scholarly journals Assessment and identification of some factors affecting the results of treatment by orthotic bracing for pectus carinatum

2018 ◽  
Vol 2 (5) ◽  
Author(s):  
Trinh Quang Dung ◽  
Nguyen Huu Chut ◽  
Tran Vinh Son
Keyword(s):  
Intervention Study ◽  
Objective Assessment ◽  
Time Of Day ◽  
Pectus Carinatum ◽  
Factors Affecting ◽  
Non Invasive ◽  
Haller Index ◽  
Results Of Treatment ◽  
End Of Treatment ◽  
Invasive Intervention

Objective: Assessment and identification of some factors affecting the outcome of treatment of children withPectus carinatum by orthotic bracing (Non - Invasive Intervention).Subjectives: 86 children with Pectus carinatum end of treatment and re-examination at the RehabilitationDepartment of Viet Nam National Children’s Hospital from January 2015 to January 2017.Methods: The intervention study no control group.Result: 100% of children improved on deformity. The Haller Index increased from 1.81 before interventionto 2.23 after 36 months of intervention (p <0.001). Some factors related to progression: The Haller Index beforetreatment (B = 0.383, p <0.001). Time of day Wearing the brace (B = 0.017; p <0.001).

A Single-Center Trial to Evaluate the Efficacy and Tolerability of Four Microneedling Treatments on Fine Lines and Wrinkles of Facial and Neck Skin in Subjects With Fitzpatrick Skin Types I-IV: An Objective Assessment Using Non-Invasive Devices and 0.33mm Microbiopsies

2021 ◽  
Author(s):  
Christine E Wamsley ◽  
Mikaela Kislevitz ◽  
Jennifer Barillas ◽  
Deniz Basci ◽  
Vishal Kandagatla ◽  
...  
Keyword(s):  
Gene Expression ◽  
Objective Assessment ◽  
Standard Of Care ◽  
Transepidermal Water Loss ◽  
Post Treatment ◽  
Non Invasive ◽  
Muscle Formation ◽  
The Face ◽  
High Resolution Ultrasonography ◽  
Elastin Gene

Abstract Background While ablative techniques have been standard of care for the treatment of fine lines and wrinkles, microneedling is a minimally invasive alternative. Objectives The purpose of this study was to assess the efficacy of microneedling on facial and neck fine lines and wrinkles. Methods 35 subjects between 44 and 65 years old with Fitzpatrick skin types I-IV received four monthly microneedling treatments over the face and neck. Subjects returned one and three months post-treatment. At every visit, high-resolution ultrasonography, optical coherence tomography, transepidermal water loss and BTC-2000 were performed. 0.33mm microbiopsies were collected pre-treatment, before the fourth treatment and three months post-treatment. Results 32 subjects (93.75% female, 6.25% male) completed all seven visits. Facial dermal and epidermal density increased 101.86% and 19.28%, respectively from baseline at three months post-treatment. Facial elasticity increased 28.2% from baseline three months post-treatment. Facial attenuation coefficient increased 15.65% and 17.33% one and three months post-treatment. At study completion, blood flow 300µm deep decreased 25.8% in the face and 42.3% in the neck. Relative collagen type III and elastin gene expression was statistically higher three months post-treatment. However, total elastin protein levels unchanged compared to baseline. 58% of biopsies extracted three months post-treatment showed dermal muscle formation, compared to baseline 15.3%. Conclusions The results illustrate the effects of microneedling treatments. Non-invasive measurements and biopsy data showed changes in skin architecture and collagen/elastin gene expression suggesting skin rejuvenation, with new extracellular matrix production and muscle formation.

scholarly journals Effect of exergaming on wellbeing of residents in a nursing home: a single blinded intervention study

2021 ◽  
Author(s):  
Marlies Gunst ◽  
Isabelle De Meyere ◽  
Hannah Willems ◽  
Birgitte Schoenmakers
Keyword(s):  
Intervention Study ◽  
Positive Impact ◽  
Objective Assessment ◽  
Intervention Group ◽  
Social Contact ◽  
Mental Wellbeing ◽  
Vulnerable Groups ◽  
Future Research ◽  
Control Group ◽  
Average Intensity

