scholarly journals The effect of antiviral treatment on SARS-CoV-2 infectious disease progression: A comparison of the multi-state models

2021 ◽  
Author(s):  
Nihan Potas ◽  
Keyword(s):  
Infectious Disease ◽  
Risk Factors ◽  
Disease Progression ◽  
Antiviral Treatment ◽  
Treatment Algorithm ◽  
State Model ◽  
Health Crisis ◽  
Complete Uncertainty ◽  
The Republic ◽  
State Models

Combating SARS-CoV-2 is the first concern and goal of the whole world faced with the global health crisis. Since 2019, the SARS-CoV-2 infection (COVID-19) and even mutated infection cases have been increasing rapidly. From 2019 through 27 August 2021, a total of 214,468,601 individuals were confirmed cases of SARS-CoV-2, including 4,470,969 death toll. Some of these individuals were able to access treatment and some could not, but for a while there was complete uncertainty. It was not known whether those who accessed treatment were lucky, but treatment was based on trial and error because of this uncertainty around the world until data was collected. Therefore, the aim of this study was to model SARS-CoV-2 infectious disease progression from the date of polymerase chain reaction (PCR) test to the date of negative outcome via Bayesian multi-state model approaches considering risk factors such as gender, age, and antiviral treatment. Data from 746 inpatients were collected from August 1st until the December 1st, 2020. For the multi-state model, five various discrete states were selected according to the Republic of Turkey Ministery of Health treatment algorithm. The results showed that Bayesian multi-state models with the Weibull distributed baseline hazard function were more appropriate models in the presence of risk factors and antiviral treatment.

Risk factors for the development of age-related cataracts in the Republic of Bashkortostan

2020 ◽  
pp. 22-23
Author(s):  
G.Z. Israfilova ◽  
◽  
T.R. Gilmanshin ◽  
R.M. Zainullin ◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
Age Related ◽  
Republic Of Bashkortostan ◽  
The Republic

scholarly journals Hepatitis C Virus Prevalence and Risk Factors in a Village in Northeastern Romania—A Population-Based Screening—The First Step to Viral Micro-Elimination

Healthcare ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 651
Author(s):  
Laura Huiban ◽  
Carol Stanciu ◽  
Cristina Maria Muzica ◽  
Tudor Cuciureanu ◽  
Stefan Chiriac ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Treatment ◽  
Population Based ◽  
Hcv Infection ◽  
World Health ◽  
Hcv Rna ◽  
Virus Eradication ◽  
Tertiary Center

(1) Background: The World Health Organization adopted a strategy for the Global Health Sector on Viral Hepatitis in 2016, with the main objective of eliminating hepatitis C virus (HCV) by 2030. In this work, we aimed to evaluate the prevalence of HCV infection and risk factors in a Romanian village using population-based screening as part of the global C virus eradication program. (2) Methods: We conducted a prospective study from March 2019 to February 2020, based on a strategy as part of a project designed to educate, screen, treat and eliminate HCV infection in all adults in a village located in Northeastern Romania. (3) Results: In total, 3507 subjects were invited to be screened by rapid diagnostic orientation tests (RDOT). Overall, 2945 (84%) subjects were tested, out of whom 78 (2.64%) were found to have positive HCV antibodies and were scheduled for further evaluation in a tertiary center of gastroenterology/hepatology in order to be linked to care. In total, 66 (85%) subjects presented for evaluation and 55 (83%) had detectable HCV RNA. Of these, 54 (98%) completed antiviral treatment and 53 (99%) obtained a sustained virological response. (4) Conclusions: The elimination of hepatitis C worldwide has a higher chance of success if micro-elimination strategies based on mass screening are adopted.

scholarly journals The hemocyte counts as a potential biomarker for predicting disease progression in COVID-19: a retrospective study

