Change in Redox Status and Biochemical Parameters in Patient with Desminopathy T341p Several Years after Disease Symptoms Onset

AbstractAdequate hydration represents the balance between the water intake and loss and has an unambiguous significance for public health and it is essential to sustain life. The changes in electrolyte balance which occur during and after training affect on athletes health and performance. Therefore, fluid replacement with adequate mineral composition is of utmost importance. The aim of the present study was to examine the influence of low mineral water from the well Sneznik-1/79 on anthropometric, functional, biochemical parameters and redox status of professional basketball players. In total, 17 male basketball players were included, during the pre-competitive mesocycle, and after the initial testing, they were randomly divided into two groups: group 1 – consumed the commercial drinking water for four weeks (n = 7), and group 2 – consumed water from the well Sneznik-1/79 for four weeks (n = 10).Determination of the anthropometric, functional, biochemical parameters and redox status was performed. Our results pointed out that consumption of mineral water from the well Sneznik is completely safe from the aspect of affecting various anthropometric, functional and biochemical parameters as well as systemic oxidative stress of professional athletes. In addition, existence of discretely better effects over commercial drinking water indicates that a long period of monitoring may certainly be of interest for further investigation.

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Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16020274 ◽

2019 ◽

Vol 16 (2) ◽

pp. 274 ◽

Cited By ~ 62

Author(s):

Milena Andjelkovic ◽

Aleksandra Buha Djordjevic ◽

Evica Antonijevic ◽

Biljana Antonijevic ◽

Momcilo Stanic ◽

...

Keyword(s):

Toxic Metals ◽

Biochemical Parameters ◽

Real Life ◽

Redox Status ◽

Single Exposure ◽

Accumulation Of Metals ◽

Liver And Kidney ◽

Mixture Group ◽

Hematological And Biochemical Parameters ◽

Cadmium And Lead

Background: Cadmium and lead are widespread and non-biodegradable pollutants of great concern to human health. In real life scenarios, we are exposed to mixtures of chemicals rather than single chemicals, and it is therefore of paramount importance to assess their toxicity. In this study, we investigated the toxicity of Cd and Pb alone and as a mixture in an animal model of acute exposure. Methods: Experimental groups received a single treatment of aqueous solution of Cd-chloride (15 and 30 mg/kg body weight (b.w.) and Pb-acetate (150 mg/kg b.w.), while the mixture group received 15 mg Cd/kg b.w. and 150 mg Pb/kg b.w. Toxic effects of individual metals and their mixture were investigated on hematological and biochemical parameters, and the redox status in the plasma, liver, and kidneys of treated Wistar rats. Results: Tissue-specific changes were recorded in various parameters of oxidative damage, while the accumulation of metals in tissues accompanied the disturbances of both hematological and biochemical parameters. It was observed that the level of toxic metals in tissues had a different distribution pattern after mixture and single exposure. Conclusions: Comprehensive observations suggest that exposure to Cd and Pb mixtures produces more pronounced effects compared to the response observed after exposure to single metal solutions. However, further research is needed to confirm toxicokinetic or toxicodynamic interactions between these two toxic metals in the organisms.

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Effects of Cottonseed Meal on Growth Performance, Liver Redox Status, and Serum Biochemical Parameters in Goslings

10.21203/rs.3.rs-175518/v1 ◽

2021 ◽

Author(s):

Jun Yu ◽

Haiming Yang ◽

Qingyu Sun ◽

Xuean Xu ◽

Zhengfeng Yang ◽

...

Keyword(s):

