scholarly journals Les tumeurs de Krukenberg de l'ovaire d'origine rectale

2021 ◽  
Vol 8 (1) ◽  
pp. 92-95
Author(s):  
Raouf Menoura ◽  
◽  
Rym Bouhraoua ◽  
Sofia Bicha ◽  
Fateh Hammoudi ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Pelvic Pain ◽  
Ovarian Tumors ◽  
Krukenberg Tumor ◽  
Synchronous Tumors ◽  
Ovarian Metastases ◽  
Rare Tumors ◽  
Ovarian Stroma ◽  
Krukenberg Tumors ◽  
Surgery Department

Krukenberg tumors (TK) define themselves as ovarian metastases from cancer more often digestive. These are rare tumors that represent 1 to 2% of ovarian tumors. They are characterized by the presence of “kitten ring” cells filled with mucus and a pseudo-sarcomatous proliferation of the ovarian stroma. Their evolution is quickly fatal. We report 1 case of Krukenberg tumor observed and operated on in June 2020 at the surgery Department B CHU Constantine. The symptoms began with a rectal syndrome with transient episodes of pelvic pain. In this regard, we will recall the epidemiological, clinical, and evolutionary characteristics of this disease. Keywords: Krukenberg tumor, rectal cancer, ovarian metastases, synchronous tumors, posterior pelvectomy.

scholarly journals Krukenberg Tumor in Association with Ureteral Stenosis Due to Peritoneal Carcinomatosis from Pulmonary Adenocarcinoma: A Case Report

Medicina ◽  
2020 ◽  
Vol 56 (4) ◽  
pp. 187
Author(s):  
Irina Balescu ◽  
Nona Bejinariu ◽  
Simona Slaniceanu ◽  
Mircea Gongu ◽  
Brandusa Masoud ◽  
...  
Keyword(s):  
Peritoneal Carcinomatosis ◽  
Pulmonary Adenocarcinoma ◽  
Krukenberg Tumor ◽  
Ureteral Stenosis ◽  
Ovarian Metastases ◽  
Pulmonary Lesions ◽  
Krukenberg Tumors ◽  
The Right ◽  
Immunohistochemical Studies ◽  
Rare Situation

Krukenberg tumors from pulmonary adenocarcinoma represent an extremely rare situation; only a few cases have been reported. The aim of this paper is to report an unusual such case in which almost complete dysphagia and ureteral stenosis occurred. The 62-year-old patient was initially investigated for dysphagia and weight loss. Computed tomography showed the presence of a thoracic mass compressing the esophagus in association with a few suspect pulmonary and peritoneal nodules, one of them invading the right ureter. A biopsy was performed laparoscopically on the peritoneal nodules. The right adnexa presented an atypical aspect; right adnexectomy was also found. The histopathological and immunohistochemical studies confirmed that the primitive origin was pulmonary adenocarcinoma. Although both peritoneal carcinomatosis and ovarian metastases from pulmonary adenocarcinoma represent a very uncommon situation, this pathology should not be excluded, especially in cases presenting suspect pulmonary lesions.

scholarly journals Krukenberg tumor in a young female arising from a primary adenocarcinoma of stomach: a case report

2021 ◽  
Vol 10 (6) ◽  
pp. 2523
Author(s):  
Riddhi Parmar ◽  
Mansi Davda ◽  
Navin Patel ◽  
Keval Arvindbhai Patel
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Young Female ◽  
Primary Site ◽  
Young Age ◽  
Ovarian Tumors ◽  
Primary Adenocarcinoma ◽  
Krukenberg Tumor ◽  
Bilateral Involvement ◽  
Krukenberg Tumors

Krukenberg tumor is a malignancy of ovary that metastasizes from a primary site. Krukenberg tumors are uncommon and account for less than 2% of all ovarian tumors. It is usually a bilateral involvement of ovaries from the metastatic deposit from adenocarcinoma of the stomach. Krukenberg tumors mostly occur after 40 years. Metastatic ovarian tumors in young age are very rare. Here, we reported a very rare case of bilateral Krukenberg tumors of the ovaries arising from a primary adenocarcinoma of the stomach in a 20 year old Indian female.