2020 ◽  
Vol 58 (7) ◽  
pp. 1106-1115 ◽  
Author(s):  
Yufen Zheng ◽  
Ying Zhang ◽  
Hongbo Chi ◽  
Shiyong Chen ◽  
Minfei Peng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Platelet Count ◽  
Disease Progression ◽  
Neutrophil Count ◽  
Calibration Curve ◽  
Lymphocyte Count ◽  
Severe Disease ◽  
Clinical Impact ◽  
Predictive Tool ◽  
Potential Biomarker

AbstractObjectivesIn December 2019, there was an outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, and since then, the disease has been increasingly spread throughout the world. Unfortunately, the information about early prediction factors for disease progression is relatively limited. Therefore, there is an urgent need to investigate the risk factors of developing severe disease. The objective of the study was to reveal the risk factors of developing severe disease by comparing the differences in the hemocyte count and dynamic profiles in patients with severe and non-severe COVID-19.MethodsIn this retrospectively analyzed cohort, 141 confirmed COVID-19 patients were enrolled in Taizhou Public Health Medical Center, Taizhou Hospital, Zhejiang Province, China, from January 17, 2020 to February 26, 2020. Clinical characteristics and hemocyte counts of severe and non-severe COVID patients were collected. The differences in the hemocyte counts and dynamic profiles in patients with severe and non-severe COVID-19 were compared. Multivariate Cox regression analysis was performed to identify potential biomarkers for predicting disease progression. A concordance index (C-index), calibration curve, decision curve and the clinical impact curve were calculated to assess the predictive accuracy.ResultsThe data showed that the white blood cell count, neutrophil count and platelet count were normal on the day of hospital admission in most COVID-19 patients (87.9%, 85.1% and 88.7%, respectively). A total of 82.8% of severe patients had lymphopenia after the onset of symptoms, and as the disease progressed, there was marked lymphopenia. Multivariate Cox analysis showed that the neutrophil count (hazard ratio [HR] = 4.441, 95% CI = 1.954–10.090, p = 0.000), lymphocyte count (HR = 0.255, 95% CI = 0.097–0.669, p = 0.006) and platelet count (HR = 0.244, 95% CI = 0.111–0.537, p = 0.000) were independent risk factors for disease progression. The C-index (0.821 [95% CI, 0.746–0.896]), calibration curve, decision curve and the clinical impact curve showed that the nomogram can be used to predict the disease progression in COVID-19 patients accurately. In addition, the data involving the neutrophil count, lymphocyte count and platelet count (NLP score) have something to do with improving risk stratification and management of COVID-19 patients.ConclusionsWe designed a clinically predictive tool which is easy to use for assessing the progression risk of COVID-19, and the NLP score could be used to facilitate patient stratification management.

scholarly journals How does globalization affect COVID-19 responses?

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Steve J. Bickley ◽  
Ho Fai Chan ◽  
Ahmed Skali ◽  
David Stadelmann ◽  
Benno Torgler
Keyword(s):  
Infectious Disease ◽  
Disease Transmission ◽  
State Capacity ◽  
International Travel ◽  
Health Crisis ◽  
Government Effectiveness ◽  
Policy Responses ◽  
Travel Restrictions ◽  
High Government

