scholarly journals Dalchini (cinnamomum zeylanicum): a versatile spice with significant therapeutic potential

2021 ◽  
pp. 126-136
Author(s):  
Shifali Thakur ◽  
Bhawna Walia ◽  
Gitika Chaudhary
Keyword(s):  
Therapeutic Potential ◽  
Biological Activities ◽  
Active Principle ◽  
Cinnamomum Zeylanicum ◽  
Traditional System ◽  
Therapeutic Uses ◽  
Chewing Gums ◽  
Ancient Times ◽  
Modern Era ◽  
Anti Hiv

Cinnamomum zeylanicum is a widely utilized condiment for its therapeutic uses since ancient times. It is indigenous to Sri Lanka and Southern India. Cinnamon is one of the ancient spice which belongs to the Lauraceae family. In the modern era, it is widely used in industrial products like candies, chewing gums, mouthwash, and toothpaste. It is a well-considered plant remedy used in the treatment of many diseases in a traditional system like Ayurveda and the Folk system of medicine. It is used in many polyherbal formulations for curing various ailments. The plant is enriched with many vital oils and other derivatives such as cinnamaldehyde, cinnamic acid, and cinnamate. Eugenol is the active principle constituent associated with many biological activities. The main therapeutic actions of the plant are antimicrobial, wound healing, antidiabetic, anti-HIV, anti-anxiety, and anti-Parkinson’s. The present review has summarized the therapeutic and pharmacological value of Cinnamomum zeylanicum along with its utilization in the Folklore medicinal system.   

scholarly journals A REVIEW ON THERAPEUTIC POTENTIAL OF HETEROCYCLIC PYRIMIDINE DERIVATIVES AS POTENT ANTIVIRAL AGENTS

2020 ◽  
pp. 30-34
Author(s):  
SAGMA EG ◽  
BASKAR LAKSHMANAN
Keyword(s):  
Therapeutic Potential ◽  
Biological Activities ◽  
Antiviral Agents ◽  
Viral Disease ◽  
Review Article ◽  
Pharmacological Activities ◽  
Therapeutic Uses ◽  
Wide Range ◽  
Derivatives Of ◽  
Anti Hiv

Pyrimidine nucleus exhibited remarkable pharmacological activities. The review of an article indicates that the compounds having pyrimidine nucleus have a wide range of therapeutic uses that include antiviral, anti-inflammatory, antibacterial, anticancer, antiviral, anti-HIV, antihypertensive, sedatives and hypnotics, anticonvulsant, and antihistaminic. This review article is intended to describe the antiviral activity of a compound containing the pyrimidine nucleus. The chemistry of pyrimidine is a thriving field for the study of their pharmacological uses. Numerous methods for the synthesis of pyrimidine as also their diverse reactions offer enormous scope in the field of medicinal chemistry. The review article aims to reveal the work reported on the antiviral synthetic pyrimidine compound and the chemistry and biological activities of pyrimidine during the past few decades. During this review article, we are mainly focusing the viral activities in different derivatives of pyrimidine nucleus. Therefore, we are going to discuss some important issues such as the good ideas to resist our increasing viral disease and the importance of a pyrimidine nucleus in the viral drugs. Hence, these are the main things we are going to discuss in this article.

scholarly journals Phytochemistry, Food Application, and Therapeutic Potential of the Medicinal Plant (Withania coagulans): A Review

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6881
Author(s):  
Muhammad Issa Khan ◽  
Maria Maqsood ◽  
Raakia Anam Saeed ◽  
Amna Alam ◽  
Amna Sahar ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Physical Problems ◽  
Withania Coagulans ◽  
Health Related ◽  
Herbal Plants ◽  
Ancient Times ◽  
Therapeutic Properties ◽  
Anti Fungal

Herbal plants have been utilized to treat and cure various health-related problems since ancient times. The use of Ayurvedic medicine is very significant because of its least reported side effects and host of advantages. Withania coagulans (Family; Solanaceae), a valuable medicinal plant, has been used to cure abnormal cell growth, wasting disorders, neural as well as physical problems, diabetes mellitus, insomnia, acute and chronic hepatic ailments. This review provides critical insight regarding the phytochemistry, biological activities, and pharmacognostic properties of W. coagulans. It has been known to possess diuretic, anti-inflammatory, anti-bacterial, anti-fungal, cardio-protective, hepato-protective, hypoglycemic, anti-oxidative, and anti-mutagenic properties owing to the existence of withanolides, an active compound present in it. Apart from withanolides, W. coagulans also contains many phytochemicals such as flavonoids, tannins, and β-sterols. Several studies indicate that various parts of W. coagulans and their active constituents have numerous pharmacological and therapeutic properties and thus can be considered as a new drug therapy against multiple diseases.