Immunoexpression of Inhibin α Subunit, Inhibin/Activin βA Subunit and CD99 in Ovarian Tumors

2000 ◽  
Vol 124 (4) ◽  
pp. 563-569 ◽  
Author(s):  
Yoon-La Choi ◽  
Hy-Sook Kim ◽  
Geunghwan Ahn
Keyword(s):  
Differential Diagnosis ◽  
Granulosa Cell ◽  
Mucinous Carcinoma ◽  
Ovarian Tumors ◽  
Serous Carcinoma ◽  
Α Subunit ◽  
Stromal Tumors ◽  
Epithelial Tumors ◽  
Krukenberg Tumors ◽  
Sex Cord Stromal Tumors

Abstract Objective.—Anti–inhibin α and inhibin/activin βA subunit and anti-CD99 monoclonal antibodies (mAbs) have recently been demonstrated to be able to label ovarian granulosa cells; thus, they may be of value in the diagnosis of granulosa cell tumors. The present study aimed to determine what combination of these mAbs may be useful for the differential diagnosis of sex cord–stromal tumors of ovary. Design.—Immunohistochemical analyses with anti–inhibin α and inhibin/activin βA subunit antibody and anti-CD99 mAb were performed on 42 ovarian tumors, including sex cord–stromal tumors (29), ovarian epithelial cancers (10), and Krukenberg tumors (3). Results.—All sex cord–stromal tumors were positive for inhibin α subunit, and 17 cases (58.6%) of sex cord–stromal tumors were immunoreactive for inhibin/activin βA subunit. Epithelial tumors and Krukenberg tumors were all negative for inhibin/activin βA subunit except mucinous carcinoma, which showed strong cytoplasmic immunoreactivity. All sex cord–stromal tumors except one granulosa cell tumor showed membranous staining for CD99. A case of serous carcinoma and a case of mucinous carcinoma were positive for CD99, and the remaining epithelial tumors and Krukenberg tumor were all negative for CD99. Conclusions.—The results of immunohistochemical analysis, together with literature review, suggest that inhibin α subunit may be a useful diagnostic marker for sex cord–stromal tumor of the ovary. In addition, anti-CD99 antibody may be useful for the differential diagnosis between ovarian tumors. Inhibin/activin βA subunit has a limited usefulness in the differential diagnosis of ovarian tumor because of its wider immunoreactivity for both sex cord–stromal tumors and mucinous carcinomas. The differential diagnosis of sex cord–stromal tumors of the ovary would be better made with a combined use of both anti–inhibin α subunit and anti-CD99 mAbs.

Phẫu thuật bảo tồn hậu môn điều trị ung thư trực tràng thấp tại Bệnh Viện Ung Bướu TPHCM

2020 ◽  
Author(s):  
Cuong Pham Hung
Keyword(s):  
Rectal Cancer ◽  
Rectal Carcinoma ◽  
Early Stage ◽  
Anal Verge ◽  
Low Rectal Cancer ◽  
Resection Rate ◽  
Sphincter Saving Resection ◽  
Sphincter Saving ◽  
Surgery Department ◽  
Significant Increment

Purpose: To analyse changes in performing sphincter-saving resection procedures for low rectal cancer in HCMC Oncology Hospital in the last 15 years (2004-2019). Patients and Methods: Medical records of 17 cases of low rectal carcinoma operated on from January through Juin, 2019 in Surgery Department No 2, HCMC Oncology Hospital were studied retrospectively. Data were compared to that of cases of low rectal carcinoma also operated on in HCMC Oncology Hospital from January, 2000 through December, 2004 (2004 group). Results: Compared with 2004 group, the sphincter-saving resection rate significantly increased (53% vs 4%, p<0.001); although there were higher proportions of men (77% vs 36%, p=0.003) and of early stage patients (29% stage I vs 4%, p<0.001). Sphincter-saving resection procedures were performed for 53% low rectal cancer patients (95% CI: 28-77%). All patients with tumors more than 3cm from the anal verge were operated on with sphincter-saving resection procedures. Conclusion: There was a significant increment of sphincter-saving resection for low rectal cancer in HCMC Oncology Hospital in the last 15 years (2004-2019). It was not different from worldwide trends.

scholarly journals Systemic treatment of Krukenberg tumors

2017 ◽  
Vol 30 (4) ◽  
pp. 180-183
Author(s):  
Agnieszka Kolak ◽  
Michal Lozinski ◽  
Slawomir Mandziuk
Keyword(s):  
Colorectal Cancer ◽  
Residual Disease ◽  
Diagnostic Procedures ◽  
Health Condition ◽  
Ovarian Tumors ◽  
Future Research ◽  
Abdominal Girth ◽  
Cancer Symptoms ◽  
Primary Ovarian Cancer ◽  
Krukenberg Tumors