Abstract Background The ongoing COVID-19 pandemic has highlighted the vast differences in approaches to the control and containment of coronavirus across the world and has demonstrated the varied success of such approaches in minimizing the transmission of coronavirus. While previous studies have demonstrated high predictive power of incorporating air travel data and governmental policy responses in global disease transmission modelling, factors influencing the decision to implement travel and border restriction policies have attracted relatively less attention. This paper examines the role of globalization on the pace of adoption of international travel-related non-pharmaceutical interventions (NPIs) during the coronavirus pandemic. This study aims to offer advice on how to improve the global planning, preparation, and coordination of actions and policy responses during future infectious disease outbreaks with empirical evidence. Methods and data We analyzed data on international travel restrictions in response to COVID-19 of 185 countries from January to October 2020. We applied time-to-event analysis to examine the relationship between globalization and the timing of travel restrictions implementation. Results The results of our survival analysis suggest that, in general, more globalized countries, accounting for the country-specific timing of the virus outbreak and other factors, are more likely to adopt international travel restrictions policies. However, countries with high government effectiveness and globalization were more cautious in implementing travel restrictions, particularly if through formal political and trade policy integration. This finding is supported by a placebo analysis of domestic NPIs, where such a relationship is absent. Additionally, we find that globalized countries with high state capacity are more likely to have higher numbers of confirmed cases by the time a first restriction policy measure was taken. Conclusions The findings highlight the dynamic relationship between globalization and protectionism when governments respond to significant global events such as a public health crisis. We suggest that the observed caution of policy implementation by countries with high government efficiency and globalization is a by-product of commitment to existing trade agreements, a greater desire to ‘learn from others’ and also perhaps of ‘confidence’ in a government’s ability to deal with a pandemic through its health system and state capacity. Our results suggest further research is warranted to explore whether global infectious disease forecasting could be improved by including the globalization index and in particular, the de jure economic and political, and de facto social dimensions of globalization, while accounting for the mediating role of government effectiveness. By acting as proxies for a countries’ likelihood and speed of implementation for international travel restriction policies, such measures may predict the likely time delays in disease emergence and transmission across national borders.

scholarly journals COVID-19 and Parental Burnout: Parents Locked Down but Not More Exhausted

2021 ◽  
pp. 0192513X2110300
Author(s):  
Sarah Le Vigouroux ◽  
Astrid Lebert-Charron ◽  
Jaqueline Wendland ◽  
Emilie Boujut ◽  
Céline Scola ◽  
...  
Keyword(s):  
Risk Factors ◽  
Emotional Experience ◽  
Daily Functioning ◽  
Age Group ◽  
Health Crisis ◽  
Environmental Consequences ◽  
Number Of Children ◽  
Two Samples ◽  
Parenting Role ◽  
At Home

Lockdowns put in place in response to the COVID-19 health crisis have changed daily functioning for families and potentially the emotional experience of individuals in their parenting role. Our study aimed to highlight the importance of the environmental consequences associated with lockdowns on parental burnout. We compared data on parental burnout levels from two French samples: the first collected in 2018 ( N = 1332) and the second collected during the last month of lockdown ( N = 522). Our results show that parents included during the lockdown period reported significantly, but slightly, higher saturation (a dimension of the parental burnout construct) than parents included 2 years earlier. However, the number of children per age group, maintaining employment, and having to provide schooling at home are not variables that explain differences in the level of parental burnout between our two samples. Our results are discussed with regard to the risk factors identified and the French context.

scholarly journals Calcium and phosphate levels after kidney transplantation and long-term patient and allograft survival

2020 ◽  
Author(s):  
Julio Chevarria ◽  
Donal J Sexton ◽  
Susan L Murray ◽  
Chaudhry E Adeel ◽  
Patrick O’Kelly ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Transplant ◽  
Graft Failure ◽  
Graft Function ◽  
Renal Transplant Recipients ◽  
Post Transplant ◽  
All Cause Mortality ◽  
Transplant Function ◽  
The Republic ◽  
The Impact