scholarly journals LITHISTID SPONGES DERIVED COMPOUNDS AND THEIR IMPORTANCE IN BIOLOGICAL RESEARCH - A REVIEW

2018 ◽  
Vol 11 (6) ◽  
pp. 57
Author(s):  
Abirla M ◽  
Brindha Devi P
Keyword(s):  
Antifungal Activity ◽  
Cyclic Peptides ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Natural Compounds ◽  
Biomedical Science ◽  
Biological Research ◽  
Bacterial Origin ◽  
Anti Hiv

Lithistid sponges have an important source of complex natural compounds with biological activities. The lithistid sponges are of interest to biomedical science because of the great variety of pharmaceutically relevant biological activities of their chemical extracts and are considered as economically important. The compounds identified in these sponges have therapeutic potential and have been frequently hypothesized to contain compounds of bacterial origin. The peptides identified from these lithistid sponges are found to be the sources of antifungal activity. The active agents of these sponges also have cytotoxic and immunosuppressive activities. Many of the cyclic peptides of lithistid represent the anti-HIV activity. The different structure and biological activities of the compounds derived from these sponges have more chemical aspects too.

scholarly journals A Review on Medicinal Uses of Cinnamomum verum (Cinnamon)

2021 ◽  
Vol 11 (6-S) ◽  
pp. 161-166
Author(s):  
Rashmi Pathak ◽  
Himanshu Sharma
Keyword(s):  
Pharmaceutical Preparations ◽  
Morphological Description ◽  
Volatile Oils ◽  
Cinnamomum Zeylanicum ◽  
Medicinal Uses ◽  
Southern States ◽  
Current Period ◽  
Chewing Gums ◽  
Wide Range ◽  
Anti Hiv

Cinnamomum verum is a spice plant that is well-known for its medicinal and pharmacological qualities. The old botanical synonym for this tree, Cinnamomum zeylanicum, is derived from Sri Lanka's former name, Ceylon. Since ancient times, Cinnamomum zeylanicum has been frequently used as a medicinal condiment. It's native to Sri Lanka and India's southern states. Cinnamomum verum belongs to the Lauraceae family and is also known by the synonym Cinnamomum zeylanicum Blume. It's a dried bark that's been stripped of its outer cork and underlying parenchyma. Cinnamomum verum is a popular medicinal herb with a wide range of applications It has long been used to flavour food and in pharmaceutical preparations to treat a variety of ailments. For commercial purposes, it is commonly used as candies, chewing gums, mouthwash, and toothpaste in the current period. Many volatile oils, primarily cinnamaldehyde, cinnamic acid, and cinnamate, are abundant in the plant. Eugenol is the active principal ingredient linked to a variety of biological functions. This herb is found in almost every pharmacological system on the planet. Each of these features is essential for human health development. Antimicrobial, wound healing, antidiabetic, anti-HIV, anti-anxiety, and anti-are Parkinson's among of the plant's key medical characteristics. The major components of the Cinnamomum verum plant include eugenol, cinnamaldehyde, cinnamyl acetate, copane, and camphor. The pharmacological effects of cinnamon aldehyde have been extensively researched. Every aspect of the plant was thoroughly examined in this study, from its morphological description to its phytochemical profile and therapeutic action. In this review, we've attempted to compile a comprehensive list of its medical and pharmacological qualities. Keywords: Cinnamomum verum, Dalchini, Medicinal Properties, volatile oils, Antimicrobial, Anti-HIV, antidiabetic

scholarly journals Therapeutic Potential of Hydrazones as Anti-Inflammatory Agents

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Anu Kajal ◽  
Suman Bala ◽  
Neha Sharma ◽  
Sunil Kamboj ◽  
Vipin Saini
Keyword(s):  
Therapeutic Potential ◽  
Biological Activities ◽  
Chemical Properties ◽  
Basic Structure ◽  
Active Centers ◽  
Carbon And Nitrogen ◽  
Wide Range ◽  
Anti Inflammatory ◽  
Physical And Chemical ◽  
Anti Hiv

Hydrazones are a special class of organic compounds in the Schiff base family. Hydrazones constitute a versatile compound of organic class having basic structure (R1R2C=NNR3R4). The active centers of hydrazone, that is, carbon and nitrogen, are mainly responsible for the physical and chemical properties of the hydrazones and, due to the reactivity toward electrophiles and nucleophiles, hydrazones are used for the synthesis of organic compound such as heterocyclic compounds with a variety of biological activities. Hydrazones and their derivatives are known to exhibit a wide range of interesting biological activities like antioxidant, anti-inflammatory, anticonvulsant, analgesic, antimicrobial, anticancer, antiprotozoal, antioxidant, antiparasitic, antiplatelet, cardioprotective, anthelmintic, antidiabetic, antitubercular, trypanocidal, anti-HIV, and so forth. The present review summarizes the efficiency of hydrazones as potent anti-inflammatory agents.