Abstract Of all ovarian tumors with distinct biological features, 10-25% are secondary ovarian tumors. Among the most common cancers that cause ovarian metastasis are breast cancer, colorectal cancer, endometrium, as well as gastric and lateral cancer. Krukenberg tumors remain asymptomatic until the tumor reaches a certain size, as in the case of primary ovarian cancer. Symptoms are non-specific: abdominal pain (42%), postmenopausal bleeding (18%), weight loss (6%) and an increasing abdominal girth (15%). Diagnostic procedures should include physical examination, basic blood and biochemistry tests, radiographic imaging and endoscopy. There are currently no uniform guidelines to be followed in order to treat this cancer. However, the survival rate of selected subgroups of patients may be enhanced by means of cytoreductive surgery (performable among patients with good general health condition), where the metastases are limited only to the ovaries, where the primary tumor is derived from the colorectal cancer, and where there is the absence or minimal residual disease. It is still controversial to use adjuvant chemotherapy following the metastasectomy of Krukenberg tumors. Although this type of treatment seems to provide a survival benefit, there are currently no randomized prospective trials available so as to confirm or deny. Future research should, therefore, be focused on the potentially synergistic effect of surgery and perioperative administration of cytotoxic therapies targeted at high response rates. Studies on new molecularly targeted drugs can also be beneficial.

scholarly journals Krukenberg Tumor: A Rare Cause of Ovarian Torsion

2012 ◽  
Vol 2 ◽  
pp. 6 ◽  
Author(s):  
Sameer Sandhu ◽  
Omar Arafat ◽  
Harshad Patel ◽  
Chandana Lall
Keyword(s):  
Computed Tomography ◽  
Cystic Teratoma ◽  
Primary Site ◽  
Ovarian Torsion ◽  
Krukenberg Tumor ◽  
Radiological Findings ◽  
Acute Presentation ◽  
The Common ◽  
Krukenberg Tumors ◽  
Ct Features

Ovarian torsion is the fifth most common gynecological surgical emergency. Ovarian torsion is usually associated with a cyst or a tumor, which is typically benign. The most common is mature cystic teratoma. We report the case of a 43-year-old woman who came to the Emergency Department with rare acute presentation of bilateral Krukenberg tumors, due to unilateral ovarian torsion. In this case report, we highlight the specific computed tomography (CT) features of ovarian torsion and demonstrate the unique radiological findings on CT imaging. Metastasis to the ovary is not rare and 5 to 10% of all ovarian malignancies are metastatic. The stomach is the common primary site in most Krukenberg tumors (70%); an acute presentation of metastatic Krukenberg tumors with ovarian torsion is rare and not previously reported in radiology literature.

scholarly journals Pancreatic Cancer With Ovarian Metastasis: Clinical Features, Diagnosis and Management

2020 ◽  
Author(s):  
Xingtong Zhou ◽  
Hongtao Cao ◽  
Banbo Zhao ◽  
Zhibo Zheng ◽  
Cheng Qin ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Clinical Features ◽  
Elevated Serum ◽  
Ovarian Metastasis ◽  
The Body ◽  
Ovarian Tumors ◽  
Pancreatic Tumors ◽  
Pancreatic Metastasis ◽  
Ovarian Metastases ◽  
Diagnosis And Management

Abstract Background: To summarize the clinical features, diagnosis and management of pancreatic cancer with ovarian metastasis.Methods: We retrospectively analyzed the clinical data of patients with ovarian metastases of primary pancreatic cancer who were admitted to our hospital from 01/01/1985 to 04/01/2020.Results: In total, there were 3757 female pancreatic-cancer patients. 9 of them were diagnosed with ovarian metastasis at an average age of 51.89 (38-69) years. The reason for the patients’ visit was generally a mass in the lower abdomen and/or abdominal pain. 7 patients had significantly higher serum CA19-9 levels. 8 patients had pancreatic tumors located in the body or tail; 1 patient, in the pancreatic head. All patients underwent excision of ovarian tumors and resection or biopsy of pancreatic tumors. 6 patients had pancreatic ductal adenocarcinoma (PDAC), 2 had pancreatic cystadenocarcinoma (PCC), and 1 had pancreatic neuroendocrine carcinoma (PNEC), all revealed by the pathological results. Ovarian tumors were assessed by pathology and were consistent with pancreatic metastasis. Currently, 2 patients are still alive (followed until 04/2020). The median survival time for all patients was 7 months (2.9-22 months).Conclusions: Pancreatic cancer with ovarian metastases is rare and easily misdiagnosed. When ovarian tumors are suspected to be metastatic, elevated serum CA19-9 may indicate that the primary cancer is pancreatic. Enhanced CT can facilitate diagnostic localization. In addition, if the pancreatic tumor cannot be removed, the ovarian tumor should still be resected to reduce the tumor load and improve quality of life.