Growth Performance ◽

Cottonseed Meal ◽

Feed Intake ◽

Biochemical Parameters ◽

Average Daily Gain ◽

Radical Scavenging ◽

Redox Status ◽

Serum Biochemical Parameters ◽

High Concentration ◽

Serum Biochemical

Abstract Background: Cottonseed meal (CSM), a relatively rich source of protein and amino acids, is used as an inexpensive alternative to soybean meal (SBM) in poultry diets. Two experiments were conducted to investigate the effects of CSM on growth performance, liver redox status, and serum biochemical parameters in goslings. In experiment 1, 300 1-d-old male goslings were randomly divided into 5 groups (10 goslings/replicate, 6 replicates/group) and subjected to a 28-d experiment. In experiment 2, 240 28-d-old male goslings were randomly divided into 5 groups (8 goslings/replicate, 6 replicates/group) and subjected to a 35-d experiment. Five isonitrogenous and isoenergetic diets were formulated to produce diets in which 0% (control), 25% (CSM25), 50% (CSM50), 75% (CSM75), and 100% (CSM100) of protein from SBM was replaced by protein from CSM.Results: In experiment 1, dietary CSM was associated with linear decreases in body weight, average daily feed intake and average daily gain and linear increases in the feed-to-gain ratio and mortality from 1 to 28 d of age (P < 0.05). Increased dietary CSM was associated with linear decreases in the hydroxyl radical scavenging ability and superoxide dismutase, catalase and glutathione peroxidase activities in the liver (P < 0.05). Dietary CSM was associated with linear decreases in serum total protein, albumin, and globulin concentrations and linear increases in serum uric acid concentrations (P < 0.05). In experiment 2, the growth performance from 29 to 63 d, redox status indicators (except for malondialdehyde [MDA]) in the liver, and serum biochemical parameters at d 63 were not affected by dietary CSM concentrations (P > 0.05). The MDA content in the liver in the CSM100 group was lower than those in the other four groups (P < 0.05).Conclusion: CSM in gosling diets should not exceed 7.08% in the early growth stage (d 1 to 28), but it can be increased to 22.65% from d 29 to 63. A high concentration of CSM may reduce growth performance in 1- to 28-d-old goslings due to decreases in feed intake, liver metabolism and antioxidant capacity.

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The evaluation of glutathione concentration in whole blood of Holstein dairy calves

Acta Veterinaria Brno ◽

10.2754/avb201988020129 ◽

2019 ◽

Vol 88 (2) ◽

pp. 129-141

Author(s):

Andrea Nečasová ◽

Alena Pechová ◽

R. Bodor ◽

M. Masár ◽

Milada Holasová

Keyword(s):

Aspartate Aminotransferase ◽

Biochemical Parameters ◽

Metabolic Profile ◽

Reduced Glutathione ◽

Redox Status ◽

Dairy Calves ◽

Gamma Glutamyltransferase ◽

Holstein Calves ◽

Transition Milk ◽

Metabolic Indices

The aim of this study was to evaluate the concentrations of total (T-GSH), oxidized (GSSG) and reduced glutathione (GSH) in blood of clinically healthy calves, to assess the effect of sex and age together with the type of feeding on its concentrations, and to assess the relationships between glutathione and metabolic indices. A total of 117 Holstein calves at the age of 1 day to 6 months were divided according to age and together with the type of feeding into 4 groups: colostrum and transition milk (n = 20), native milk (n = 39), milk replacer (n = 29) and total mixed ration (n = 29). Blood serum was used for the assessment of the metabolic profile of calves. The concentrations of individual forms of glutathione (mean ± SEM) were as follows: T-GSH: 789.1 ± 19.4 µmol/l, GSSG: 54.2 ± 4.3 µmol/l, GSH: 681.6 ± 15.3 µmol/l, and GSH/GSSG: 41.1 ± 5.9, with the coefficients of variability of 26.6%, 85.3%, 24.3% and 157.4%, respectively. Age and the type of feeding affected GSSG (P ≤ 0.01) and GSH/GSSG (P ≤ 0.01). The relationships between glutathione and biochemical parameters were mostly weak. T-GSH correlated with creatinine (P ≤ 0.05) and chlorides (P ≤ 0.05); GSSG correlated with albumin (P ≤ 0.01), creatinine (P ≤ 0.01), cholesterol (P ≤ 0.05), aspartate aminotransferase (P ≤ 0.01), alanine aminotransferase (P ≤ 0.01), gamma-glutamyltransferase (P ≤ 0.05) and calcium (P ≤ 0.05); GSH/GSSG ratio correlated with creatinine (P ≤ 0.01), cholesterol (P ≤ 0.05), aspartate aminotransferase (P ≤ 0.05), gamma-glutamyltransferase (P ≤ 0.01) and calcium (P ≤ 0.05). The evaluation of individual forms of glutathione helps in estimation of redox status in healthy animals and their monitoring can detect the stress extent.