Abstract Introduction To improve the quality of life in nursing homes, meaningful activities and social contact are indispensable. Exergames can play a role addressing these needs. Methods In a randomized single blinded controlled intervention study, we investigated the effect of playing exergames on general wellbeing, fun and on social interaction. Results Thirty-five residents participated: 18 residents took part in the intervention group and 17 in the control group. The median mental wellbeing score of the intervention group increased from 42/50 to 45. The median sleep score of the intervention increased from 23/30 to 28. The median pain score of the intervention group improved from 18/20 to 20. The median score on subjective cognition increased from 24/30 to 26 while the mean scores on the objective assessment decreased from 1.8/2 to 1.7. Coaches gave an average fun score of 8.9/10 and an average intensity of exercise score of 11.6/20. Residents and coaches appreciated the social contact. Coaches reported a high feasibility (average of 4.1/5) but a low accessibility and a high intensity of supervision. Conclusions Exergaming is a feasible and pleasant complement to the usual activities with a positive impact on wellbeing, sleep, pain, and perceived cognition. Future research should focus on vulnerable groups and aim to develop a study in an implementation design.

What Are the Factors Affecting Total Sleep Time During Video Polysomnography in Infants?

2020 ◽  
Author(s):  
Grace R. Paul ◽  
Don Hayes ◽  
Dmitry Tumin ◽  
Ish Gulati ◽  
Sudarshan Jadcherla ◽  
...  
Keyword(s):  
Total Sleep Time ◽  
Sleep Time ◽  
Time Of Day ◽  
Apnea Hypopnea Index ◽  
Clinical Factors ◽  
Initial Management ◽  
Factors Affecting ◽  
Modifiable Factors ◽  
Key Points ◽  
Medical Complexity

Objective The aim of the study is to investigate factors affecting total sleep time (TST) during infant polysomnography (PSG) and assess if <4 hours of TST is sufficient for accurate interpretation. Study Design Overall, 242 PSGs performed in 194 infants <6 months of chronological age between March 2013 and December 2015 were reviewed to identify factors that affect TST, including age of infant, location and timing of study, presence of medical complexity, and presence of nasal tubes. A continuum of apnea-hypopnea index (AHI) in relation to TST was reviewed. Data were examined in infants who had TST <4 hours and low AHI. Results Greater TST (p < 0.001) was noted among infants during nocturnal PSGs, at older chronological and post-menstrual ages, and without medical complexity. The presence of nasogastric/impedance probes reduced TST (p = 0.002). Elevated AHIs were identified even in PSGs with TST <4 hours. Short TST may have affected interpretation and delayed initial management in one infant without any inadvertent complications. Conclusion Clinical factors such as PMA and medical complexity, and potentially modifiable factors such as time of day and location of study appeared to affect TST during infant PSGs. TST < 4 hours can be sufficient to identify high AHI allowing physician interpretation. Key Points

Factors affecting pollinator visitation and reproductive success in Sonneratia caseolaris and Aegiceras corniculatum in a mangrove forest in India

2001 ◽  
Vol 17 (3) ◽  
pp. 431-447 ◽  
Author(s):  
SHALINI PANDIT ◽  
B. C. CHOUDHURY
Keyword(s):  
Reproductive Success ◽  
Mangrove Forest ◽  
Time Of Day ◽  
Pollinator Visitation ◽  
Aegiceras Corniculatum ◽  
Factors Affecting ◽  
Plant Reproductive Success ◽  
Sonneratia Caseolaris ◽  
Exclusion Experiments ◽  
Selfing Species

Pollinator visitation to, and the reproductive success of, Sonneratia caseolaris (Sonneratiaceae) and Aegiceras corniculatum (Myrsinaceae) was investigated in a mangrove forest in India. S. caseolaris was shown to be primarily outcrossed and A. corniculatum was shown to be a selfing species. The flowers of both plant species attracted several diurnal and nocturnal visitors. Earlier reports had indicated that S. caseolaris flowered for one night and was exclusively night-pollinated. But flowers of this species were found to be in bloom both at night and during the day, and diurnal visitors to the flowers were more diverse and frequent than nocturnal ones. This was related to the higher volume and energy value of nectar in the morning. The effects of time of day and temperature on visitation rates were quantified. The importance of visitors to plant reproductive success was investigated via controlled visitor-exclusion experiments. Pollinators were expected to be more important for the outcrossing species than for the selfing species, and this was confirmed by the results of the exclusion experiments. In S. caseolaris reproductive success was determined both by pollinator availability and the intensity of flower and fruit predation, while in A. corniculatum it is likely to be resource limited.