Diagnostic Discordance in Intraoperative Frozen Section Diagnosis of Ovarian Tumors: A Literature Review and Analysis of 871 Cases Treated at a Japanese Cancer Center

2020 ◽  
pp. 106689692096051
Author(s):  
Hiroshi Yoshida ◽  
Hiroki Tanaka ◽  
Takafumi Tsukada ◽  
Naoko Abeto ◽  
Mayumi Kobayashi-Kato ◽  
...  
Keyword(s):  
Literature Review ◽  
Frozen Section ◽  
Malignant Potential ◽  
Ovarian Tumors ◽  
Serous Carcinoma ◽  
Low Grade ◽  
Borderline Tumor ◽  
Mucinous Tumor ◽  
Ovarian Metastases ◽  
Frozen Section Diagnosis

Background This study examined the accuracy and pitfalls associated with frozen section diagnosis of primary ovarian tumors and ovarian metastases based on the 2014 World Health Organization classification (WHO) criteria and proposed improvements from a pathologist’s perspective. Methods We microscopically reviewed 871 cases of primary ovarian tumor (N = 802) and ovarian metastasis (N = 69) and compared the results of frozen sections with the final diagnosis. Malignant potential concordance (benign, borderline, or malignant) and specific discordant diagnosis rates were analyzed. Finally, we conducted a unique literature review of specific diagnostic errors in the frozen section diagnosis of primary ovarian tumors. Results Of 802 primary ovarian tumors, 50 (6.2%) cases showed discordant diagnoses in which mucinous carcinoma (40.5%), low-grade serous carcinoma (LGSC; 31.3%), and mucinous borderline tumor (18.4%) were frequently misinterpreted. Of 69 ovarian metastases, all 4 cases of low-grade appendiceal mucinous neoplasm (LAMN) were misdiagnosed as primary ovarian mucinous tumor. A literature review revealed that mucinous/serous borderline tumor or carcinoma accounted for approximately 70% of 217 reported discordant diagnoses. Conclusion In the present study, the concordance rate of malignant potential of the tumor was comparable to that previously reported. Even in the 2014 WHO classification, primary ovarian mucinous borderline tumor/carcinoma and LGSC still comprised the majority of discordant cases. Grossing methods that reduce sampling error are required. LAMN was frequently misinterpreted as a benign or borderline ovarian mucinous tumor. To prevent this error, a differential algorithm integrating clinical information and gross findings should be developed.

Survival benefit of oophorectomy in stage IV gastric cancer patients with Krukenberg tumors.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e16566-e16566
Author(s):  
Ahmed Abdelhakeem ◽  
Brian D. Badgwell ◽  
Naruhiko Ikoma ◽  
Larissa Meyer ◽  
Meina Zhao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Stage Iv ◽  
Primary Objective ◽  
Standard Chemotherapy ◽  
Ovarian Metastases ◽  
Stage Iv Gastric Cancer ◽  
Treatment Data ◽  
Krukenberg Tumors ◽  
Gastric Cancer Patients

e16566 Background: The management of Krukenberg tumors from primary gastric cancer remains unclear and it is unknown if oophorectomy improves survival. The purpose of this study was to compare the overall survival (OS) of patients with ovarian metastases from gastric cancer treated with standard chemotherapy to chemotherapy and oophorectomy. Methods: Between January 2008 and August 2019, we retrospectively analyzed the clinicopathological features and treatment data of 97 patients with stage IV gastric cancer patients with ovarian metastases. Patients were categorized into two groups: Oophorectomy plus standard chemotherapy treatment vs. standard chemotherapy only (non-oophorectomy). The primary objective was to assess OS. Results: A total of 97 patients were identified. 37 (38.1%) patients had oophorectomy and 60 (61.9%) patients did not have oophorectomy. OS was better in the oophorectomy group relative to the non-oophorectomy group (37 months vs. 20 months; P= 0.0554). Survival from the time of diagnosis of ovarian metastases was significantly better in oophorectomy group relative to the non-oophorectomy group (26 months vs. 12 months; P= 0.0006). Conclusions: Our results showed that Oophorectomy in addition to systemic chemotherapy in this unique population seems to confer survival advantage in this retrospective analysis. Prospective evaluation is warranted.

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