scholarly journals The Biological Activities and Therapeutic Potentials of Baicalein Extracted from Oroxylum indicum: A Systematic Review

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5677
Author(s):  
Nik Nur Hakimah Nik Salleh ◽  
Farah Amna Othman ◽  
Nur Alisa Kamarudin ◽  
Suat Cheng Tan
Keyword(s):  
Systematic Review ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Complementary Therapy ◽  
Active Constituent ◽  
Oroxylum Indicum ◽  
Wide Range ◽  
Ancient Times

In Southeast Asia, traditional medicine has a longestablished history and plays an important role in the health care system. Various traditional medicinal plants have been used to treat diseases since ancient times and much of this traditional knowledge remains preserved today. Oroxylum indicum (beko plant) is one of the medicinal herb plants that is widely distributed throughout Asia. It is a versatile plant and almost every part of the plant is reported to possess a wide range of pharmacological activities. Many of the important bioactivities of this medicinal plant is related to the most abundant bioactive constituent found in this plant—the baicalein. Nonetheless, there is still no systematic review to report and vindicate the biological activities and therapeutic potential of baicalein extracted from O. indicum to treat human diseases. In this review, we aimed to systematically present in vivo and in vitro studies searched from PubMed, ScienceDirect, Scopus and Google Scholar database up to 31 March 2020 based on keywords “Oroxylum indicum” and “baicalein”. After an initial screening of titles and abstracts, followed by a full-text analysis and validation, 20 articles that fulfilled all the inclusion and exclusion criteria were included in this systematic review. The searched data comprehensively reported the biological activities and therapeutic potential of baicalein originating from the O. indicum plant for anti-cancer, antibacterial, anti-hyperglycemia, neurogenesis, cardioprotective, anti-adipogenesis, anti-inflammatory and wound healing effects. Nonetheless, we noticed that there was a scarcity of evidence on the efficacy of this natural active compound in human clinical studies. In conclusion, this systematic review article provides new insight into O. indicum and its active constituent baicalein as a prospective complementary therapy from the perspective of modern and scientific aspect. We indicate the potential of this natural product to be developed into more conscientious and judicious evidencebased medicine in the future. However, we also recommend more clinical research to confirm the efficacy and safety of baicalein as therapeutic medicine for patients.

Current Advances in the Biological Activity of Polysaccharides in Dendrobium with Intriguing Therapeutic Potential

2018 ◽  
Vol 25 (14) ◽  
pp. 1663-1681 ◽  
Author(s):  
Chun-Ting Lee ◽  
Heng-Chun Kuo ◽  
Yung-Hsiang Chen ◽  
Ming-Yen Tsai
Keyword(s):  
Biological Activity ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Biological Effects ◽  
Herbal Medicines ◽  
Research Field ◽  
Protective Effects ◽  
Pharmacological Effects ◽  
The Family ◽  
Anti Tumor Activity

The polysaccharides in many plants are attracting worldwide attention because of their biological activities and medical properties, such as anti-viral, anti-oxidative, antichronic inflammation, anti-hypertensive, immunomodulation, and neuron-protective effects, as well as anti-tumor activity. Denodrobium species, a genus of the family orchidaceae, have been used as herbal medicines for hundreds of years in China due to their pharmacological effects. These effects include nourishing the Yin, supplementing the stomach, increasing body fluids, and clearing heat. Recently, numerous researchers have investigated possible active compounds in Denodrobium species, such as lectins, phenanthrenes, alkaloids, trigonopol A, and polysaccharides. Unlike those of other plants, the biological effects of polysaccharides in Dendrobium are a novel research field. In this review, we focus on these novel findings to give readers an overall picture of the intriguing therapeutic potential of polysaccharides in Dendrobium, especially those of the four commonly-used Denodrobium species: D. huoshanense, D. offininale, D. nobile, and D. chrysotoxum.