Abstract Background Non-traditional cardiovascular risk factors, including calcium and phosphate derangement, may play a role in mortality in renal transplant. The data regarding this effect are conflicting. Our aim was to assess the impact of calcium and phosphate derangements in the first 90 days post-transplant on allograft and recipient outcomes. Methods We performed a retrospective cohort review of all-adult, first renal transplants in the Republic of Ireland between 1999 and 2015. We divided patients into tertiles based on serum phosphate and calcium levels post-transplant. We assessed their effect on death-censored graft survival and all-cause mortality. We used Stata for statistical analysis and did survival analysis and spline curves to assess the association. Results We included 1525 renal transplant recipients. Of the total, 86.3% had hypophosphataemia and 36.1% hypercalcaemia. Patients in the lowest phosphate tertile were younger, more likely female, had lower weight, more time on dialysis, received a kidney from a younger donor, had less delayed graft function and better transplant function compared with other tertiles. Patients in the highest calcium tertile were younger, more likely male, had higher body mass index, more time on dialysis and better transplant function. Adjusting for differences between groups, we were unable to show any difference in death-censored graft failure [phosphate = 1.14, 95% confidence interval (CI) 0.92–1.41; calcium = 0.98, 95% CI 0.80–1.20] or all-cause mortality (phosphate = 1.10, 95% CI 0.91–1.32; calcium = 0.96, 95% CI 0.81–1.13) based on tertiles of calcium or phosphate in the initial 90 days. Conclusions Hypophosphataemia and hypercalcaemia are common occurrences post-kidney transplant. We have identified different risk factors for these metabolic derangements. The calcium and phosphate levels exhibit no independent association with death-censored graft failure and mortality.

P146 Disease progression in del (5q) MDS patients treated with lenalidomide: analysis of risk factors and long-term outcome in 44 patients

2007 ◽  
Vol 31 ◽  
pp. S120-S121
Author(s):  
A.A.N. Giagounidis ◽  
S. Haase ◽  
V. Lohrbacher ◽  
M. Heinsch ◽  
B. Schuran ◽  
...  
Keyword(s):  
Risk Factors ◽  
Disease Progression ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals 478. Psychological Distress among Infectious Disease Physicians during the Response to the COVID-19 Outbreak in the Republic of Korea

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S305-S305
Author(s):  
Se Yoon Park ◽  
Bongyoung Kim ◽  
Dong Sik Jung ◽  
Sook In Jung ◽  
Won Sup Oh ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Psychological Distress ◽  
Infection Control ◽  
Personal Protective Equipment ◽  
Text Message ◽  
Disease Outbreaks ◽  
Maslach Burnout Inventory ◽  
Republic Of Korea ◽  
Protective Equipment ◽  
The Republic

Abstract Background This study aimed to investigate psychological distress among infectious disease (ID) physicians during the coronavirus disease (COVID-19) outbreak in the Republic of Korea. Methods Using an online-based survey link sent via text message and email, we conducted a survey from April 21 to 25, 2020, targeting all ID physicians currently working in ID (n = 265). The questionnaire was based on the Maslach Burnout Inventory-Human Services Survey and the Depression, Anxiety, and Stress Scales, and information was collected on factors protecting against psychological distress and difficulties in relation to COVID-19. Results Of 265 ID physicians, 115 (43.3%) responded, showing burnout (97, 90.4%), depression (20, 17.4%), anxiety (23, 20.0%), and stress (5, 4.3%). There were no differences in terms of distress between ID physicians who were directly involved in the care of patients with COVID-19 or not (Table 1). Greater than 50% of physicians valued their work and felt recognized by others, whereas < 10% indicated that sufficient human and financial support and private time had been provided during the outbreak. The most challenging issues concerned a lack of human resources for COVID-19 treatment or infection control, a shortage of personal protective equipment or airborne infection isolation rooms, pressure for research, and lack of guidelines for COVID-19 management (Figure 1). Table 1. Figure 1. Difficulties in response to the COVID-19 outbreak. Abbreviations: COVID-19, coronavirus disease 19; HCWs, healthcare workers; ICPs, infection control practitioners; IRB, Institutional Review Board; PPE, personal protective equipment Conclusion During the COVID-19 outbreak in the ROK, most respondents reported psychological distress. Preparing strategies for infectious disease outbreaks that support ID physicians is essential. Disclosures All Authors: No reported disclosures

Gait Risk Factors for Disease Progression Differ Between Non-traumatic and Post-traumatic Knee Osteoarthritis

2021 ◽  
Author(s):  
Shawn M. Robbins ◽  
Jean-Pierre Pelletier ◽  
François Abram ◽  
Mathieu Boily ◽  
John Antoniou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Knee Osteoarthritis ◽  
Disease Progression ◽  
Post Traumatic
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