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Effects of Dietary Microalgae Nannochloropsis gaditana on Serum and Redox Status in Obese Rats Subjected to a High Fat Diet

Phytothérapie ◽

10.3166/phyto-2018-0019 ◽

2018 ◽

Vol 17 (4) ◽

pp. 177-187 ◽

Cited By ~ 2

Author(s):

A. Bendaoud ◽

F.Z. Baba Ahmed ◽

H. Merzouk ◽

S. Bouanane ◽

S. Bendimerad

Keyword(s):

Bioactive Compounds ◽

High Fat Diet ◽

Biochemical Parameters ◽

Redox Status ◽

Male Rats ◽

High Fat ◽

Nannochloropsis Gaditana ◽

Tissue Lipids ◽

The Subject ◽

Antioxidant Markers

Marine organisms, including microalgae, are among major subjects of investigation for the research of new molecules with biological activity that may improve responses to metabolic treatment. Microalgae Nannochloropsis gaditana are rich sources of diverse bioactive compounds. In this context, the present study was conducted to evaluate the effects of dietary microalgae Nannochloropsis gaditana in the modulation of biochemical parameters and oxidant/antioxidant markers in rats subjected to a high fat diet. Male rats were fed on control or high fat diet (hyperlipidic/hypercaloric diet), supplemented or not with Nannochloropsis gaditana (10%) for two months. At the end of the experiment, plasma and tissues biochemical parameters and oxidant/antioxidant markers were determined. Our results show that the high fat diet induced a significant increase in body weight, food intake, and adverse alterations in biochemical parameters such as an increase in plasma glucose, triglyceride, cholesterol, and oxidant markers. Nannochloropsis gaditana supplementation in high fat diet induced a reduction in weight gain, plasma, and tissue lipids and attenuates oxidative stress, thus, improving the metabolic status. In conclusion, Nannochloropsis gaditana by the properties of their bioactive compounds seem to have a hypoglycemic, hypolipidemic nature and improves the redox status of the subject, which could prevent and/or attenuate some metabolic disorders associated with obesity.

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Dietary Tea Catechin Inclusion Changes Plasma Biochemical Parameters, Hormone Concentrations and Glutathione Redox Status in Goats

Asian-Australasian Journal of Animal Sciences ◽

10.5713/ajas.2011.11007 ◽

2011 ◽

Vol 24 (12) ◽

pp. 1681-1689 ◽

Cited By ~ 8

Author(s):

Rongzhen Zhong ◽

Wenjun Xiao ◽

Guopu Ren ◽

Daowei Zhou ◽

Chuanyan Tan ◽

...

Keyword(s):

Biochemical Parameters ◽

Redox Status ◽

Glutathione Redox

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The influences of chokeberry extract supplementation on redox status and body composition in handball players during competition phase

Canadian Journal of Physiology and Pharmacology ◽

10.1139/cjpp-2020-0095 ◽

2020 ◽

Author(s):

Nikola Cikiriz ◽

Isidora Milosavljevic ◽

Biljana Jakovljevic ◽

Stefani Bolevich ◽

Jovana Jeremic ◽

...

Keyword(s):

Body Composition ◽

High Density Lipoprotein ◽

Blood Cells ◽

Biochemical Parameters ◽

Density Lipoprotein ◽

Redox Status ◽

The Other ◽

Beneficial Effects ◽

Wide Range ◽

Biochemical Testing

The aim of our study was to investigate the influence of twelve-week consumption of chokeberry extract on redox status, body composition, lipid profile and biochemical parameters in active handball players. The study included 16 handball players, aged 16-24 years (20.26±2.86 years). Every morning before training players received 30mL of liquid chokeberry extract for 12 weeks, during regular competition season. The research consisted of morphofunctional and biochemical testing, which was performed at three points (at the beginning of the study, 6 and 12 weeks after extract consumption). After the chokeberry extract treatment, we noticed significant changes in three main aspects. The 12-week supplementation with chokeberry extract decreased the levels of pro-oxidants (TBARS and nitrites) and increased catalase activity. Analyzing the dynamic of body composition showed a decrease in body fat (9.4±0.5 vs. 7.3±0.6kg), as well as its percent in a body (11.4±0.4 vs. 8.8±0.4%). On the other hand, the analysis showed an increase of high-density lipoprotein (1.3±0.3 vs. 1.6±0.2mmol/L) and hemoglobin (144.4±11.7 vs. 151.7±9.9g/L) after 6-week treatment. At the same time, a decrease in leukocytes (7.2±2.8 vs. 6.5±1.2 109/L) and an increase in red blood cells count (4.9±0.4 vs. 5.5±0.5 109/L) were noticed. Overall, these results emphatically show that the use of chokeberry extract dietary supplement induced a wide range of beneficial effects in the examined group of athletes.

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