Synthesis and Biological Activity of Quaternary Quinolinium Salts: A Review

2020 ◽  
Vol 23 (21) ◽  
pp. 2271-2294 ◽  
Author(s):  
Divya Utreja ◽  
Shivali Sharma ◽  
Akhil Goyal ◽  
Komalpreet Kaur ◽  
Sonia Kaushal
Keyword(s):  
Tyrosine Kinases ◽  
Biological Activities ◽  
Polymeric Materials ◽  
Tubulin Polymerization ◽  
Quinoline Derivatives ◽  
Heterocyclic Chemistry ◽  
Biological Profile ◽  
Drug Candidates ◽  
Anti Hiv ◽  
Quinolinium Salts

Heterocyclic chemistry is the only branch of chemistry that has applications in varied areas such as dyes, photosensitizers, coordination compounds, polymeric materials, biological, and many other fields. Quinoline and its derivatives have always engrossed both synthetic chemists and biologists because of their diverse chemical and pharmacological properties as these ring systems can be easily found in various natural products, especially in alkaloids. Among alkaloids, quinoline derivatives i.e. quinolinium salts have attracted much attention nowadays owing to their diverse biological profile such as antimicrobial, antitumor, antifungal, hypotensive, anti-HIV, analgesics and anti-inflammatory, etc. Quinoline and its analogs have recently been examined for their modes of function in the inhibition of tyrosine kinases, proteasome, tubulin polymerization, topoisomerase, and DNA repair. These observations have been guiding scientists for the expansion of new quinoline derivatives with improved and varied biological activities. Quinolinium salts have immense possibilities and scope to investigate these compounds as potential drug candidates. Therefore, we shall present a concise compilation of this work to aid in present knowledge and to help researchers explore an interesting quinoline class having medicinal potential.

Structure and Activity of Pentacyclic Triterpenes Codrugs. A Review

2021 ◽  
Vol 21 ◽  
Author(s):  
Justyna Żwawiak ◽  
Anna Pawełczyk ◽  
Dorota Olender ◽  
Lucjusz Zaprutko
Keyword(s):  
Biological Activities ◽  
Anticancer Activities ◽  
Drug Molecule ◽  
Pentacyclic Triterpene ◽  
Formation Pathway ◽  
Chemical Systems ◽  
Drug Molecules ◽  
Wide Range ◽  
Anti Hiv ◽  
Structure And Activity

: Triterpenes are a wide and important group of compounds that have several promising pharmacological properties, such as hepatoprotective, anti-inflammatory, anti-HIV, antioxidant, or anticancer activities. Such potent substances can be successfully incorporated in more complex chemical systems e.g. codrugs or pro-drugs that have better pharmacological profile. The codrug is connected with a drug formation pathway to chemically cohere at least two drug molecules to improve positive therapeutic efficiency or decrease side effects. The codrug can be cleaved in the organism to generate effective compounds previously used as substrates. This article presents an overview of codrugs that consist of pentacyclic triterpene moiety that is chosen as a basic codrug moiety due to their wide range of vital activities and another drug molecule fragment. It was found that triterpenoid codrugs are characterized by a wide range of biological activities. However, most of them have anticancer potency.

Antimicrobial Potential of Benzimidazole Derived Molecules

2019 ◽  
Vol 19 (8) ◽  
pp. 624-646 ◽  
Author(s):  
Yogita Bansal ◽  
Manjinder Kaur ◽  
Gulshan Bansal
Keyword(s):  
Biological Activities ◽  
Benzimidazole Derivative ◽  
Structural Similarity ◽  
Living System ◽  
Axial Ligand ◽  
Benzimidazole Derivatives ◽  
Research Groups ◽  
Structural Resemblance ◽  
Privileged Structure ◽  
Anti Hiv

Structural resemblance of benzimidazole nucleus with purine nucleus in nucleotides makes benzimidazole derivatives attractive ligands to interact with biopolymers of a living system. The most prominent benzimidazole compound in nature is N-ribosyldimethylbenzimidazole, which serves as an axial ligand for cobalt in vitamin B12. This structural similarity prompted medicinal chemists across the globe to synthesize a variety of benzimidazole derivatives and to screen those for various biological activities, such as anticancer, hormone antagonist, antiviral, anti-HIV, anthelmintic, antiprotozoal, antimicrobial, antihypertensive, anti-inflammatory, analgesic, anxiolytic, antiallergic, coagulant, anticoagulant, antioxidant and antidiabetic activities. Hence, benzimidazole nucleus is considered as a privileged structure in drug discovery, and it is exploited by many research groups to develop numerous compounds that are purported to be antimicrobial. Despite a large volume of research in this area, no novel benzimidazole derived compound has emerged as clinically effective antimicrobial drug. In the present review, we have compiled various reports on benzimidazole derived antimicrobials, classified as monosubstituted, disubstituted, trisubstituted and tetrasubstituted benzimidazoles, bisbenzimidazoles, fused-benzimidazoles, and benzimidazole derivative-metal complexes. The purpose is to collate these research reports, and to generate a generalised outlay of benzimidazole derived molecules that can assist the medicinal chemists in selecting appropriate combination of substituents around the nucleus for designing potent antimicrobials.

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