Investigation of the nature of the process of delivering a batch of containers from the rear terminal to the port

2021 ◽  
Vol 18 (3) ◽  
pp. 385-392
Author(s):  
Gennadiy M. GROSHEV ◽  
◽  
Alexey G. KOTENKO ◽  
Nadezhda V. KLIMOVA ◽  
Natalia B. FEDOROVA ◽  
...  
Keyword(s):  
Objective Assessment ◽  
Practical Importance ◽  
Process Models ◽  
Delivery Time ◽  
Factors Affecting ◽  
Transport Services ◽  
Factors Influencing ◽  
Simulation Based ◽  
Random Nature ◽  
Technological Model

Objective: Assessment of the need to study the process of delivering a batch of containers from the rear terminal to the port to ensure uninterrupted communication between the rear terminal and the seaport and delivery a batch of containers exactly on time. As a primary task, the problem of analyzing the factors affecting the nature of the delivery process is solved. Methods: The methods of the theory of probability and mathematical statistics were applied in terms of determining the factors that affect the nature of the delivery process. The method of constructing process models was used to create a technological model for the delivery of containers by a block train to the port. Results: A technological model of container delivery by block train is presented. Diagrams were built showing the share of the main deviations from the schedule of container trains by types of operations for traffic, traction, corporate transport services. The main factors influencing the duration of individual operations with container block trains en route and the increase in the delivery time for a batch of containers from rear terminals to the seaport as a whole are identified. The random nature of the duration of the delivery of containers by block trains following the schedule has been established. Practical importance: The need to improve the methodology for choosing a method for delivering containers from the rear terminal to the port using simulation based on the identified factors influencing individual elements of the technological model of container delivery by a block train, deviations from the delivery time of containers, scheduled running of block trains is shown.

Objective duplex ultrasound evaluation of the extracranial circulation in multiple sclerosis patients undergoing venoplasty of internal jugular vein stenoses: A pilot study

2013 ◽  
Vol 30 (2) ◽  
pp. 98-104 ◽  
Author(s):  
P Thibault ◽  
W Lewis ◽  
S Niblett
Keyword(s):  
Multiple Sclerosis ◽  
Blood Flow ◽  
Cerebral Perfusion ◽  
Objective Assessment ◽  
Duplex Ultrasound ◽  
Additional Parameter ◽  
Non Invasive ◽  
Venous Circulation ◽  
Ultrasound Evaluation ◽  
Multiple Sclerosis Patients

Objective Chronic cerebrospinal venous insufficiency (CCSVI) is a condition associated with multiple sclerosis (MS) and manifested by stenoses in the extracranial venous circulation. There is a need for an objective non-invasive assessment of CCSVI that is able to accurately identify the location of stenoses and quantify physiological changes in blood flows following treatment. Method A duplex ultrasound method, extracranial duplex ultrasound (ECDU), is described where the internal jugular veins (IJVs) and vertebral veins (VVs) were examined in the supine and sitting position before and after venoplasty in eight patients with clinically diagnosed MS. High-resolution B-mode imaging was used to detect obvious stenoses, intra-luminal membranes, valve abnormalities and vein wall thickening. ECDU was then used to assess blood flow including reflux. To assess obstruction, venous blood volume flows (BVFs) were taken bilaterally from the proximal (J1), mid (J2) and distal (J3) segments of the IJVs and the mid cervical VVs. To assess cerebral perfusion, bilateral BVF measurements were taken, in the supine position only, from the proximal internal carotid arteries (ICA) and mid cervical vertebral arteries (VA). The global arterial cerebral blood flow (GACBF) was then calculated as the sum of the ICA and VA measurements. Results Pre-venography ECDU detected IJV stenoses or obstruction in all patients. Venography findings were consistent with those of the pre-treatment ECDU with the exception of the detection of bilateral IJV stenoses in two patients diagnosed with unilateral IJV stenosis by ECDU. A significant improvement in GACBF was evident following venoplasty ( p < 0.05). A trend to improvement in the post-treatment BVFs of both the IJVs and the mid cervical VVs was also observed. This improvement was most marked in the left VVs ( p = 0.052) and the J2 segment of right IJVs ( p < 0.05). Conclusion The ECDU examination described provides a reliable objective assessment of IJV and VV stenoses and, with the use of BVFs, can quantify the degree of obstruction. These results support the use of ECDU as a non-invasive post-operative assessment of the success of venoplasty. The ability of ECDU to measure GACBF provides an additional parameter to monitor vascular pathophysiology in MS patients. The current findings support the view that the early symptomatic benefits observed after venoplasty for stenoses in the extracranial venous circulation may be the result of increased cerebral perfusion.

scholarly journals Non-invasive assessment of vasospasm following aneurysmal SAH using C-arm FDCT parenchymal blood volume measurement in the neuro-interventional suite: Technical feasibility

