Reasonable Application of Moxifloxacin in the Clinical Treatment of Severe Smear-positive Pulmonary Tuberculosis

Background. Sputum smear-positive pulmonary tuberculosis patients expel infectious viable bacilli for a period following the commencement of treatment. Objective. To determine the time to sputum smear conversion and study the factors influencing it. Design. A prospective study was undertaken at our hospital in Rabat over a six-month period on a cohort of 119 sputum smear positive patients. Patients were followed up fortnightly. At each followup, specimens were collected and processed for microscopy using standard protocol. Results. 96.6% of our patients completed the study (4 deaths). Sputum conversion rate was 42% after two weeks, 73% after one month, and 95% after two months. Univariate and stepwise regression analysis showed that patients who had high smear grading, miliary, and bilateral radiologic lesions were more likely to undergo delayed sputum conversion (P<0.05). Other factors were thought to influence sputum conversion but were not statistically proven in our study. Conclusion. Since viable bacilli continue to be expelled for up to two months, infection control measures should be maintained for such a time. Patients with high smear grading, miliary, and bilateral radiologic lesions need to be monitored more closely.

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High initial default in patients with smear-positive pulmonary tuberculosis at a regional hospital in Accra, Ghana

Transactions of the Royal Society of Tropical Medicine and Hygiene ◽

10.1016/j.trstmh.2012.05.002 ◽

2012 ◽

Vol 106 (8) ◽

pp. 511-513 ◽

Cited By ~ 14

Author(s):

F.K. Afutu ◽

R. Zachariah ◽

S.G. Hinderaker ◽

H. Ntoah-Boadi ◽

E. Apori Obeng ◽

...

Keyword(s):

Pulmonary Tuberculosis ◽

Regional Hospital ◽

Smear Positive Pulmonary Tuberculosis

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Relationship Physical Environmental in Bedroom and Familyroom with New Cases of Smear Positive Pulmonary Tuberculosis in the work area of Puskesmas Songgon Banyuwangi

Window of Health Jurnal Kesehatan ◽

10.33368/woh.v1i3.72 ◽

2018 ◽

pp. 141-153

Author(s):

Ayudita Ismiyanti ◽

Corie Indria Prasasti ◽

Erni Astutik

Keyword(s):

Pulmonary Tuberculosis ◽

Simple Random Sampling ◽

Control Group ◽

Case Group ◽

Chi Square ◽

The People ◽

Work Area ◽

Smear Positive Pulmonary Tuberculosis ◽

Chi Square Analysis ◽

Physical Environmental Factors

Tuberculosis (TB) is a contagious infectious disease due to the bacterium Mycobacterium tuberculosis. Until now, TB disease is still one of the world's health problems and its existence is often linked to environmental problems. This study aims to analyze the physical environmental factors of the house, especially in the bedroom and familiy room associated with smear positive pulmonary tuberculosis new cases in the work area of Puskesmas Songgon Banyuwangi. The design of this research is case control, with the comparison of case:control is 1: 2. A total of 15 people from the case group were taken from SITT (Integrated Tuberculosis Information System) Puskesmas Songgon Banyuwangi and selected using simple random sampling method, while 30 control group were neighbors of case group matching based on gender. Dependent variables is new cases of smear positive pulmonary tuberculosis in the work area of Puskesmas Songgon Banyuwangi and independent variables include ventilation, temperature, humidity, and lighting in bedroom and famiy room. The result of chi square analysis showed that there was a significant correlation between bedroom lighting (OR=4,667; 95%CI=1,237-17,600; p=0,043) and family room lighting (OR=4,571; 95%CI=1,182-17,678; p=0,039) with a new case of smear positive pulmonary TB in the work area of Puskesmas Songgon Banyuwangi. Therefore, the need for awareness to the community, especially the people with pulmonary tuberculosis, by health personnel Pukesmas Songgon Banyuwangi about the importance of keeping the home environment to stay healthy, one of them by allowing air to change and sunlight can enter the house by opening the window in every room house in the morning, and replace the brick tile with glass tile. Keywords : Pulmonary Tuberculosis, smear, lighting, bedroom, family room

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Risk factors for mortality among inpatients with smear positive pulmonary tuberculosis

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.35.5.919 ◽

2019 ◽

Vol 35 (5) ◽

Cited By ~ 1

Author(s):

Sidra Hameed ◽

Faisal Faiyaz Zuberi ◽

Sagheer Hussain ◽

Syed Khalid Ali

Keyword(s):

Risk Factors ◽

Pulmonary Tuberculosis ◽

Demographic Data ◽

Sampling Technique ◽

Cross Sectional Study ◽

University Hospital ◽

Smoking History ◽

Cross Sectional ◽

Creative Commons ◽

Smear Positive Pulmonary Tuberculosis

Objective: To evaluate risk factors having significant effect on mortality of smear positive Pulmonary Tuberculosis (PTB) inpatients. Methods: A descriptive cross-sectional study was conducted at Ojha Institute of Chest Diseases, Dow University Hospital Ojha Campus, Karachi. One hundred and seventy (170) inpatients of smear positive PTB confirmed by Acid Fast Bacilli (AFB) smear, aged between 13-80 years were enrolled by using consecutive sampling technique while patients with drug resistant Tuberculosis (TB) and extra pulmonary TB were excluded from the study. Selected patients were interviewed for collecting demographic data and risk factor data by using a standard questionnaire. Results: Out of 170 PTB inpatients, mortality was observed in 23 (13.5%) patients among which male patients were 12 (52.2%), and female were 11 (47.8%). Mortality was significantly associated with increasing age (p=0.003), socioeconomic status (p=0.019), anemia (p=0.03), Chronic Liver Disease (CLD) (p=0.005), Diabetes Mellitus (DM) (p=0.001), Human Immunodeficiency Virus (HIV) (p=0.007), Hypertension (HTN) (p=0.006), recurrent TB (p=0.001), and smoking (p=0.001). Conclusion: Increasing age, poverty, smoking history, and presence of comorbidities like DM, CLD, HIV, hypertension, and anemia are associated with higher mortality in smear positive PTB cases. doi: https://doi.org/10.12669/pjms.35.5.919 How to cite this:Hameed S, Zuberi FF, Hussain S, Ali SK. Risk factors for mortality among inpatients with smear positive pulmonary tuberculosis. Pak J Med Sci. 2019;35(5):---------. doi: https://doi.org/10.12669/pjms.35.5.919 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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