thirty days. The elements in the leaves and seeds (K, Ca, S, Si, Cl, Fe, Al, P, Mg, Ti, Mn, Zn, Sr, Cu, V, Br and Zr) were determined by energy-dispersive X-ray fluorescence (EDXRF) spectroscopy. K content was the highest in seeds (5.469 ± 0.021%), Ca and S the highest in leaves (2.461 ± 0.019%, 1.254 ± 0.022 % respectively). The elements Ti, Mn, Sr, V, Br and Zr were detected in the leaves with range concentration 0.062-0.002%. The elements Si, Cl, Fe, Al, P, Mg and Zn concentration in seeds varied from 0.002 to 0.942% and in leaves varied from 0.014 to 0.346%. The concentration of these elements did not exceed the standard dangerous toxic levels. The effects of oral administration of leaves and seeds extracts to 60 healthy rats over 30 days were evaluated by monitoring the chemical changes of stomach contents. The analysis by gas chromatography-mass spectrometry (GC-MS) of aqueous and methanolic extracts revealed the presence of alkaloids (scopolamine, atropine and hyoscyamine), fatty acids, esters, amides, amino acids, ketones, coummarins, terpinoids, phenols, alcohols and hydrocarbons compounds. New compounds appeared in the stomach contents in the treated groups and this suggest that some compounds were metabolized and circulated in the body after the oral administration of leaves and seeds extract. The study concluded that the toxicity of seeds and leaves (methanolic and aqueous) extracts are nearly have the same toxic effects on rats due to their same active ingredients (alkaloids) and the oral administration of the extracts was found to be safe up to 40 mg/kg.


Fingerprint analysis by HPTLC is an effective and powerful tool for linking the bioactive components profile of the plants with botanical identity and for estimation of chemical biomarkers. Tephrosia apollinea has been used in folk medicine to treat inflammation and relieving pain, as well as for diarrhea and abdominal pain. A densitometric High Performance Thin Layer Chromatography (HPTLC) fingerprinting method has been developed for the simultaneous determination and quantification of (-)-pseudosemiglabrin (SSG) and isoglabratephrin (IGP) in different parts of Tephrosia apollinea collected in summer and winter. The study revealed that SSG and IGP are the major components in T. apollinea and found in all parts of the plant at different amount. The proposed HPTLC method was found to be convenient for rapid screening of active components present in ethanol extracts of T. apollinea and can be used for analysis and routine quality control of the raw materials as well as formulations containing Tephrosia species


Introduction : Music has been widely used in our daily life and has an impact on performance in sports and exercise settings. Many researchers have explored the benefits of different type of music during sports activity and athletic performance. Purpose : This study aims to investigate the effect of self-selected/preferred type of music while on shooting performance. Method : This is a quasi-experimental study done among 46 female netball players. Participants need to complete 12 trials shots at three different positions in front of the netball post with and without music within one-week interval between the two settings. Subsequently, after completion of the shooting performance, participants were required to rate the motivational qualities of their selected music using the Brunel Music Rating Inventory-2 (BMRI-2) questionnaire. Result : The result revealed no significant effect on shooting performance between the two settings (p>0.05). However, there was a slight increase in shooting performance displayed when listening with self -selected music. Most of the participants preferred to use fast music type compared to slow and medium music during sports activity. Conclusion : Listening to their selected motivational music minimally improve their shooting performance.


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