2015 ◽  
Vol 21 (4) ◽  
pp. 479-489 ◽  
Author(s):  
Mudassar Kamran ◽  
Jonathan Downer ◽  
Rufus Corkill ◽  
James V Byrne
Keyword(s):  
Blood Volume ◽  
Objective Assessment ◽  
Transcranial Doppler Sonography ◽  
Aneurysmal Subarachnoid Haemorrhage ◽  
Mr Perfusion ◽  
Treatment Unit ◽  
Non Invasive ◽  
Major Vessel ◽  
Parenchymal Blood Volume ◽  
Perfusion Maps

Introduction Cerebral vasospasm is the leading cause of morbidity and mortality in patients with aneurysmal subarachnoid haemorrhage (SAH) surviving the initial ictus. Commonly used techniques for vasospasm assessment are digital subtraction angiography and transcranial Doppler sonography. These techniques can reliably identify only the major vessel spasm and fail to estimate its haemodynamic significance. To overcome these issues and to enable comprehensive non-invasive assessment of vasospasm inside the interventional suite, a novel protocol involving measurement of parenchymal blood volume (PBV) using C-arm flat detector computed tomography (FDCT) was implemented. Materials and methods Patients from the neuro-intensive treatment unit (ITU) with suspected vasospasm following aneurysmal SAH were scanned with a biplane C-arm angiography system using an intravenous contrast injection protocol. The PBV maps were generated using prototype software. Contemporaneous clinically indicated MR scan including the diffusion- and perfusion-weighted sequences was performed. C-arm PBV maps were compared against the MR perfusion maps. Results Distribution of haemodynamic impairment on C-arm PBV maps closely matched the pattern of abnormality on MR perfusion maps. On visual comparison between the two techniques, the extent of abnormality indicated PBV to be both cerebral blood flow and cerebral blood volume weighted. Conclusion C-arm FDCT PBV measurements allow an objective assessment of the severity and localisation of cerebral hypoperfusion resulting from vasospasm. The technique has proved feasible and useful in very sick patients after aneurysmal SAH. The promise shown in this early study indicates that it deserves further evaluation both for post-SAH vasospasm and in other relevant clinical settings.

Abstract TP335: Comparative Impact of Timing From Ictus to Intracerebral Hemorrhage Evacuation on Outcome in MISTIE III, STICH I & II Trials

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Sean P Polster ◽  
Julian Carrion-Penagos ◽  
Barbara A Gregson ◽  
Ying Cao ◽  
Richard E Thompson ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Functional Outcome ◽  
Previous Analysis ◽  
Surgical Removal ◽  
Crossing Over ◽  
Affected Patient ◽  
Hematoma Volume ◽  
Probability Of Survival ◽  
End Of Treatment ◽  
Invasive Intervention

Introduction: Completion of the MISTIE procedure requires a period of hematoma stability before and during hematoma removal and, if necessary, dosing of rtPA which can take days to complete. Early surgery was intended in the STICH I and II trials, yet was performed after varying delays. No previous analysis has evaluated the timing for hematoma removal on outcomes in these trials. Objective: Determine if time from ictus to completion of hematoma removal may have affected patient outcome in three large surgical clinical trials of ICH evacuation. Methods: Patients randomized to surgery in the MISTIE III (n=242), STICH I (n=464) and STICH II (n=266) trials who received the procedure were analyzed, excluding cases crossing over to surgery. Time from ictus to end of treatment, defined as 24 hours after last dose in (MISTIE III) or time to craniotomy (STICH I and II), was analyzed in relation to likelihood of survival and functional outcome at 180 days. Cubic spline models with dichotomized outcomes were used. Results: The probability of achieving an mRS 0-3 increased significantly with longer time until completion of the procedure, up to 83 hours post-ictus, and worsened with longer delays thereafter (p=0.05). Better mRS was also achieved in STICH I patients with longer time until surgical removal, up to 60 hours post-ictus (p=0.0002), but not with longer delays (p=0.49). In STICH II (lobar cases), there was greater likelihood of mRS 0-3 with longer delay after 22 hours post-ictus (p=0.004), but not with earlier surgery (p=0.19). There was no significant benefit in survival, with earlier intervention across modalities and trials. Adjustment by initial hematoma volume further validated that early procedures do not favor survival or achieving a mRS 0-3. Conclusion: Early hematoma evacuation up to 60-80 hours post-ictus does not increase the probability of survival nor a good functional outcome in non-herniating ICH patients included in clinical trials, likely in view of bleeding instability. This was true in minimally invasive intervention as well as open surgeries.

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